DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment if and ITGA6

DIOPT Version :9

Sequence 1:	NP_001162777.1	Gene:	if / 32661	FlyBaseID:	FBgn0001250	Length:	1396	Species:	Drosophila melanogaster
Sequence 2:	NP_001381857.1	Gene:	ITGA6 / 3655	HGNCID:	6142	Length:	1130	Species:	Homo sapiens

Alignment Length:	1118	Identity:	290/1118 - (25%)
Similarity:	483/1118 - (43%)	Gaps:	197/1118 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LIAMSAHGYNIDL--PSYVRFRQSSNSMFGFSIAMHKGRSGFYGNQNNVSLIVGAPKFDTSRYQQ 86
            |::.....:|:|.  .:.:|......|:||||:|||....    .::...|:||||:.:....|:
Human    16 LLSRLGAAFNLDTREDNVIRKYGDPGSLFGFSLAMHWQLQ----PEDKRLLLVGAPRAEALPLQR 76

  Fly    87 GVTEAGGVFKCSLN-DDDCKLVPFDSKGNNRNVDKEVVDRKSYQWLGATVATGRDSDLVVACAPR 150
             ....||::.|.:. ...|..:.||:..:..:..||      .||:|.||.:......||.||.|
Human    77 -ANRTGGLYSCDITARGPCTRIEFDNDADPTSESKE------DQWMGVTVQSQGPGGKVVTCAHR 134

  Fly   151 YV----FHTMTPSRAFRIDPVGTCFT-SHNFE-----EFYEVSPCRTNNWGYHRQGSCQAGFSAA 205
            |.    .:|...||    |..|.|:. |.|..     :..:.|.|.....|:.:.||||.|.:|.
Human   135 YEKRQHVNTKQESR----DIFGRCYVLSQNLRIEDDMDGGDWSFCDGRLRGHEKFGSCQQGVAAT 195

  Fly   206 INGNGSRLFIGAPGSWYWQGQTYSIPPDAKFPFKPPLYQ--PFGTGGMASSHD---VTRPENQ-- 263
            ...:...:..||||::.|:|.......:..| |...:::  |:..|| .:.||   |..|.|.
Human   196 FTKDFHYIVFGAPGTYNWKGIVRVEQKNNTF-FDMNIFEDGPYEVGG-ETEHDESLVPVPANSYL 258

  Fly   264 --VFSTSESASVND---------------------DSYLGYSMVTGDFDGDRSED---VAIGMPR 302
              :|.||.|.:..|                     :||||:|:.:|  .|..|:|   ...|.||
Human   259 GLLFLTSVSYTDPDQFVYKTRPPREQPDTFPDVMMNSYLGFSLDSG--KGIVSKDEITFVSGAPR 321

  Fly   303 GGNLVGRIVVNRWNM-------ANIFNITGRQIGEYFGYSLATSDVDGDGLDDLLIGAPMYTDPD 360
             .|..|.:|:.:.:|       .:||:  |..:...|||.:|..|::.||..|::||||.|.|.|
Human   322 -ANHSGAVVLLKRDMKSAHLLPEHIFD--GEGLASSFGYDVAVVDLNKDGWQDIVIGAPQYFDRD 383

  Fly   361 NVEGKYDVGRVYILLQGGPTEEKRW-TTEHIRDGYHSKGRFGLALTTLGDVNGDGYGDFAVGAPY 424
            ...|    |.||:.:    .::.|| ..:.||........||:|:..:||:|.|||.|.||||||
Human   384 GEVG----GAVYVYM----NQQGRWNNVKPIRLNGTKDSMFGIAVKNIGDINQDGYPDIAVGAPY 440

  Fly   425 DGPEGRGVVYIFHGSPMGPLAKPSQIIKSEQLVEGAPYPRTFGFALSGGLDMDGNTYPDLAVGAY 489
            |   ..|.|:|:|||..|...||:|::|..     :||   ||::::|.:|:|.|:|||:|||:.
Human   441 D---DLGKVFIYHGSANGINTKPTQVLKGI-----SPY---FGYSIAGNMDLDRNSYPDVAVGSL 494

  Fly   490 SSDQVFIFKSRPVAAVNAETSFASNSKLISLDDR-SCQLVRDHKKVP---CMLLTTCWSYTGRYL 550
             ||.|.||:||||  :|.:.:.......|.|..: :|       ..|   |:.:.:|:.||....
Human   495 -SDSVTIFRSRPV--INIQKTITVTPNRIDLRQKTAC-------GAPSGICLQVKSCFEYTANPA 549

