Protein Alignment if and ITGA3

DIOPT Version :10

• Sequence 1: NP_523378.2
• Gene: if / 32661
• FlyBaseID: FBgn0001250
• Length: 1396
• Species: Drosophila melanogaster
• Sequence 2: NP_002195.1
• Gene: ITGA3 / 3675
• HGNCID: 6139
• Length: 1051
• Species: Homo sapiens
• Alignment Length: 1475
• Identity: 322/1475 - (21%)
• Similarity: 513/1475 - (34%)
• Gaps: 570/1475 - (38%)

  Fly    12 ALHCPITSLILLLIAMSAHG-----YNIDLPSYVRF---RQSSN--SMFGFSIAMHKGRSGFYGN 66
            |...|...|..|.:.::|.|     :|:|    .||   :::.|  |:||:|:|:|:...    .
Human     8 APRAPRLMLCALALMVAAGGCVVSAFNLD----TRFLVVKEAGNPGSLFGYSVALHRQTE----R 64

  Fly    67 QNNVSLIVGAPKFDTSRYQQGVT-EAGGVFKCSL--NDDDCKLVPFDSKGN-NRNVDKEVVDRKS 127
            |....|:.|||:  ......|.| ..|.|:.|.|  :.|||:.:....|.: ..::.:::
Human    65 QQRYLLLAGAPR--ELAVPDGYTNRTGAVYLCPLTAHKDDCERMNITVKNDPGHHIIEDM----- 122

  Fly   128 YQWLGATVATGRDSDLVVACAPRYVFHTMTPSRAFRIDPVGTCFTSHNFEEF--------YEVSP 184
              |||.|||:...:..|:.||.||.....:.|...| ..||.|:...|..|.        |....
Human   123 --WLGVTVASQGPAGRVLVCAHRYTQVLWSGSEDQR-RMVGKCYVRGNDLELDSSDDWQTYHNEM 184

  Fly   185 CRTNNWGYHRQGSCQAGFSAAINGNGSRLFIGAPGSWYWQGQTYSIPPD----AKFPFKPPLYQP 245
            |.:|. .|...|.||.|.|.....|  .::.||||::.|:|.:|.|...    :::.:|.
Human   185 CNSNT-DYLETGMCQLGTSGGFTQN--TVYFGAPGAYNWKGNSYMIQRKEWDLSEYSYKD----- 241

  Fly   246 FGTGGMASSHDVTRPENQVFSTSESASVNDDSYLGYSMVTGDFD-GDRSEDVAIGMPR------- 302
                          ||:|           .:.|:||:|..|.|. ..::..:..|.||
Human   242 --------------PEDQ-----------GNLYIGYTMQVGSFILHPKNITIVTGAPRHRHMGAV 281

  Fly   303 -------GGNLVGRIVVNRWNMANIFNITGRQIGEYFGYSLATSDVDGDGLDDLLIGAPMYTDPD 360
                   ||:|..|.|           :.|.|:|.|||.::|.:|::.||..|||:|||.|
Human   282 FLLSQEAGGDLRRRQV-----------LEGSQVGAYFGSAIALADLNNDGWQDLLVGAPYY---- 331

  Fly   361 NVEGKYDV-GRVYI--------------LLQGGPTEEKRWTTEHIRDGYHSKGRFGLALTTLGDV 410
             .|.|.:| |.:|:              ||..||                |...|||::.::||:
Human   332 -FERKEEVGGAIYVFMNQAGTSFPAHPSLLLHGP----------------SGSAFGLSVASIGDI 379

  Fly   411 NGDGYGDFAVGAPYDGPEGRGVVYIFHGSPMGPLAKPSQIIKSEQLVEGAPYPRTFGFALSGGLD 475
            |.||:.|.|||||:   ||.|.|||:|.|..|.|.:|.|:|..|:|  |.|...|||::|||.:|
Human   380 NQDGFQDIAVGAPF---EGLGKVYIYHSSSKGLLRQPQQVIHGEKL--GLPGLATFGYSLSGQMD 439

  Fly   476 MDGNTYPDLAVGAYSSDQVFIFKSRPVAAVNAETSFASNSKLIS----LDDRSCQLVRDHKKVPC 536
            :|.|.||||.||:. ||.:.:.::|||..:..:|       |:.    ||...|      ....|
Human   440 VDENFYPDLLVGSL-SDHIVLLRARPVINIVHKT-------LVPRPAVLDPALC------TATSC 490

  Fly   537 MLLTTCWSY-----TGRYLPEQLDFDVSWLLDA-KKLLNPRMFFLRDEGKNIRNQTIRLNYGQKY 595
            :.:..|::|     ...|   :.:..:::.|:| :....||:.|...|......   ..:..:..
Human   491 VQVELCFAYNQSAGNPNY---RRNITLAYTLEADRDRRPPRLRFAGSESAVFHG---FFSMPEMR 549

  Fly   596 CLNETVYLLDKVQDKLTPLEVEARYNLRSSRPLDPMVRHRRSILEPVIDQNREIVLRDAINIQKN 660
            |....:.|:|.::|||.|:.:...|:|....|..|.:..|.....|:::|.:.:.....:..||.
Human   550 CQKLELLLMDNLRDKLRPIIISMNYSLPLRMPDRPRLGLRSLDAYPILNQAQALENHTEVQFQKE 614

