DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment if and Itgad

DIOPT Version :9

Sequence 1:	NP_001162777.1	Gene:	if / 32661	FlyBaseID:	FBgn0001250	Length:	1396	Species:	Drosophila melanogaster
Sequence 2:	NP_001025043.3	Gene:	Itgad / 381924	MGIID:	3578624	Length:	1202	Species:	Mus musculus

Alignment Length:	918	Identity:	230/918 - (25%)
Similarity:	346/918 - (37%)	Gaps:	247/918 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 ILLLIAMSA-----HGYNIDLPSYV--RFRQSSNSMFGFSIAMHKGRSGFYGNQNNVSLIVGAPK 78
            :|||...||     | ||..:|.:|  |.|.|...:|      |.........:..:.:|....|
Mouse   247 LLLLRVWSALKPGCH-YNTHMPWWVWQRVRFSWKELF------HSKNGARKSAKKILIVITDGQK 304

  Fly    79 F-DTSRYQQGVTEA--GGVFKCSLNDDDCKLVPFDSKGNNRNVDKEVVDRKSYQWLGATVATGRD 140
            | |...|:..:.||  .|:.:.::...|....|...:..|                  |:.:...
Mouse   305 FRDPLEYRHVIPEAEKAGIIRYAIGVGDAFREPTALQELN------------------TIGSAPS 351

  Fly   141 SDLVVACAPRYVFHTMTPSRAFRIDPVGTCFTSHNF-----------EEFYEVSPCRTNNWGYHR 194
            .|.|                          |...||           |:.:.:....:.:....:
Mouse   352 QDHV--------------------------FKVGNFVALRSIQRQIQEKIFAIEGTESRSSSSFQ 390

  Fly   195 QGSCQAGFSAAINGNGSRLFIGAPGSWYWQGQTYSIPPDAKFPFKPPLYQPFGTGGMASSHDVTR 259
            ....|.|||:|::.:|.  .:||.||:.|.|..:..|.:.:..|.          .|:..::..|
Mouse   391 HEMSQEGFSSALSMDGP--VLGAVGSFSWSGGAFLYPSNMRSTFI----------NMSQENEDMR 443

  Fly   260 PENQVFSTSESASVNDDSYLGYSMVTGDFDGDRSEDVAIGMPRGGNLVGRIVV-----NRWNMAN 319
                            |:|||||.....:.|..|  :.:|.||..: .|::|:     ..|...:
Mouse   444 ----------------DAYLGYSTALAFWKGVHS--LILGAPRHQH-TGKVVIFTQESRHWRPKS 489

  Fly   320 IFNITGRQIGEYFGYSLATSDVDGDGLDDL-LIGAPMYTDPDNVEGKYDVGRVYILLQGG----- 378
              .:.|.|||.|||.||.:.|:|.||..|| |||.|.|               |...:||
Mouse   490 --EVRGTQIGSYFGASLCSVDMDRDGSTDLVLIGVPHY---------------YEHTRGGQVSVC 537

  Fly   379 --PTEEKRW---TTEHIRDGYHSKGRFGLALTTLGDVNGDGYGDFAVGAPYDGPEGRGVVYIFHG 438
              |....||   ||.|...| |..||||.|||.|||||||...|.|:|||.: .|.||.||||||
Mouse   538 PMPGVRSRWHCGTTLHGEQG-HPWGRFGAALTVLGDVNGDSLADVAIGAPGE-EENRGAVYIFHG 600

  Fly   439 SPMGPLA-KPSQIIKSEQLVEGAPYPRTFGFALSGGLDMDGNTYPDLAVGAYSSDQVFIFKSRPV 502
            :....:| .|||.:...||.....|   ||.:||||.|:..:...||||||  ...|.:.:|.|:
Mouse   601 ASRQDIAPSPSQRVTGSQLFLRLQY---FGQSLSGGQDLTQDGLVDLAVGA--QGHVLLLRSLPL 660

  Fly   503 AAVNAETSFASNSKLISLDDRSCQLVRDHKKVPCMLLTT---CWSYTGRYL-------------- 550
            ..|.....||                      |..:..|   ||..|...|
Mouse   661 LKVGISIRFA----------------------PSEVAKTVYQCWGRTPTVLEAGEATVCLTVRKG 703

  Fly   551 -PEQLD-------FDVSWLLDAKKLLNPRMFFLRDEGKN---IRNQTIRLNYGQKYCLNETVYLL 604
             |:.|.       :|::  ||..:|::..:|   ||.||   .|.:|:.|.   .:|  ||:.||
Mouse   704 SPDLLGDVQSSVRYDLA--LDPGRLISRAIF---DETKNCTLTRRKTLGLG---DHC--ETMKLL 758

  Fly   605 --DKVQDKLTPLEVEARYNLRSSRPLDPMVRHRRSILEPVIDQNREIVLRDAINIQKNCGPDNIC 667
              |.|:|.:||:.:  |.||..:....|...     |.||:....:..:..:...:|||..:.:|
Mouse   759 LPDCVEDAVTPIIL--RLNLSLAGDSAPSRN-----LRPVLAVGSQDHVTASFPFEKNCKQELLC 816

  Fly   668 EPDL--KLKVSTVDKYLFGSPEPLVIEVFISNTNEDAFEAAFYMVTPPDLQFRKLQQLGEKKDTP 730
            |.:|  ....|.:.....||...|.:.|.:.|..||::........|.:|.:|::.:..:....|
Mouse   817 EGNLGVSFNFSGLQVLEVGSSPELTVTVTVWNEGEDSYGTLIKFYYPAELSYRRVTRAQQPHPYP 881

  Fly   731 --ITC--SPPTPENNHTLKCDIGNPL-ESGKIAHFKISLVPEEKYGSSSSYDFYWEA---NSTNL 787
              :.|  .|...|:..:..|.|.:|: ..|..|.|.|            ::|..::|   :...|
Mouse   882 LRLACEAEPTGQESLRSSSCSINHPIFREGAKATFMI------------TFDVSYKAFLGDRLLL 934

  Fly   788 EKPGSEYDNKIRQSVGIWVDTDLDIKGTSLPDYQLY-----KADDYKELENATKEDDIGPQVVHI 847
            ....|..:||...|...: ..:|.:|      |.:|     :.|..|....::...:...:..|.
Mouse   935 RASASSENNKPETSKTAF-QLELPVK------YTVYTVISRQEDSTKHFNFSSSHGERQKEAEHR 992

  Fly   848 YEIRNNRP 855
            |.:.|..|
Mouse   993 YRVNNLSP 1000

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_001162777.1	Int_alpha	46..110	CDD:214549	12/66 (18%)
		Int_alpha	275..>316	CDD:214549	13/45 (29%)
		Int_alpha	398..451	CDD:214549	32/53 (60%)
		Int_alpha	466..>497	CDD:214549	14/30 (47%)
		Integrin_alpha2	499..893	CDD:285619	87/402 (22%)
		DUF2756	<1120..1178	CDD:298627
Itgad	NP_001025043.3	vWA_integrins_alpha_subunit	156..367	CDD:238746	32/170 (19%)
		Int_alpha	496..546	CDD:214549	22/64 (34%)
		Int_alpha	559..614	CDD:214549	32/55 (58%)
		Int_alpha	624..>648	CDD:214549	12/26 (46%)
		Integrin_alpha2	666..>1003	CDD:285619	84/393 (21%)
		Integrin_alpha	1165..1178	CDD:278771
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832096
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740