Protein Alignment if and Itgal

DIOPT Version :10

• Sequence 1: NP_523378.2
• Gene: if / 32661
• FlyBaseID: FBgn0001250
• Length: 1396
• Species: Drosophila melanogaster
• Sequence 2: NP_001240801.1
• Gene: Itgal / 16408
• MGIID: 96606
• Length: 1162
• Species: Mus musculus
• Alignment Length: 1174
• Identity: 274/1174 - (23%)
• Similarity: 425/1174 - (36%)
• Gaps: 375/1174 - (31%)

  Fly    22 LLLIAM----SAHGYNIDLPSYVRFRQSSNSMFGFSIAMHKGRSGFYGNQNNVSLIVGAPKFDTS 82
            |||:.:    .|..||:|......|...:...||:.:.           |....::||||
Mouse    10 LLLLGLQLFAKAWSYNLDTRPTQSFLAQAGRHFGYQVL-----------QIEDGVVVGAP----- 58

  Fly    83 RYQQGVTEAGGVFKCSLNDDDCKLVPFDSKGNNRNVDKEVVDRKSYQWLGATVATGRDSDLVVAC 147
              .:| ...||::.|..:.:.|:  |....|:|.          :.::||.|:||......::||
Mouse    59 --GEG-DNTGGLYHCRTSSEFCQ--PVSLHGSNH----------TSKYLGMTLATDAAKGSLLAC 108

  Fly   148 APR---------------YVFHTMTPSRAFRIDP---------VGTCF----------------- 171
            .|.               |:|.........:..|         |...|
Mouse   109 DPGLSRTCDQNTYLSGLCYLFPQSLEGPMLQNRPAYQECMKGKVDLVFLFDGSQSLDRKDFEKIL 173

  Fly   172 ------------TSHNFEEFYEVSPCRT--NNWGYHRQ--------GSCQAGF-----SAAINGN 209
                        ||:.|......:.|||  ....|.:|        ||.|..|     ..|||..
Mouse   174 EFMKDVMRKLSNTSYQFAAVQFSTDCRTEFTFLDYVKQNKNPDVLLGSVQPMFLLTNTFRAINYV 238

  Fly   210 GSRLFIGAPGSWYWQGQTYSIPPDAKFPFKPPLYQPFGTGGMASSHDVTR--------------- 259
            .:.:|....|:.....:...|..|.:...|         |.::::||:||
Mouse   239 VAHVFKEESGARPDATKVLVIITDGEASDK---------GNISAAHDITRYIIGIGKHFVSVQKQ 294

  Fly   260 ---------PENQ---VFSTSE--------------------------------SASVNDDSYLG 280
                     |..:   :..|.|                                |:.::.|...|
Mouse   295 KTLHIFASEPVEEFVKILDTFEKLKDLFTDLQRRIYAIEGTNRQDLTSFNMELSSSGISADLSKG 359

  Fly   281 YSMV----TGDFDG---DRSEDVA----IGMP------RGGNL---------------------- 306
            :::|    ..|:.|   |..||:.    :|..      |||.|
Mouse   360 HAVVGAVGAKDWAGGFLDLREDLQGATFVGQEPLTSDVRGGYLGYTVAWMTSRSSRPLLAAGAPR 424

  Fly   307 ---VGRIVV-------NRWNMANIFNITGRQIGEYFGYSLATSDVDGDG-LDDLLIGAPMYTDPD 360
               ||::::       .|||...  .|.|.|||.|||..|.:.|:|.|| .:.||||||::.
Mouse   425 YQHVGQVLLFQAPEAGGRWNQTQ--KIEGTQIGSYFGGELCSVDLDQDGEAELLLIGAPLFF--- 484

  Fly   361 NVEGKYDVGRVYIL------------LQGGPTEEKRWTTEHIRDGYHSKGRFGLALTTLGDVNGD 413
               |:...|||:..            |||.|             || ..||||.|:|.|.|:|||
Mouse   485 ---GEQRGGRVFTYQRRQSLFEMVSELQGDP-------------GY-PLGRFGAAITALTDINGD 532

  Fly   414 GYGDFAVGAPYDGPEGRGVVYIFHGSPMGPLAKPSQIIKSEQLVEGAPYPRTFGFALSGGLDMDG 478
            ...|.|||||.   |.:|.||||:|.|.|...:|||.|:..|:..|.   |.||.::.|..|:.|
Mouse   533 RLTDVAVGAPL---EEQGAVYIFNGKPGGLSPQPSQRIQGAQVFPGI---RWFGRSIHGVKDLGG 591

