DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment if and pat-2

DIOPT Version :9

Sequence 1:	NP_001162777.1	Gene:	if / 32661	FlyBaseID:	FBgn0001250	Length:	1396	Species:	Drosophila melanogaster
Sequence 2:	NP_498948.1	Gene:	pat-2 / 176240	WormBaseID:	WBGene00003929	Length:	1226	Species:	Caenorhabditis elegans

Alignment Length:	1493	Identity:	393/1493 - (26%)
Similarity:	620/1493 - (41%)	Gaps:	402/1493 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RRMALHCPITSLILLLIAMSAHGYNIDLPSYVRFRQSSNSMFGFSIAMHKGRSGFYGNQNNVS-L 72
            ||:.|   :..|:.||..::.  :|||..:.|....:.| .||:|:       .||..|..:. |
Worm     8 RRIGL---LLGLLGLLAGVAT--FNIDTKNVVVHHMAGN-YFGYSL-------DFYHEQKGMPVL 59

  Fly    73 IVGAPKFDTSRYQ-QGVTEAGGVFKCSLNDDDCKLVPFDS-KGNNRNVDKE---VVDRKSYQWLG 132
            :||||:.:::... .|:...|.|:.||:|...|:.|..|. |||.:.::..   .::.||:|:.|
Worm    60 VVGAPEAESNNPNLAGIRRPGAVYACSVNRATCREVHVDKMKGNLKKLNGSHLVPIEEKSHQFFG 124

  Fly   133 ATVATGRDSDLVVACAPRYVFHTMTPSRAFRIDPVGTCFTSHN-FEEFYEVSPCRTN--NWGYHR 194
            |||.:....|.:|.|||:|.:..   |:...|:||||||.:.| |:...|.|.|:..  ..|.||
Worm   125 ATVRSNDKHDKIVVCAPKYTYFY---SKFEVIEPVGTCFYAENGFDNAEEFSSCKQEPARHGRHR 186

  Fly   195 QGSCQAGFSAAING--NGSRLFIGAPGSWYWQGQTYSIPPDAKFPFKPPLYQPFGTGGMASSHDV 257
            .|..|.|||||:.|  |.:|:||||||.|||||..:|                     ....:..
Worm   187 LGYGQCGFSAAVPGKKNQNRVFIGAPGVWYWQGAMFS---------------------QNIKNQT 230

  Fly   258 TRPENQVFSTSESASVNDDSYLGYSMVTGDFDGDRSEDVAIGMPRGGNLVGRIVVNRWNMANIFN 322
            .||     :|...:...|...:|||..|||||||..:|:..|:|||.:|.|::|:....:..:.|
Worm   231 DRP-----NTEYGSKEYDHDMMGYSTATGDFDGDGIDDIVAGVPRGNDLHGKLVLYTSKLKMMIN 290

  Fly   323 IT---GRQIGEYFGYSLATSDVDGDGLDDLLIGAPMYTDPDNVEG--------KYDVGRVYILLQ 376
            :|   ..|.|:|.|.|:|.:||:.||.||:::|.|.|||..:|:.        :||||:|.::||
Worm   291 LTDEVSTQHGQYCGGSVAVADVNKDGRDDIIMGCPFYTDYGSVKDAKTQERKPQYDVGKVIVMLQ 355

  Fly   377 GGP---------TEEKRWTTEHIRDGYHSKGRFGLALTTLGDVNGDGYGDFAVGAPYDGPEGRGV 432
            ..|         ..:.:|            ||||.|:...||:|.|||.|..|||||.|...:|.
Worm   356 TAPGVFGKQIAVVGDDQW------------GRFGHAVAAAGDLNLDGYNDVIVGAPYAGKNKQGA 408

  Fly   433 VYIFHGSPMGPLAKPSQIIKSEQLVEGAPYPRTFGFALSGGLDMDGNTYPDLAVGAYSSDQVFIF 497
            ||:.|||..|....|:|.|:...:..|  ..::|||:|:|..|:|||..||:||||:.|....:.
Worm   409 VYVIHGSKDGVRELPTQKIEGANIGHG--NIKSFGFSLTGNEDVDGNGMPDIAVGAWKSGNAAVL 471

