DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment if and ITGA4

DIOPT Version :9

Sequence 1:NP_001162777.1 Gene:if / 32661 FlyBaseID:FBgn0001250 Length:1396 Species:Drosophila melanogaster
Sequence 2:NP_000876.3 Gene:ITGA4 / 3676 HGNCID:6140 Length:1032 Species:Homo sapiens


Alignment Length:1100 Identity:261/1100 - (23%)
Similarity:462/1100 - (42%) Gaps:218/1100 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 RRMALHCPITSLILLLIAM---SAHGYNIDLPSYVRFRQSSNSMFGFSIAMHKGRSGFYGNQNNV 70
            ||.|    :...::||:.:   :...||:|..|.:.::...|::||:|:.:|       .:..|.
Human    12 RRAA----VRETVMLLLCLGVPTGRPYNVDTESALLYQGPHNTLFGYSVVLH-------SHGANR 65

  Fly    71 SLIVGAPKFDTSRY--QQGVTEAGGVFKCSLNDD---DCKLVPFDSKGNNRNVDKEVVDRKSYQW 130
            .|:||||   |:.:  ...|...|.:::|.:..:   .|:.:...|. |.....|..::.:..||
Human    66 WLLVGAP---TANWLANASVINPGAIYRCRIGKNPGQTCEQLQLGSP-NGEPCGKTCLEERDNQW 126

  Fly   131 LGATVA--TGRDSDLVVACAPRY--VFHTMTPSRAFRIDPVGTCF---TSHNFEEFYEVSPCRTN 188
            ||.|::  .|.:.. :|.|..|:  :|:....::.    |.|.|:   .....|....::||..:
Human   127 LGVTLSRQPGENGS-IVTCGHRWKNIFYIKNENKL----PTGGCYGVPPDLRTELSKRIAPCYQD 186

  Fly   189 NWGYHRQ-----GSCQAGFSAAINGNGSRLFIGAPGSWYWQGQTYSIPPDAKFPFKPPLYQPFGT 248
               |.::     .|||||.|:....:  .:.:|||||.||.|..:                    
Human   187 ---YVKKFGENFASCQAGISSFYTKD--LIVMGAPGSSYWTGSLF-------------------- 226

  Fly   249 GGMASSHDVTRPENQVFSTSESASVNDDSYLGYSMVTGDFDGDRSEDVAIGMPRGGNLVGRIVVN 313
                 .:::|..:.:.|...:: .|...||||||:..|.|....:.:|..|.|: ...:|:    
Human   227 -----VYNITTNKYKAFLDKQN-QVKFGSYLGYSVGAGHFRSQHTTEVVGGAPQ-HEQIGK---- 280

  Fly   314 RWNMANIFNI-----------TGRQIGEYFGYSLATSDVDGDGLDDLLIGAPMYTDPDNVEGKYD 367
                |.||:|           .|:::|.|||.|:...|::.||..|||:||||.:.      ..:
Human   281 ----AYIFSIDEKELNILHEMKGKKLGSYFGASVCAVDLNADGFSDLLVGAPMQST------IRE 335

  Fly   368 VGRVYILLQGGPTEEKRWTTEHIRDGYHSKGRFGLALTTLGDVNGDGYGDFAVGAPYDGPEGRGV 432
            .|||::.:..|..........::........|||.::..|||::.||:.|.|:|||.: .:.:|.
Human   336 EGRVFVYINSGSGAVMNAMETNLVGSDKYAARFGESIVNLGDIDNDGFEDVAIGAPQE-DDLQGA 399

  Fly   433 VYIFHGSPMGPLAKPSQIIKSEQLVEGAPYPRTFGFALSGGLDMDGNTYPDLAVGAYSSDQVFIF 497
            :||::|...|..:..||.|:..|:.:..   ..||.::||.:|.|.|.|.|:||||:.||...:.
Human   400 IYIYNGRADGISSTFSQRIEGLQISKSL---SMFGQSISGQIDADNNGYVDVAVGAFRSDSAVLL 461

  Fly   498 KSRPVAAVNAETSFASNSKLISLDDRSCQLVRDHKKVPCMLLTTCWSYTGRYLPEQ--LDFDVSW 560
            ::|||..|:|..|...:......|   |  |.:.....|:.||.|:||.|:.:|..  |.:::|.
Human   462 RTRPVVIVDASLSHPESVNRTKFD---C--VENGWPSVCIDLTLCFSYKGKEVPGYIVLFYNMSL 521

