DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment if and ITGA2

DIOPT Version :9

Sequence 1:	NP_001162777.1	Gene:	if / 32661	FlyBaseID:	FBgn0001250	Length:	1396	Species:	Drosophila melanogaster
Sequence 2:	NP_002194.2	Gene:	ITGA2 / 3673	HGNCID:	6137	Length:	1181	Species:	Homo sapiens

Alignment Length:	1041	Identity:	229/1041 - (21%)
Similarity:	397/1041 - (38%)	Gaps:	265/1041 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 SNSMF--------------GFSIAMHKGRSGFYGNQNNVSLIVGAPKF-----------DTSRYQ 85
            |||::              |..|...|.:.|.....||..::.....:           .||:|.
Human   182 SNSIYPWDAVKNFLEKFVQGLDIGPTKTQVGLIQYANNPRVVFNLNTYKTKEEMIVATSQTSQYG 246

  Fly    86 QGVTEAGGVFKCS------------LNDDDCKLVPFDSKGNNRNVDKEVVDRKSYQ--------W 130
            ..:|...|..:.:            .:.....:|..|.:.::.::.|.|:|:.::.        .
Human   247 GDLTNTFGAIQYARKYAYSAASGGRRSATKVMVVVTDGESHDGSMLKAVIDQCNHDNILRFGIAV 311

  Fly   131 LGATVATGRDS-DLV-----VACAP--RYVFHTMTPSRAFRIDPVGTCFTSHNFEEFYEVSPCRT 187
            ||.......|: :|:     :|..|  ||.|:  ....|..::..||.     .|:.:.:.....
Human   312 LGYLNRNALDTKNLIKEIKAIASIPTERYFFN--VSDEAALLEKAGTL-----GEQIFSIEGTVQ 369

  Fly   188 NNWGYHRQGSCQAGFSAAINGNGSRLFIGAPGSWYWQGQTYSIPPDAKFPFKPPLYQPFGTGGMA 252
            ....:..:.| |.||||..:.....|.:||.|::.|.                      ||....
Human   370 GGDNFQMEMS-QVGFSADYSSQNDILMLGAVGAFGWS----------------------GTIVQK 411

  Fly   253 SSHDVTRPENQVFSTSESASV----NDDSYLGYSMV---TGDFDGDRSEDVAIGMPRGGNLVGRI 310
            :||.     :.:|.......:    |..||||||:.   ||:     |.....|.|| .|..|:|
Human   412 TSHG-----HLIFPKQAFDQILQDRNHSSYLGYSVAAISTGE-----STHFVAGAPR-ANYTGQI 465

  Fly   311 VVNRWNMANIFNIT------GRQIGEYFGYSLATSDVDGDGLDD-LLIGAPMYTDPDNVEGKYDV 368
            |:  :::....|||      |.|||.|||..|.:.|||.|.:.| ||:|||||..    :.|.:.
Human   466 VL--YSVNENGNITVIQAHRGDQIGSYFGSVLCSVDVDKDTITDVLLVGAPMYMS----DLKKEE 524

  Fly   369 GRVYI--LLQG---------GPTEEKRWTTEHIRDGYHSKGRFGLALTTLGDVNGDGYGDFAVGA 422
            ||||:  :.:|         ||            :|..:. |||.|:..|.|:|.||:.|..||:
Human   525 GRVYLFTIKEGILGQHQFLEGP------------EGIENT-RFGSAIAALSDINMDGFNDVIVGS 576

  Fly   423 PYDGPEGRGVVYIFHGSPMGPLAKPSQIIKSEQLVEGA--PYPRTFGFALSGGLDMDGNTYPDLA 485
            |.:. :..|.|||::|.......|.||.|...   :||  .:.:.||.:|.|..|::|::..|::
Human   577 PLEN-QNSGAVYIYNGHQGTIRTKYSQKILGS---DGAFRSHLQYFGRSLDGYGDLNGDSITDVS 637

  Fly   486 VGAYSSDQVFIFKSRPVAAVNAETSFASNSKLISLDDRSCQLVRDHKKVPCMLLTTCWSYTGRYL 550
            :||:.  ||....|:.:|.|..|.||....  |:|.:::.|::          |..|:|  .::.
Human   638 IGAFG--QVVQLWSQSIADVAIEASFTPEK--ITLVNKNAQII----------LKLCFS--AKFR 686

