DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment if and Itgae

DIOPT Version :9

Sequence 1:	NP_001162777.1	Gene:	if / 32661	FlyBaseID:	FBgn0001250	Length:	1396	Species:	Drosophila melanogaster
Sequence 2:	NP_032425.2	Gene:	Itgae / 16407	MGIID:	1298377	Length:	1167	Species:	Mus musculus

Alignment Length:	944	Identity:	196/944 - (20%)
Similarity:	340/944 - (36%)	Gaps:	274/944 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 NIDLPSYVRFRQSSNSMFGFSIAMHKGRSGFYGNQNNVSLIVGAPKFDTSRYQQGVTE----AGG 93
            ||.:||    |.|........:.:..|  ..:|:..|::.::.:||      .|||..    .|.
Mouse   284 NIFIPS----RGSRKKALKVMVVLTDG--DIFGDPLNLTTVINSPK------MQGVVRFAIGVGD 336

  Fly    94 VFKCSLNDDDCKLVPFDSKGNNRNVDKEVVDRKSYQWLGATVATGRDSDLVVACAPRYVFHTMTP 158
            .||                  |.|..:|:                    .::|..|:.. ||...
Mouse   337 AFK------------------NNNTYREL--------------------KLIASDPKEA-HTFKV 362

  Fly   159 SRAFRIDPVGTCFTSHNFEEFYEVSPCRTNNWGYHRQGS---------CQAGFSAAINGNGSRLF 214
            :....:|.:.:....|.                .|.:|:         .|.||||.|...| ::.
Mouse   363 TNYSALDGLLSKLQQHI----------------VHMEGTVGDALQYQLAQTGFSAQILDKG-QVL 410

  Fly   215 IGAPGSWYWQGQTYSIPPDAKFPFKPPLYQPFGTGGMASSHDVTRPENQVFSTSESASVNDDSYL 279
            :|..|::.|.|...             ||......|...        ||  :..|.:.....|||
Mouse   411 LGTVGAFNWSGGAL-------------LYSTQNGRGCFL--------NQ--TAKEDSRTVQYSYL 452

  Fly   280 GYSMVTGDFDGDRSEDVAIGMPRGGNLVGRIV----VNRWNMANIFNITGRQIGEYFGYSLATSD 340
            |||:..  ...........|.|| ..|.|.:.    .:|...|.:..|.|.|:|.|||..|...|
Mouse   453 GYSLAV--LHKAHGVSYVAGAPR-HKLRGAVFELRKEDREEDAFVRRIEGEQMGSYFGSVLCPVD 514

  Fly   341 VDGDGLDD-LLIGAPMYTDPDNVEGKYDVGRVYILLQGGPTEEKRWTTEHIRDGYH--SKGRFGL 402
            :|.||..| ||:.||.|    ::.|  :.||||:...  |.::..::..|...|:.  :..|||.
Mouse   515 IDMDGTTDFLLVAAPFY----HIRG--EEGRVYVYQV--PEQDASFSLAHTLSGHPGLTNSRFGF 571

  Fly   403 ALTTLGDVNGDGYGDFAVGAPYDG---PEGR--GVVYIFHGSPMGPLAKPSQIIKSEQLVEGAPY 462
            |:..:||:|.|.:.|.|:|||.:|   .:|.  |.|||::|...|....|||.|::..:..|..|
Mouse   572 AMAAVGDINQDKFTDVAIGAPLEGFGAGDGASYGSVYIYNGHSGGLYDSPSQQIRASSVASGLHY 636

  Fly   463 PRTFGFALSGGLDMDGNTYPDLAVGAYSSDQVFIFKSRPVAAVNAETSFASNSK----LISLDDR 523
               ||.::|||||.:|:...|:.||  |.|...:.:||||..:....:|..::.    :..:|.:
Mouse   637 ---FGMSVSGGLDFNGDGLADITVG--SRDSAVVLRSRPVVDLTVSMTFTPDALPMVFIGKMDVK 696

