Protein Alignment if and itga2b

DIOPT Version :9

• Sequence 1: NP_001162777.1
• Gene: if / 32661
• FlyBaseID: FBgn0001250
• Length: 1396
• Species: Drosophila melanogaster
• Sequence 2: NP_001003857.1
• Gene: itga2b / 445380
• ZFINID: ZDB-GENE-051031-1
• Length: 1037
• Species: Danio rerio
• Alignment Length: 1054
• Identity: 305/1054 - (28%)
• Similarity: 490/1054 - (46%)
• Gaps: 177/1054 - (16%)

  Fly    20 LILLLIAMSAHGYNIDLPSYVRFRQSSNSMFGFSIAMHKGRSGFYGNQNNVSLIVGAPKFDTSRY 84
            |.:|:......|:|:||..|..|....:|.||||:..::..|      .:||::||||:.:|:
Zfish    12 LSILIFTNHIRGFNLDLNQYTVFSGPEDSYFGFSVDFYQSSS------KSVSVVVGAPRANTN-- 68

  Fly    85 QQGVTEAGGVFKC--SLNDDDCKLVPFDSKGNNRNV---DKEVVDRKSYQWLGATVATGRDSDLV 144
            |.||:..|.||.|  :.....|:.:.||.|| :.|:   :..::..||.|||||:|.|  .::.:
Zfish    69 QSGVSHGGSVFMCPWATRGQSCQTLNFDQKG-DENITFGNMLLMAHKSNQWLGASVRT--YNNYI 130

  Fly   145 VACAPRYVFHTMTPSRAFRIDPVGTC-FTSHNFEEFYEVSPCRTN------NWGYHRQGSCQAGF 202
            :||||.:.::.:.........|||.| ..:....|....:|||..      ..||..:..|:|||
Zfish   131 LACAPLFHWNVLVDQEEAMNTPVGNCQLLNMKTGELANYAPCREEYVYAIYTRGYPDRRYCEAGF 195

  Fly   203 SAAINGNGSRLFIGAPGSWYWQGQ--TYSIPPDAKFPFKPPLYQPFGTGGMASSHDVTRPENQVF 265
            :..|..|| |:.:||||.:|:|||  |.|:                 ...|:|....| |::.:.
Zfish   196 TTDITKNG-RVVLGAPGGYYFQGQIITASL-----------------VNIMSSGSSFT-PKHSMN 241

  Fly   266 STSESASVND--DSYLGYSMVTGDFDGDRSEDVAIGMPRGGNLVGRIVVNRWNMANIFN------ 322
            ..:::....|  |.|||||:..|.|:.|...|..:|:|...:..|.:        .|.|
Zfish   242 GETKTPQRRDYYDLYLGYSVAAGKFNNDNIPDYVVGVPNDLHTAGSV--------KIINGATVPL 298

  Fly   323 -----ITGRQIGEYFGYSLATSDVDGDGLDDLLIGAPMYTDPDNVEGKYDVGRVYILLQ------ 376
                 |:|.||..|||:|:|.:|::.||.||:|||||::.:..:.:...:||:||:.||
Zfish   299 QIMKAISGTQIASYFGHSVAVTDINRDGWDDILIGAPLFMEQLSTQKFREVGQVYVYLQRNDFSF 363

  Fly   377 -GGPTEEKRWTTEHIRDGYHSKGRFGLALTTLGDVNGDGYGDFAVGAPYDGPEGRGVVYIFHGSP 440
             ..|.:        |..|.::.||||.|:..|||::.||:.|.|||||  |....|.|:|:.|..
Zfish   364 ASRPNQ--------ILAGTYAYGRFGSAIAPLGDLDHDGFNDVAVGAP--GSVDGGKVFIYLGKS 418

  Fly   441 MGPLAKPSQIIKS--EQLVEGAPYPRTFGFALSGGLDMDGNTYPDLAVGAYSSDQVFIFKSRPVA 503
            .|...:..|:|:|  ..|::    |..|||::.||.|:|.|.||||.:||:.:.:|..::::.|.
Zfish   419 GGLSTQYVQVIESPFRSLID----PPMFGFSIRGGTDIDDNGYPDLIIGAWGASKVVTYRAQAVV 479

  Fly   504 AVNAETSFASNSKLISLDDRSCQLVRDHKKVPCMLLTTCWSYTGRYLPEQLDFDVSWLLDAKKLL 568
            ...|..||..:  |::.:|:.|||.:....:.|..:..|...:|..:|:|:.|:....||..|..
Zfish   480 RTQARLSFFPD--LLNPEDKFCQLQQSGTYITCFTIMACIRVSGHRIPQQIVFNTELQLDRMKQS 542