  Fly   551 PEQLDFDVSWL----LDA---KKLLNPRMFFLRDEGKNIRNQTIRLNYGQKYCLNETVYLLDKVQ 608
            |.:.:..|:.:    |||   ...:..|..| ::..:....:.:.:|..|. |....:|:.:
Human   687 PTKQNNQVAIVYNITLDADGFSSRVTSRGLF-KENNERCLQKNMVVNQAQS-CPEHIIYIQE--- 746

  Fly   609 DKLTPLEVEARYNLRSSRPLDPMVRHRRSILEPVIDQNREIVLRDAINIQKNCGPDNICEPDLKL 673
                |.:|....:||....|:      .....|.::...|.....:|...|:||.|.:|..||.|
Human   747 ----PSDVVNSLDLRVDISLE------NPGTSPALEAYSETAKVFSIPFHKDCGEDGLCISDLVL 801

  Fly   674 KVSTVDKYLFGSPEPLVI---------EVFISNTNEDAFEAAFYMVTPPDLQFRKLQQLGEKKDT 729
            .|..:..   ...:|.::         .|.:.|..|.|:.....:....:|.|.....  ....|
Human   802 DVRQIPA---AQEQPFIVSNQNKRLTFSVTLKNKRESAYNTGIVVDFSENLFFASFSL--PVDGT 861

  Fly   730 PITCSPPTPENNHTLKCDIGNPLESGKIAHFKISLVPEEKYGSSSSYDFYWEANSTNLEKPGS-- 792
            .:||.  ...:..::.||:|.|           :|..|::...:.::||    |..||:...|
Human   862 EVTCQ--VAASQKSVACDVGYP-----------ALKREQQVTFTINFDF----NLQNLQNQASLS 909

  Fly   793 -----------EYDNKIRQSVGIWVDTDLDI-KGTSLPDYQLYKADDYKELENATKEDDIGPQVV 845
                       :.||.:...:.:..|.::.: :.|::..|::....:...:.::.  :|:||:
Human   910 FQALSESQEENKADNLVNLKIPLLYDAEIHLTRSTNINFYEISSDGNVPSIVHSF--EDVGPK-- 970

  Fly   846 HIYEIRNNRPSI-IEEAEVFIHLPYETIVGDPLMYLLN-QPETGGKIQCD-------------DV 895
            .|:.::....|: :..|.|.||:|..|...:|||||.. |.:..|.|.|:             .|
Human   971 FIFSLKVTTGSVPVSMATVIIHIPQYTKEKNPLMYLTGVQTDKAGDISCNADINPLKIGQTSSSV 1035

  Fly   896 AFNEYNL-------------------LLDEKLVKKSYLQAQGAIWNSAQVSGQSSSSSSSGGASV 941
            :|...|.                   |.|..:..:.::.....|||....|....:...:..|.:
Human  1036 SFKSENFRHTKELNCRTASCSNVTCWLKDVHMKGEYFVNVTTRIWNGTFASSTFQTVQLTAAAEI 1100

  Fly   942 H 942
            :
Human  1101 N 1101

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_001162777.1	Int_alpha	46..110	CDD:214549	15/100 (15%)
		Int_alpha	275..>316	CDD:214549	16/43 (37%)
		Int_alpha	398..451	CDD:214549	21/52 (40%)
		Int_alpha	466..>497	CDD:214549	11/30 (37%)
		Integrin_alpha2	499..893	CDD:285619	86/425 (20%)
		DUF2756	<1120..1178	CDD:298627
ITGA2	NP_002194.2	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	34..92
		Int_alpha	47..95	CDD:214549
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	101..161
		vWA_integrins_alpha_subunit	173..353	CDD:238746	29/172 (17%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	366..420		15/81 (19%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	423..475		17/59 (29%)
		Int_alpha	433..475	CDD:214549	16/49 (33%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	477..539		27/65 (42%)
		Int_alpha	487..>532	CDD:214549	23/48 (48%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	540..598		21/71 (30%)
		Int_alpha	551..604	CDD:214549	21/54 (39%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	602..664		21/66 (32%)
		Int_alpha	614..>642	CDD:214549	9/27 (33%)
		Integrin_alpha2	655..1060	CDD:285619	88/459 (19%)
		Interaction with HPS5	1155..1161
		GFFKR motif	1157..1161
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141994
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740