Protein Alignment if and ITGAL

DIOPT Version :9

• Sequence 1: NP_001162777.1
• Gene: if / 32661
• FlyBaseID: FBgn0001250
• Length: 1396
• Species: Drosophila melanogaster
• Sequence 2: NP_002200.2
• Gene: ITGAL / 3683
• HGNCID: 6148
• Length: 1170
• Species: Homo sapiens
• Alignment Length: 1123
• Identity: 259/1123 - (23%)
• Similarity: 400/1123 - (35%)
• Gaps: 393/1123 - (34%)

  Fly    17 ITSLILLLIA-----MSAHGYNIDLPSYVRFRQS-----SNSMFGFSIAMHKGRSGFYGNQNNVS 71
            ||.:.:.|::     ..|..||:|    ||..:|     :...||:.:..       .||    .
Human     6 ITVMAMALLSGFFFFAPASSYNLD----VRGARSFSPPRAGRHFGYRVLQ-------VGN----G 55

  Fly    72 LIVGAPKFDTSRYQQGVTEAGGVFKCSLNDDDCKLVPFDSKGNNRNVDKEVVDRKSYQWLGATVA 136
            :|||||....|        .|.:::|......|  :|...:|:|          .:.::||.|:|
Human    56 VIVGAPGEGNS--------TGSLYQCQSGTGHC--LPVTLRGSN----------YTSKYLGMTLA 100

  Fly   137 TGRDSDLVVACAPRYVFHTMTPSRAFRIDPVGTCFTSHNFEEFYEVSPC---RTNNWGYHRQGSC 198
            |......::||.|..       ||        ||     .:..|....|   |.|..|...||
Human   101 TDPTDGSILACDPGL-------SR--------TC-----DQNTYLSGLCYLFRQNLQGPMLQG-- 143

  Fly   199 QAGFSAAINGNGSRLFI--GAPG-----------------------SWYWQGQTYSIPPDAKFPF 238
            :.||...|.||...:|:  |:..                       |:.:....:|.....:|.|
Human   144 RPGFQECIKGNVDLVFLFDGSMSLQPDEFQKILDFMKDVMKKLSNTSYQFAAVQFSTSYKTEFDF 208

  Fly   239 ------KPP------------LYQPFG----------------------------------TGGM 251
                  |.|            |...||                                  :|.:
Human   209 SDYVKRKDPDALLKHVKHMLLLTNTFGAINYVATEVFREELGARPDATKVLIIITDGEATDSGNI 273

  Fly   252 ASSHDVTR---PENQVFSTSES------------------------------------------- 270
            .::.|:.|   ...:.|.|.||
Human   274 DAAKDIIRYIIGIGKHFQTKESQETLHKFASKPASEFVKILDTFEKLKDLFTELQKKIYVIEGTS 338

  Fly   271 -------------------------------------------ASVNDDS--------------Y 278
                                                       |.:.||:              |
Human   339 KQDLTSFNMELSSSGISADLSRGHAVVGAVGAKDWAGGFLDLKADLQDDTFIGNEPLTPEVRAGY 403

  Fly   279 LGYSMVTGDFDGDRSEDVAIGMPRGGNLVGRIVV-------NRWNMANIFNITGRQIGEYFGYSL 336
            |||: ||......::..:|.|.||..:: ||:::       ..|  :.:..|.|.|||.|||..|
Human   404 LGYT-VTWLPSRQKTSLLASGAPRYQHM-GRVLLFQEPQGGGHW--SQVQTIHGTQIGSYFGGEL 464

  Fly   337 ATSDVDGDGLDD-LLIGAPMYTDPDNVEGKYDVGRVYIL------------LQGGPTEEKRWTTE 388
            ...|||.||..: ||||||::      .|:...|||:|.            |||.|
Human   465 CGVDVDQDGETELLLIGAPLF------YGEQRGGRVFIYQRRQLGFEEVSELQGDP--------- 514

  Fly   389 HIRDGYHSKGRFGLALTTLGDVNGDGYGDFAVGAPYDGPEGRGVVYIFHGSPMGPLAKPSQIIKS 453
                || ..||||.|:|.|.|:||||..|.|||||.   |.:|.||||:|...|...:|||.|:.
Human   515 ----GY-PLGRFGEAITALTDINGDGLVDVAVGAPL---EEQGAVYIFNGRHGGLSPQPSQRIEG 571

