DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment if and Itgam

DIOPT Version :9

Sequence 1:	NP_001162777.1	Gene:	if / 32661	FlyBaseID:	FBgn0001250	Length:	1396	Species:	Drosophila melanogaster
Sequence 2:	XP_006230276.1	Gene:	Itgam / 25021	RGDID:	2926	Length:	1152	Species:	Rattus norvegicus

Alignment Length:	1220	Identity:	274/1220 - (22%)
Similarity:	429/1220 - (35%)	Gaps:	402/1220 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 ILLLIAMSAHGYNIDLPSYVRFRQSSNSMFGFSIAMHKGRSGFYGNQNNVSLIVGAPKFDTSRYQ 85
            :|:.:....||:|:|..:.:.|::::.. ||.|:.          ......::|.||     :..
  Rat     6 LLVTVLTLCHGFNLDTENPMTFQENARG-FGQSVI----------QLGETRVVVAAP-----QEV 54

  Fly    86 QGVTEAGGVFKCSLNDDDCKLVP------------------------------------------ 108
            :.|.:.|.:::|..:.:.|..:|
  Rat    55 KAVNQTGALYQCDYSTNRCDPIPLQVPPEAVNMSLGLSLAATTVPPQLLACGPTVHQNCKENTYV 119

  Fly   109 -----------------------------------FDSKGNNRNVD----KEVV----------- 123
                                               .|..|:..::|    ||.|
  Rat   120 NGLCYLFGSNLLRKPQQFPEALRGCPQQESDIAFLIDGSGSINSIDFQKMKEFVSTVMDQFQKSK 184

  Fly   124 -------------------------DRKSY-----QWLGAT-VATG---------------RDSD 142
                                     |.||:     |..|.| .|:|               ||:.
  Rat   185 TLFSLMQYSDEFRTHFTFNDFKRNPDPKSHVRPIRQLNGRTKTASGIRKVVRELFQKINGARDNA 249

  Fly   143 ---LVV----------------------ACAPRYV------FHTMTPSRAFRIDPVGT------C 170
               |||                      |...|||      ||  .|.....:|.:.:      .
  Rat   250 AKILVVITDGEKFGDPLNYEDVIPEAEEAGIIRYVIGVGNAFH--KPQSRRELDTIASKPAGDHV 312

  Fly   171 FTSHNF-----------EEFYEVSPCRTNNWGYHRQGSCQAGFSAAINGNGSRLFIGAPGSWYWQ 224
            |...||           |:.:.:...:|.:.........|.||||||..||.  .:|:.||:.|.
  Rat   313 FQVDNFEALNTIRNQLQEKIFAIEGTQTGSTSSFEHEMSQEGFSAAITSNGP--LLGSVGSFDWA 375

  Fly   225 GQTYSIPPDAKFPFKPPLYQPFGTGGMASSHDVTRPENQVFSTSESASVNDDSYLGYSMVTGDFD 289
            |..:..|...|..|                          .:|:...|..:|:||||:...  ..
  Rat   376 GGAFLYPSKDKATF--------------------------INTTRIDSDMNDAYLGYASAV--IS 412

  Fly   290 GDRSEDVAIGMPRGGNLVGRIVVNRWNMA---NIFNITGRQIGEYFGYSLATSDVDGDGLDDL-L 350
            .:|.:.:.:|.||..: :|.:|:.:.|..   ...:|.|.|||.|||.||.:.|:|.||..:| |
  Rat   413 RNRVQSLVLGAPRYQH-IGLVVMFKQNFGAWEPHTDIKGSQIGSYFGASLCSVDMDADGNTNLIL 476

  Fly   351 IGAPMYTDPDNVEGKYDVGRVYI--LLQGGPTEEKRWTTEHIRDG--YHSKGRFGLALTTLGDVN 411
            ||||.:.:      |...|:|.:  |.:|   :..||..|.|..|  .|..||||.|||.|||||
  Rat   477 IGAPHHYE------KTRGGQVSVCPLPRG---QRARWQCEAILHGDQGHPWGRFGAALTVLGDVN 532

  Fly   412 GDGYGDFAVGAPYDGPEGRGVVYIFHGSPMGPLAKP-SQIIKSEQLVEGAPYPRTFGFALSGGLD 475
            ||...|.|:|||.: .|.:|.||||||:.:..::.| ||.|...:...|..|   ||.:||||.|
  Rat   533 GDKLTDVAIGAPGE-QENQGAVYIFHGASVASISTPHSQRIAGARFSPGLQY---FGQSLSGGKD 593

