DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment if and ITGAM

DIOPT Version :9

Sequence 1:	NP_001162777.1	Gene:	if / 32661	FlyBaseID:	FBgn0001250	Length:	1396	Species:	Drosophila melanogaster
Sequence 2:	NP_001139280.1	Gene:	ITGAM / 3684	HGNCID:	6149	Length:	1153	Species:	Homo sapiens

Alignment Length:	1236	Identity:	271/1236 - (21%)
Similarity:	436/1236 - (35%)	Gaps:	407/1236 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 MALHCPITSLILLLIAMS-AHGYNIDLPSYVRFRQSSNSMFGFSIAMHKGRSGFYGNQNNVSLIV 74
            |||.      :|||.|:: .||:|:|..:.:.|::::.. ||.|:...:|.          .::|
Human     1 MALR------VLLLTALTLCHGFNLDTENAMTFQENARG-FGQSVVQLQGS----------RVVV 48

  Fly    75 GAPKFDTSRYQQGVTEAGGVFKCSLNDDDCKLVPFDSKGNNRNVDKEVVDRKSYQWLGATVATGR 139
            |||:...:..|:     |.:::|..:...|:.:       ...|..|.|:..    ||.::|...
Human    49 GAPQEIVAANQR-----GSLYQCDYSTGSCEPI-------RLQVPVEAVNMS----LGLSLAATT 97

  Fly   140 DSDLVVACAP------------------------------------------------------- 149
            ....::||.|
Human    98 SPPQLLACGPTVHQTCSENTYVKGLCFLFGSNLRQQPQKFPEALRGCPQEDSDIAFLIDGSGSII 162

  Fly   150 ------------------------------------RYVF-----------------------HT 155
                                                .:.|                       ||
Human   163 PHDFRRMKEFVSTVMEQLKKSKTLFSLMQYSEEFRIHFTFKEFQNNPNPRSLVKPITQLLGRTHT 227

  Fly   156 MTPSR----------------AFRI-----------DP---------------------VGTCFT 172
            .|..|                ||:|           ||                     ||..|.
Human   228 ATGIRKVVRELFNITNGARKNAFKILVVITDGEKFGDPLGYEDVIPEADREGVIRYVIGVGDAFR 292

  Fly   173 S----------------------HNF-----------EEFYEVSPCRTNNWGYHRQGSCQAGFSA 204
            |                      :||           |:.:.:...:|.:.........|.||||
Human   293 SEKSRQELNTIASKPPRDHVFQVNNFEALKTIQNQLREKIFAIEGTQTGSSSSFEHEMSQEGFSA 357

  Fly   205 AINGNGSRLFIGAPGSWYWQGQTYSIPPDAKFPFKPPLYQPFGTGGMASSHDVTRPENQVFSTSE 269
            ||..||.  .:...||:.|.|..:......|..|                .::||.::.:
Human   358 AITSNGP--LLSTVGSYDWAGGVFLYTSKEKSTF----------------INMTRVDSDM----- 399

  Fly   270 SASVNDDSYLGYSMVTGDFDGDRSEDVAIGMPRGGNLVGRIVVNRWNMA---NIFNITGRQIGEY 331
                 :|:||||:...  ...:|.:.:.:|.||..: :|.:.:.|.|..   :..|:.|.|||.|
Human   400 -----NDAYLGYAAAI--ILRNRVQSLVLGAPRYQH-IGLVAMFRQNTGMWESNANVKGTQIGAY 456

  Fly   332 FGYSLATSDVDGDGLDDL-LIGAPMYTDPDNVEGKYDVGRVYILLQGGPT--------EEKRWTT 387
            ||.||.:.|||.:|..|| |||||.|               |...:||..        :..||..
Human   457 FGASLCSVDVDSNGSTDLVLIGAPHY---------------YEQTRGGQVSVCPLPRGQRARWQC 506

  Fly   388 EHIRDGYHSK--GRFGLALTTLGDVNGDGYGDFAVGAPYDGPEGRGVVYIFHG-SPMGPLAKPSQ 449
            :.:..|...:  ||||.|||.|||||||...|.|:|||.: .:.||.||:||| |..|.....||
Human   507 DAVLYGEQGQPWGRFGAALTVLGDVNGDKLTDVAIGAPGE-EDNRGAVYLFHGTSGSGISPSHSQ 570

  Fly   450 IIKSEQLVEGAPYPRTFGFALSGGLDMDGNTYPDLAVGAYSSDQVFIFKSRPVAAVNAETSFASN 514
            .|...:|   :|..:.||.:||||.|:..:...||.|||  ...|.:.:|:||..|.|...|  |
Human   571 RIAGSKL---SPRLQYFGQSLSGGQDLTMDGLVDLTVGA--QGHVLLLRSQPVLRVKAIMEF--N 628

