DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment if and ITGA5

DIOPT Version :9

Sequence 1:	NP_001162777.1	Gene:	if / 32661	FlyBaseID:	FBgn0001250	Length:	1396	Species:	Drosophila melanogaster
Sequence 2:	NP_002196.4	Gene:	ITGA5 / 3678	HGNCID:	6141	Length:	1049	Species:	Homo sapiens

Alignment Length:	1414	Identity:	349/1414 - (24%)
Similarity:	562/1414 - (39%)	Gaps:	425/1414 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 RRRMALHCPITSLILLLIAMSAH--GYNIDLPSYVRFRQSSNSMFGFSIAMHK-GRSGFYGNQNN 69
            |||.    |:..|:|||:.....  |:|:|..:.........|.||||:..:: |..|
Human    20 RRRP----PLLPLLLLLLPPPPRVGGFNLDAEAPAVLSGPPGSFFGFSVEFYRPGTDG------- 73

  Fly    70 VSLIVGAPKFDTSRYQQGVTEAGGVFKC--SLNDDDCKLVPFDSKGN-------NRNVDKEVVDR 125
            ||::|||||.:||  |.||.:.|.|:.|  ..:...|..:.|||||:       :.:..:|.|:.
Human    74 VSVLVGAPKANTS--QPGVLQGGAVYLCPWGASPTQCTPIEFDSKGSRLLESSLSSSEGEEPVEY 136

  Fly   126 KSYQWLGATVATGRDSDLVVACAPRYVFHTMTPSRAFRIDPVGTCFTS-HNFEEFYEVSPCRTN- 188
            ||.||.||||.....|  ::||||.|.:.|.....:   ||||||:.| .||....|.:|||::
Human   137 KSLQWFGATVRAHGSS--ILACAPLYSWRTEKEPLS---DPVGTCYLSTDNFTRILEYAPCRSDF 196

  Fly   189 NWGYHRQGSCQAGFSAAINGNGSRLFIGAPGSWYWQGQTYSIPPDAKFPFKPPLYQPFGTGGMAS 253
            :|. ..||.||.||||.....| |:.:|.|||::||||..|...:.                :|.
Human   197 SWA-AGQGYCQGGFSAEFTKTG-RVVLGGPGSYFWQGQILSATQEQ----------------IAE 243

  Fly   254 SHDVTRPENQV------FSTSESASVNDDSYLGYSMVTGDFDGDRSEDVAIGMPRGGNLVGRI-V 311
            |:   .||..:      ..|.:::|:.||||||||:..|:|.||.:||...|:|:|....|.: :
Human   244 SY---YPEYLINLVQGQLQTRQASSIYDDSYLGYSVAVGEFSGDDTEDFVAGVPKGNLTYGYVTI 305

  Fly   312 VNRWNMANIFNITGRQIGEYFGYSLATSDVDGDGLDDLLIGAPMYTD--PDNVEGK-YDVGRVYI 373
            :|..::.:::|.:|.|:..||||::|.:||:||||||||:|||:..|  ||   |: .:|||||:
Human   306 LNGSDIRSLYNFSGEQMASYFGYAVAATDVNGDGLDDLLVGAPLLMDRTPD---GRPQEVGRVYV 367

  Fly   374 LLQ--GG--PTEEKRWTTEHIRDGYHSKGRFGLALTTLGDVNGDGYGDFAVGAPYDGPEGRGVVY 434
            .||  .|  ||.....|      |:...||||.:||.|||::.|||.|.|:|||:.|...:|||:
Human   368 YLQHPAGIEPTPTLTLT------GHDEFGRFGSSLTPLGDLDQDGYNDVAIGAPFGGETQQGVVF 426

  Fly   435 IFHGSPMGPLAKPSQIIKSEQLVEGAPYPRTFGFALSGGLDMDGNTYPDLAVGAYSSDQVFIFKS 499
            :|.|.|.|..:||||::  :.|...:..|..||.||.||.|:|||.||||.||::..|:..:::.
Human   427 VFPGGPGGLGSKPSQVL--QPLWAASHTPDFFGSALRGGRDLDGNGYPDLIVGSFGVDKAVVYRG 489

  Fly   500 RPVAAVNAETSFASNSKLISLDDRSCQLVRDHKKVPCMLLTTCWSYTGRYLPEQLDFDVSWLLDA 564
            ||:  |:|..|......:.:.::|||.|  :...|.|:.|:.|.:.:|:::.:.:.|.|...||.
Human   490 RPI--VSASASLTIFPAMFNPEERSCSL--EGNPVACINLSFCLNASGKHVADSIGFTVELQLDW 550

  Fly   565 KKLLN--PRMFFLRDEGKNIRNQTIRLNYGQKYCLNETVYLLD--KVQDKLTPLEVEARYNLRSS 625
            :|...  .|..||......:....:..|..::.|....:||.:  :.:|||:|:.:...::|...
Human   551 QKQKGGVRRALFLASRQATLTQTLLIQNGAREDCREMKIYLRNESEFRDKLSPIHIALNFSLDPQ 615

  Fly   626 RPLDPMVRHRRSILEPVIDQNREIVLRDAINIQKNCGPDNICEPDLKLKVSTVDKYLF-GSPEPL 689
            .|:|   .|.   |.|.:....:..:.|...|..:||.||||.|||:|:|.....::: |....|
Human   616 APVD---SHG---LRPALHYQSKSRIEDKAQILLDCGEDNICVPDLQLEVFGEQNHVYLGDKNAL 674

