DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment if and Itga2

DIOPT Version :9

Sequence 1:	NP_001162777.1	Gene:	if / 32661	FlyBaseID:	FBgn0001250	Length:	1396	Species:	Drosophila melanogaster
Sequence 2:	XP_345157.5	Gene:	Itga2 / 170921	RGDID:	621632	Length:	1178	Species:	Rattus norvegicus

Alignment Length:	1183	Identity:	263/1183 - (22%)
Similarity:	407/1183 - (34%)	Gaps:	396/1183 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LILLLIA---MSAHGYNIDLPSYVRFRQSSNSMFGFSIAMHKGRSGFYGNQNNVSLIVGAP--KF 79
            |.|||:.   :|...||:.||....|..||:..||:|:.......|.:       |:||:|  .|
  Rat    12 LQLLLLTQGLLSCLAYNVGLPGAKIFSGSSSEQFGYSVQQLTTPQGNW-------LLVGSPWSGF 69

  Fly    80 DTSRYQQGVTEAGGVFKC--SLNDDDCKLVPFDSKGNNRNVDKEVVDRKSYQWLGATV------- 135
            ..:|       .|.|:||  .|....|:.:...:..:..|    |.:.|:...||.|:
  Rat    70 PDNR-------MGDVYKCPVDLPTATCEKLNLQNSASISN----VTEIKTNMSLGLTLTRNPGTG 123

  Fly   136 ------------------ATGRDS-----------------------DLVVAC------------ 147
                              |||..|                       |:||.|
  Rat   124 GFLTCGPLWAHQCGNQYYATGICSDVSPDFQSLTSFSPAVQACPSLVDVVVVCDESNSIYPWEAV 188

  Fly   148 ---------------------------APRYVFHTMTPSR------------------------- 160
                                       .||.||:..|...
  Rat   189 KNFLEKFVQGLDIGPKKTQVALIQYANDPRVVFNLTTYKNKEDMVQATSETRQYGGDLTNTFKAI 253

  Fly   161 -----------------AFRIDPVGTCFTSHN--------------------------------- 175
                             |.::..|.|...||:
  Rat   254 QFARDIAYLPESGGRPGATKVMVVVTDGESHDGSKLQTVIQQCNDDEILRFGIAVLGYLNRNALD 318

  Fly   176 ----FEEFYEVSPCRTNNW-----------------GYH-------RQGS-------CQAGFSAA 205
                .:|...::...|..:                 |.|       .||.       .|.||||.
  Rat   319 TKNLIKEIKAIASTPTERYFFNVADEAALLEKAGTLGEHIFSIEGTVQGGDNFQMEMAQVGFSAD 383

  Fly   206 INGNGSRLFIGAPGSWYWQGQTYSIPPDAKFPFKPPLYQPFGTGGMASSHDVTRPENQVFSTSES 270
            .:.....|.:||.|::.|.|...                           ..|..|:.:|.....
  Rat   384 YSPQNDILMLGAVGAFDWSGTVV---------------------------QETSYEHLIFPKQAF 421

  Fly   271 ASV----NDDSYLGYSMVTGDFDGDRSEDVAIGMPRGGNLVGRIV---VNR-WNMANIFNITGRQ 327
            ..|    |..|:||||:..  ...:.......|.|| .|..|:||   ||: .|:..|.:..|.|
  Rat   422 DQVLQDRNHSSFLGYSVAA--ISTENGVHFVAGAPR-ANYTGQIVLYSVNKHGNVTVIQSHRGDQ 483

  Fly   328 IGEYFGYSLATSDVDGDGLDD-LLIGAPMYTDPDNVEGKYDVGRVYILLQGGPTEEKRWTTEH-I 390
            ||.|||..|.:.|||.|.:.| ||:|||||.:    :.|.:.|:||:.     |..|....:| .
  Rat   484 IGSYFGSVLCSVDVDKDTITDVLLVGAPMYMN----DLKKEEGKVYLF-----TITKGVLNQHQF 539

  Fly   391 RDGYHSKG--RFGLALTTLGDVNGDGYGDFAVGAPYDGPEGRGVVYIFHGSPMGPLAKPSQIIKS 453
            .:|....|  |||.|:..|.|:|.||:.|..||:|.:. |..|.|||::|.......|.||.|..
  Rat   540 LEGPEGTGNARFGSAIAALSDINMDGFNDVIVGSPVEN-ENSGAVYIYNGHQGTIRTKYSQKILG 603

