DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment if and Itga10

DIOPT Version :9

Sequence 1:	NP_001162777.1	Gene:	if / 32661	FlyBaseID:	FBgn0001250	Length:	1396	Species:	Drosophila melanogaster
Sequence 2:	NP_001101169.2	Gene:	Itga10 / 310683	RGDID:	1305152	Length:	1167	Species:	Rattus norvegicus

Alignment Length:	974	Identity:	228/974 - (23%)
Similarity:	377/974 - (38%)	Gaps:	234/974 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 PSY---VRFRQSSNSMFGFSIAMHKGRSGFYGNQNNVSLIVGAPKFDTSRYQQGVTEAG--GVFK 96
            |:|   |.....|||::.:|..           |..:..:||....|..:.|.|:.:.|  .|.:
  Rat   163 PTYMDVVIVLDGSNSIYPWSEV-----------QTFLRRLVGRLFIDPEQIQVGLVQYGENPVHE 216

  Fly    97 CSLNDDDCKLVPFDSKGNNRNVDKEVV------DRKSYQWLGATVATGRDS----DLVVACAPRY 151
            .||.|       |.:|       :|||      .|:.          ||::    .::|||...:
  Rat   217 WSLGD-------FRTK-------EEVVRAARNLSRRE----------GRETRTAQAIMVACTEGF 257

  Fly   152 VFHTMTPSRAFRIDPVGTCFTSHNFEEFYEVSPCRTNNWGYHRQGSCQAG----FSAAINGNGSR 212
            .........|.|:..|.|...||:.||.    |....        :|:||    :..|:.|:..|
  Rat   258 SESRGGRPEAARLLVVVTDGESHDGEEL----PAALK--------ACEAGRVTRYGIAVLGHYLR 310

  Fly   213 LFIGAPGSWYWQGQTYSIPPDAKFPF-------------------------KPPLYQPFGTG--- 249
            . ...|.|:..:.:..:..||.:|.|                         :......||..
  Rat   311 R-QRDPSSFLREIRAIASDPDERFFFNVTDEAALTDIVDALGDRIFGLEGSRGENESSFGLEMSE 374

  Fly   250 --------------GMASSHD-------------VTRPENQVFSTSESASVNDDSYLGYSMVTGD 287
                          ||..::|             :..|...:......|..|..:|||||:.:..
  Rat   375 IGFSIHRLQDGILFGMVGAYDWGGSVLWLEEGRRLFPPRTALEDEFPPALQNHAAYLGYSVSSML 439

  Fly   288 FDGDRSEDVAIGMPRGGNLVGRIVVNRWNMANIFNIT----GRQIGEYFGYSLATSDVDGDGLDD 348
            ..|.|...:: |.||..:. |:::..:.....:..:|    |.|||.|||..|...|.|.||:.:
  Rat   440 LPGGRRLFLS-GAPRFRHR-GKVIAFQLKKDGVVKVTQSLQGDQIGSYFGSELCPLDTDMDGITN 502

  Fly   349 -LLIGAPMYTDPDNVEGKYDVGRVYI---------LLQGGPTEEKRWTTEHIRDGYHSKGRFGLA 403
             ||:.|||:..|.|.|    .||:|:         :|||        |.:..|.   ...|||.|
  Rat   503 ILLVAAPMFLGPQNKE----TGRIYVYVVGQQNLLMLQG--------TLQPDRS---QDSRFGFA 552

  Fly   404 LTTLGDVNGDGYGDFAVGAPY-DGPEGRGVVYIFHGSPMGPLAKPSQIIKSEQLVEGAPYPRTFG 467
            :..|.|:|.||:.|.|||||. ||.:  |.:|::||:..|....|:|.|.:..:.:...|   ||
  Rat   553 MAALPDLNHDGFSDVAVGAPLEDGHQ--GALYLYHGTQTGIRPHPTQRIAAGSMPQALRY---FG 612

