Protein Alignment if and ITGAE

DIOPT Version :9

• Sequence 1: NP_001162777.1
• Gene: if / 32661
• FlyBaseID: FBgn0001250
• Length: 1396
• Species: Drosophila melanogaster
• Sequence 2: XP_024306508.1
• Gene: ITGAE / 3682
• HGNCID: 6147
• Length: 1217
• Species: Homo sapiens
• Alignment Length: 1052
• Identity: 221/1052 - (21%)
• Similarity: 375/1052 - (35%)
• Gaps: 306/1052 - (29%)

  Fly    21 ILLLIAMSAHGYNIDLPSYVRFRQSSNSMFGFSIAMHKGRSGFYGNQNNVSLIVGAPKFD-TSRY 84
            :|..|..|:||..         |::|..|    :.:..|  |.:.:..|::.::.:||.. ..|:
Human   305 VLDSIFTSSHGSR---------RKASKVM----VVLTDG--GIFEDPLNLTTVINSPKMQGVERF 354

  Fly    85 QQGVTEAGGVFKCSLNDDDCKLVPFDSKGNNRNVDKEVVDRKSYQWLGATVATGRDSDLVVACAP 149
            ..||   |..||.:....:..|:..|..           :..:::........|..|.|
Human   355 AIGV---GEEFKSARTARELNLIASDPD-----------ETHAFKVTNYMALDGLLSKL------ 399

  Fly   150 RYVFHTMTPSRAFRIDPVGTCFTSHNFEEFYEVSPCRTNNWGYHRQGSCQAGFSAAINGNGSRLF 214
            ||...:|..:       ||...       .|:::               |.||||.|. :..::.
Human   400 RYNIISMEGT-------VGDAL-------HYQLA---------------QIGFSAQIL-DERQVL 434

  Fly   215 IGAPGSWYWQGQTYSIPPDAKFPFKPPLYQPFGTGGMASSHDVTRPENQVFSTSESASVNDDSYL 279
            :||.|::.|.|...             ||......|        |..||..:.:..|.....|||
Human   435 LGAVGAFDWSGGAL-------------LYDTRSRRG--------RFLNQTAAAAADAEAAQYSYL 478

  Fly   280 GYSMVTGDFDGDRSEDVAIGMPR------------GGNLVGRIVVNRWNMANIFNITGRQIGEYF 332
            ||::..  .....|.....|.||            .|.....:.|          :.|.|:|.||
Human   479 GYAVAV--LHKTCSLSYIAGAPRYKHHGAVFELQKEGREASFLPV----------LEGEQMGSYF 531

  Fly   333 GYSLATSDVDGDGLDD-LLIGAPMYTDPDNVEGKYDVGRVYILL---QGGPTEEKRWTTEHIRDG 393
            |..|...|:|.||..| ||:.||.|    :|.|  :.||||:..   |.|.....|..:.|  .|
Human   532 GSELCPVDIDMDGSTDFLLVAAPFY----HVHG--EEGRVYVYRLSEQDGSFSLARILSGH--PG 588

  Fly   394 YHSKGRFGLALTTLGDVNGDGYGDFAVGAPYDG---PEGR--GVVYIFHGSPMGPLAKPSQIIKS 453
            : :..|||.|:..:||::.|...|.|:|||.:|   .:|.  |.|||::|...|..|.|||.|::
Human   589 F-TNARFGFAMAAMGDLSQDKLTDVAIGAPLEGFGADDGASFGSVYIYNGHWDGLSASPSQRIRA 652

  Fly   454 EQLVEGAPYPRTFGFALSGGLDMDGNTYPDLAVGAYSSDQVFIFKSRPVAAVNAETSFASNSKLI 518
            ..:..|..|   ||.:::||.|:.|:...|:.||...  |..:|:||||..:....:|..::..|
Human   653 STVAPGLQY---FGMSMAGGFDISGDGLADITVGTLG--QAVVFRSRPVVRLKVSMAFTPSALPI 712