  Fly   498 KSRPVAAVNAETSFASNSKLISLDDRSCQLVRDHKKVPCMLLTTCWSYTGR-YLPEQLDFDVSWL 561
            .::||..|..:|.  ..|.|||::|::|.:.....|..|..:.||:.|.|: ..|..|:||:.:.
Worm   472 LTKPVVTVTGQTE--PESALISVEDKNCDVDGKLGKQACKHINTCFKYEGKGDTPNDLEFDLRFN 534

  Fly   562 LDAKKLLNPRMFFLRDEGKNIRN-----------------QTIRLNYGQKYCLNETVYLLDKVQD 609
            ||... ..||.:||:.:.|:.|:                 |.:||..|::.|.....:....::|
Worm   535 LDDHS-PEPRAYFLQKDVKSDRSIKVAQGSKTRDHPSSIEQRVRLEKGRQKCFRHRFFASSTMKD 598

  Fly   610 KLTPLEVEARYNLRSSRPLDPMVRHRRSILEPVIDQNREIVLRDAINIQKNCGPDNICEPDLKL- 673
            ||:|:.....|....|:    ..:.|...|||.||....:..::.|||..|||.|::|.||||:
Worm   599 KLSPIHWSVNYTYVESK----TGKLRGDKLEPAIDTTVPLSFQNKINIANNCGKDDLCVPDLKVT 659

  Fly   674 KVSTVDKYLFGSPE-PLVIEVFISNTNEDAFEAAFYMVTPPDLQFRKLQQLG--EKKDTPITCSP 735
            .|:..:|:|.|:.: .::|.|.:.|..||::|...|...|...::..::.:|  ..|..| .|||
Worm   660 AVADREKFLLGTQDNTMLINVTVQNGGEDSYETKLYFDVPQGFEYGGIESVGGDGSKSAP-ACSP 723

  Fly   736 ----PTPENNHTLKCDIGNPLESGKIAHFKISLVPEEKYGSSSSYDFYWEANSTNLEKPGSEYDN 796
                |..:...|..||:||||.:.|:....:.:.........:........||:|.|:..:..||
Worm   724 TSDEPDSDGKWTFACDLGNPLPANKVVSSVVRVTASSDKPPLAPISINAHVNSSNDEEAHTVADN 788

  Fly   797 KIRQSVGIWVDTDLDIKGTSLPDYQLYKADDYKELENATKEDDIGPQVVHIYEIRNNRPSIIEEA 861
            |:..::.:.....|.:.|.|.|: |:..:...|...:|..:::|||.|.|:|:|.|..||.::.|
Worm   789 KVTFTIPVDFKNQLSLNGRSNPE-QVDFSMTNKTRVDAFDDNEIGPVVSHLYQISNRGPSEVDSA 852

  Fly   862 EVFIHLPYETIVGDPLMYLLNQPETGGKIQCDDVAFNEYNLLLDEKLVKKSYLQAQGAIWNSAQV 926
            .:.|..|..:..|..|:|::.:|
Worm   853 TLDIFWPSFSTEGGHLLYIITEP------------------------------------------ 875

  Fly   927 SGQSSSSSSSGGASVHIEKARGEGFVRGVLVSNSTDAGDKLSPKQVEQRRQEDTLEALGDASFVH 991
                                          |.|..:.|    ..:|:|.:..:.|..
Worm   876 ------------------------------VVNPPNKG----RCRVKQLQNVNPLNL-------- 898

  Fly   992 RDRASQAVQEPQVNQTSFTTYSTSSSSSGSGAPSAQLRGHSTQGHIQMAGPVQHTSSSSSSNYRS 1056
            |........||.|.:|                |:...|....:.:..     :.|:.|.|:.::|
Worm   899 RITNEHVPTEPPVAKT----------------PNEYSREEDDESYED-----ETTTQSQSTRHQS 942

