DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment if and Itga11

DIOPT Version :9

Sequence 1:	NP_001162777.1	Gene:	if / 32661	FlyBaseID:	FBgn0001250	Length:	1396	Species:	Drosophila melanogaster
Sequence 2:	XP_038937421.1	Gene:	Itga11 / 315744	RGDID:	1311711	Length:	1188	Species:	Rattus norvegicus

Alignment Length:	777	Identity:	186/777 - (23%)
Similarity:	315/777 - (40%)	Gaps:	132/777 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 FHTMTPSRAFR--IDPVGTCFTSHNFEEFYEVSPCRTNNWGYHRQGSCQAGFSAAINGNGSRLFI 215
            |..:|...|.:  :|.:|        :..:.:.....|...:..:.| |.|||:.:..:|  :.:
  Rat   329 FFNVTDEAALKDIVDALG--------DRIFSLEGTNKNETSFGLEMS-QTGFSSHVVEDG--VLL 382

  Fly   216 GAPGSWYWQGQTYSIPPDAK-FPFKPPLYQPFGTGGMASSHDVTRPENQVFSTSESASVNDDSYL 279
            ||.|::.|.|.........| .|.:....:.|             ||.         ..|..:||
  Rat   383 GAVGAYDWNGAVLKETSAGKVIPLRESYLKEF-------------PEE---------LKNHAAYL 425

  Fly   280 GYSMVTGDFDGDRSEDVAIGMPRGGNLVGRIVV-----NRWNMANIFNITGRQIGEYFGYSLATS 339
            ||: ||......:......|.|| .|..|::::     || ::.....:.|.|||.|||..:.:.
  Rat   426 GYT-VTSVVSSKQGRVYVAGAPR-FNHTGKVILFSIHTNR-SLTIHQALRGEQIGSYFGSEITSV 487

  Fly   340 DVDGDGLDD-LLIGAPMYTDPDNVEGKYDVGRVYILLQGGPTEEKRWTTEHIRDGYHS--KGRFG 401
            |::.|.:.| ||:|||||..    ||: :.|:||:.    ...:.|:.........||  ..|||
  Rat   488 DINNDRVTDVLLVGAPMYFS----EGR-ERGKVYVY----NLRQNRFVFNGTLKDSHSYQNARFG 543

  Fly   402 LALTTLGDVNGDGYGDFAVGAPYDGPEGRGVVYIFHGSPMGPLAKPSQIIKSEQLVEGAPYPRTF 466
            ..:.::.|:|.|.|.|..||||.:... ||.:|||||.....|.||.|.|.:.:|..|..:   |
  Rat   544 SCIASVQDLNQDSYNDVVVGAPLEDSH-RGAIYIFHGFQTNILKKPVQRISASELAPGLQH---F 604

  Fly   467 GFALSGGLDMDGNTYPDLAVGAYSSDQVFIFKSRPVAAVNAETSFASNSKLISLDDRSCQLVRDH 531
            |.::.|.||::.:...||||||..:  ..:..:|||..:||...|..:.  |::..:.|:  |:.
  Rat   605 GCSIHGQLDLNEDGLVDLAVGALGN--AVVLWARPVVQINASLHFEPSK--INIFHKDCK--RNG 663

  Fly   532 KKVPCMLLTTCWS---YTGRYLPEQLDFDVSWLLDAKKLLNPRMFFLRDEGKN-IRNQTIRLNYG 592
            :...|:....|:.   ....:....:....:..:|.::.: ||...  |||.: ..|:.:.|:.|
  Rat   664 RDATCLAAFLCFGPIFLAPHFHTATVGIRYNATMDERRYM-PRAHL--DEGADQFTNRAVLLSSG 725

  Fly   593 QKYCLNETVYLLDKVQDKLTPLEVEARYNLRSSRPLDPMVRHRRSILEPVIDQNREIVLRDAINI 657
            |::|.....::|| ..|.:.|:.....|:|.     ||  .|     .|::|......||.::..
  Rat   726 QEHCQRINFHVLD-TADYVKPVAFSVEYSLE-----DP--DH-----GPMLDNGWPTTLRVSVPF 777

  Fly   658 QKNCGPDNICEPDLKL----KVSTVDKY-------------------------LFGSPEPLVIEV 693
            ...|..|..|.|||.|    .:.|..:|                         :..:...:.:|.
  Rat   778 WNGCNEDEHCVPDLVLDARSDLPTAMEYCQQVLRRPAQDCSSYTLSFDTTVFIIESTRRRVAVEA 842

  Fly   694 FISNTNEDAFEAAFYMVTPPDLQFRKLQQLGEKKDTPITCSPPTPENN-HTLKCDIGNPLESGKI 757
            .:.|..|:|:.|...:....:|||..|.| .:..|..|.|  ...|.. |...|::..|....|.
  Rat   843 TLENRGENAYSAVLNISQSENLQFASLIQ-KDDSDNSIEC--VNEERRLHKKVCNVSYPFFRAKA 904

  Fly   758 AHFKISLVPEEKYGSS---SSYDFYWEANSTNLEKPGSEYDNKIRQSVGIWVDTD-LDIKGTSLP 818
               |::...:.::..|   .....:..|.|.:.|:..:..||.......:..:.| |..:.:||.
  Rat   905 ---KVAFRLDFEFSKSVFLHHLQIHLGAGSDSHEQDSTADDNTALLRFHLKYEADVLFTRSSSLS 966

  Fly   819 DYQLYKADDYKELENATKEDDIGPQVVHIYEIRNNRPSIIEEAEVFIHLPYETIVGDPLMYL 880
            .::: ||:...|     ..|.|||....:::::|.....|....:.|.:|..|..|:.|:.|
  Rat   967 HFEV-KANSSLE-----SYDGIGPPFNCVFKVQNLGFFPIHGVMMKITVPIATRGGNRLLML 1022

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_001162777.1	Int_alpha	46..110	CDD:214549
		Int_alpha	275..>316	CDD:214549	13/45 (29%)
		Int_alpha	398..451	CDD:214549	23/52 (44%)
		Int_alpha	466..>497	CDD:214549	11/30 (37%)
		Integrin_alpha2	499..893	CDD:285619	88/420 (21%)
		DUF2756	<1120..1178	CDD:298627
Itga11	XP_038937421.1	Int_alpha	37..86	CDD:214549
		vWA_integrins_alpha_subunit	163..341	CDD:238746	3/11 (27%)
		Int_alpha	476..523	CDD:214549	20/55 (36%)
		Int_alpha	538..592	CDD:214549	23/54 (43%)
		Integrin_alpha2	635..1064	CDD:400650	88/420 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335758
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740