DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment if and ITGA2B

DIOPT Version :9

Sequence 1:	NP_001162777.1	Gene:	if / 32661	FlyBaseID:	FBgn0001250	Length:	1396	Species:	Drosophila melanogaster
Sequence 2:	NP_000410.2	Gene:	ITGA2B / 3674	HGNCID:	6138	Length:	1039	Species:	Homo sapiens

Alignment Length:	931	Identity:	279/931 - (29%)
Similarity:	441/931 - (47%)	Gaps:	132/931 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 CPITSL-----ILLLI----AMSAHGYNIDLPSYVRFRQSSN-SMFGFSIAMHKGRSGFYGNQNN 69
            ||:.:|     :|||:    |..|...|:| |..:.|....| |.||||:..||...|      .
Human     6 CPLQALWLLEWVLLLLGPCAAPPAWALNLD-PVQLTFYAGPNGSQFGFSLDFHKDSHG------R 63

  Fly    70 VSLIVGAPKFDTSRYQQGVTEAGGVFKCSLNDD--DCKLVPFDSKGNNRNVDKEVVDR-KSYQWL 131
            |:::||||:  |....|  .|.||||.|....:  .|..:.||.:...|||..:.:.. |:.|.|
Human    64 VAIVVGAPR--TLGPSQ--EETGGVFLCPWRAEGGQCPSLLFDLRDETRNVGSQTLQTFKARQGL 124

  Fly   132 GATVATGRDSDLVVACAPRYVFHTMTPSRAFRIDPVGTCFTSH-NFEEFYEVSPCRTN------- 188
            ||:|.:.  ||::|||||...::.:..:......|||:||.:. ......|.||||.|
Human   125 GASVVSW--SDVIVACAPWQHWNVLEKTEEAEKTPVGSCFLAQPESGRRAEYSPCRGNTLSRIYV 187

  Fly   189 ----NWGYHRQGSCQAGFSAAINGNGSRLFIGAPGSWYWQGQTYSIPPDAKFPFKPPLYQPFGTG 249
                :|.   :..|:||||:.:...| .|.:||||.:|:.|.....|....|....|....:...
Human   188 ENDFSWD---KRYCEAGFSSVVTQAG-ELVLGAPGGYYFLGLLAQAPVADIFSSYRPGILLWHVS 248

  Fly   250 GMASSHDVTRPENQVFSTSESASVNDDSYLGYSMVTGDFDGD-RSEDVAIGMPRGGNLVGRIVVN 313
            ..:.|.|.:.||  .|          |.|.|||:..|:|||| .:.:..:|.|.....:|.:.:.
Human   249 SQSLSFDSSNPE--YF----------DGYWGYSVAVGEFDGDLNTTEYVVGAPTWSWTLGAVEIL 301

  Fly   314 RWNMANIFNITGRQIGEYFGYSLATSDVDGDGLDDLLIGAPMYTDPDNVEGKYDVGRVYILLQ-- 376
            ......:..:.|.|:..|||:|:|.:||:|||..|||:|||:|.:........:|||||:.||
Human   302 DSYYQRLHRLRGEQMASYFGHSVAVTDVNGDGRHDLLVGAPLYMESRADRKLAEVGRVYLFLQPR 366

  Fly   377 -----GGPTEEKRWTTEHIRDGYHSKGRFGLALTTLGDVNGDGYGDFAVGAPYDGPEGRGVVYIF 436
                 |.|:        .:..|....||||.|:..|||::.|||.|.||.|||.||.|||.|.:|
Human   367 GPHALGAPS--------LLLTGTQLYGRFGSAIAPLGDLDRDGYNDIAVAAPYGGPSGRGQVLVF 423

  Fly   437 HGSPMGPLAKPSQIIKSEQLVEGAPYP--RTFGFALSGGLDMDGNTYPDLAVGAYSSDQVFIFKS 499
            .|...|..::|||::.|       |:|  ..|||:|.|.:|:|.|.||||.||||.::||.::::
Human   424 LGQSEGLRSRPSQVLDS-------PFPTGSAFGFSLRGAVDIDDNGYPDLIVGAYGANQVAVYRA 481