  Fly   468 FALSGGLDMDGNTYPDLAVGAYSSDQVFIFKSRPVAAVNAETSFASNSKLISLDDRSCQLVRDHK 532
            .::.|.||:||:...|:||||:.:  ..:|.|:|:  ::...:.......||:..:.|:  |..:
  Rat   613 RSVDGRLDLDGDDLVDVAVGAHGA--AILFSSQPI--IHLIPTLDVMPPHISVVQKDCK--RRGQ 671

  Fly   533 KVPCMLLTTCWSYTGRYLPEQLD------FDVS---WLLDAKKLLNPRMFFLRDEGKNIRNQTIR 588
            :..|:..:.|:....: .|.:.|      |..|   |...|:...:       ..|:.:....:|
  Rat   672 EAACLTASLCFQVKSQ-TPGRWDRRFHIRFSASLDEWTAGARAAFD-------GSGQRLSPGQLR 728

  Fly   589 LNYGQKYCLNETVYLLDKVQDKLTPLEVEARYNL-RSSRPLDPMVRHRRSILEPVIDQNREIVLR 652
            |:.|...|.....:.|| ..|.|.|:.:...:.| .:::|            .||:.:.....:|
  Rat   729 LSVGNVTCEQLHFHALD-TSDYLRPVALTVTFALDNTTKP------------GPVLAEGSSTSIR 780

  Fly   653 DAINIQKNCGPDNICEPDLKLKVSTVDKYLFGS-PEPLVIE-----VFISNTNEDAFEAAFYMVT 711
            ..|...|:|||||.|..||.|:   .|..:.|| ..|.|::     |.:|.|.|:..|.|:.  |
  Rat   781 KLIPFSKDCGPDNECITDLVLQ---ADMDIRGSRKSPFVVQGGRQKVLVSVTLENKKENAYN--T 840

  Fly   712 PPDLQFRKLQQLG-----EKKDTPITCSPPTPENNHTLKCDIGNPL-ESGKIAHFKISLVPEEKY 770
            ...|.|.:...|.     ..|...:.|:.|:|   |...|.:|:|: ::|.    |:|.:.|.::
  Rat   841 SLSLSFSRNLHLASLTPQRAKSVKVECAVPSP---HARLCIVGHPVFQAGA----KVSFLLEFEF 898

  Fly   771 GSS---SSYDFYWEANSTNLEKPGSEYDNKIRQSVGIWVDTDLDIKGTSLPDYQLYKADDYK--- 829
            ..:   |.......|:|::||:..:..||..:.|..|..:..|.....|  ....|:...|:
  Rat   899 SCTFLLSQVSVRLTASSSSLERNETLQDNTAQTSAYIRYEPHLMFSSES--TLHRYEVHPYRALP 961

  Fly   830 -----ELENATKEDDIGPQVVHIYEIRNNRPSIIEEAEVFIHLPYETIVGDPLMYLLNQPETGG 888
                 |.:...:..::|..||....:....|::......|:.|. :.|.|:....:.|..:..|
  Rat   962 VGPGPEFKTTLRVQNLGCHVVSGLVVSALLPAVAHGGNYFLSLS-QVISGNASCTVQNLTDPPG 1024

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_001162777.1	Int_alpha	46..110	CDD:214549	15/65 (23%)
		Int_alpha	275..>316	CDD:214549	11/40 (28%)
		Int_alpha	398..451	CDD:214549	24/53 (45%)
		Int_alpha	466..>497	CDD:214549	12/30 (40%)
		Integrin_alpha2	499..893	CDD:285619	91/423 (22%)
		DUF2756	<1120..1178	CDD:298627
Itga10	NP_001101169.2	Int_alpha	41..81	CDD:214549
		vWA_integrins_alpha_subunit	166..346	CDD:238746	48/227 (21%)
		Int_alpha	482..>525	CDD:214549	21/46 (46%)
		Int_alpha	545..599	CDD:214549	24/55 (44%)
		Integrin_alpha2	642..1050	CDD:285619	91/423 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335702
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740