DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment if and scb

DIOPT Version :9

Sequence 1:	NP_001162777.1	Gene:	if / 32661	FlyBaseID:	FBgn0001250	Length:	1396	Species:	Drosophila melanogaster
Sequence 2:	NP_523750.2	Gene:	scb / 36692	FlyBaseID:	FBgn0286785	Length:	1115	Species:	Drosophila melanogaster

Alignment Length:	1071	Identity:	267/1071 - (24%)
Similarity:	450/1071 - (42%)	Gaps:	249/1071 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LILLLIAMSAH--GYN--------IDLPSYVRF--RQSSNSMFGFSIAMHKGRSGFYGNQNNVSL 72
            :.|.|:|:.:|  .:|        |:.|.:::|  .|:.:|.||:::.:.:           .|:
  Fly    11 IFLALLALISHIEAFNFMPRPSRVINSPKHLKFHINQTRSSYFGYTLVIRQ-----------TSI 64

  Fly    73 IVGAPKF-DTSRYQQGVTEAGGVFKCSLNDDDCKLVPFDSKGN------NRNVDKEVVDRKSYQW 130
            |||||:. .|...|:.:.|.|.:::|||.:..|.....||:||      ....|.|   ||.:||
  Fly    65 IVGAPRAQSTLESQRTINETGAIYRCSLTNGVCSPYVLDSRGNVDAPYSEYTFDSE---RKDFQW 126

  Fly   131 LGATVATG-RDSDLVVACAPRY----------------VFHTM--TPSRAFRIDPVGTCFTSHNF 176
            ||.::..| :|:|.::.||||:                |.:|:  ||....||.|:.  ..|...
  Fly   127 LGGSMDGGTKDTDKLLVCAPRFYAPSSRDNHLHGVCYWVNNTVASTPQHVTRISPLR--LKSEQV 189

  Fly   177 EE---------FYEVSPCRTNNWGYHRQGSCQAGFSAAINGNGSRLFIGAPGSWYWQGQTYSIPP 232
            :|         ||.:.               :.|.||.:..:.::..|||||...|:|..
  Fly   190 KEEDNGNKASFFYIMG---------------ELGLSAHVADDNTKFLIGAPGINTWRGSV----- 234

  Fly   233 DAKFPFKPPLYQPFGTGGMASSHDVTRPENQVFSTSESASVND--------------------DS 277
             ..:....|:..|     .||..|.::...:.:...:|   ||                    ||
  Fly   235 -ILYRQVDPVDNP-----TASRRDTSKALRRTYRDVDS---NDYTPEHYAPEIPTPGLWGQEEDS 290

  Fly   278 YLGYSMVTGDFDGDRSEDV--AIGMPRGGNLVGRIVVNRWNMANIFNITGR-----------QIG 329
            |.||::.:|.||......:  ....|:.....|.        |.||::.|:           |.|
  Fly   291 YFGYAVSSGFFDSSNPTKLLYVATAPQANKQSGE--------AYIFDVRGKSIHKYHVFRGEQFG 347

  Fly   330 EYFGYSLATSDVDGDGLDDLLIGAPMYTDPDNVEGKYDVGRVYILLQGGPTEEKRWTTEHIRDGY 394
            ||||||:...|::|||..|:::.||.:.    :|..:|.|.:|:.:..|....:|   :.:|...
  Fly   348 EYFGYSVLAEDLNGDGKTDVIVSAPQHA----LEDSHDNGAIYVFINKGFFNFER---QILRSPV 405

  Fly   395 HSKGRFGLALTTLGDVNGDGYGDFAVGAPYDGPEGRGVVYIFHGSPMGPLAKPSQIIKSEQLVEG 459
            .:..|||.||:.|||:|.|||.|.|||||:   .|.|.|:|:.||..|...:|||.:.:......
  Fly   406 ETMARFGTALSRLGDINHDGYNDVAVGAPF---AGNGTVFIYLGSENGLRDQPSQRLDAPSQQPS 467

  Fly   460 APYPRTFGFALSGGLDMDGNTYPDLAVGAYSSDQVFIFKSRPVAAVNAETSFASNSKLISLDDRS 524
            ......||..||.|.|:|||.:.|.|:||.:::.|:::::.||..|:|           ::...|
  Fly   468 KYGSHMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKVHA-----------TVKSES 521

