Protein Alignment if and itga3a

DIOPT Version :10

• Sequence 1: NP_523378.2
• Gene: if / 32661
• FlyBaseID: FBgn0001250
• Length: 1396
• Species: Drosophila melanogaster
• Sequence 2: XP_017210291.1
• Gene: itga3a / 407685
• ZFINID: ZDB-GENE-090805-3
• Length: 1073
• Species: Danio rerio
• Alignment Length: 1455
• Identity: 319/1455 - (21%)
• Similarity: 532/1455 - (36%)
• Gaps: 524/1455 - (36%)

  Fly     7 HRRRMALHCPITSLILLLIAMSAHGYNIDLP-SYVRFRQSSNSMFGFSIAMHKGRSGFYGNQNNV 70
            ||:.:.|    |.:.:|..|.....:|:|:. :.|:..:::.|:||.|:|:|:.    ..|:...
Zfish     5 HRKGLRL----TLVFVLSAARLCQAFNLDVSFAVVKEGKTAGSLFGLSVALHEQ----VVNEKRH 61

  Fly    71 SLIVGAPKFDTSRYQQGVT--EAGGVFKCSLNDD--DCKLVPFDSKGNNRNVDKEVVDRKSY--- 128
            .|:|||||   .:.:.|::  |.|.|:.|.::.|  ||..:...|....   ||.  |.|:|
Zfish    62 MLLVGAPK---EKAESGLSANETGDVYACPISADSKDCARLNLISSNPE---DKP--DLKNYVID 118

  Fly   129 -QWLGATVAT-----GRDSDLVVACAPRYVFHTMTPSRAFRIDPVGTCF----------TSHNFE 177
             .|||.::.:     ||    ||||..||: ...|.:  ||:  :|.|:          :.:.::
Zfish   119 GMWLGVSIVSQSQPGGR----VVACGHRYI-RNFTSN--FRM--IGRCYVRGNDLQLNLSDYQWQ 174

  Fly   178 EFYEV-SPCRTNNWGYHRQGSCQAGFSAAINGNGSRLFIGAPGSWYWQGQTYS---IPPDAKFPF 238
            .:.|: .|....|    .:|.|..|.|||:  ..|.:|.||||.:.|||..:|   .|.|.....
Zfish   175 SYDEICDPREAQN----SEGMCLLGMSAAV--TFSEIFFGAPGCFNWQGNIFSKWHNPADEFHLL 233

  Fly   239 KPPLYQPFGTGGMASSHDVTRPENQVFSTSESASVNDDSYLGYSMVTGDFDGD---RSED-VAIG 299
            |..|                 |:::          ..:.|:|||.:.   |.|   :.:| |..|
Zfish   234 KSKL-----------------PDSR----------KGNIYIGYSTIV---DQDVLVKGKDTVVTG 268

  Fly   300 MPRG---GNLVGRIVVNRWNMANI---FNITGRQIGEYFGYSLATSDVDGDGLDDLLIGAPMYTD 358
            .||.   |:::...|:.......:   ..:||.|:|.|||.|:|..|::.||..||::|||.|.|
Zfish   269 APRDEAKGSVMMAEVLKSGGSGEVKIKVTVTGEQVGSYFGNSVAVVDLNNDGWKDLIVGAPFYFD 333

  Fly   359 PDNVEGKYDVGRVYILL-QGGPTEEKRWTTEHIRDGYHSKGRFGLALTTLGDVNGDGYGDFAVGA 422
            ....:|    |.||:.: |.|....|   ::.:..|....| ||:::..:||||.||:.||||||
Zfish   334 RKMDKG----GAVYVYMNQNGSFRNK---SDVVLTGPKDSG-FGMSVVAIGDVNQDGFQDFAVGA 390

  Fly   423 PYDGPEGRGVVYIFHGSPMGPLAKPSQIIKSEQLVEGAPYPRTFGFALSGGLDMDGNTYPDLAVG 487
            ||   ...|.|.|:.||..|...:|||:|..:.:..|.  .:|||:::|.|||:|.|.|||:|||
Zfish   391 PY---HSTGRVSIWTGSKTGISQEPSQVIDGKDIPGGG--FQTFGYSISRGLDVDRNGYPDIAVG 450

  Fly   488 AYSSDQVFIFKSRPVAAVNAETSFASNSKLISLDDRSCQLVRDHKKVPCMLLTTCWSY---TGRY 549
            :. .|:|.:.:||||  ::.:.:|.....:|:|:|  |        |.|:....|:||   ||..
Zfish   451 SL-DDRVVLLRSRPV--IHLKNTFTVTPMVINLED--C--------VACIEAKVCFSYTYSTGTA 502

  Fly   550 LPEQ---LDFDVSWLLDAKKLLNPRMFFL-RDEGKNIRNQTIRLNYGQKYCLNETVYLLDK-VQD 609
            ..::   |.:.|.  .|.:...:||:.|| .::||.....::..: |.  |.:..:.|..| :||
Zfish   503 SSQKAVTLQYTVE--ADQQSSRSPRVSFLDNNKGKYTGKMSVNPS-GD--CHSLKLELASKTIQD 562

  Fly   610 KLTPLEVEARYNLRSSRPLDPMVRHRRSILE----PVIDQNREIVLRDAINIQKNCGPDNICEPD 670
            |::.:..:...::     :||.....:.:.:    |||.|...:..|..|:|||.||.||.||.:
Zfish   563 KVSAIIFQLSVSV-----VDPPPSGGKMLEDLSAFPVISQRDALTGRAEIHIQKACGLDNKCESN 622

