DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment if and Itgav

DIOPT Version :9

Sequence 1:	NP_001162777.1	Gene:	if / 32661	FlyBaseID:	FBgn0001250	Length:	1396	Species:	Drosophila melanogaster
Sequence 2:	XP_038962373.1	Gene:	Itgav / 296456	RGDID:	1310613	Length:	1043	Species:	Rattus norvegicus

Alignment Length:	1407	Identity:	353/1407 - (25%)
Similarity:	564/1407 - (40%)	Gaps:	412/1407 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LILLLIAM---SAHGYNIDLPSYVRFRQSSNSMFGFSIAMHKGRSGFY--GNQNNVSLIVGAPKF 79
            |:|||:.:   .|..:|:|:.|...:.....|.|||::       .|:  ...:.:.|:|||||.
  Rat    16 LLLLLLGLLLPFAGSFNLDVESPAEYAGPEGSYFGFAV-------DFFVPSTSSRMFLLVGAPKA 73

  Fly    80 DTSRYQQGVTEAGGVFKCSLNDD-DCKLVPFDSKGNNRNVDKEVVDRKSYQWLGATVATGRDSDL 143
            :|:  |.|:.|.|.|.||..:.. .|:.:.|||.||......:.::.||:||.||:|.:.:|.
  Rat    74 NTT--QPGIIEGGQVLKCDCSSSRRCQPIEFDSTGNRDYAKDDPLEFKSHQWFGASVRSKQDK-- 134

  Fly   144 VVACAPRYVFHTMTPSRAFRIDPVGTCFTSHNFEEFYEVSPCRTNNWGYHRQGSCQAGFSAAING 208
            ::||||.|  |..|..:..| :||||||.... .:..|.:|||:.|.....||.||.|||....
  Rat   135 ILACAPLY--HWRTEMKQER-EPVGTCFLQDG-TKTVEYAPCRSKNIDADGQGFCQGGFSIDFT- 194

  Fly   209 NGSRLFIGAPGSWYWQGQTYSIP-PDAKFPFKPPLYQPFGTGGMASSHDVTRPENQVFSTSESAS 272
            ...|:.:|.|||:|||||..|.. .:....:.|.:|.             .:..||: :|..:.:
  Rat   195 KADRVLLGGPGSFYWQGQLISDQVAEIISKYDPNVYS-------------IKYNNQL-ATRTAQA 245

  Fly   273 VNDDSYLGYSMVTGDFDGDRSEDVAIGMPRGGNLVGRI-VVNRWNMANIFNITGRQIGEYFGYSL 336
            :.||||||||:..|||:||..||...|:||....:|.: :.:..||:::.|.||.|:..|||:|:
  Rat   246 IFDDSYLGYSVAVGDFNGDGIEDFVSGVPRAARTLGMVYIYDGKNMSSLHNFTGEQMAAYFGFSV 310

  Fly   337 ATSDVDGDGLDDLLIGAPMYTDPDNVEGK-YDVGRVYILLQGGPTEEKRWTTEHIRDGYHSKGRF 400
            |.:|::||...|:.||||::.|..: :|| .:||:|.:.||....:.:  ||:  .:|:....||
  Rat   311 AATDINGDDYADVFIGAPLFMDRGS-DGKLQEVGQVSVSLQRASGDFQ--TTK--LNGFEVFARF 370

  Fly   401 GLALTTLGDVNGDGYGDFAVGAPYDGPEGRGVVYIFHGSPMGPLAKPSQIIKSEQLVEGAPYPRT 465
            |.|:..|||::.||:.|.|:.|||.|.:.:|:||||:|...|..:.||||::.:...:.  .|.:
  Rat   371 GSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGLVYIFNGRSTGLNSVPSQILQGQWAAQS--MPPS 433

  Fly   466 FGFALSGGLDMDGNTYPDLAVGAYSSDQVFIFKSRPVAAVNAETSFASNSKLISLDDRSCQLVRD 530
            ||:::.|..|:|.|.||||.|||:..|:..::::|||..|||  .......:::.|::.|.|...
  Rat   434 FGYSMKGATDVDRNGYPDLVVGAFGVDRAVLYRARPVVTVNA--GLEVYPSILNQDNKICPLPGT 496

  Fly   531 HKKVPCMLLTTCWSYTGR-YLPEQLDFDVSWLLDAKKLLNP--RMFFLRDEGKNIRNQTIRLNYG 592
            ..||.|..:..|....|: .||.:|:|.|..|||..|....  |..||.:..............|
  Rat   497 ALKVSCFNVRFCLKADGKGTLPRKLNFQVELLLDKLKQKGAIRRALFLHNRSPGHSKDMTVFRGG 561

  Fly   593 QKYCLNETVYLLD--KVQDKLTPLEVEARYNLRSSRPLDPMVRHRRSILEPVIDQNREIVLRDAI 655
            |..|.....||.|  :.:|||||:.:...|.|......|      .:.|:|:::|.....:....
  Rat   562 QTQCEELVAYLRDESEFRDKLTPITIFMEYRLDQRTAAD------ATGLQPILNQFTPANVSRQA 620

  Fly   656 NIQKNCGPDNICEPDLKLKVSTVDKYLF-GSPEPLVIEVFISNTNEDAFEAAFYMVTPPDLQF-- 717
            :|..:||.||:|:|.|::.|.:..|.:: |...||.:.|...|..|.|:||...:..||...|
  Rat   621 HILLDCGEDNVCKPKLEVSVDSDQKKIYIGDDNPLTLTVKAQNQGEGAYEAELIVSIPPQADFIG 685

