DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment if and ITGAX

DIOPT Version :9

Sequence 1:	NP_001162777.1	Gene:	if / 32661	FlyBaseID:	FBgn0001250	Length:	1396	Species:	Drosophila melanogaster
Sequence 2:	NP_001273304.1	Gene:	ITGAX / 3687	HGNCID:	6152	Length:	1169	Species:	Homo sapiens

Alignment Length:	1037	Identity:	253/1037 - (24%)
Similarity:	400/1037 - (38%)	Gaps:	269/1037 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 SYVRFRQSSN---------SMFGFSI-------AMHKGRSGFYGNQNNVSLIV-----GAPKFDT 81
            ::..||:|||         .:.||:.       .:|:.....||.:.:.:.|:     |..:.|:
Human   202 TFEEFRRSSNPLSLLASVHQLQGFTYTATAIQNVVHRLFHASYGARRDAAKILIVITDGKKEGDS 266

  Fly    82 SRYQQGV--TEAGGVFKCSLNDDDCKLVPFDSKGNNRNVDKEVVDRKSYQWLGATVATGRDSDLV 144
            ..|:..:  .:|.|:.:.::...    :.|    .|||..||:.|
Human   267 LDYKDVIPMADAAGIIRYAIGVG----LAF----QNRNSWKELND-------------------- 303

  Fly   145 VACAPRYVFHTMTPSRAFRIDPVGTCFTSHN--FEEFYEVSPCRTNNWGYHRQGSCQAGFSAAIN 207
            :|..|       :....|:::.........|  .|:.:.:....|.:.........|.||||...
Human   304 IASKP-------SQEHIFKVEDFDALKDIQNQLKEKIFAIEGTETTSSSSFELEMAQEGFSAVFT 361

  Fly   208 GNGSRLFIGAPGSWYWQGQTYSIPPDAKFPFKPPLYQPFGTGGMASSHDVTRPENQVFSTSESAS 272
            .:|.  .:||.||:.|.|..:..||:....|                         :..:.|:..
Human   362 PDGP--VLGAVGSFTWSGGAFLYPPNMSPTF-------------------------INMSQENVD 399

  Fly   273 VNDDSYLGYSMVTGDFDGDRSEDVAIGMPR----GGNLVGRIVVNRWNMANIFNITGRQIGEYFG 333
            :. |||||||.....:.|.:|  :.:|.||    |..::...|..:|.|.  ..:||.|||.|||
Human   400 MR-DSYLGYSTELALWKGVQS--LVLGAPRYQHTGKAVIFTQVSRQWRMK--AEVTGTQIGSYFG 459

  Fly   334 YSLATSDVDGDGLDDL-LIGAPMYTDPDNVEGKYDVGRVYILLQGG-------PTEEKRWTTEHI 390
            .||.:.|||.||..|| |||||.|               |...:||       |...:||..:.:
Human   460 ASLCSVDVDSDGSTDLVLIGAPHY---------------YEQTRGGQVSVCPLPRGWRRWWCDAV 509

  Fly   391 RDGY--HSKGRFGLALTTLGDVNGDGYGDFAVGAPYDGPEGRGVVYIFHGSPMGPLAKP--SQII 451
            ..|.  |..||||.|||.|||||||...|..:|||.: .|.||.||:||| .:||...|  ||.|
Human   510 LYGEQGHPWGRFGAALTVLGDVNGDKLTDVVIGAPGE-EENRGAVYLFHG-VLGPSISPSHSQRI 572

  Fly   452 KSEQLVEGAPYPRTFGFALSGGLDMDGNTYPDLAVGAYSSDQVFIFKSRPVAAVNAETSF----- 511
            ...||.....|   ||.|||||.|:..:...||||||  ..||.:.::|||..|.....|
Human   573 AGSQLSSRLQY---FGQALSGGQDLTQDGLVDLAVGA--RGQVLLLRTRPVLWVGVSMQFIPAEI 632

  Fly   512 -----------ASNSKLIS------LDDRSCQLVRDHKKVPCMLLTTCWSYTGRYLPEQLDFDVS 559
                       .|...|:.      :|.||..|:                 ..|.|...:..|::
Human   633 PRSAFECREQVVSEQTLVQSNICLYIDKRSKNLL-----------------GSRDLQSSVTLDLA 680

