DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment if and ITGAD

DIOPT Version :9

Sequence 1:	NP_001162777.1	Gene:	if / 32661	FlyBaseID:	FBgn0001250	Length:	1396	Species:	Drosophila melanogaster
Sequence 2:	XP_011544137.1	Gene:	ITGAD / 3681	HGNCID:	6146	Length:	1190	Species:	Homo sapiens

Alignment Length:	1159	Identity:	254/1159 - (21%)
Similarity:	395/1159 - (34%)	Gaps:	410/1159 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 SLILLLIAMSAHGYNIDLPSYVRFRQSSNSMFGFSIAMHKGRSGFYGNQNNVSLIVGAPKFDTSR 83
            :::||.:..|.||:|:|:.....|::.:.. ||.|:..      |.|::    |:||||....:
Human     5 TVLLLSVLASYHGFNLDVEEPTIFQEDAGG-FGQSVVQ------FGGSR----LVVGAPLEVVA- 57

  Fly    84 YQQGVTEAGGVFKCSLNDDDCKLVPFDSKGNNRNVDKEVVDRKSYQWLGATVATGRDSDLVVACA 148
                ..:.|.::.|:.....|:.:|.       ::..|.|:..    ||.|:|...:...::||.
Human    58 ----ANQTGRLYDCAAATGMCQPIPL-------HIRPEAVNMS----LGLTLAASTNGSRLLACG 107

  Fly   149 P---------------------------------------------------------------- 149
            |
Human   108 PTLHRVCGENSYSKGSCLLLGSRWEIIQTVPDATPECPHQEMDIVFLIDGSGSIDQNDFNQMKGF 172

  Fly   150 ------------------RY-----VFHTMT-----PSRAFRIDPV----GTCFTS--------- 173
                              :|     :..|.|     ||:...:||:    |..||:
Human   173 VQAVMGQFEGTDTLFALMQYSNLLKIHFTFTQFRTSPSQQSLVDPIVQLKGLTFTATGILTVVTQ 237

  Fly   174 ---------------------------------------------------HNF----------- 176
                                                               |.|
Human   238 LFHHKNGARKSAKKILIVITDGQKYKDPLEYSDVIPQAEKAGIIRYAIGVGHAFQGPTARQELNT 302

  Fly   177 ---------------------------EEFYEVSPCRTNNWGYHRQGSCQAGFSAAIN------- 207
                                       |:.|.|...::......:....|.|||.|:.
Human   303 ISSAPPQDHVFKVDNFAALGSIQKQLQEKIYAVEGTQSRASSSFQHEMSQEGFSTALTMSLPSPG 367

  Fly   208 --GNGSRLFIGAPGSWYWQGQTYSIPPDAKFPFKPPLYQPFGTGGMASSHDVTRPENQVFSTSES 270
              .:...||:||.||:.|.|..:..||:....|                         :..:.|:
Human   368 ILSSQDGLFLGAVGSFSWSGGAFLYPPNMSPTF-------------------------INMSQEN 407

  Fly   271 ASVNDDSYLGYSMVTGDFDGDRSEDVAIGMPR----GGNLVGRIVVNRWNMANIFNITGRQIGEY 331
            ..:. |||||||.....:.|  .:::.:|.||    |..::...|..:|...  ..:||.|||.|
Human   408 VDMR-DSYLGYSTELALWKG--VQNLVLGAPRYQHTGKAVIFTQVSRQWRKK--AEVTGTQIGSY 467

  Fly   332 FGYSLATSDVDGDGLDDL-LIGAPMYTDPDNVEGKYDVGRVYI--LLQGGPTEEKRWTTEHIRDG 393
            ||.||.:.|||.||..|| |||||.|.  :...|    |:|.:  |.:|   :..:|..:.:..|
Human   468 FGASLCSVDVDSDGSTDLILIGAPHYY--EQTRG----GQVSVCPLPRG---QRVQWQCDAVLRG 523

  Fly   394 Y--HSKGRFGLALTTLGDVNGDGYGDFAVGAPYDGPEGRGVVYIFHG-SPMGPLAKPSQIIKSEQ 455
            .  |..||||.|||.|||||.|...|.|:|||.: .|.||.||:||| |..|.....||.|.|.|
Human   524 EQGHPWGRFGAALTVLGDVNEDKLIDVAIGAPGE-QENRGAVYLFHGASESGISPSHSQRIASSQ 587

