DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment if and Itga1

DIOPT Version :9

Sequence 1:	NP_001162777.1	Gene:	if / 32661	FlyBaseID:	FBgn0001250	Length:	1396	Species:	Drosophila melanogaster
Sequence 2:	NP_112256.1	Gene:	Itga1 / 25118	RGDID:	2923	Length:	1180	Species:	Rattus norvegicus

Alignment Length:	1173	Identity:	250/1173 - (21%)
Similarity:	429/1173 - (36%)	Gaps:	343/1173 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IHRRRMALHCPITSLILLLIAMS-AHGYNIDLPSYVRFRQSSNSMFGFSIAMHKGRSG---FYGN 66
            :.||..:|...:..:.||.:.:. ...:|:|:.:.:.|......|||:::..::...|   ..|
  Rat     2 VPRRPASLEVTVACIWLLTVILGFCVSFNVDVKNSMSFSGPVEDMFGYTVQQYENEEGKWVLIG- 65

  Fly    67 QNNVSLIVGAPKFDTSRYQQGVTEAGGVFKCSLNDD---DC-KL-VPFDSKGNNRNVDKEVVDRK 126
                |.:||.||..|          |.|:||.:..:   .| || :|.::...|      |.:.|
  Rat    66 ----SPLVGQPKART----------GDVYKCPVGRERAMPCVKLDLPVNTSIPN------VTEIK 110

  Fly   127 SYQWLGATVATGRDSDLVVACAPRYVF-----HTMT-----PSRAFRI----DPVGTCFT----- 172
            .....|:|:.|..:... :||.|.|.:     |..|     .|..|::    .||..|.|
  Rat   111 ENMTFGSTLVTNPNGGF-LACGPLYAYRCGHLHYTTGICSDVSPTFQVVNSFAPVQECSTQLDIV 174

  Fly   173 --------------------------------------------SHNF----------------- 176
                                                        :|.|
  Rat   175 IVLDGSNSIYPWESVIAFLNDLLKRMDIGPKQTQVGIVQYGENVTHEFNLNKYSSTEEVLVAANK 239

  Fly   177 --------------------EEFYE-----------------------------VSPCRTNN--- 189
                                |.|.|                             :..|...|
  Rat   240 IGRQGGLQTMTALGIDTARKEAFTEARGARRGVKKVMVIVTDGESHDNYRLKQVIQDCEDENIQR 304

  Fly   190 -----WGYHRQGS---------------------------------------------------- 197
                 .|::.:|:
  Rat   305 FSIAILGHYNRGNLSTEKFVEEIKSIASEPTEKHFFNVSDELALVTIVKALGERIFALEATADQS 369

  Fly   198 --------CQAGFSAAINGNGSRLFIGAPGSWYWQGQTYSIPPDAKFPFKPPLYQPFGTGGMASS 254
                    .|.||||..:.:.  :.:||.|::.|.                      ||..|..:
  Rat   370 AASFEMEMSQTGFSAHYSQDW--VMLGAVGAYDWN----------------------GTVVMQKA 410

  Fly   255 HDVTRPENQVFSTSESASVNDD--SYLGYSMVTGDFDGDRSEDVAIGMPRGGNLVGRIVVNRWNM 317
            :.:..|.|..|.| |.|.:|:.  |||||::.:....||..  ...|.|| .|..|::|:.:...
  Rat   411 NQMVIPHNTTFQT-EPAKMNEPLASYLGYTVNSATIPGDVL--YIAGQPR-YNHTGQVVIYKMED 471

  Fly   318 ANIFNIT----GRQIGEYFGYSLATSDVDGDGLDD-LLIGAPMYTDPDNVEGKYDVGRVYILLQG 377
            .|| ||.    |.|||.|||..|.|.|:|.|...| ||:|||||...:    |.:.|:||:....
  Rat   472 GNI-NILQTLGGEQIGSYFGSVLTTIDIDKDSYTDLLLVGAPMYMGTE----KEEQGKVYVYAVN 531

  Fly   378 GPTEEKRWTTEHIR--------DGYHSK--------GRFGLALTTLGDVNGDGYGDFAVGAPYDG 426
            ....|.:.:.|.||        |...:|        .|||.|:..:.|:|.||:.|..:|||.:
  Rat   532 QTRFEYQMSLEPIRQTCCSSLKDNSCTKENKNEPCGARFGTAIAAVKDLNVDGFNDVVIGAPLE- 595