  Fly   561 LLDAKKLLNPRMFFLRDEGKNIRNQTIRLNYGQKYCLNETVYLLDKVQDKLTPLEVEARYNLRSS 625
            .::.|....||.:|..:...::...:|:::..:..|.....::...|:|.|||:::||.|:    
Human   522 DVNRKAESPPRFYFSSNGTSDVITGSIQVSSREANCRTHQAFMRKDVRDILTPIQIEAAYH---- 582

  Fly   626 RPLDPMVRHRRSI-----LEPVIDQNRE-IVLRDAINIQKNCGPDNICEPDLK-------LKVST 677
              |.|.|..:||.     |:|::.|.:| .:::..||..:.|..:| |..||:       ||...
Human   583 --LGPHVISKRSTEEFPPLQPILQQKKEKDIMKKTINFARFCAHEN-CSADLQVSAKIGFLKPHE 644

  Fly   678 VDKYL-FGSPEPLVIEVFISNTNEDAFEAAFYMVTPPDLQFRKLQQLGEKKDTPITCSPPTPENN 741
            ...|| .||.:.|::.|.:.|..:||:|...::..|..|.|.|:.:|.||:   |.|........
Human   645 NKTYLAVGSMKTLMLNVSLFNAGDDAYETTLHVKLPVGLYFIKILELEEKQ---INCEVTDNSGV 706

  Fly   742 HTLKCDIGNPLESGKIAHFKISLVPEEKYGSSSSYDFYWEANST--NLEKPGSEYDNKIRQSVGI 804
            ..|.|.||. :....::...||.:.:....|.:..|.....::|  |.|:..:...:::..::.:
Human   707 VQLDCSIGY-IYVDHLSRIDISFLLDVSSLSRAEEDLSITVHATCENEEEMDNLKHSRVTVAIPL 770

  Fly   805 WVDTDLDIKGTSLPDYQLYKADDYKELENATKEDDIGPQVVHIYEIRNNRPSIIEEAEVFIHLPY 869
            ..:..|.:.|...|...:|.::|..|.|....|     ::...:.:.|...|:.....|.|.:|.
Human   771 KYEVKLTVHGFVNPTSFVYGSNDENEPETCMVE-----KMNLTFHVINTGNSMAPNVSVEIMVPN 830

  Fly   870 ----ETIVGDPLMYLLNQPETGGKIQCDDVAFNEYNLLLDEKLVKKSYLQAQGAIWNSAQVS--- 927
                :|   |.|..:|:...|.|  :|.   |..|..:...:..|.:....:|.:...::..   
Human   831 SFSPQT---DKLFNILDVQTTTG--ECH---FENYQRVCALEQQKSAMQTLKGIVRFLSKTDKRL 887

  Fly   928 -----------------GQSSSSSSSGGASVHIE------------------KARGEGFVRGVLV 957
                             |:..|...   |||||:                  :.|..||      
Human   888 LYCIKADPHCLNFLCNFGKMESGKE---ASVHIQLEGRPSILEMDETSALKFEIRATGF------ 943

  Fly   958 SNSTDAGDKLSPKQVEQRRQEDTLEALGDASFVHRDRASQAVQEPQVNQTSFTTYSTSSS 1017
                   .:.:|:.:|..:.|:....|.:.  :|..|..:          .||....|||
Human   944 -------PEPNPRVIELNKDENVAHVLLEG--LHHQRPKR----------YFTIVIISSS 984

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ifNP_001162777.1 Int_alpha 46..110 CDD:214549 16/68 (24%)
Int_alpha 275..>316 CDD:214549 12/40 (30%)
Int_alpha 398..451 CDD:214549 20/52 (38%)
Int_alpha 466..>497 CDD:214549 15/30 (50%)
Integrin_alpha2 499..893 CDD:285619 100/415 (24%)
DUF2756 <1120..1178 CDD:298627
ITGA4NP_000876.3 FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 35..100 18/74 (24%)
Int_alpha 48..105 CDD:214549 16/66 (24%)
FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 110..177 16/71 (23%)
FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 185..237 16/81 (20%)
FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 238..291 18/62 (29%)
FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 292..351 20/64 (31%)
Int_alpha 303..352 CDD:214549 19/54 (35%)
FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 355..412 18/57 (32%)
Int_alpha 366..418 CDD:214549 20/52 (38%)
FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 416..478 24/64 (38%)
Int_alpha 428..479 CDD:214549 21/50 (42%)
Integrin_alpha2 463..902 CDD:285619 105/467 (22%)
SG1 606..616 1/9 (11%)
GFFKR motif 1003..1007
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165142046
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3637
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.740

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