  Fly   454 EQLVEGAPYPRTFGFALSGGLDMDGNTYPDLAVGAYSSDQVFIFKSRPVAAVNAETSFASNSKLI 518
            .|::.|..:   ||.::.|..|::|:...|:||||.|  |:.:..||||  |:..|..:.:...|
Human   572 TQVLSGIQW---FGRSIHGVKDLEGDGLADVAVGAES--QMIVLSSRPV--VDMVTLMSFSPAEI 629

  Fly   519 SLDDRSCQLVRDHKKVPCMLLTTCW-------SYTGRYLPEQLDFDVSWLLDAKKLLNPRMFFLR 576
            .:.:..|.....:|....:.:|.|:       .:.|| |...|.:.:.  ||..:.....:|
Human   630 PVHEVECSYSTSNKMKEGVNITICFQIKSLIPQFQGR-LVANLTYTLQ--LDGHRTRRRGLF--- 688

  Fly   577 DEGKNIRNQTIRLNYGQKYCLNETVYLLDKVQDKLTPLEVEARYNL--RSSRPLDPMVRHRRSIL 639
            ..|::...:.|.:..... |.:.:.:....|||.::|:.|...::|  ....|.|...
Human   689 PGGRHELRRNIAVTTSMS-CTDFSFHFPVCVQDLISPINVSLNFSLWEEEGTPRDQRA------- 745

  Fly   640 EPVIDQNREI--VLRDAIN-------IQKNCGPDNICEPDLKLKVS-----TVDKYLFGSPEPLV 690
                 |.::|  :||.:::       .:||||.|..||.:|::..|     .:....|.|   |.
Human   746 -----QGKDIPPILRPSLHSETWEIPFEKNCGEDKKCEANLRVSFSPARSRALRLTAFAS---LS 802

  Fly   691 IEVFISNTNEDAFEAAFYMVTPPDLQFRKLQQLGEKKDTPITCSPPTPEN---NHTLKCDIGNPL 752
            :|:.:||..|||:.....:..||.|.|||::.|......|::|.....|:   :..|.|::.:|:
Human   803 VELSLSNLEEDAYWVQLDLHFPPGLSFRKVEMLKPHSQIPVSCEELPEESRLLSRALSCNVSSPI 867

  Fly   753 ESGKIAH-----FKISLVPEEKYGSSSSYDFYWEANST-NLEKPGSEYDNKIRQSVGIWVDTDLD 811
              .|..|     ...:.:....:|.|...    .||.| |.|......||.....:.|....::.
Human   868 --FKAGHSVALQMMFNTLVNSSWGDSVEL----HANVTCNNEDSDLLEDNSATTIIPILYPINIL 926

  Fly   812 IKGTSLPDYQLYKADDYKELENATKEDDIGP---QVVHIYEIRNNRPSIIEEAEVFIHLP-YETI 872
            |:...  |..||.:...|           ||   ||.|:|::| .:|||.:.     ::| .|.:
Human   927 IQDQE--DSTLYVSFTPK-----------GPKIHQVKHMYQVR-IQPSIHDH-----NIPTLEAV 972

  Fly   873 VGDPLMYLLNQPETGGKI 890
            ||.|      ||.:.|.|
Human   973 VGVP------QPPSEGPI 984

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_001162777.1	Int_alpha	46..110	CDD:214549	14/63 (22%)
		Int_alpha	275..>316	CDD:214549	14/61 (23%)
		Int_alpha	398..451	CDD:214549	29/52 (56%)
		Int_alpha	466..>497	CDD:214549	12/30 (40%)
		Integrin_alpha2	499..893	CDD:285619	100/428 (23%)
		DUF2756	<1120..1178	CDD:298627
ITGAL	NP_002200.2	FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	31..82		15/71 (21%)
		FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	83..141		19/87 (22%)
		vWA_integrins_alpha_subunit	155..323	CDD:238746	18/167 (11%)
		I-domain (insertion domain)	170..349		16/178 (9%)
		FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	390..445		12/56 (21%)
		Int_alpha	402..451	CDD:214549	13/52 (25%)
		FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	446..506		25/65 (38%)
		Int_alpha	456..503	CDD:214549	22/52 (42%)
		FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	507..563		32/72 (44%)
		Int_alpha	517..569	CDD:214549	29/54 (54%)
		FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	567..627		22/66 (33%)
		Int_alpha	579..>603	CDD:214549	8/26 (31%)
		Integrin_alpha2	612..983	CDD:285619	98/425 (23%)
		GFFKR motif	1115..1119
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1128..1170

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141999
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740