  Fly   690 VIEVFISNTNE-DAFEAAFYMVTPPDLQFRKLQQLGEKKDTPITCSPPTPENNHTLKCDIGNPLE 753
            .:.....|..| .|:||...:..||:.::..|.: .....:.::|.......:..|.||:|||::
Human   675 NLTFHAQNVGEGGAYEAELRVTAPPEAEYSGLVR-HPGNFSSLSCDYFAVNQSRLLVCDLGNPMK 738

  Fly   754 SGKIAHFKISLVPEEKYGSSSSYDFYWEANSTNLEKPGSEYDNKIRQSVGIWVDTDLDIKGTSLP 818
            :|......:.........:..:..|.::..|.||....|:.   :...:.:.....:.:.|.|.|
Human   739 AGASLWGGLRFTVPHLRDTKKTIQFDFQILSKNLNNSQSDV---VSFRLSVEAQAQVTLNGVSKP 800

  Fly   819 DYQLYKADDYKELENATKEDDIGPQVVHIYEIRNNRPSIIEEAEVFIHLPYETIVGDPLMYLLNQ 883
            :..|:...|:...:...||:|:||.|.|:||:.|..||.|.:..:.:..| :.:.|..|:|:
Human   801 EAVLFPVSDWHPRDQPQKEEDLGPAVHHVYELINQGPSSISQGVLELSCP-QALEGQQLLYV--- 861

  Fly   884 PETGGKIQCDDVAFNEYNLLLDEKLVKKSYLQAQGAIWNSAQVSGQSSSSSSSGGASVHIEKARG 948
                                                    .:|:|.:.:::
Human   862 ----------------------------------------TRVTGLNCTTN-------------- 872

  Fly   949 EGFVRGVLVSNSTDAGDKLSPKQVEQRRQEDTLEALGDASFVHRDRASQAVQEPQVNQTSFTTYS 1013
                            ..::||.:|
Human   873 ----------------HPINPKGLE---------------------------------------- 881

  Fly  1014 TSSSSSGSGAPSAQLRGHSTQGHIQMAGPVQHTSSSSSSNYRSWPAQQQQQHQQLLLAGSGGSGL 1078

Human   882 ----------------------------------------------------------------- 881

  Fly  1079 GSPVTFNDKSQFGGRNNNFHTGTLDLGTLNRGNVDNELYRSQGQYQNPSQSLGQSQGQFQANANQ 1143
                                   ||                      |..||
Human   882 -----------------------LD----------------------PEGSL------------- 888

  Fly  1144 GHYQGQNQAQFQARNPGFQGQTSYQGQTQYSGQPGGYQTHHVTYSSGSKPYYGRENEDFYDEDNL 1208
             |:|.:.:|
Human   889 -HHQQKREA-------------------------------------------------------- 896

  Fly  1209 QQATPGHWSSSSSSSSSSGTRRLRRSNDKDGATEKPLQIDLNSPCQSARCKSIRCVVTNLGTEDG 1273
                      .|.||:|||.:.|:                    |..|.|..:||.:..|..::.
Human   897 ----------PSRSSASSGPQILK--------------------CPEAECFRLRCELGPLHQQES 931

  Fly  1274 DAAFVAIRARMVAKTMEKLASNVPLNVSTLAVANVTLLPFIGAPKDAIVKTHEIFYKAEPEPLQV 1338
            .:  :.:..|:.|||..: ..:.|.::...||.....:|:...|:....|..::....:....:.
Human   932 QS--LQLHFRVWAKTFLQ-REHQPFSLQCEAVYKALKMPYRILPRQLPQKERQVATAVQWTKAEG 993

  Fly  1339 PDVVPLWVVVLAACAGALIFLLLVWLLYKCGFFNRNRPTDHSQERQPLR 1387
            ...||||:::||...|.|:..||:::|||.|||.|:.|...:.|:..|:
Human   994 SYGVPLWIIILAILFGLLLLGLLIYILYKLGFFKRSLPYGTAMEKAQLK 1042

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_001162777.1	Int_alpha	46..110	CDD:214549	23/66 (35%)
		Int_alpha	275..>316	CDD:214549	19/41 (46%)
		Int_alpha	398..451	CDD:214549	29/52 (56%)
		Int_alpha	466..>497	CDD:214549	17/30 (57%)
		Integrin_alpha2	499..893	CDD:285619	94/399 (24%)
		DUF2756	<1120..1178	CDD:298627	6/57 (11%)
ITGA5	NP_002196.4	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	43..108		24/73 (33%)
		Int_alpha	56..114	CDD:214549	23/66 (35%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	128..188		26/64 (41%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	192..245		23/70 (33%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	259..311		21/51 (41%)
		Int_alpha	268..>310	CDD:214549	19/41 (46%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	312..377		33/67 (49%)
		Int_alpha	322..379	CDD:214549	31/59 (53%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	378..437		28/64 (44%)
		Int_alpha	389..443	CDD:214549	29/53 (55%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	441..504		25/66 (38%)
		Int_alpha	455..498	CDD:214549	21/44 (48%)
		Integrin_alpha2	490..921	CDD:312071	117/768 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	877..907		17/259 (7%)
		Interaction with HPS5	1021..1028		5/6 (83%)
		GFFKR motif	1024..1028		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	175	1.000	Domainoid score	I3647
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	497	1.000	Inparanoid score	I1389
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D325432at33208
OrthoFinder	1	1.000	-	-		FOG0001619
OrthoInspector	1	1.000	-	-		otm41436
orthoMCL	1	0.900	-	-		OOG6_102088
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2711
SonicParanoid	1	1.000	-	-		X587
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.860