  Fly   476 MDGNTYPDLAVGAYSSDQVFIFKSRPVAAVN----------AETSFASNSKLISLDD----RSCQ 526
            :..:...||||||  ..::.:.:::||..:.          |.:.||...:::...|    |.|.
  Rat   594 LTMDGLMDLAVGA--QGRLLLIRAQPVLRLEATMEFSPKNLARSVFACQEEVVKNKDAGEVRVCL 656

  Fly   527 LVRDHKKVPCMLLTTCWSYTGRYLPEQL-DFDVSWLLDAKKLLNP-----RMFFLRDEGKNIRNQ 585
            .||.:.|                  ::| :.|:...:.....|:|     |.||  ||.||...:
  Rat   657 HVRKNTK------------------DRLREGDIQSTVTYDLALDPGRSVVRAFF--DETKNGILR 701

  Fly   586 TIRLNYG--QKYCLNETVYLLDKVQDKLTPLEVEARYN-----LRSSRPLDPMVRHRRSILEPVI 643
            .||: :|  || |....:.|.|.|.:.::|:.:...|.     |||||.           |.||:
  Rat   702 RIRV-FGLTQK-CETLKLILPDCVDNSVSPIILRLNYTLVGEPLRSSRD-----------LRPVL 753

  Fly   644 DQNREIVLRDAINIQKNCGPDNICEPDLKLKVST--VDKYLFGSPEPLVIEVFISNTNEDAFEAA 706
            ....:.:.......:||||.|.||:.||.:.||:  |:..:.|......:.|.:.|..||::...
  Rat   754 AMEAQRIFTAMFPFEKNCGNDTICQDDLSITVSSIRVNTLVVGDSRDFDVSVTLRNDGEDSYGTK 818

  Fly   707 FYMVTPPDLQFRKL---QQLGEKKDTPITCSPPTPENNHTLKC---DIGNPLESGKIAHFKISLV 765
            .....|..|.:||:   |....||...:...|.:.|....||.   ||.:|:
  Rat   819 VTCYYPSGLSYRKVSASQNQFSKKPWRVIAEPSSSEGQGVLKSTIWDINHPI------------- 870

  Fly   766 PEEKYGSSSSYDFYWEANSTNLEKPGSEYDNKIRQSVGIWVD-----TDLDIKGTSLP-DYQLYK 824
                :.::|...|    |.|......:...||:...|.:..:     ||.......|| .|.:|.
  Rat   871 ----FPANSEVTF----NVTFDVDSDASLGNKLLLKVVVTSENNVSRTDKTESQLELPVKYAIYM 927

  Fly   825 A-----DDYKELENATKEDDIGPQVVHIYEIRNNRPSIIEEAEVFIHLPYE---TIVGDPLMYLL 881
            .     ...|.| |.|..:.....:.|.|:..|........:.|| .:|.:   ..:.||.....
  Rat   928 VVTSGESSIKYL-NFTASEMTSKVIQHQYQFNNLGQRSFPVSVVF-WIPVQINKVTIWDPPQVTF 990

  Fly   882 NQPETG-------------------------------GKIQCDDVAFNE---YNLLLDEKLVKKS 912
            :|..:.                               .:||||..:||.   :|:.|...|:...
  Rat   991 SQNLSSVCRTEQKSPSHSKFQDELERTPVLNCSVAVCKRIQCDIPSFNSKEIFNVTLQGNLLFDW 1055

  Fly   913 YLQAQG---AIWNSAQVSGQSSSSSSSGGASVHIEKARGEGFVRGVLVSN 959
            |::...   .:.::|::....|:.:...|....: ||:.|..|....|.|
  Rat  1056 YIETSHDHLLLVSTAEILFNDSAFALLPGQETFV-KAQTETKVEPYKVHN 1104

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_001162777.1	Int_alpha	46..110	CDD:214549	11/140 (8%)
		Int_alpha	275..>316	CDD:214549	11/40 (28%)
		Int_alpha	398..451	CDD:214549	30/53 (57%)
		Int_alpha	466..>497	CDD:214549	13/30 (43%)
		Integrin_alpha2	499..893	CDD:285619	100/473 (21%)
		DUF2756	<1120..1178	CDD:298627
Itgam	XP_006230276.1	vWA_integrins_alpha_subunit	149..324	CDD:238746	30/176 (17%)
		Int_alpha	453..510	CDD:214549	25/65 (38%)
		Int_alpha	517..570	CDD:214549	28/53 (53%)
		Int_alpha	582..>606	CDD:214549	12/26 (46%)
		Integrin_alpha2	615..1032	CDD:285619	99/472 (21%)
		Integrin_alpha	1129..1141	CDD:278771
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900