Protein Alignment if and ITGA4

DIOPT Version :10

• Sequence 1: NP_523378.2
• Gene: if / 32661
• FlyBaseID: FBgn0001250
• Length: 1396
• Species: Drosophila melanogaster
• Sequence 2: NP_000876.3
• Gene: ITGA4 / 3676
• HGNCID: 6140
• Length: 1032
• Species: Homo sapiens
• Alignment Length: 1100
• Identity: 261/1100 - (23%)
• Similarity: 462/1100 - (42%)
• Gaps: 218/1100 - (19%)

  Fly     9 RRMALHCPITSLILLLIAM---SAHGYNIDLPSYVRFRQSSNSMFGFSIAMHKGRSGFYGNQNNV 70
            ||.|    :...::||:.:   :...||:|..|.:.::...|::||:|:.:|       .:..|.
Human    12 RRAA----VRETVMLLLCLGVPTGRPYNVDTESALLYQGPHNTLFGYSVVLH-------SHGANR 65

  Fly    71 SLIVGAPKFDTSRY--QQGVTEAGGVFKCSLNDD---DCKLVPFDSKGNNRNVDKEVVDRKSYQW 130
            .|:||||   |:.:  ...|...|.:::|.:..:   .|:.:...|. |.....|..::.:..||
Human    66 WLLVGAP---TANWLANASVINPGAIYRCRIGKNPGQTCEQLQLGSP-NGEPCGKTCLEERDNQW 126

  Fly   131 LGATVA--TGRDSDLVVACAPRY--VFHTMTPSRAFRIDPVGTCF---TSHNFEEFYEVSPCRTN 188
            ||.|::  .|.:.. :|.|..|:  :|:....::.    |.|.|:   .....|....::||..:
Human   127 LGVTLSRQPGENGS-IVTCGHRWKNIFYIKNENKL----PTGGCYGVPPDLRTELSKRIAPCYQD 186

  Fly   189 NWGYHRQ-----GSCQAGFSAAINGNGSRLFIGAPGSWYWQGQTYSIPPDAKFPFKPPLYQPFGT 248
               |.::     .|||||.|:....:  .:.:|||||.||.|..:
Human   187 ---YVKKFGENFASCQAGISSFYTKD--LIVMGAPGSSYWTGSLF-------------------- 226

  Fly   249 GGMASSHDVTRPENQVFSTSESASVNDDSYLGYSMVTGDFDGDRSEDVAIGMPRGGNLVGRIVVN 313
                 .:::|..:.:.|...:: .|...||||||:..|.|....:.:|..|.|: ...:|:
Human   227 -----VYNITTNKYKAFLDKQN-QVKFGSYLGYSVGAGHFRSQHTTEVVGGAPQ-HEQIGK---- 280

  Fly   314 RWNMANIFNI-----------TGRQIGEYFGYSLATSDVDGDGLDDLLIGAPMYTDPDNVEGKYD 367
                |.||:|           .|:::|.|||.|:...|::.||..|||:||||.:.      ..:
Human   281 ----AYIFSIDEKELNILHEMKGKKLGSYFGASVCAVDLNADGFSDLLVGAPMQST------IRE 335

  Fly   368 VGRVYILLQGGPTEEKRWTTEHIRDGYHSKGRFGLALTTLGDVNGDGYGDFAVGAPYDGPEGRGV 432
            .|||::.:..|..........::........|||.::..|||::.||:.|.|:|||.: .:.:|.
Human   336 EGRVFVYINSGSGAVMNAMETNLVGSDKYAARFGESIVNLGDIDNDGFEDVAIGAPQE-DDLQGA 399

  Fly   433 VYIFHGSPMGPLAKPSQIIKSEQLVEGAPYPRTFGFALSGGLDMDGNTYPDLAVGAYSSDQVFIF 497
            :||::|...|..:..||.|:..|:.:..   ..||.::||.:|.|.|.|.|:||||:.||...:.
Human   400 IYIYNGRADGISSTFSQRIEGLQISKSL---SMFGQSISGQIDADNNGYVDVAVGAFRSDSAVLL 461

  Fly   498 KSRPVAAVNAETSFASNSKLISLDDRSCQLVRDHKKVPCMLLTTCWSYTGRYLPEQ--LDFDVSW 560
            ::|||..|:|..|...:......|   |  |.:.....|:.||.|:||.|:.:|..  |.:::|.
Human   462 RTRPVVIVDASLSHPESVNRTKFD---C--VENGWPSVCIDLTLCFSYKGKEVPGYIVLFYNMSL 521