  Fly   427 PEGRGVVYIFHGSPMGPLAKPSQIIKSEQLVEGAPYP--RTFGFALSGGLDMDGNTYPDLAVGAY 489
            .:..|.|||:|||     .|..:...::::..|....  :.||.::.|.:|::|:...|:.:|..
  Rat   596 DDHAGAVYIYHGS-----GKTIREAYAQRIPSGGDGKTLKFFGQSIHGEMDLNGDGLTDVTIGGL 655

  Fly   490 SSDQVFIFKSRPVAAVNAETSFASNSKLISLDDRSCQLVRDHKKVPCMLLTTCWSYTGRYLPEQL 554
            ..  ..:|.:|.||.|....:|..|.  :::..::|::  :.|:..|:..|.|:....:...:.:
  Rat   656 GG--AALFWARDVAVVKVTMNFEPNK--VNIQKKNCRV--EGKETVCINATMCFHVKLKSKEDSI 714

  Fly   555 ---DFDVSWLLDAKKLLNPRMFFLRDEGKNIRNQTIRLNYGQKYCLNETVYLLDKVQDKLTPLEV 616
               |......||:.:.::...|....|.|..||.|:|    :..|:..:.|:||| .|....:.|
  Rat   715 YEADLQYRVTLDSLRQISRSFFSGTQERKIQRNITVR----ESECIRHSFYMLDK-HDFQDSVRV 774

  Fly   617 EARYNLRSSRPLDPMVRHRRSILE--PVIDQNREIVLRDAINIQKNCGPDNICEPDLKLKVSTVD 679
            ...:||     .||         |  ||:|......:.:.|...|:||....|..||.|.|||.:
  Rat   775 TLDFNL-----TDP---------ENGPVLDDALPNSVHEHIPFAKDCGNKERCISDLTLNVSTTE 825

  Fly   680 KYLF---GSPEPLVIEVFISNTNEDAFEAAFYMVTPPDLQFRKLQQLGEKKDTPITCSPPTPENN 741
            |.|.   ...:...:.:.:.|..:.|:.....:...|:|.|..::::  :||   :|     |:|
  Rat   826 KSLLIVKSQHDKFNVSLTVKNKGDSAYNTRTVVQHSPNLIFSGIEEI--QKD---SC-----ESN 880

  Fly   742 HTLKCDIGNP-LESGKIAHFKISLVPEEKYGSSSSYDFYWEANSTNLEKPGSEYDNKIRQSVGIW 805
            ..:.|.:|.| |.:|:...|||.......:.|.::. .:..|.|.:.|...|..||::..|:.:.
  Rat   881 QNITCRVGYPFLRAGETVTFKIIFQFNTSHLSENAI-IHLSATSDSEEPLESLNDNEVNISIPVK 944

  Fly   806 VDTDLDIKGTSLPDYQLYKADD-YKELENATKEDDIGPQVVHIYEIRNNRPSIIEEAEVFIHLPY 869
            .:..|....::...:....|:: ..|..|:|  :|||.::...|.||......:.|.::.|..|.
  Rat   945 YEVGLQFYSSASEHHISVAANETIPEFINST--EDIGNEINVFYTIRKRGHFPMPELQLSISFPN 1007

  Fly   870 ETIVGDPLMYLLNQPETGGKIQCDDVAFNE-YNLLLDEKL-VKKSYLQAQGAIWNSAQVSGQSSS 932
            .|..|.|::|.:.. .:...:.|...:..: :.:...:|: :.||.:..:|.|.:.:...|.::.
  Rat  1008 LTADGYPVLYPIGW-SSSDNVNCRPRSLEDPFGINSGKKMTISKSEVLKRGTIQDCSSTCGVATI 1071

  Fly   933 SSS 935
            :.|
  Rat  1072 TCS 1074

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_001162777.1	Int_alpha	46..110	CDD:214549	19/71 (27%)
		Int_alpha	275..>316	CDD:214549	13/42 (31%)
		Int_alpha	398..451	CDD:214549	20/52 (38%)
		Int_alpha	466..>497	CDD:214549	7/30 (23%)
		Integrin_alpha2	499..893	CDD:285619	93/403 (23%)
		DUF2756	<1120..1178	CDD:298627
Itga1	NP_112256.1	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	30..91		18/75 (24%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	101..160		14/65 (22%)
		vWA_integrins_alpha_subunit	171..351	CDD:238746	9/179 (5%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	365..417		12/75 (16%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	422..474		17/55 (31%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	475..537		26/65 (40%)
		Int_alpha	485..>528	CDD:214549	22/46 (48%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	556..614		21/63 (33%)
		Int_alpha	567..620	CDD:214549	20/58 (34%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	618..678		14/61 (23%)
		Integrin_alpha2	663..1073	CDD:285619	100/446 (22%)
		GFFKR motif	1168..1172
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335760
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840