  Fly   479 NTYPDLAVGAYSSDQVFIFKSRPVAAVNAETSFASNSKLISLDDRSCQLVRDHKKVPCMLLTTCW 543
            :...|:.|||  ..:|.:..||||..|..|.||:...  |.:.:..|......::...:.|..|:
Mouse   592 DRLADVVVGA--EGRVVVLSSRPVVDVVTELSFSPEE--IPVHEVECSYSAREEQKHGVKLKACF 652

  Fly   544 -------SYTGRYLPEQLDFDVSWLLDAKKLLNPRMFFLRDEGKNIRNQTIRLNYGQKYCLNETV 601
                   .:.||.| ..|.:.:.  ||..::.:..:|   .:|.:..:....:. ..|.||:...
Mouse   653 RIKPLTPQFQGRLL-ANLSYTLQ--LDGHRMRSRGLF---PDGSHELSGNTSIT-PDKSCLDFHF 710

  Fly   602 YLLDKVQDKLTPLEVEARYNL--RSSRPLDPMV-RHRRSILEPVIDQNREIVLRDAINIQKNCGP 663
            :....:||.::|:.|...::|  ....|.|..| |..:.||.|.|.     .:...|..:||||.
Mouse   711 HFPICIQDLISPINVSLNFSLLEEEGTPRDQKVGRAMQPILRPSIH-----TVTKEIPFEKNCGE 770

  Fly   664 DNICEPDLKLKVSTVDKYL-FGSPEPLVIEVFISNTNEDAFEAAFYMVTPPDLQFRKLQQLGEKK 727
            |..||.:|.|........| ..|...|.:|..:||:.|||:.....:..|..|.|||::.|....
Mouse   771 DKKCEANLTLSSPARSGPLRLMSSASLAVEWTLSNSGEDAYWVRLDLDFPRGLSFRKVEMLQPHS 835

  Fly   728 DTPITCSPPTPENN---HTLKCDIGNPL-ESGKIAHFKISLVPEEKYGSSSSYDFYWEANST--- 785
            ..|::|...|..::   .||||::.:|: ::|:    ::||........:||::.:.|.|.|
Mouse   836 RMPVSCEELTEGSSLLTKTLKCNVSSPIFKAGQ----EVSLQVMFNTLLNSSWEDFVELNGTVHC 896

  Fly   786 NLEKPGSEYDNKIRQSVGIWVDTDLDIKGTSLPDYQLYKADDY-KELENATKEDDIGP------Q 843
            ..|....:.||.               ..|.:|  .||..:.. ||.||:|......|      |
Mouse   897 ENENSSLQEDNS---------------AATHIP--VLYPVNILTKEQENSTLYISFTPKGPKTQQ 944

  Fly   844 VVHIYEIR-------NNRPSIIEEAEVFIHLPYETIVGDPLMYL---------------LNQPET 886
            |.|:|::|       :|.|::  ||.|.:..|:..   ||:.|.               |.:|.:
Mouse   945 VQHVYQVRIQPSAYDHNMPTL--EALVGVPWPHSE---DPITYTWSVQTDPLVTCHSEDLKRPSS 1004

  Fly   887 --------GGKIQCDDVAFNEYNLLLDEKLVKKSYLQAQGAIWNSAQVSGQS-----SSSSSSGG 938
                    |.:.:| .:.|.           ::..:|..|.:..|.::...|     ||.|.|..
Mouse  1005 EAEQPCLPGVQFRC-PIVFR-----------REILIQVTGTVELSKEIKASSTLSLCSSLSVSFN 1057

  Fly   939 ASVH 942
            :|.|
Mouse  1058 SSKH 1061

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_523378.2	Int_alpha	46..110	CDD:214549	13/63 (21%)
		Int_alpha	275..>316	CDD:214549	16/89 (18%)
		Int_alpha	398..451	CDD:214549	29/52 (56%)
		Int_alpha	466..>497	CDD:214549	10/30 (33%)
		Integrin_alpha2	500..892	CDD:462478	106/446 (24%)
		Glutenin_hmw	<1121..1216	CDD:367362
Itgal	NP_001240801.1	FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	28..79		13/71 (18%)
		FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	80..138		12/67 (18%)
		vWFA	152..321	CDD:469594	30/177 (17%)
		FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	336..387		9/50 (18%)
		FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	390..443		6/52 (12%)
		Int_alpha	399..449	CDD:214549	8/51 (16%)
		FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	444..504		24/67 (36%)
		Int_alpha	454..500	CDD:214549	20/51 (39%)
		FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	505..561		32/72 (44%)
		Int_alpha	515..567	CDD:214549	29/54 (54%)
		FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	565..625		23/64 (36%)
		Int_alpha	578..622	CDD:214549	16/45 (36%)
		Integrin_alpha2	611..1002	CDD:462478	104/430 (24%)
		Integrin_alpha	1110..1124	CDD:459778
		GFFKR motif	1112..1116
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1124..1162