  Fly   671 LKLKVSTVDK-----------YLFG---SPEPLVIEVFISNT------NEDAFEAAFYMVTPPDL 715
            |::..:..|:           .:|.   ..:.|.:.|.:||.      .|||:.|...:..|..|
Zfish   623 LQMTAAFTDEKNTPFLMQEDHQIFNYTTDIKKLKLLVNVSNVPSEGRKAEDAYNAILNITIPSSL 687

  Fly   716 QFRKLQQLGEKKDTPITCSPPTPENNHTLKCDIGNPLESGKIAHFKISLVPEEKYGSSSSYDFYW 780
            .|..|     ....|.|.:.........|.|.:|:|.:|.:....:|:.
Zfish   688 SFSSL-----NPKLPSTLNGDPSSGGSYLLCTLGDPFKSNQRVEIEITF---------------- 731

  Fly   781 EANSTNLEKPGSEYDNKIRQSVGIWVDTDLDIKGTSLPDYQLYKADDYKELENATKEDDIGPQVV 845
                               ::.||.:|              :.:.:...:|...:.::|:.|.
Zfish   732 -------------------ETSGISID--------------MQEIETELQLSTLSDQNDLRPL-- 761

  Fly   846 HIYEIRNNRPSIIEEAEVFIHLPYETIVGDPLMYLLNQPETGGKIQCDDVAFNEYNLLLDEKLVK 910
                   :|..::|                   |:| ||              .:||:
Zfish   762 -------SRVLLVE-------------------YIL-QP--------------LFNLI------- 778

  Fly   911 KSYLQAQGAIWNSAQVSGQSSSSSSSGGASVHIEKARGEGFVRGVLVSNSTDAGDKLSPKQVEQR 975
             .|.:|:    .|..|.|:|:..|:
Zfish   779 -PYFRAE----FSGNVVGESAMKST---------------------------------------- 798

  Fly   976 RQEDTLEALGDASFVHRDRASQAVQEPQVNQTSFTTYSTSSSSSGSGAPSAQLRGHSTQGHIQMA 1040
                                                                             
Zfish   799 ----------------------------------------------------------------- 798

  Fly  1041 GPVQHTSSSSSSNYRSWPAQQQQQHQQLLLAGSGGSGLGSPVTFNDKSQFGGRNNNFHTGTLDLG 1105
                                               |.:||||.||......|:         .||
Zfish   799 -----------------------------------SDIGSPVEFNISVDISGK---------PLG 819

  Fly  1106 TLN--------RGNVDNE---LYRSQGQYQNPSQSLGQSQGQFQANANQGHYQGQNQAQFQARNP 1159
            .|.        ...|.||   ||.|:.|....|:|...::|                    ..||
Zfish   820 NLGFLEVVFQWPSAVANEKWLLYLSEIQMTGTSESFCVAKG--------------------IVNP 864

  Fly  1160 GFQGQTSYQGQTQYSGQPGGYQTHHVTYSSGSKPYYGRENEDFYDEDNLQQATPGHWSSSSSSSS 1224
                                     :..:...:....|:.::...|..|              :.
Zfish   865 -------------------------LNLTVSERKSRRRKRDEVLSESKL--------------AM 890

  Fly  1225 SSGTRRLRRSNDKDGATEKPLQIDLNSPCQSARCKSIRCVVTNLGTEDGDAAFVAIRARMVAKTM 1289
            |..||:         ...||.:: ||....:|||::..|.::.:.|    :|.:.:|||:...||
Zfish   891 SQKTRQ---------GQNKPREV-LNCTKGTARCQTFSCPLSAMKT----SAMLTVRARVWNSTM 941

  Fly  1290 --EKLASNVPLNVSTLAVANVTLLPFIGAPKDAIVKTHEI-FYKAEPEPL---QVPDVVPLWVVV 1348
              :..|..|.:..|.:..        :...|..|...:.| .:..|.:|.   ::|...|||:::
Zfish   942 LEDYRAKGVSVQGSVMLT--------LKTDKKNIKMNNNIREFTVEIDPAVAEELPYEAPLWIII 998

  Fly  1349 LAACAGALIFLLLVWLLYKCGFFNR 1373
            ::..:|.::..::|.||:|.|||.|
Zfish   999 VSVLSGVVMLGVIVILLWKSGFFTR 1023

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_523378.2	Int_alpha	46..110	CDD:214549	21/67 (31%)
		Int_alpha	275..>316	CDD:214549	13/47 (28%)
		Int_alpha	398..451	CDD:214549	26/52 (50%)
		Int_alpha	466..>497	CDD:214549	16/30 (53%)
		Integrin_alpha2	500..892	CDD:462478	83/423 (20%)
		Glutenin_hmw	<1121..1216	CDD:367362	9/94 (10%)
itga3a	XP_017210291.1	Int_alpha	41..102	CDD:214549	21/67 (31%)
		Int_alpha	304..360	CDD:214549	23/62 (37%)
		Int_alpha	365..416	CDD:214549	26/54 (48%)
		Int_alpha	429..>451	CDD:214549	13/21 (62%)
		Integrin_alpha2	462..919	CDD:462478	128/805 (16%)