DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment if and ITGAV

DIOPT Version :9

Sequence 1:	NP_001162777.1	Gene:	if / 32661	FlyBaseID:	FBgn0001250	Length:	1396	Species:	Drosophila melanogaster
Sequence 2:	NP_002201.2	Gene:	ITGAV / 3685	HGNCID:	6150	Length:	1048	Species:	Homo sapiens

Alignment Length:	1420	Identity:	352/1420 - (24%)
Similarity:	572/1420 - (40%)	Gaps:	411/1420 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 RRRMALHCPITSLIL--LLIAMSAHGYNIDLPSYVRFRQSSNSMFGFSIAMHKGRSGFY--GNQN 68
            |||:.|......|:|  ||:.: ...:|:|:.|...:.....|.|||::       .|:  ...:
Human     6 RRRLRLGPRGLPLLLSGLLLPL-CRAFNLDVDSPAEYSGPEGSYFGFAV-------DFFVPSASS 62

  Fly    69 NVSLIVGAPKFDTSRYQQGVTEAGGVFKCSLNDD-DCKLVPFDSKGNNRNVDKEVVDRKSYQWLG 132
            .:.|:|||||.:|:  |.|:.|.|.|.||..:.. .|:.:.||:.||......:.::.||:||.|
Human    63 RMFLLVGAPKANTT--QPGIVEGGQVLKCDWSSTRRCQPIEFDATGNRDYAKDDPLEFKSHQWFG 125

  Fly   133 ATVATGRDSDLVVACAPRYVFHTMTPSRAFRIDPVGTCFTSHNFEEFYEVSPCRTNNWGYHRQGS 197
            |:|.:.:|.  ::||||.|  |..|..:..| :||||||.... .:..|.:|||:.:.....||.
Human   126 ASVRSKQDK--ILACAPLY--HWRTEMKQER-EPVGTCFLQDG-TKTVEYAPCRSQDIDADGQGF 184

  Fly   198 CQAGFSAAINGNGSRLFIGAPGSWYWQGQTYSIP-PDAKFPFKPPLYQPFGTGGMASSHDVTRPE 261
            ||.|||.... ...|:.:|.|||:|||||..|.. .:....:.|.:|.             .:..
Human   185 CQGGFSIDFT-KADRVLLGGPGSFYWQGQLISDQVAEIVSKYDPNVYS-------------IKYN 235

  Fly   262 NQVFSTSESASVNDDSYLGYSMVTGDFDGDRSEDVAIGMPRGGNLVGRI-VVNRWNMANIFNITG 325
            ||: :|..:.::.||||||||:..|||:||..:|...|:||....:|.: :.:..||::::|.||
Human   236 NQL-ATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVPRAARTLGMVYIYDGKNMSSLYNFTG 299

  Fly   326 RQIGEYFGYSLATSDVDGDGLDDLLIGAPMYTDPDNVEGK-YDVGRVYILLQGGPTEEKRWTTEH 389
            .|:..|||:|:|.:|::||...|:.||||::.|..: :|| .:||:|.:.||....:.:  ||:
Human   300 EQMAAYFGFSVAATDINGDDYADVFIGAPLFMDRGS-DGKLQEVGQVSVSLQRASGDFQ--TTK- 360

  Fly   390 IRDGYHSKGRFGLALTTLGDVNGDGYGDFAVGAPYDGPEGRGVVYIFHGSPMGPLAKPSQIIKSE 454
             .:|:....|||.|:..|||::.||:.|.|:.|||.|.:.:|:||||:|...|..|.||||::.:
Human   361 -LNGFEVFARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGIVYIFNGRSTGLNAVPSQILEGQ 424

  Fly   455 QLVEGAPYPRTFGFALSGGLDMDGNTYPDLAVGAYSSDQVFIFKSRPVAAVNAETSFASNSKLIS 519
            .....  .|.:||:::.|..|:|.|.||||.|||:..|:..::::|||..|||  .......:::
Human   425 WAARS--MPPSFGYSMKGATDIDKNGYPDLIVGAFGVDRAILYRARPVITVNA--GLEVYPSILN 485