  Fly   561 LLDAKKLLNPRMFFLRDEGKNIRNQTIRLNYGQKYCLNETVYLLDKVQDKLTPLEVEARYNLRSS 625
            .::.|....||.:|..:...::...:|:::..:..|.....::...|:|.|||:::||.|:
Human   522 DVNRKAESPPRFYFSSNGTSDVITGSIQVSSREANCRTHQAFMRKDVRDILTPIQIEAAYH---- 582

  Fly   626 RPLDPMVRHRRSI-----LEPVIDQNRE-IVLRDAINIQKNCGPDNICEPDLK-------LKVST 677
              |.|.|..:||.     |:|::.|.:| .:::..||..:.|..:| |..||:       ||...
Human   583 --LGPHVISKRSTEEFPPLQPILQQKKEKDIMKKTINFARFCAHEN-CSADLQVSAKIGFLKPHE 644

  Fly   678 VDKYL-FGSPEPLVIEVFISNTNEDAFEAAFYMVTPPDLQFRKLQQLGEKKDTPITCSPPTPENN 741
            ...|| .||.:.|::.|.:.|..:||:|...::..|..|.|.|:.:|.||:   |.|........
Human   645 NKTYLAVGSMKTLMLNVSLFNAGDDAYETTLHVKLPVGLYFIKILELEEKQ---INCEVTDNSGV 706

  Fly   742 HTLKCDIGNPLESGKIAHFKISLVPEEKYGSSSSYDFYWEANST--NLEKPGSEYDNKIRQSVGI 804
            ..|.|.||. :....::...||.:.:....|.:..|.....::|  |.|:..:...:::..::.:
Human   707 VQLDCSIGY-IYVDHLSRIDISFLLDVSSLSRAEEDLSITVHATCENEEEMDNLKHSRVTVAIPL 770

  Fly   805 WVDTDLDIKGTSLPDYQLYKADDYKELENATKEDDIGPQVVHIYEIRNNRPSIIEEAEVFIHLPY 869
            ..:..|.:.|...|...:|.::|..|.|....|     ::...:.:.|...|:.....|.|.:|.
Human   771 KYEVKLTVHGFVNPTSFVYGSNDENEPETCMVE-----KMNLTFHVINTGNSMAPNVSVEIMVPN 830

  Fly   870 ----ETIVGDPLMYLLNQPETGGKIQCDDVAFNEYNLLLDEKLVKKSYLQAQGAIWNSAQVS--- 927
                :|   |.|..:|:...|.|  :|.   |..|..:...:..|.:....:|.:...::..
Human   831 SFSPQT---DKLFNILDVQTTTG--ECH---FENYQRVCALEQQKSAMQTLKGIVRFLSKTDKRL 887

  Fly   928 -----------------GQSSSSSSSGGASVHIE------------------KARGEGFVRGVLV 957
                             |:..|...   |||||:                  :.|..||
Human   888 LYCIKADPHCLNFLCNFGKMESGKE---ASVHIQLEGRPSILEMDETSALKFEIRATGF------ 943

  Fly   958 SNSTDAGDKLSPKQVEQRRQEDTLEALGDASFVHRDRASQAVQEPQVNQTSFTTYSTSSS 1017
                   .:.:|:.:|..:.|:....|.:.  :|..|..:          .||....|||
Human   944 -------PEPNPRVIELNKDENVAHVLLEG--LHHQRPKR----------YFTIVIISSS 984

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_523378.2	Int_alpha	46..110	CDD:214549	16/68 (24%)
		Int_alpha	275..>316	CDD:214549	12/40 (30%)
		Int_alpha	398..451	CDD:214549	20/52 (38%)
		Int_alpha	466..>497	CDD:214549	15/30 (50%)
		Integrin_alpha2	500..892	CDD:462478	100/413 (24%)
		Glutenin_hmw	<1121..1216	CDD:367362
ITGA4	NP_000876.3	FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	35..100		18/74 (24%)
		Int_alpha	48..105	CDD:214549	16/66 (24%)
		FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	110..177		16/71 (23%)
		FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	185..237		16/81 (20%)
		FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	238..291		18/62 (29%)
		FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	292..351		20/64 (31%)
		Int_alpha	303..352	CDD:214549	19/54 (35%)
		FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	355..412		18/57 (32%)
		Int_alpha	366..418	CDD:214549	20/52 (38%)
		FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	416..478		24/64 (38%)
		Int_alpha	428..479	CDD:214549	21/50 (42%)
		Integrin_alpha2	464..902	CDD:462478	105/466 (23%)
		SG1	606..616		1/9 (11%)
		GFFKR motif	1003..1007