  Fly   519 SLDD----RSC-------------------------QLVRDHKKVPCMLLTTC------WSYTGR 548
            ..:.    |.|                         .:.:..:::.|..:.:|      || :|.
Human   713 GFNGVVNVRLCFEISSVTTASESGLREALLNFTLDVDVGKQRRRLQCSDVRSCLGCLREWS-SGS 776

  Fly   549 YLPEQLDFDVSWLLDAKKLLNPRMFFLRDEGKNIRNQTIRLNYGQKYCLNETVYLLDKVQDKLTP 613
            .|.|.|            ||.|      .||              :.|          .:|..:.
Human   777 QLCEDL------------LLMP------TEG--------------ELC----------EEDCFSN 799

  Fly   614 LEVEARYNLRSSRPLDPMVRHRRSILEPVIDQNREIVLRDAINIQKNCGPDNICEPDLKLKVSTV 678
            ..|:..|.|::.   :....|.    :|::|:..|......:..:|.|.....|..:|:|..:..
Human   800 ASVKVSYQLQTP---EGQTDHP----QPILDRYTEPFAIFQLPYEKACKNKLFCVAELQLATTVS 857

  Fly   679 DKYL-FGSPEPLVIEVFISNTNEDAFEAAFYMVTPPDLQFRKLQQLGEKKDTP-ITCSPPTP-EN 740
            .:.| .|..:.|.:.:.::|:.||::..:..:..|.:||.:::|    |..:| |.|..|.| .:
Human   858 QQELVVGLTKELTLNINLTNSGEDSYMTSMALNYPRNLQLKRMQ----KPPSPNIQCDDPQPVAS 918

  Fly   741 NHTLKCDIGNP-LESGKIAHFKISLVPEEKYGSSSSY------DFYWEANSTNLEKPGSEYDNKI 798
            ...:.|.||:| |:...::.|  .|:....:.:...:      ...|:     ||:  :.:.|:
Human   919 VLIMNCRIGHPVLKRSSVSRF--GLIRSSHHPAVGVFCILAHVSVVWQ-----LEE--NAFPNR- 973

  Fly   799 RQSVGIWVDTDLDIKGTSLPDYQLYKADDYKELENATKEDDIGPQVVHIYEIRN------NRPSI 857
                    ..|:.:..|:        :::.:.|.|.|          |..:.|:      ::|||
Human   974 --------TADITVTVTN--------SNERRSLANET----------HTLQFRHGFVAVLSKPSI 1012

  Fly   858 I---------EEAEVFIHLPYETIVGDPLMYLLNQPETGGKIQCDDVAFNEYNLLLDEKLVKKSY 913
            :         ...|...|:..|.:.|......:          |.........::..:||.:
Human  1013 MYVNTGQGLSHHKEFLFHVHGENLFGAEYQLQI----------CVPTKLRGLQVVAVKKLTR--- 1064

  Fly   914 LQAQG-AIWNSAQVSGQSSSSSSSGGASVHIEKARGEGFVRGVLVSNSTDAGDKLSPKQVEQRRQ 977
            .||.. ..|:..:....||..        |:|:......|......|.|.|.:.......|..:.
Human  1065 TQASTVCTWSQERACAYSSVQ--------HVEEWHSVSCVIASDKENVTVAAEISWDHSEELLKD 1121

  Fly   978 EDTLEALGDASF 989
            ...|:.||:.||
Human  1122 VTELQILGEISF 1133

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_001162777.1	Int_alpha	46..110	CDD:214549	14/64 (22%)
		Int_alpha	275..>316	CDD:214549	11/52 (21%)
		Int_alpha	398..451	CDD:214549	24/57 (42%)
		Int_alpha	466..>497	CDD:214549	10/30 (33%)
		Integrin_alpha2	499..893	CDD:285619	76/453 (17%)
		DUF2756	<1120..1178	CDD:298627
ITGAE	XP_024306508.1	vWA_integrins_alpha_subunit	218..395	CDD:238746	21/118 (18%)
		Int_alpha	527..578	CDD:214549	23/56 (41%)
		Int_alpha	591..650	CDD:214549	24/58 (41%)
		Int_alpha	660..>695	CDD:214549	13/39 (33%)
		Integrin_alpha2	693..>942	CDD:312071	57/304 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141990
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D743479at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750