  Fly  1057 WPAQQQQQHQQLLLAGSGGSGLGSPVTFNDKSQFGGRNNNFHTGTLDLGTLNRGNVDNELYRSQG 1121
              .|.|..||         ||   ||               |.
Worm   943 --TQHQTHHQ---------SG---PV---------------HV---------------------- 956

  Fly  1122 QYQNPSQSLGQSQGQFQANANQGHYQGQNQAQFQARNPGFQGQTSYQGQTQYSGQPGGYQTHHVT 1186
             |:...:.:.|:.|.:|                               ..:...:.|.|:
Worm   957 -YEKDEEKIRQNTGNWQ-------------------------------YVEDKKKKGDYE----- 984

  Fly  1187 YSSGSKPYYGRENEDFYDEDNLQQATPGHWSSSSSSSSSSGTRRLRRS----NDKDGATEK--PL 1245
            |....:.|.|   :||.:||:             .....:|::|::|:    ..|.|...:  |.
Worm   985 YIPDDQEYDG---DDFEEEDD-------------EDFDRAGSKRVKRNPTPKKKKKGGEHRGEPR 1033

  Fly  1246 Q---------------------IDLNSP-------CQSARCKSIRCVVTNLGTEDGDAAFVAIRA 1282
            .                     :|...|       |.|.||..|.|.:.:|  ::.:...|.|.:
Worm  1034 SDKARFSDLREAVKLSKEAGGVVDYKGPLSRASVDCNSLRCTHIECDIYDL--KEDEFVLVEIFS 1096

  Fly  1283 RMVAKTM--EKLASNVPLNVSTLAVANV-----------TLLPFIGAPKDAIVKTHEIFYKAEPE 1334
            |:...|:  ||   |...::|:||:|.|           ||:..:....:||         |..|
Worm  1097 RLYTNTLVDEK---NPGGDISSLALARVTSTKYNLPHKPTLITAVSTNMNAI---------ASEE 1149

  Fly  1335 PLQVPDVVPLWVVVLAACAGALIFLLLVWLLYKCGFFNRNR-PTDHSQ---ERQPLRNGYHGD 1393
            ...    :|.|:.:||...|..|.:||:.||::||||.||| ||:|::   :|||  |..:.|
Worm  1150 GRD----LPWWLYLLAILIGLAILILLILLLWRCGFFKRNRPPTEHAELRADRQP--NAQYAD 1206

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_001162777.1	Int_alpha	46..110	CDD:214549	20/65 (31%)
		Int_alpha	275..>316	CDD:214549	19/40 (48%)
		Int_alpha	398..451	CDD:214549	27/52 (52%)
		Int_alpha	466..>497	CDD:214549	16/30 (53%)
		Integrin_alpha2	499..893	CDD:285619	115/419 (27%)
		DUF2756	<1120..1178	CDD:298627	4/57 (7%)
pat-2	NP_498948.1	Int_alpha	39..98	CDD:214549	20/66 (30%)
		Int_alpha	299..359	CDD:214549	24/59 (41%)
		Int_alpha	372..427	CDD:214549	28/66 (42%)
		Int_alpha	440..>462	CDD:214549	13/21 (62%)
		Integrin_alpha2	473..920	CDD:285619	127/555 (23%)
		Integrin_alpha	1178..1192	CDD:278771	9/13 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160488
Domainoid	1	1.000	166	1.000	Domainoid score	I2356
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37396
Inparanoid	1	1.050	488	1.000	Inparanoid score	I784
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D325432at33208
OrthoFinder	1	1.000	-	-		FOG0001619
OrthoInspector	1	1.000	-	-		oto18264
orthoMCL	1	0.900	-	-		OOG6_102088
Panther	1	1.100	-	-	LDO	PTHR23220
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2711
SonicParanoid	1	1.000	-	-		X587
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790