  Fly   454 EQLVEGA--PYPRTFGFALSGGLDMDGNTYPDLAVGAYSSDQVFIFKSRPVAAVNAETSFASNSK 516
            .   :||  .:.:.||.:|.|..|::|::..|:::||..  ||....|:.||.|..|.||..: |
  Rat   604 S---DGAFKSHLQFFGRSLDGYGDLNGDSITDVSIGALG--QVVQLWSQSVADVATEASFTPD-K 662

  Fly   517 LISLDDRSCQLVRDHKKVPCMLLTTCWSYTGRYLPEQLDFDVSWL----LDAKKL---LNPRMFF 574
            :|.|:           |...:.|..|  :..::.|...:..|:.|    |||.:.   :..|..|
  Rat   663 IILLN-----------KEAKITLKLC--FRAKFRPPGQNHQVAILFNMTLDADQYSSRVTSRGIF 714

  Fly   575 LRDEGKNIRNQTIRLNYGQKYCLNETVYLLDKVQDKLTPLEVEARYNLRSSRPLDPMVRHRRSIL 639
             |:..:....:|:.::..:. | :|....:.|..|.:.||::  |.::...:|          ..
  Rat   715 -RENSERFLQKTMVVSEVEN-C-SEYHISIQKPSDVVNPLDL--RVDISLEKP----------GT 764

  Fly   640 EPVIDQNREIVLRDAINIQKNCGPDNICEPDLKLKVSTVDKYLFGSP-------EPLVIEVFISN 697
            .|.::...|.|...:|...|.||.|.||..||.|.|..:.. |...|       :.|...|.:.|
  Rat   765 SPALEAYSETVKVFSIPFYKECGSDGICISDLILDVRQLPA-LRNQPFIVSNQNKRLTFSVTLKN 828

  Fly   698 TNEDAFEAAFYMVTPPDLQFRKLQQLGEKKDTPITCSPPTPENNHTLKCDIGNPLESGKIAHFKI 762
            ..|.|:..|.......:|.|.....  ....|.:||...:.:.:.|  ||:|.|
  Rat   829 RGESAYNTAVLAEFSENLFFASFSM--PVDGTEVTCQIGSSQKSVT--CDVGYP----------- 878

  Fly   763 SLVPEEKYGSSSSYDFYWEANSTNLEKPG---------SEYDNKIRQSVGIWV----DTDLDI-K 813
            :|..|::...:.::||    |..||:...         |:..||...||.:.|    |.:|.: :
  Rat   879 ALKSEQQVTFTINFDF----NLQNLQNQAAINFQAFSESQETNKADNSVSLIVPLLYDAELHLTR 939

  Fly   814 GTSLPDYQLYKADDYKELENATKEDDIGPQVVHIYEI-RNNRPSIIEEAEVFIHLPYETIVGDPL 877
            .|::..|::...::...:.|:.  :||||:.:...:| ..:.|  :..|.|.||:|..|...:||
  Rat   940 STNINFYEISSDENAPSVINSV--EDIGPEFIFSLKITAGSAP--VSMASVTIHIPLHTKEKNPL 1000

  Fly   878 MYLLN-QPETGGKIQC-------------DDVAFNEYNL-------------------LLDEKLV 909
            :||.. |.:..|.|.|             ..|:|...|.                   |.|..:.
  Rat  1001 LYLTGIQTDKAGDISCRAEINPLNLPHTASPVSFKSENFRHMKELDCKTTSCSNVSCWLKDLHMK 1065

  Fly   910 KKSYLQAQGAIWN 922
            .:.::.....:||
  Rat  1066 AEYFINVTTRVWN 1078

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_001162777.1	Int_alpha	46..110	CDD:214549	17/67 (25%)
		Int_alpha	275..>316	CDD:214549	14/44 (32%)
		Int_alpha	398..451	CDD:214549	23/54 (43%)
		Int_alpha	466..>497	CDD:214549	11/30 (37%)
		Integrin_alpha2	499..893	CDD:285619	101/436 (23%)
		DUF2756	<1120..1178	CDD:298627
Itga2	XP_345157.5	Int_alpha	44..92	CDD:214549	16/61 (26%)
		vWA_integrins_alpha_subunit	170..350	CDD:238746	16/179 (9%)
		Int_alpha	430..473	CDD:214549	14/45 (31%)
		Int_alpha	484..535	CDD:214549	24/59 (41%)
		Int_alpha	548..601	CDD:214549	22/53 (42%)
		Int_alpha	611..>637	CDD:214549	7/25 (28%)
		Integrin_alpha2	646..1057	CDD:285619	104/463 (22%)
		Integrin_alpha	1152..1166	CDD:278771
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335711
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840