  Fly   718 --RKLQQLGEKKDTPITCSPPTPENNHTLKCDIGNPLESGK--IAHFKISLVPEEKYGSSSSYDF 778
              |..:.|..     ::|:..|......:.||:|||:::|.  :|..:.|:..:.:..:|..:|.
  Rat   686 VVRNNEALAR-----LSCAFKTENQTRQVVCDLGNPMKAGTQLLAGLRFSVHQQSEMDTSVKFDL 745

  Fly   779 YWEANSTNLEKPGSEYDN---KIRQSVGIWVDTDLDIKGTSLPDYQLYKADDYKELENATKEDDI 840
              :..|:|      .:||   .:...|.:.|...::|:|.|.||:......:::..|....|:|:
  Rat   746 --KIQSSN------SFDNVSPVVSYKVDLAVLAAVEIRGVSSPDHIFLPIPNWEYKETPETEEDV 802

  Fly   841 GPQVVHIYEIRNNRPSIIEEAEVFIHLPYETIVGDPLMYLLNQPETGGKIQCDDVAFNEYNLLLD 905
            ||.|.||||:|||.||...:|.:.:..||: ...:.|:|:|:. :..|.:.|  .|..|.|.|
  Rat   803 GPVVQHIYELRNNGPSSFSKAILNLQWPYK-YNNNTLLYILHY-DIDGPMNC--TADTEINPL-- 861

  Fly   906 EKLVKKSYLQAQGAIWNSAQVSGQSSSSSSSGGASVHIEKARGEGFVRGVLVSNSTDAGDKLSPK 970

  Rat   862 ----------------------------------------------------------------- 861

  Fly   971 QVEQRRQEDTLEALGDASFVHRDRASQAVQEPQVNQTSFTTYSTSSSSSGSGAPSAQLRGHSTQG 1035
                                       .::.|:.|.|:
  Rat   862 ---------------------------RIKTPEKNDTA--------------------------- 872

  Fly  1036 HIQMAGPVQHTSSSSSSNYRSWPAQQQQQHQQLLLAGSGGSGLGSPVTFNDKSQFGGRNNNFHTG 1100
                                   |:|                             ||||   |..
  Rat   873 -----------------------AEQ-----------------------------GGRN---HLI 882

  Fly  1101 TLDLGTLNRGNVDNELYRSQGQYQNPSQSLGQSQGQFQANANQGHYQGQNQAQFQARNPGFQGQT 1165
            |....:|:.|:|               .:||
  Rat   883 TKRDLSLSEGDV---------------HTLG---------------------------------- 898

  Fly  1166 SYQGQTQYSGQPGGYQTHHVTYSSGSKPYYGRENEDFYDEDNLQQATPGHWSSSSSSSSSSGTRR 1230

  Rat   899 ----------------------------------------------------------------- 898

  Fly  1231 LRRSNDKDGATEKPLQIDLNSPCQSARCKSIRCVVTNLGTEDGDAAFVAIRARMVAKT-MEKLAS 1294
                                  |.:|:|..|.|.|..|  :.|.:|.:.:::.:..:| |.|...
  Rat   899 ----------------------CGTAQCLQITCQVGRL--DRGKSAILYVKSLLWTETFMNKENQ 939

  Fly  1295 NVPLNVSTLAVANVTLLPFIGAPKD----AIVKTHEIFYKAEPEPLQVPDVVPLWVVVLAACAGA 1355
            |...::.:.|..|:...|:...|.:    :.:.|..|.:..:|.|:.    ||:||::||..||.
  Rat   940 NHSYSLKSSASFNIIEFPYKNLPIEDLFNSTLVTTNITWGIQPAPMP----VPVWVIILAVLAGL 1000

  Fly  1356 LIFLLLVWLLYKCGFFNRNRPTDHSQER---QPLRNGYHGDE 1394
            |:..:||:::|:.|||.|.||....|||   ||..||....|
  Rat  1001 LLLAVLVFVMYRMGFFKRVRPPQEEQEREQLQPHENGEGNSE 1042

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_001162777.1	Int_alpha	46..110	CDD:214549	20/66 (30%)
		Int_alpha	275..>316	CDD:214549	19/41 (46%)
		Int_alpha	398..451	CDD:214549	25/52 (48%)
		Int_alpha	466..>497	CDD:214549	14/30 (47%)
		Integrin_alpha2	499..893	CDD:285619	112/408 (27%)
		DUF2756	<1120..1178	CDD:298627	2/57 (4%)
Itgav	XP_038962373.1	Int_alpha	46..103	CDD:214549	20/65 (31%)
		WD40 repeat	126..183	CDD:293791	22/62 (35%)
		WD40 repeat	188..248	CDD:293791	19/74 (26%)
		VCBS	221..271	CDD:404411	20/63 (32%)
		Int_alpha	248..>288	CDD:214549	19/39 (49%)
		WD40 repeat	254..298	CDD:293791	16/43 (37%)
		Int_alpha	302..355	CDD:214549	21/53 (40%)
		WD40 repeat	307..362	CDD:293791	21/59 (36%)
		Int_alpha	367..421	CDD:214549	25/53 (47%)
		WD40 repeat	371..422	CDD:293791	24/50 (48%)
		Int_alpha	434..476	CDD:214549	20/43 (47%)
		Integrin_alpha2	467..909	CDD:400650	137/778 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335697
Domainoid	1	1.000	174	1.000	Domainoid score	I3572
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	492	1.000	Inparanoid score	I1353
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D325432at33208
OrthoFinder	1	1.000	-	-		FOG0001619
OrthoInspector	1	1.000	-	-		otm45551
orthoMCL	1	0.900	-	-		OOG6_102088
Panther	1	1.100	-	-	LDO	PTHR23220
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X587
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.900