  Fly   520 LDDRSCQLVRDHKKVPCMLLTTCWSYTGR-YLPEQLDFDVSWLLD---AKKLLNPRMFFLRDEGK 580
            .|:::|.|.....||.|..:..|....|: .||.:|:|.|..|||   .|..:...:|.......
Human   486 QDNKTCSLPGTALKVSCFNVRFCLKADGKGVLPRKLNFQVELLLDKLKQKGAIRRALFLYSRSPS 550

  Fly   581 NIRNQTIRLNYGQKYCLNETVYLLD--KVQDKLTPLEVEARYNLRSSRPLDPMVRHRRSILEPVI 643
            :.:|.||... |...|.....||.|  :.:|||||:.:...|.|......|      .:.|:|::
Human   551 HSKNMTISRG-GLMQCEELIAYLRDESEFRDKLTPITIFMEYRLDYRTAAD------TTGLQPIL 608

  Fly   644 DQNREIVLRDAINIQKNCGPDNICEPDLKLKVSTVDKYLF-GSPEPLVIEVFISNTNEDAFEAAF 707
            :|.....:....:|..:||.||:|:|.|::.|.:..|.:: |...||.:.|...|..|.|:||..
Human   609 NQFTPANISRQAHILLDCGEDNVCKPKLEVSVDSDQKKIYIGDDNPLTLIVKAQNQGEGAYEAEL 673

  Fly   708 YMVTPPDLQF----RKLQQLGEKKDTPITCSPPTPENNHTLKCDIGNPLESGK--IAHFKISLVP 766
            .:..|....|    |..:.|..     ::|:..|......:.||:|||:::|.  :|..:.|:..
Human   674 IVSIPLQADFIGVVRNNEALAR-----LSCAFKTENQTRQVVCDLGNPMKAGTQLLAGLRFSVHQ 733

  Fly   767 EEKYGSSSSYDFYWEANSTNLEKPGSEYDN---KIRQSVGIWVDTDLDIKGTSLPDYQLYKADDY 828
            :.:..:|..:|.  :..|:||      :|.   .:...|.:.|...::|:|.|.||:......::
Human   734 QSEMDTSVKFDL--QIQSSNL------FDKVSPVVSHKVDLAVLAAVEIRGVSSPDHVFLPIPNW 790

  Fly   829 KELENATKEDDIGPQVVHIYEIRNNRPSIIEEAEVFIHLPYETIVGDPLMYLLNQPETGGKIQC- 892
            :..||...|:|:||.|.||||:|||.||...:|.:.:..||: ...:.|:|:|:. :..|.:.|
Human   791 EHKENPETEEDVGPVVQHIYELRNNGPSSFSKAMLHLQWPYK-YNNNTLLYILHY-DIDGPMNCT 853

  Fly   893 DDVAFNEYNLLLDEKLVKKSYLQAQGAIWNSAQVSGQSSSSSSSGGASVHIEKARGEGFVRGVLV 957
            .|:..|...:
Human   854 SDMEINPLRI------------------------------------------------------- 863

  Fly   958 SNSTDAGDKLSPKQVEQRRQEDTLEALGDASFVHRDRASQAVQEPQVNQTSFTTYSTSSSSSGSG 1022
                    |:|..|..::  .||:...|:     ||
Human   864 --------KISSLQTTEK--NDTVAGQGE-----RD----------------------------- 884

  Fly  1023 APSAQLRGHSTQGHIQMAGPVQHTSSSSSSNYRSWPAQQQQQHQQLLLAGSGGSGLGSPVTFNDK 1087
                         |:                                            :|..|.
Human   885 -------------HL--------------------------------------------ITKRDL 892