  Fly   524 SC-------------------------QLVRDHKKVPCMLLTTC------WSYTGRYLPEQLDFD 557
            .|                         .:.:..:::.|...:.|      |: .|.:|.|..
Mouse   697 LCFEVDSSGVASEPGLREMFLNFTVDVDVTKQRQRLQCEDSSGCQSCLRKWN-GGSFLCEHF--- 757

  Fly   558 VSWLLDAKKLLNPRMFFLRDEGKNIRNQTIRLNYGQKYCLNETVYLLDKVQDKLTPLEVEARYNL 622
              ||:..::|..                                      :|..:.:.::..|..
Mouse   758 --WLISTEELCE--------------------------------------EDCFSNITIKVTYEF 782

  Fly   623 RSSRPLDPMVRHRRSILEPVIDQNREIVLRDAINIQKNCGPDNICEPDLKLKVS-TVDKYLFGSP 686
            ::|       ..||....|.:|..:|......:..:|:|.....|..:::|..: :..:.:.|..
Mouse   783 QTS-------GGRRDYPNPTLDHYKEPSAIFQLPYEKDCKNKVFCIAEIQLTTNISQQELVVGVT 840

  Fly   687 EPLVIEVFISNTNEDAFEAAFYMVTPPDLQFRKLQQLGEKKDTP-ITCSPPTP-ENNHTLKCDIG 749
            :.:.:.:.::|:.||::.....:..|.:|||:|:|    |..:| :.|..|.| .:...:.|.||
Mouse   841 KEVTMNISLTNSGEDSYMTNMALNYPRNLQFKKIQ----KPVSPDVQCDDPKPVASVLVMNCKIG 901

  Fly   750 NPLESGKIAHFKISLVPEEKYGSSSSYDFYWEANSTN--------------------LEKPGSEY 794
            :|:......:..::...||....:.:.|.....:::|                    |.:|...|
Mouse   902 HPILKRSSVNVSVTWQLEESVFPNRTADITVTISNSNEKSLARETRSLQFRHAFIAVLSRPSVMY 966

  Fly   795 DNKIRQSVGIWVDTDLDIKGTS---------------LPDYQ------LYKADDYKELENATKED 838
            .| ..||.....:...::.|.:               |.|:|      |.|..|:.|...:.:..
Mouse   967 MN-TSQSPSDHKEFFFNVHGENLFGAVFQLQICVPIKLQDFQIVRVKNLTKTQDHTECTQSQEPA 1030

  Fly   839 DIGPQVVHIYE-------IRNNRPSIIEEAEVFI 865
            .....|.|:.|       |.:|:.::...||:.:
Mouse  1031 CGSDPVQHVKEWHSVVCAITSNKENVTVAAEISV 1064

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_001162777.1	Int_alpha	46..110	CDD:214549	11/67 (16%)
		Int_alpha	275..>316	CDD:214549	12/44 (27%)
		Int_alpha	398..451	CDD:214549	24/57 (42%)
		Int_alpha	466..>497	CDD:214549	13/30 (43%)
		Integrin_alpha2	499..893	CDD:285619	72/453 (16%)
		DUF2756	<1120..1178	CDD:298627
Itgae	NP_032425.2	FG-GAP 1	27..81
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	84..142
		X-domain (extra domain)	149..192
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	163..191
		vWA_integrins_alpha_subunit	196..371	CDD:238746	25/137 (18%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	383..435		15/65 (23%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	438..491		14/57 (25%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	492..552		25/67 (37%)
		Int_alpha	502..558	CDD:214549	22/63 (35%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	555..619		23/63 (37%)
		Int_alpha	566..625	CDD:214549	24/58 (41%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	623..683		22/64 (34%)
		Int_alpha	636..>659	CDD:214549	12/27 (44%)
		Integrin_alpha2	668..>939	CDD:285619	50/325 (15%)
		GFFKR motif	1140..1144
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832035
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D743479at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750