  Fly   551 PEQLDFDVSWLLDAKKL-----LNPRMFFLRDEG---KNIRNQTIRLNYGQKYCLNETVYLLDKV 607
            .......:...|:|:|.     |:.|:.| |::|   |..:..|:: ...||.|:.||::|.|.:
Human   550 GYNPSISIVGTLEAEKERRKSGLSSRVQF-RNQGSEPKYTQELTLK-RQKQKVCMEETLWLQDNI 612

  Fly   608 QDKLTPLEVEARYNLRSSRPLDPMVRHRRSILE---PVIDQNREIVLR-DAINIQKNCGPDNICE 668
            :|||.|:.:.|...::     :|..|.|.:.|.   |:::.:...... |...:::.||.||:|.
Human   613 RDKLRPIPITASVEIQ-----EPSSRRRVNSLPEVLPILNSDEPKTAHIDVHFLKEGCGDDNVCN 672

  Fly   669 PDLKL------KVSTVDKYLF-----GSPE-------PLVIEVFISNT----------NEDAFEA 705
            .:|||      :....||:.:     |.||       .:.:|:.::|:          .:||.||
Human   673 SNLKLEYKFCTREGNQDKFSYLPIQKGVPELVLKDQKDIALEITVTNSPSNPRNPTKDGDDAHEA 737

  Fly   706 AFYMVTPPDLQFRKLQQLGEKKDTPITCSPPTPENNHTLKCDIGNPLESGKIAHFKISLVPEEKY 770
            ......|..|.:...::|....:..::|  ...:|.....|::|||.:......|.:.|...|..
Human   738 KLIATFPDTLTYSAYRELRAFPEKQLSC--VANQNGSQADCELGNPFKRNSNVTFYLVLSTTEVT 800

  Fly   771 GSSSSYDFYWEANSTNLEKPGSEYDN--KIRQSVGIWVDTDLDIKGTSLPDYQLYKADDYKELEN 833
            ..:...|...:..:|      |..||  .|.....:.::..|.:.|.:.|. |:|........:.
Human   801 FDTPDLDINLKLETT------SNQDNLAPITAKAKVVIELLLSVSGVAKPS-QVYFGGTVVGEQA 858

  Fly   834 ATKEDDIGPQVVHIYEIRN-NRP-SIIEEAEVFIHLPYETIVGDPLMYLLNQPETG-GKIQCD-D 894
            ...||::|..:.:.:.:.| .:| :.:..|.:.|..|.|...|..|:||:.....| .|:.|: .
Human   859 MKSEDEVGSLIEYEFRVINLGKPLTNLGTATLNIQWPKEISNGKWLLYLVKVESKGLEKVTCEPQ 923

  Fly   895 VAFNEYNLLLDEKLVKKSYLQAQGAIWNSAQVSGQSSSSSSSGGASVHIEKARGEGFVRG----- 954
            ...|..||.......||..: .:..|.::.:.|..:.....:...||::........:||
Human   924 KEINSLNLTESHNSRKKREI-TEKQIDDNRKFSLFAERKYQTLNCSVNVNCVNIRCPLRGLDSKA 987

  Fly   955 --VLVS---NST--DAGDKLSPKQVEQRRQEDTLEALGDASFVHRDRASQAVQEPQV-NQTSFTT 1011
              :|.|   |||  :...||:...:..|            :|:....|::.::.|.. .|...|.
Human   988 SLILRSRLWNSTFLEEYSKLNYLDILMR------------AFIDVTAAAENIRLPNAGTQVRVTV 1040

  Fly  1012 YSTSSSSSGSGAP 1024
            :.:.:.:..||.|
Human  1041 FPSKTVAQYSGVP 1053

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_001162777.1	Int_alpha	46..110	CDD:214549	18/64 (28%)
		Int_alpha	275..>316	CDD:214549	16/64 (25%)
		Int_alpha	398..451	CDD:214549	27/52 (52%)
		Int_alpha	466..>497	CDD:214549	15/30 (50%)
		Integrin_alpha2	499..893	CDD:285619	98/442 (22%)
		DUF2756	<1120..1178	CDD:298627
ITGA6	NP_001381857.1	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	30..95		18/69 (26%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	101..166		21/74 (28%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	176..229		15/53 (28%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	283..339		16/58 (28%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	340..402		24/71 (34%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	403..458		26/57 (46%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	459..518		28/69 (41%)
		Interaction with HPS5	1077..1083
		GFFKR motif	1079..1083
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142048
Domainoid	1	1.000	59	1.000	Domainoid score	I10671
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D325432at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750