  Fly   500 RPVAAVNAETSFASNSKLISLDD-----RSCQLVRDHKKVPCMLLTTCWSYTGRYLPEQLDFDVS 559
            :||...:.:        |:..|.     :||.|.:....|.|..:..|...||..:|::|..:..
Human   482 QPVVKASVQ--------LLVQDSLNPAVKSCVLPQTKTPVSCFNIQMCVGATGHNIPQKLSLNAE 538

  Fly   560 WLLDAKKLLNPRMFFLRDEGKNIRNQTIRLNYGQKY---CLNETVYLLDKV--QDKLTPLEVEAR 619
            ..||.:|....|...|.  |......|:.|:.|.|:   |.....:|.|:.  :|||:|:.:...
Human   539 LQLDRQKPRQGRRVLLL--GSQQAGTTLNLDLGGKHSPICHTTMAFLRDEADFRDKLSPIVLSLN 601

  Fly   620 YNLRSSRPLDPMVRHRRSILEPVIDQNREIVLRDAINIQKNCGPDNICEPDLKLKVS-TVDKYLF 683
            .:|..:          .:.:.|.:..:.:..:::...|..:||.|::|.|.|:|..| |....|.
Human   602 VSLPPT----------EAGMAPAVVLHGDTHVQEQTRIVLDCGEDDVCVPQLQLTASVTGSPLLV 656

  Fly   684 GSPEPLVIEVFISNTNEDAFEAAFYMVTPPDLQF-RKLQQL-GEKKDTPITCSPPTPENNHTLKC 746
            |:...|.:::..:|..|.|:||...:..|....: |.|..: |.::   :.|:.........:.|
Human   657 GADNVLELQMDAANEGEGAYEAELAVHLPQGAHYMRALSNVEGFER---LICNQKKENETRVVLC 718

  Fly   747 DIGNPLESGKIAHFKISLVPE----EKYGSSSSYDFYWEANSTNLEKPGSEYDNKIRQSVGIWVD 807
            ::|||::  |.|...|:::..    |:.|.|.|  |..:..|.|.:.|.|:.   :...|.:..:
Human   719 ELGNPMK--KNAQIGIAMLVSVGNLEEAGESVS--FQLQIRSKNSQNPNSKI---VLLDVPVRAE 776

  Fly   808 TDLDIKGTSLPDYQLYKADDYKELENATKEDDIGPQVVHIYEIRNNRPSIIEEAEVFIHLPYETI 872
            ..::::|.|.|...:..|::.:..:|:.  |..||:|.|.||:.||.|..:....:.||||.::.
Human   777 AQVELRGNSFPASLVVAAEEGEREQNSL--DSWGPKVEHTYELHNNGPGTVNGLHLSIHLPGQSQ 839

  Fly   873 VGDPLMYLLN-QPETGGKIQC 892
            ..| |:|:|: ||:  |.:||
Human   840 PSD-LLYILDIQPQ--GGLQC 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_001162777.1	Int_alpha	46..110	CDD:214549	23/66 (35%)
		Int_alpha	275..>316	CDD:214549	13/41 (32%)
		Int_alpha	398..451	CDD:214549	29/52 (56%)
		Int_alpha	466..>497	CDD:214549	18/30 (60%)
		Integrin_alpha2	499..893	CDD:285619	101/412 (25%)
		DUF2756	<1120..1178	CDD:298627
ITGA2B	NP_000410.2	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	35..96		25/71 (35%)
		Int_alpha	46..102	CDD:214549	23/65 (35%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	110..173		19/64 (30%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	187..238		16/54 (30%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	251..305		18/65 (28%)
		Int_alpha	262..>302	CDD:214549	14/49 (29%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	306..371		26/64 (41%)
		Int_alpha	316..367	CDD:214549	24/50 (48%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	373..432		28/66 (42%)
		Int_alpha	384..438	CDD:214549	29/53 (55%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	435..496		26/75 (35%)
		Int_alpha	445..>485	CDD:214549	19/39 (49%)
		Integrin_alpha2	481..921	CDD:285619	101/412 (25%)
		Integrin_alpha	1020..1034	CDD:278771
		GFFKR motif	1022..1026
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142044
Domainoid	1	1.000	144	1.000	Domainoid score	I4610
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	497	1.000	Inparanoid score	I1389
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D325432at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41436
orthoMCL	1	0.900	-	-		OOG6_102088
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X587
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.760