  Fly   456 LVEGAPYPRTFGFALSGGLDMDGNTYPDLAVGAYSSDQVFIFKSRPVAAVNAETSFASNSKLISL 520
            |   :|..:.||.|||||.|:..:...||||||  ..||.:.:|.||..|.....|       |.
Human   588 L---SPRLQYFGQALSGGQDLTQDGLMDLAVGA--RGQVLLLRSLPVLKVGVAMRF-------SP 640

  Fly   521 DDRSCQLVRDHKKVPCML----LTTCWSYTGRYLPEQLD------FDVSWLLDAKKLLNPRMFFL 575
            .:.:..:.|..::.|..|    .|.|.:.....|.:..|      ||::  ||..:|.:..:|
Human   641 VEVAKAVYRCWEEKPSALEAGDATVCLTIQKSSLDQLGDIQSSVRFDLA--LDPGRLTSRAIF-- 701

  Fly   576 RDEGKN---IRNQTIRLNYGQKYCLNETVYLL--DKVQDKLTPLEVEARYNL-RSSRPLDPMVRH 634
             :|.||   .|.:|:.|..   :|  ||:.||  |.|:|.::|:.:...::| |...|....:|
Human   702 -NETKNPTLTRRKTLGLGI---HC--ETLKLLLPDCVEDVVSPIILHLNFSLVREPIPSPQNLR- 759

  Fly   635 RRSILEPVIDQNREIVLRDAINIQKNCGPDNICEPDL--KLKVSTVDKYLFGSPEPLVIEVFISN 697
                  ||:....:.:...::..:||||.|.:||.||  .|..|.:.....||...|.:.|.:.|
Human   760 ------PVLAVGSQDLFTASLPFEKNCGQDGLCEGDLGVTLSFSGLQTLTVGSSLELNVIVTVWN 818

  Fly   698 TNEDAFEAAFYMVTPPDLQFRKL---QQLGEKKDTPITCS--PPTPENNHTLKCDIGNPL-ESGK 756
            ..||::.....:..|..|..|::   |:...:....:.|.  |...|...:.:|.:.:|: ..|.
Human   819 AGEDSYGTVVSLYYPAGLSHRRVSGAQKQPHQSALRLACETVPTEDEGLRSSRCSVNHPIFHEGS 883

  Fly   757 IAHF------------------KISLVPEEKYGSSSSYDFY------------------------ 779
            ...|                  :.|...|....|||...|.
Human   884 NGTFIVTFDVSYKATLGDRMLMRASASSENNKASSSKATFQLELPVKYAVYTMISRCPVPGLPLG 948

  Fly   780 -------WEANSTNL-------EKPGSEYDNKIRQ----------SVGIWV----------DTDL 810
                   |:..||..       ||...|.:::.|.          |:..||          |..:
Human   949 PLAFLYAWQEESTKYFNFATSDEKKMKEAEHRYRVNNLSQRDLAISINFWVPVLLNGVAVWDVVM 1013

  Fly   811 DIKGTSLPDYQLYKADDYKE-LENATKEDDIGPQVVHIYEIRNNRPSIIEEAEV 863
            :....|||.....|...:.: |...::...:...:....:.|.:.||...:.|:
Human  1014 EAPSQSLPCVSERKPPQHSDFLTQISRSPMLDCSIADCLQFRCDVPSFSVQEEL 1067

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_001162777.1	Int_alpha	46..110	CDD:214549	14/63 (22%)
		Int_alpha	275..>316	CDD:214549	13/44 (30%)
		Int_alpha	398..451	CDD:214549	30/53 (57%)
		Int_alpha	466..>497	CDD:214549	16/30 (53%)
		Integrin_alpha2	499..893	CDD:285619	95/466 (20%)
		DUF2756	<1120..1178	CDD:298627
ITGAD	XP_011544137.1	vWA_integrins_alpha_subunit	149..324	CDD:238746	12/174 (7%)
		Int_alpha	464..>506	CDD:214549	23/47 (49%)
		Int_alpha	528..583	CDD:214549	30/55 (55%)
		Int_alpha	593..>625	CDD:214549	16/33 (48%)
		Integrin_alpha2	628..>933	CDD:285619	74/328 (23%)
		Integrin_alpha	1153..1167	CDD:278771
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142040
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740