DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment if and Itgam

DIOPT Version :9

Sequence 1:	NP_001162777.1	Gene:	if / 32661	FlyBaseID:	FBgn0001250	Length:	1396	Species:	Drosophila melanogaster
Sequence 2:	NP_001076429.1	Gene:	Itgam / 16409	MGIID:	96607	Length:	1154	Species:	Mus musculus

Alignment Length:	1208	Identity:	265/1208 - (21%)
Similarity:	412/1208 - (34%)	Gaps:	412/1208 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 ITSLILLLIAMS-AHGYNIDLPSYVRFRQSSNSMFGFSIAMHKGRSGFYGNQNNVSLIVGAPKFD 80
            :|...||:.|:: .||:|:|....:.|::::.. ||.|:....|          .|::|.||
Mouse     1 MTLKALLVTALALCHGFNLDTEHPMTFQENAKG-FGQSVVQLGG----------TSVVVAAP--- 51

  Fly    81 TSRYQQGVTEAGGVFKCSLNDDDCKLVPFDSKGNNRNVDKEVVDRKSYQWLGATVATGRDSDLVV 145
              :..:.|.:.|.:::|..:...|..:|.       .|..|.|:..    ||.::|.......::
Mouse    52 --QEAKAVNQTGALYQCDYSTSRCHPIPL-------QVPPEAVNMS----LGLSLAVSTVPQQLL 103

  Fly   146 ACAP------------------------------------------------------------- 149
            ||.|
Mouse   104 ACGPTVHQNCKENTYVNGLCYLFGSNLLRPPQQFPEALRECPQQESDIVFLIDGSGSINNIDFQK 168

  Fly   150 ---------------RYVFHTMTPSRAFRI----------------------------------- 164
                           :.:|..|..|..|||
Mouse   169 MKEFVSTVMEQFKKSKTLFSLMQYSDEFRIHFTFNDFKRNPSPRSHVSPIKQLNGRTKTASGIRK 233

  Fly   165 ------------------------------DP---------------------VGTCFTS----- 173
                                          ||                     ||..|..
Mouse   234 VVRELFHKTNGARENAAKILVVITDGEKFGDPLDYKDVIPEADRAGVIRYVIGVGNAFNKPQSRR 298

  Fly   174 -----------------HNF-----------EEFYEVSPCRTNNWGYHRQGSCQAGFSAAINGNG 210
                             .||           |:.:.:...:|.:.........|.||||:|..||
Mouse   299 ELDTIASKPAGEHVFQVDNFEALNTIQNQLQEKIFAIEGTQTGSTSSFEHEMSQEGFSASITSNG 363

  Fly   211 SRLFIGAPGSWYWQGQTYSIPPDAKFPFKPPLYQPFGTGGMASSHDVTRPENQVFSTSESASVND 275
            .  .:|:.||:.|.|..:             ||        .|...||     ..:|:...|..:
Mouse   364 P--LLGSVGSFDWAGGAF-------------LY--------TSKDKVT-----FINTTRVDSDMN 400

  Fly   276 DSYLGYSMVTGDFDGDRSEDVAIGMPRGGNLVGRIVVNRWNMAN---IFNITGRQIGEYFGYSLA 337
            |:||||:...  ...:|.:.:.:|.||..: :|.:|:.|.|...   ..:|.|.|||.|||.||.
Mouse   401 DAYLGYASAV--ILRNRVQSLVLGAPRYQH-IGLVVMFRENFGTWEPHTSIKGSQIGSYFGASLC 462

  Fly   338 TSDVDGDGLDDL-LIGAPMYTDPDNVEGKYDVGRVYI--LLQGGPTEEKRWTTEHIRDG--YHSK 397
            :.|:|.||..:| |||||.|.:      |...|:|.:  |.:|   :..||..|.:..|  .|..
Mouse   463 SVDMDADGNTNLILIGAPHYYE------KTRGGQVSVCPLPRG---QRARWQCEALLHGDQGHPW 518

  Fly   398 GRFGLALTTLGDVNGDGYGDFAVGAPYDGPEGRGVVYIFHGSPMGPL-AKPSQIIKSEQLVEGAP 461
            ||||.|||.|||||||...|.|:|||.: .|.:|.||||:|:.:..| |..||.|.......|..
Mouse   519 GRFGAALTVLGDVNGDKLTDVAIGAPGE-QENQGAVYIFYGASIASLSASHSQRIIGAHFSPGLQ 582

  Fly   462 YPRTFGFALSGGLDMDGNTYPDLAVGAYSSDQVFIFKSRPVAAVN----------AETSFASNSK 516
            |   ||.:||||.|:..:...||||||  ...:.:.:::||..:.          |.:.||...:
Mouse   583 Y---FGQSLSGGKDLTMDGLMDLAVGA--QGHLLLLRAQPVLRLEATMEFSPKKVARSVFACQEQ 642