  Fly  1088 SQFGGRNNNFHTGTLDLGTLNRGNVDNELYRSQGQYQNPSQSLGQSQGQFQANANQGHYQGQNQA 1152
            :                  |:.|::               .:||
Human   893 A------------------LSEGDI---------------HTLG--------------------- 903

  Fly  1153 QFQARNPGFQGQTSYQGQTQYSGQPGGYQTHHVTYSSGSKPYYGRENEDFYDEDNLQQATPGHWS 1217

Human   904 ----------------------------------------------------------------- 903

  Fly  1218 SSSSSSSSSGTRRLRRSNDKDGATEKPLQIDLNSPCQSARCKSIRCVVTNLGTEDGDAAFVAIRA 1282
                                               |..|:|..|.|.|..|  :.|.:|.:.:::
Human   904 -----------------------------------CGVAQCLKIVCQVGRL--DRGKSAILYVKS 931

  Fly  1283 RMVAKT-MEKLASNVPLNVSTLAVANVTLLPFIGAPKDAIVK----THEIFYKAEPEPLQVPDVV 1342
            .:..:| |.|...|...::.:.|..||...|:...|.:.|..    |..:.:..:|.|:.    |
Human   932 LLWTETFMNKENQNHSYSLKSSASFNVIEFPYKNLPIEDITNSTLVTTNVTWGIQPAPMP----V 992

  Fly  1343 PLWVVVLAACAGALIFLLLVWLLYKCGFFNRNRPTDHSQER---QPLRNGYHGDE 1394
            |:||::||..||.|:..:||:::|:.|||.|.||....|||   ||..||....|
Human   993 PVWVIILAVLAGLLLLAVLVFVMYRMGFFKRVRPPQEEQEREQLQPHENGEGNSE 1047

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_001162777.1	Int_alpha	46..110	CDD:214549	20/66 (30%)
		Int_alpha	275..>316	CDD:214549	18/41 (44%)
		Int_alpha	398..451	CDD:214549	26/52 (50%)
		Int_alpha	466..>497	CDD:214549	14/30 (47%)
		Integrin_alpha2	499..893	CDD:285619	113/410 (28%)
		DUF2756	<1120..1178	CDD:298627	2/57 (4%)
ITGAV	NP_002201.2	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	32..98		22/74 (30%)
		Int_alpha	46..103	CDD:214549	20/65 (31%)
		WD40 repeat	51..120	CDD:293791	21/77 (27%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	109..170		23/66 (35%)
		WD40 repeat	126..183	CDD:293791	21/62 (34%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	173..225		19/52 (37%)
		WD40 repeat	188..248	CDD:293791	19/74 (26%)
		VCBS	221..271	CDD:316075	19/63 (30%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	237..291		20/54 (37%)
		Int_alpha	248..>288	CDD:214549	18/39 (46%)
		WD40 repeat	254..298	CDD:293791	15/43 (35%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	292..357		25/65 (38%)
		Int_alpha	302..355	CDD:214549	21/53 (40%)
		WD40 repeat	307..362	CDD:293791	21/59 (36%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	358..415		25/58 (43%)
		Int_alpha	367..421	CDD:214549	26/53 (49%)
		WD40 repeat	371..422	CDD:293791	25/50 (50%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	419..482		23/66 (35%)
		Int_alpha	434..476	CDD:214549	20/43 (47%)
		Integrin_alpha2	467..914	CDD:312071	134/780 (17%)
		GFFKR motif	1019..1023		3/3 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1027..1048		8/21 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141980
Domainoid	1	1.000	175	1.000	Domainoid score	I3647
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	497	1.000	Inparanoid score	I1389
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D325432at33208
OrthoFinder	1	1.000	-	-		FOG0001619
OrthoInspector	1	1.000	-	-		otm41436
orthoMCL	1	0.900	-	-		OOG6_102088
Panther	1	1.100	-	-	LDO	PTHR23220
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X587
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.760