DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment if and itga9

DIOPT Version :9

Sequence 1:	NP_001162777.1	Gene:	if / 32661	FlyBaseID:	FBgn0001250	Length:	1396	Species:	Drosophila melanogaster
Sequence 2:	NP_001311427.1	Gene:	itga9 / 394012	ZFINID:	ZDB-GENE-040426-1129	Length:	1032	Species:	Danio rerio

Alignment Length:	920	Identity:	240/920 - (26%)
Similarity:	405/920 - (44%)	Gaps:	176/920 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 AHGYNIDLPSYVRFRQSSNSMFGFSIAMHKGRSGFYGNQNNVSLIVGAPKFDTSRYQQGVTEAGG 93
            |:.:||||...|.||....:.||:|:..|.       :.|...::||||:.::| :...|...|.
Zfish    28 AYSFNIDLQYPVVFRGPDATFFGYSVLEHV-------HDNTRWIVVGAPRANSS-FSSSVQSPGA 84

  Fly    94 VFKCSL-NDDDCKLVPFD-SKGNNR--NVDKEVVDRKSYQWLGATVA-TGRDSDLVVACAPRY-- 151
            |:||.: |:.:.:....| .:||.:  :..|.....::.:|:|.::| ..:.:..::|||.|:
Zfish    85 VYKCRIRNNPEQRCTEMDLGRGNKQRESCGKTCQGDRNDEWMGVSLARQNKPNGKILACAHRWKN 149

  Fly   152 VFH-----------TMTPSR-AFRIDPVGTCFTSHNFEEFYEVSPCRTNNWGYHRQGSCQAGFSA 204
            |::           ::.|:. ..:..|:..|:..|.            ..:| ...||||||.:.
Zfish   150 VYYESEYILPHGYCSIIPANLQGKSQPLIPCYEDHK------------KTYG-EEHGSCQAGIAG 201

  Fly   205 AINGNGSRLFIGAPGSWYWQGQTYSIPPDAKFPFKPPLYQPFGTGGMASSHDVTRPENQVFSTSE 269
            ..  ....:.:|||||:||.|..                                   :||:.:.
Zfish   202 VF--TEELVVMGAPGSYYWTGTV-----------------------------------KVFNMTS 229

  Fly   270 SASVN---DD------SYLGYSMVTGDFDGDRSEDVAIGMPR--GGNLVGRIVVNRWN---MANI 320
            :...|   ||      |||||::..|.|....:.|||.|.|:  ||   |::.|.|..   :..|
Zfish   230 NTHYNLNQDDLSPHRYSYLGYAVTAGHFSSPNTIDVAAGAPQDSGG---GKVYVFRIEGTALVKI 291

  Fly   321 FNITGRQIGEYFGYSLATSDVDGDGLDDLLIGAPMYTDPDNVEGKYDVGRVYILLQGGPTEEKRW 385
            |..:|:.:|.|||.||...|::.|||.|||:||||:::..: ||:..   ||:....|..||..
Zfish   292 FQASGKMMGSYFGSSLCAVDLNADGLSDLLVGAPMHSEIRD-EGQVS---VYLSSGNGVMEEVA- 351

  Fly   386 TTEHIRDGYHS-KGRFGLALTTLGDVNGDGYGDFAVGAPYDGPEGRGVVYIFHGSPMGPLAKPSQ 449
                |.:|.:: ...||..:|:|||::.|||.|.|:|||.:...| |.|||:||...|.:.|.|.
Zfish   352 ----ILNGDNAYNAHFGECITSLGDIDDDGYQDVAIGAPEEDDYG-GAVYIYHGDARGIVNKYSM 411

  Fly   450 IIKSEQLVEGAPYPRTFGFALSGGLDMDGNTYPDLAVGAYSSDQVFIFKSRPVAAVNAETSFASN 514
            .:....:   .|..:.||.::||.:|||||.|||:.:||:.:|.|.:.:||||.:|:.......:
Zfish   412 RLSGRSI---NPTLQMFGQSISGNVDMDGNGYPDVTIGAFMADSVVLLRSRPVISVDVSIFLPVS 473