  Fly   517 LISLDD----RSCQLVRDHKKVPCMLLTTCWSYTGRYLPEQL-DFDVSWLLDAKKLLNP-----R 571
            ::...|    |.|..||.:.|                  ::| :.|:...:.....|:|     |
Mouse   643 VLKNKDAGEVRVCLRVRKNTK------------------DRLREGDIQSTVTYDLALDPGRSRIR 689

  Fly   572 MFFLRDEGK-NIRNQTIRLNYGQKYCLNETVYLLDKVQDKLTPLEVEARYNLRSSRPLDPMVRHR 635
            .||  ||.| |.|.:|......|| |....:.|.|.|.|.::|:.:...|.| ...||
Mouse   690 AFF--DETKNNTRRRTQVFGLMQK-CETLKLILPDCVDDSVSPIILRLNYTL-VGEPL------- 743

  Fly   636 RSI--LEPVIDQNREIVLRDAINIQKNCGPDNICEPDLKLKVST--VDKYLFGSPEPLVIEVFIS 696
            ||.  |.||:..:.:.........:||||.|:||:.||.:.:|.  :|..:.|.|:...:.|.:.
Mouse   744 RSFGNLRPVLAMDAQRFFTAMFPFEKNCGNDSICQDDLSITMSAMGLDTLVVGGPQDFNMSVTLR 808

  Fly   697 NTNEDAFEAAFYMVTPPDLQFRKLQQLGEKKDTPITCSP---------PTPENNHTLKCDIGNPL 752
            |..||::.....:..|..|.:||    ......|:|..|         .:.|.:..||....|
Mouse   809 NDGEDSYGTQVTVYYPSGLSYRK----DSASQNPLTKKPWFVKPAESSSSSEGHGALKSTTWN-- 867

  Fly   753 ESGKIAHFKISLVPEEKYGSSSSYDFYWEANSTNLEKPGSEYDNKIRQSVGIWVDTDLDIKGTSL 817
                |.|.......|..:..:...|.:....:..|.|.....:|.:.::.......:|.:|
Mouse   868 ----INHPIFPANSEVTFNVTFDVDSHASFGNKLLLKAIVASENNMSRTHKTKFQLELPVK---- 924

  Fly   818 PDYQLYK--ADDYKELE--NATKEDDIGPQVVHIYEIRNNRPSIIEEAEVFIHLPYE---TIVGD 875
              |.:|.  ..|...:.  |.|..:.....:.|.|:..|.....:..:.|| .:|.:   ..|.|
Mouse   925 --YAIYMIVTSDESSIRYLNFTASEMTSKVIQHQYQFNNLGQRSLPVSVVF-WIPVQINNVTVWD 986

  Fly   876 PLMYLLNQ-------------PETG------------------GKIQCDDVAFNE---YNLLLDE 906
            ....:.:|             |.:.                  .:||||..:||.   :|:.|..
Mouse   987 HPQVIFSQNLSSACHTEQKSPPHSNFRDQLERTPVLNCSVAVCKRIQCDLPSFNTQEIFNVTLKG 1051

  Fly   907 KL-----VKKSY-----LQAQGAIWNS---AQVSGQSS 931
            .|     :|.|:     :.:...::|.   |.:.||.|
Mouse  1052 NLSFDWYIKTSHGHLLLVSSTEILFNDSAFALLPGQES 1089

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_001162777.1	Int_alpha	46..110	CDD:214549	13/63 (21%)
		Int_alpha	275..>316	CDD:214549	12/40 (30%)
		Int_alpha	398..451	CDD:214549	30/53 (57%)
		Int_alpha	466..>497	CDD:214549	13/30 (43%)
		Integrin_alpha2	499..893	CDD:285619	95/465 (20%)
		DUF2756	<1120..1178	CDD:298627
Itgam	NP_001076429.1	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	18..75		15/72 (21%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	76..135		10/69 (14%)
		vWA_integrins_alpha_subunit	149..324	CDD:238746	13/174 (7%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	339..390		19/78 (24%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	391..442		15/53 (28%)
		Int_alpha	453..>495	CDD:214549	21/47 (45%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	507..565		29/58 (50%)
		Int_alpha	517..>558	CDD:214549	25/41 (61%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	570..630		19/64 (30%)
		Int_alpha	582..>620	CDD:214549	16/42 (38%)
		Integrin_alpha2	615..1034	CDD:285619	94/464 (20%)
		Integrin_alpha	1131..1143	CDD:278771
		GFFKR motif	1133..1137
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832099
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740