  Fly   515 SKLISLDDRSC--QLVRDHKKVPCMLLTTCWSYTGRYLPE-QLDFDVSW--LLDAKKLLNPRMFF 574
            .:.::.:...|  |:|:..:.....:.......|...|.| |:...|::  .||:.:   |....
Human   629 PREVARNVFECNDQVVKGKEAGEVRVCLHVQKSTRDRLREGQIQSVVTYDLALDSGR---PHSRA 690

  Fly   575 LRDEGKN-IRNQTIRLNYGQKYCLNETVYLLDKVQDKLTPLEVEARYNLRSSRPLDPMVRHRRSI 638
            :.:|.|| .|.||..|...|. |....:.|.:.::|.::|:.:...::|..: ||...     ..
Human   691 VFNETKNSTRRQTQVLGLTQT-CETLKLQLPNCIEDPVSPIVLRLNFSLVGT-PLSAF-----GN 748

  Fly   639 LEPVIDQNREIVLRDAINIQKNCGPDNICEPDLKLKVS--TVDKYLFGSPEPLVIEVFISNTNED 701
            |.||:.::.:.:.......:||||.||||:.||.:..|  ::|..:.|.|....:.|.:.|..||
Human   749 LRPVLAEDAQRLFTALFPFEKNCGNDNICQDDLSITFSFMSLDCLVVGGPREFNVTVTVRNDGED 813

  Fly   702 AFEAAFYMVTPPDLQFRK---LQQLGEKKDTPITC-SPPTPENNHTLK---CDIGNPL--ESGKI 757
            ::........|.||.:||   ||....::...:.| |..:.|.:..||   |.|.:|:  |:.::
Human   814 SYRTQVTFFFPLDLSYRKVSTLQNQRSQRSWRLACESASSTEVSGALKSTSCSINHPIFPENSEV 878

  Fly   758 AHFKISLVPEEKYGSSSSYDFYWEANSTNLEKPGSEYDNKIRQSVGIWVDTDLDIKGTSLPDYQL 822
            . |.|:...:.|  :|.......:||.|:        :|.:.::.......:|.:|      |.:
Human   879 T-FNITFDVDSK--ASLGNKLLLKANVTS--------ENNMPRTNKTEFQLELPVK------YAV 926

  Fly   823 YKADDYKELE----NATKEDDIGPQVVHIYEIRN------------------------NRPSII- 858
            |.......:.    |.|..::....:.|.|::.|                        :||.:.
Human   927 YMVVTSHGVSTKYLNFTASENTSRVMQHQYQVSNLGQRSLPISLVFLVPVRLNQTVIWDRPQVTF 991

  Fly   859 -EEAEVFIH----LPYETIVGDPLMYLLNQPETG------GKIQCDDVAF---NEYNLLLDEKLV 909
             |......|    ||..:   |.|..|...|...      .:||||...|   .|:|..|...|.
Human   992 SENLSSTCHTKERLPSHS---DFLAELRKAPVVNCSIAVCQRIQCDIPFFGIQEEFNATLKGNLS 1053

  Fly   910 KKSYLQAQG---AIWNSAQVSGQSSSSSSSGGASVHIEKARGEGFVRGVLVSNSTDAGDKLSPKQ 971
            ...|::...   .|.::|::....|..:...|              :|..|.:.|:.  |:.|.:
Human  1054 FDWYIKTSHNHLLIVSTAEILFNDSVFTLLPG--------------QGAFVRSQTET--KVEPFE 1102

  Fly   972 V 972
            |
Human  1103 V 1103

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_001162777.1	Int_alpha	46..110	CDD:214549	12/63 (19%)
		Int_alpha	275..>316	CDD:214549	11/40 (28%)
		Int_alpha	398..451	CDD:214549	30/53 (57%)
		Int_alpha	466..>497	CDD:214549	13/30 (43%)
		Integrin_alpha2	499..893	CDD:285619	99/450 (22%)
		DUF2756	<1120..1178	CDD:298627
ITGAM	NP_001139280.1	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	18..75		15/72 (21%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	76..135		9/69 (13%)
		vWA_integrins_alpha_subunit	149..324	CDD:238746	16/174 (9%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	339..390		16/68 (24%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	391..442		14/63 (22%)
		Int_alpha	453..>495	CDD:214549	22/56 (39%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	507..565		29/58 (50%)
		Int_alpha	517..563	CDD:214549	27/46 (59%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	570..630		24/66 (36%)
		Integrin_alpha2	615..979	CDD:285619	87/392 (22%)
		Integrin_alpha	1130..1144	CDD:278771
		GFFKR motif	1132..1136
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142042
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740