DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment if and ITGA11

DIOPT Version :9

Sequence 1:	NP_001162777.1	Gene:	if / 32661	FlyBaseID:	FBgn0001250	Length:	1396	Species:	Drosophila melanogaster
Sequence 2:	NP_001004439.1	Gene:	ITGA11 / 22801	HGNCID:	6136	Length:	1188	Species:	Homo sapiens

Alignment Length:	1111	Identity:	238/1111 - (21%)
Similarity:	379/1111 - (34%)	Gaps:	375/1111 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 SSNSMFGFSIAMHKGRSGFYGNQNNVSLIVGAPKFDTSRYQQGVTEAGGVFKCSLNDDDCKLVPF 109
            |..:.||:::..| ..||      |..|:|||| .:|:.||    :.|.|:||.:...:|
Human    36 SRTAFFGYTVQQH-DISG------NKWLVVGAP-LETNGYQ----KTGDVYKCPVIHGNC----- 83

  Fly   110 DSKGN-NRNVDKEVVDRKSYQWLGATVATGRDSDLVVACAPRYVFH------------------- 154
             :|.| .|.....|.:||....||.::||....:..:||:|.:...
Human    84 -TKLNLGRVTLSNVSERKDNMRLGLSLATNPKDNSFLACSPLWSHECGSSYYTTGMCSRVNSNFR 147

  Fly   155 ---TMTPS----------------------------------RAFRIDP----VG---------- 168
               |:.|:                                  :.|.|.|    ||
Human   148 FSKTVAPALQRCQTYMDIVIVLDGSNSIYPWVEVQHFLINILKKFYIGPGQIQVGVVQYGEDVVH 212

  Fly   169 -----------------------------TCF----------------------------TSHNF 176
                                         |.|                            .||:.
Human   213 EFHLNDYRSVKDVVEAASHIEQRGGTETRTAFGIEFARSEAFQKGGRKGAKKVMIVITDGESHDS 277

  Fly   177 EEFYEV-SPCRTNN--------WGYH-RQG----------------------------------- 196
            .:..:| .....:|        .||: |:|
Human   278 PDLEKVIQQSERDNVTRYAVAVLGYYNRRGINPETFLNEIKYIASDPDDKHFFNVTDEAALKDIV 342

  Fly   197 -----------------------SCQAGFSAAINGNGSRLFIGAPGSWYWQGQTYSIPPDAK-FP 237
                                   ..|.|||:.:..:|  :.:||.|::.|.|.........| .|
Human   343 DALGDRIFSLEGTNKNETSFGLEMSQTGFSSHVVEDG--VLLGAVGAYDWNGAVLKETSAGKVIP 405

  Fly   238 FKPPLYQPFGTGGMASSHDVTRPENQVFSTSESASVNDDSYLGYSMVTGDFDGDRSEDVAIGMPR 302
            .:....:.|             ||.         ..|..:||||: ||......:......|.||
Human   406 LRESYLKEF-------------PEE---------LKNHGAYLGYT-VTSVVSSRQGRVYVAGAPR 447

  Fly   303 GGNLVGRIVVNRWNMANIFNIT------GRQIGEYFGYSLATSDVDGDGLDD-LLIGAPMYTDPD 360
             .|..|::::  :.|.|..::|      |:|||.|||..:.:.|:||||:.| ||:|||||.:..
Human   448 -FNHTGKVIL--FTMHNNRSLTIHQAMRGQQIGSYFGSEITSVDIDGDGVTDVLLVGAPMYFNEG 509

  Fly   361 NVEGK---YDVGRVYILLQGGPTEEKRWTTEHIRDGY-HSKGRFGLALTTLGDVNGDGYGDFAVG 421
            ...||   |::.:...:..|           .::|.: :...|||.::.::.|:|.|.|.|..||
Human   510 RERGKVYVYELRQNLFVYNG-----------TLKDSHSYQNARFGSSIASVRDLNQDSYNDVVVG 563

  Fly   422 APYDGPEGRGVVYIFHGSPMGPLAKPSQIIKSEQLVEGAPYPRTFGFALSGGLDMDGNTYPDLAV 486
            ||.:.... |.:|||||.....|..|.|.|.:.:|..|..|   ||.::.|.||::.:...||||
Human   564 APLEDNHA-GAIYIFHGFRGSILKTPKQRITASELATGLQY---FGCSIHGQLDLNEDGLIDLAV 624