  Fly   661 CGPDNICEPDLKLKVSTVDK--------YLFGSPEPLVIEVFISNT------NEDAFEAAFYMVT 711
            |||||.||.:|:::.:.|.:        ........|::.:.::||      .|||.||...:|.
Human   615 CGPDNKCESNLQMRAAFVSEQQQKLSRLQYSRDVRKLLLSINVTNTRTSERSGEDAHEALLTLVV 679

  Fly   712 PPDLQFRKLQQLGEKKDTPITCSPPTPENNHTLKCDIGNPLESGKIAHFKISLVPEEKYGSSSSY 776
            ||.|....::       .|..|     :.|.|:.|::|||.:..:.....|:.
Human   680 PPALLLSSVR-------PPGAC-----QANETIFCELGNPFKRNQRMELLIAF------------ 720

  Fly   777 DFYWEANSTNLEKPGSEYDNKIRQSVGIWVDT-DLDIKGTSLPDYQLYKADDYKELENATKEDDI 840
                                   :.:|:.:.| ||.:        ||       :|..::.:|::
Human   721 -----------------------EVIGVTLHTRDLQV--------QL-------QLSTSSHQDNL 747

  Fly   841 GPQVVHIYEIRNNRPSIIEEAEVFIHLPYETIVGDPLMYLLNQPETGGKIQCDDVAFNEYNLLLD 905
            .|.::                                                       .||:|
Human   748 WPMIL-------------------------------------------------------TLLVD 757

  Fly   906 EKLVKKSYLQAQGAIWNSAQVSGQSSSSSSSGGASVHIEKARGEGFVRGVLVSNSTDAGDKLSPK 970
            ..|                    |:|.|         :...|.:.|..|.::..|   |.|
Human   758 YTL--------------------QTSLS---------MVNHRLQSFFGGTVMGES---GMK---- 786

  Fly   971 QVEQRRQEDTLEALGDASFVHRDRASQAVQEPQVNQTSFTTYSTSSSSSGSGAPSAQLRGHSTQG 1035
                     |:|.:|          |....|.||
Human   787 ---------TVEDVG----------SPLKYEFQV------------------------------- 801

  Fly  1036 HIQMAGPVQHTSSSSSSNYRSWPAQQQQQHQQLLLAGSGGSGLGSPVTFNDKSQFGGRNNNFHTG 1100
                 ||:                            |.|..||                     |
Human   802 -----GPM----------------------------GEGLVGL---------------------G 812

  Fly  1101 TLDLGTLNRGNVDNELYRSQGQYQNPSQSLGQSQGQFQANANQGHYQGQNQAQFQARNPGFQGQT 1165
            ||.||.             :..|:       .|.|::..
Human   813 TLVLGL-------------EWPYE-------VSNGKWLL-------------------------- 831

  Fly  1166 SYQGQTQYSGQPGGYQTHHVTYSSGSKPYYGRENEDFYDEDNLQQATPGHWSSSSSSSSSSGTRR 1230
                          |.|....:.:||.|.  |...|..:..||..:.||...||        .:|
Human   832 --------------YPTEITVHGNGSWPC--RPPGDLINPLNLTLSDPGDRPSS--------PQR 872

  Fly  1231 LRRSNDKDG---------ATEKPLQIDLNSPCQSAR--CKSIRC------VVTNLGTEDGDAAFV 1278
            .||..|..|         |..|..:.:....|.:.|  |..:.|      ||||          |
Human   873 RRRQLDPGGGQGPPPVTLAAAKKAKSETVLTCATGRAHCVWLECPIPDAPVVTN----------V 927

  Fly  1279 AIRARMVAKT-------MEKLASN------VPLNVSTLAVANVTLLPFIGAPKDAIVKTHEIFYK 1330
            .::||:...|       .:::..|      :..::.|:.:.|.|....:....:.:.
Human   928 TVKARVWNSTFIEDYRDFDRVRVNGWATLFLRTSIPTINMENKTTWFSVDIDSELVE-------- 984

  Fly  1331 AEPEPLQVPDVVPLWVVVLAACAGALIFLLLVWLLYKCGFFNRNR 1375
                  ::|..:.||:|::|..||.|:..|::.||:|||||.|.|
Human   985 ------ELPAEIELWLVLVAVGAGLLLLGLIILLLWKCGFFKRAR 1023

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_523378.2	Int_alpha	46..110	CDD:214549	21/68 (31%)
		Int_alpha	275..>316	CDD:214549	14/55 (25%)
		Int_alpha	398..451	CDD:214549	26/52 (50%)
		Int_alpha	466..>497	CDD:214549	16/30 (53%)
		Integrin_alpha2	500..892	CDD:462478	73/416 (18%)
		Glutenin_hmw	<1121..1216	CDD:367362	14/94 (15%)
ITGA3	NP_002195.1	FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	38..103		21/70 (30%)
		Int_alpha	48..108	CDD:214549	20/65 (31%)
		FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	110..171		18/68 (26%)
		FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	185..235		17/52 (33%)
		FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	236..292		15/85 (18%)
		FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	293..354		24/76 (32%)
		Int_alpha	304..352	CDD:214549	20/52 (38%)
		FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	356..411		28/73 (38%)
		Int_alpha	365..417	CDD:214549	27/54 (50%)
		FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	415..477		28/71 (39%)
		Int_alpha	430..481	CDD:214549	21/58 (36%)
		Integrin_alpha2	463..916	CDD:462478	130/798 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	855..889		11/41 (27%)
		Interaction with HPS5	1015..1021		5/5 (100%)
		GFFKR motif	1017..1021		3/3 (100%)