  Fly   560 WLLDAKKLLNPRMFFLRDEGKNIRNQTIRLNYGQKYCLNETVYLLDKVQDKLTPLEVEARYNLRS 624
              ||..: |:||..|  .|.||.....:|:...:.:|.|..:.|...|:|.:||:.:...:.|..
Human   681 --LDPGR-LSPRATF--QETKNRSLSRVRVLGLKAHCENFNLLLPSCVEDSVTPITLRLNFTLVG 740

  Fly   625 SRPLDPMVRHRRSILEPVIDQNREIVLRDAINIQKNCGPDNICEPDLKLKVS--TVDKYLFGSPE 687
            .    |::..|.  |.|::..:.:.....::..:||||.|:||:.:|.:..|  .:...|.||..
Human   741 K----PLLAFRN--LRPMLAADAQRYFTASLPFEKNCGADHICQDNLGISFSFPGLKSLLVGSNL 799

  Fly   688 PLVIEVFISNTNEDAFEAAFYMVTPPDLQFRKL---QQLGEKKDTPITC--SPPTPENNHTLKCD 747
            .|..||.:.|..||::........|..|.:|.:   |:.|:.:...:||  :|...:...:..|.
Human   800 ELNAEVMVWNDGEDSYGTTITFSHPAGLSYRYVAEGQKQGQLRSLHLTCDSAPVGSQGTWSTSCR 864

  Fly   748 IGNPLESGK-----IAHFKISLVPEEKYG-------SSSSYDFYWEANSTNLEKPGSEYDNKIRQ 800
            |.:.:..|.     :|.|.:|  |:...|       :.||     |.|:....|...:.:..::.
Human   865 INHLIFRGGAQITFLATFDVS--PKAVLGDRLLLTANVSS-----ENNTPRTSKTTFQLELPVKY 922

  Fly   801 SVGIWVDTDLDIKGTSLPDYQLYKADDYKELENATKEDDIGPQVVHIYEIRN------------- 852
            :|...|.:          ..|..|..::.|.|.  ||..:   .:|.|::.|
Human   923 AVYTVVSS----------HEQFTKYLNFSESEE--KESHV---AMHRYQVNNLGQRDLPVSINFW 972

  Fly   853 -----NRPSIIEEAEV------FIHLPYETI---VGDPLMYLLNQP----ETGG--KIQCDDVAF 897
                 |:.::..:.||      .:....|.|   ..|.|.::...|    ...|  :.:||..:|
Human   973 VPVELNQEAVWMDVEVSHPQNPSLRCSSEKIAPPASDFLAHIQKNPVLDCSIAGCLRFRCDVPSF 1037

  Fly   898 N---EYNLLLDEKLV---KKSYLQAQGAIWNSAQVSGQSSSSSSSGGASVHIEKARGEGFVR 953
            :   |.:..|...|.   .:..||.:.::.:.|:::..:|..|...|.         |.|:|
Human  1038 SVQEELDFTLKGNLSFGWVRQILQKKVSVVSVAEITFDTSVYSQLPGQ---------EAFMR 1090

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_001162777.1	Int_alpha	46..110	CDD:214549	13/86 (15%)
		Int_alpha	275..>316	CDD:214549	14/44 (32%)
		Int_alpha	398..451	CDD:214549	31/54 (57%)
		Int_alpha	466..>497	CDD:214549	16/30 (53%)
		Integrin_alpha2	499..893	CDD:285619	95/467 (20%)
		DUF2756	<1120..1178	CDD:298627
ITGAX	NP_001273304.1	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	23..78
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	79..138
		vWA_integrins_alpha_subunit	150..325	CDD:238746	26/157 (17%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	340..391		16/77 (21%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	392..443		15/53 (28%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	444..504		28/76 (37%)
		Int_alpha	454..504	CDD:214549	24/64 (38%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	507..565		30/59 (51%)
		Int_alpha	517..>558	CDD:214549	24/41 (59%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	570..630		26/64 (41%)
		Int_alpha	582..628	CDD:214549	21/50 (42%)
		Integrin_alpha2	615..1032	CDD:285619	95/466 (20%)
		Integrin_alpha	1129..1143	CDD:278771
		GFFKR motif	1131..1135
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142047
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740