  Fly   487 GAYSSDQVFIFKSRPVAAVNAETSFASNSKLISLDDRSCQLVRDHKKVPCMLLTTCWSYTGRYLP 551
            ||..:  ..|..||||..:||...|..:.  |::..|.|:  |..:...|:....|  :|..:|.
Human   625 GALGN--AVILWSRPVVQINASLHFEPSK--INIFHRDCK--RSGRDATCLAAFLC--FTPIFLA 681

  Fly   552 EQLDFDVSWL-----LDAKKLLNPRMFFLRDEGKNIRNQTIRLNYGQKYCLNETVYLLDKVQDKL 611
            .........:     :|.:: ..||. .|.:.|....|:.:.|:.||:.|.....::|| ..|.:
Human   682 PHFQTTTVGIRYNATMDERR-YTPRA-HLDEGGDRFTNRAVLLSSGQELCERINFHVLD-TADYV 743

  Fly   612 TPLEVEARYNLRSSRPLDPMVRHRRSILEPVIDQNREIVLRDAINIQKNCGPDNICEPDLKL--- 673
            .|:.....|:|.     ||  .|     .|::|......||.::.....|..|..|.|||.|
Human   744 KPVTFSVEYSLE-----DP--DH-----GPMLDDGWPTTLRVSVPFWNGCNEDEHCVPDLVLDAR 796

  Fly   674 -KVSTVDKY-------------------------LFGSPEPLVIEVFISNTNEDAFEAAFYMVTP 712
             .:.|..:|                         :..:.:.:.:|..:.|..|:|:.....:...
Human   797 SDLPTAMEYCQRVLRKPAQDCSAYTLSFDTTVFIIESTRQRVAVEATLENRGENAYSTVLNISQS 861

  Fly   713 PDLQFRKLQQLGEKKDTPITCSPPTPENNHTLK--CDIGNPL--ESGKIA--------------H 759
            .:|||..|.| .|..|..|.|   ..|.....|  |::..|.  ...|:|              |
Human   862 ANLQFASLIQ-KEDSDGSIEC---VNEERRLQKQVCNVSYPFFRAKAKVAFRLDFEFSKSIFLHH 922

  Fly   760 FKISLVPEEKYGSSSSYDFYWEANSTNLEKPGSEYDNKIRQSVGIWVDTD-LDIKGTSLPDYQLY 823
            .:|.|.                |.|.:.|:..::.||.......:..:.| |..:.:||..|::
Human   923 LEIELA----------------AGSDSNERDSTKEDNVAPLRFHLKYEADVLFTRSSSLSHYEV- 970

  Fly   824 KADDYKELENATKEDDIGPQVVHIYEIRNNRPSIIEEAEVFIHLPYETIVGDPLM----YLLNQP 884
                 |...:..:.|.|||....|:.|:|.....|....:.|.:|..|..|:.|:    :|.::.
Human   971 -----KPNSSLERYDGIGPPFSCIFRIQNLGLFPIHGMMMKITIPIATRSGNRLLKLRDFLTDEA 1030

  Fly   885 ETGGKI 890
            .|...|
Human  1031 NTSCNI 1036

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_001162777.1	Int_alpha	46..110	CDD:214549	19/63 (30%)
		Int_alpha	275..>316	CDD:214549	11/40 (28%)
		Int_alpha	398..451	CDD:214549	21/52 (40%)
		Int_alpha	466..>497	CDD:214549	11/30 (37%)
		Integrin_alpha2	499..893	CDD:285619	96/449 (21%)
		DUF2756	<1120..1178	CDD:298627
ITGA11	NP_001004439.1	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	24..85		20/66 (30%)
		Int_alpha	39..>78	CDD:214549	18/50 (36%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	91..151		10/59 (17%)
		vWA_integrins_alpha_subunit	163..341	CDD:238746	15/177 (8%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	355..406		11/52 (21%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	411..461		16/75 (21%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	462..527		24/64 (38%)
		Int_alpha	476..>518	CDD:214549	20/41 (49%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	528..586		20/69 (29%)
		Int_alpha	538..592	CDD:214549	21/54 (39%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	590..650		24/64 (38%)
		Integrin_alpha2	635..1034	CDD:285619	95/445 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142033
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740