  Fly   515 SKLISLDDRSCQLVRDHKKVPCMLLTTCWSYTGRYLPEQLDFDVSWLLDAKKL---LNPRMFFLR 576
               |::....|.....|  :.|..:|.|.|:.|:::|..::...:...|:.|.   |.||.:|..
Zfish   474 ---INITVPQCHEGPQH--LNCFNVTVCMSFRGKHVPGHIELLYNLTADSDKRHKGLPPRAYFGN 533

  Fly   577 -DEGKNIRNQTIRLNYGQKYCLNETVYLLDKVQDKLTPLEVEARYNL----------RSSRPLDP 630
             .|...:.:|...|...::.|...|.::..:|:|....:..||.|:|          |...||.|
Zfish   534 GGEQTGVVSQRFNLEIHRQQCHQYTAFVRKEVKDVFAAIVFEAAYSLGKHIVDEHQDRDLPPLSP 598

  Fly   631 MVRHRRSILEPVIDQNREIVLRDAINIQKNCGPDNICEPDLKL--KVSTVDKYL-----FGSPEP 688
            ::|.::         ..:|..::....:|||..|: |..||:|  |:....:|:     .|..:.
Zfish   599 ILRWKK---------GEKIAAKNETWFEKNCLSDD-CAADLQLHGKLLLSGRYISSHLALGGVKN 653

  Fly   689 LVIEVFISNTNEDAFEAAFYMVTPPDLQFRKLQQLGEKKDTPITCSPPTPENNHTLKCDIGNPLE 753
            :.:.:.|||..:||::...|.....::.:....|..||   .|:|.....:   .|||.:|.|.
Zfish   654 VSLNLTISNAGDDAYDTNIYFNFSKEVHYINFLQREEK---GISCMLVELD---FLKCSVGFPF- 711

  Fly   754 SGKIAHFKISLVPEEKYGSSSSYD------------FYWEANSTNLEKPGSEYDNKIRQSVGIWV 806
                      :..:.||..|:.:|            |...|.|.|.|...:.:||.:..|:.:..
Zfish   712 ----------MRAQTKYHISALFDTSRLSGENETLLFLVHARSANPEHDNTLHDNTLELSIPLVH 766

  Fly   807 DTDLDIKGTSLPDYQLY--KADDYKELENATKEDDIGPQVVHIYEIRNNRPSIIEEAEVFIHLPY 869
            :.|..|.|...|...:|  ..|..:.::....|....| :...:::.||.||.:..:.|.|.:|:
Zfish   767 EVDTTITGVVNPTSFVYGNSVDRSRFVQLEDMECSFQP-LNFTFQVINNGPSRLPGSRVDIRIPH 830

  Fly   870 ETIVGDPLMY 879
            ......|.|:
Zfish   831 RLAGSGPEMF 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_001162777.1	Int_alpha	46..110	CDD:214549	16/64 (25%)
		Int_alpha	275..>316	CDD:214549	19/48 (40%)
		Int_alpha	398..451	CDD:214549	24/52 (46%)
		Int_alpha	466..>497	CDD:214549	16/30 (53%)
		Integrin_alpha2	499..893	CDD:285619	93/416 (22%)
		DUF2756	<1120..1178	CDD:298627
itga9	NP_001311427.1	Int_alpha	45..93	CDD:214549	15/55 (27%)
		Int_alpha	245..293	CDD:214549	18/50 (36%)
		Int_alpha	299..345	CDD:214549	21/49 (43%)
		Int_alpha	360..413	CDD:214549	24/53 (45%)
		Int_alpha	423..>465	CDD:214549	20/41 (49%)
		Integrin_alpha2	458..902	CDD:285619	93/416 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574985
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740