  Fly   569 NPRMFFLRDEGKNIRNQTIRLNYGQK-YCLNETVYLLDKVQDKLTPLEVEARYNLRSSRPLDPMV 632
            ..|...|.|..:...|..|.::...: .|.|.|.|||.:.:|||:|:.:...|:|..|:   ..|
Zfish   543 MARRTLLLDSNQPYTNFQISVDRNSRDVCRNFTAYLLPEFKDKLSPIFISVNYSLADSQ---NAV 604

  Fly   633 RHRRSILEPVIDQNREIVLRDAINIQKNCGPDNICEPDLKLK-VSTVDKYLFGSPEPLVIEVFIS 696
            .|.:|:   .:.|.|.|:         ||||||:|.|||:|| |::.:..|.|...|.::.:...
Zfish   605 LHGQSV---AVGQTRIIL---------NCGPDNVCIPDLQLKAVTSTEPILIGDENPALLIIEAE 657

  Fly   697 NTNEDAFEAAFYMVTPPDLQFRKLQQLGEKKD-TPITCSPPTPENNHTLKCDIGNPLESGKIAHF 760
            |..|.|:|...|:..|.:..::.:  |...:| :.:.|.......:..:.||:|||||:|:  ..
Zfish   658 NQGEGAYETELYISPPANTHYQGV--LSNHEDFSALVCGQKKENGSVIVVCDLGNPLEAGQ--QL 718

  Fly   761 KISLVPEEKYGSSSSYD-------FYWEANSTNLEKPGSEYDNKIRQSVGIWVDTDLDIKGTSLP 818
            |..|     |.|....:       |..:..|.|.:...|   |.::..|.:.....|:::|.|.|
Zfish   719 KAGL-----YFSMGDLEQVENHITFQMQIRSKNSQNSDS---NLVQLQVNVTAVASLEMRGVSSP 775

  Fly   819 -DYQL----YKADDYKELENATKEDDIGPQVVHIYEIRNNRPSIIEEAEVFIHLPYETIVGDPLM 878
             |..|    :::.||.|     ..|::||.:.|:||:||..||     .|.:.|..|..|.....
Zfish   776 VDCVLPISKWESKDYPE-----DLDEVGPLIEHVYELRNRGPS-----PVNVKLTLEFPVSQNES 830

  Fly   879 YLL----NQPETGGKIQCDDVAFNEYNLLLDEKLVKK---SYLQAQGAIWNSAQVSGQSSSSSSS 936
            |||    |..|.  .|.|.    .:|..:...:|||:   :...|:...:|...:| |.:.:...
Zfish   831 YLLYVFANASEE--LISCQ----TDYANIDPRRLVKQESTNITVAEVHHFNKRDLS-QKTENEQQ 888

  Fly   937 GGASVHIEKARGEGFVRGVLVSNSTDAGDKLSPKQVEQRRQEDTLEALGDASFVHRDRASQAVQE 1001
            ...:||:..:..|..|    |.:...||     .|.::|.....:..|...:|:.|
Zfish   889 WQHTVHVNCSSSEQCV----VFDCVAAG-----LQRDERAIVRVMSRLWVQTFLKR--------- 935

  Fly  1002 PQVNQTSFTTYSTS 1015
            |.||   :..:||:
Zfish   936 PYVN---YVLHSTA 946

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_001162777.1	Int_alpha	46..110	CDD:214549	21/65 (32%)
		Int_alpha	275..>316	CDD:214549	14/42 (33%)
		Int_alpha	398..451	CDD:214549	23/52 (44%)
		Int_alpha	466..>497	CDD:214549	15/30 (50%)
		Integrin_alpha2	499..893	CDD:285619	114/412 (28%)
		DUF2756	<1120..1178	CDD:298627
itga2b	NP_001003857.1	Int_alpha	256..>293	CDD:214549	13/44 (30%)
		Int_alpha	309..>358	CDD:214549	21/48 (44%)
		Int_alpha	376..429	CDD:214549	23/54 (43%)
		Int_alpha	441..>480	CDD:214549	16/38 (42%)
		Integrin_alpha2	475..908	CDD:285619	128/482 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574984
Domainoid	1	1.000	184	1.000	Domainoid score	I3343
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	509	1.000	Inparanoid score	I1285
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D325432at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24347
orthoMCL	1	0.900	-	-		OOG6_102088
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X587
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.760