  Fly   525 CQLVRDHKKVPCMLLTTCW----SYTGRYLPEQLDFDVSWLLDAKKLLNPRMFFLRDEGKNIRNQ 585
            .::..:.:||.   :|.|:    :.|.:.:.|| :..:...:| |:|  .|:.|.:.:...| :.
  Fly   522 REIKPEQEKVK---ITACYRLSTTSTDKLVQEQ-ELAIRIAMD-KQL--KRVKFTQTQTNEI-SF 578

  Fly   586 TIRLNYGQKYCLNETVYLLDKVQDKLTPLEVEARYNLRSSRPLDPMVRHRRSILEP----VIDQN 646
            .:..|:|:: |.:....:....:|..||:::|..|.|....|.........:|::|    |..||
  Fly   579 KVNANFGEQ-CRDFETQVRYSEKDIFTPIDLEMHYELTKKVPDSEEFCETCAIVDPTEPKVSTQN 642

  Fly   647 REIVLRDAINIQKNCGPDNICEPDLKLKVSTVD-KYLFGSPEPLVIEVFISNTNEDAFEAAFYMV 710
                    |.....|..| :|..||:|:...|. .|:.||.:.|.:...|:|..|.|:...|.:.
  Fly   643 --------IIFSTGCATD-VCTADLQLRSKDVSPTYILGSADTLRLNYEITNIGETAYLPQFNVT 698

  Fly   711 TPPDLQFRKLQQLGEKKDTPITCSPPTPENNHTLKCDI--GNPLESGKIAHFKISLVPEEKYGSS 773
            :...|.|.::         |..|...    :..:.||:  |.||..|......||.  :....|.
  Fly   699 STSRLAFAQV---------PGNCKVV----DAVMVCDLNRGRPLAKGDTDSVTISF--DVSQLSG 748

  Fly   774 SSYDFYWEANSTNLEKPGSEYDNKIRQSVGIWVDTDLDIKGTSLPDYQLYKADDYKELENATKED 838
            .|...:.|..||..|:  :..||:....:|:...|::|..|.     |.....|.:...|:.
  Fly   749 QSLIIHAEVFSTGYEQ--NPTDNRQTNVIGLKEFTEIDASGG-----QTNSQIDLEHYSNSA--- 803

  Fly   839 DIGPQVVHIYEIRNNRPSIIEEAEVFIHLP--YETIVGDPLMYLLNQPETGGKIQC--------- 892
                ::|:.|||::|.||:||:..|..::|  |:......::.::|  .|..|:|.
  Fly   804 ----EIVNNYEIKSNGPSVIEQLTVSFYIPIAYKVAGSTAIIPIIN--VTSLKMQASYDSQLLSI 862

  Fly   893 DDVAFNEYNLLLD------------EKLV----KKSY-LQAQGAIWNSAQV---SGQSSSSSSSG 937
            |....|...|::|            |:.|    ::|| :...|.:..:.:|   |..:::|.|..
  Fly   863 DLYDQNNTMLVVDPVEVTTTLSGGLERTVITQNRQSYDIHTSGHVHQTMEVLDTSMVATASMSRK 927

  Fly   938 GASVHIEKARGEGFVRGVLVSNSTDAGDKLS 968
            ...:....|..|.:.|   :|| ..|.|.||
  Fly   928 RRDLKALTANREQYAR---ISN-VKAHDLLS 954

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_001162777.1	Int_alpha	46..110	CDD:214549	17/64 (27%)
		Int_alpha	275..>316	CDD:214549	11/62 (18%)
		Int_alpha	398..451	CDD:214549	28/52 (54%)
		Int_alpha	466..>497	CDD:214549	14/30 (47%)
		Integrin_alpha2	499..893	CDD:285619	93/415 (22%)
		DUF2756	<1120..1178	CDD:298627
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	17/62 (27%)
		FG-GAP	350..388	CDD:280083	15/41 (37%)
		Int_alpha	409..459	CDD:214549	28/52 (54%)
		Int_alpha	473..>515	CDD:214549	17/41 (41%)
		Integrin_alpha2	507..829	CDD:285619	87/379 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439843
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D12256at50557
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23220
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850