DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment if and Itga5

DIOPT Version :9

Sequence 1:	NP_001162777.1	Gene:	if / 32661	FlyBaseID:	FBgn0001250	Length:	1396	Species:	Drosophila melanogaster
Sequence 2:	NP_034707.5	Gene:	Itga5 / 16402	MGIID:	96604	Length:	1053	Species:	Mus musculus

Alignment Length:	1400	Identity:	352/1400 - (25%)
Similarity:	556/1400 - (39%)	Gaps:	408/1400 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 PITSLILLL--IAMSAHGYNIDLPSYVRFRQSSNSMFGFSIAMHK-GRSGFYGNQNNVSLIVGAP 77
            |:..|:|||  ..:...|:|:|..:.........|:||||:..:: ||.|       ||::||||
Mouse    27 PLLPLLLLLWPPPLQVGGFNLDAEAPAVLSGPPGSLFGFSVEFYRPGRDG-------VSVLVGAP 84

  Fly    78 KFDTSRYQQGVTEAGGVFKC--SLNDDDCKLVPFDSKGNNRNVD--------KEVVDRKSYQWLG 132
            |.:||  |.||.:.|.|:.|  ..:...|..:.||||| :|.::        :|.|:.||.||.|
Mouse    85 KANTS--QPGVLQGGAVYVCPWGTSPIQCTTIQFDSKG-SRILESSLYSAKGEEPVEYKSLQWFG 146

  Fly   133 ATVATGRDSDLVVACAPRYVFHT-MTPSRAFRIDPVGTCFTS-HNFEEFYEVSPCRTNNWGYHRQ 195
            |||.....|  ::||||.|.:.| ..|..    ||||||:.| .||....|.:|||::......|
Mouse   147 ATVRAHGSS--ILACAPLYSWRTEKDPQN----DPVGTCYLSTENFTRILEYAPCRSDFGSAAGQ 205

  Fly   196 GSCQAGFSAAINGNGSRLFIGAPGSWYWQGQTYSIPPDAKFPFKPPLYQPFGTGGMASSHDVTRP 260
            |.||.||||.....| |:.:|.|||::||||..|...:.......|.|             :..|
Mouse   206 GYCQGGFSAEFTKTG-RVVLGGPGSYFWQGQILSATQEQISESYYPEY-------------LINP 256

  Fly   261 ENQVFSTSESASVNDDSYLGYSMVTGDFDGDRSEDVAIGMPRGGNLVGRI-VVNRWNMANIFNIT 324
            ......|.:::||.||||||||:..|:|.||.:||...|:|:|....|.: |:|..::.:::|::
Mouse   257 VQGQLQTRQASSVYDDSYLGYSVAVGEFSGDDTEDFVAGVPKGNLTYGYVTVLNGSDIHSLYNVS 321

  Fly   325 GRQIGEYFGYSLATSDVDGDGLDDLLIGAPMYTDPDNVEGK-YDVGRVYILLQG----GPTEEKR 384
            |.|:..||||::|.:|.:||||||||:|||:..: ...:|: .:||||||.||.    .||....
Mouse   322 GEQMASYFGYAVAATDTNGDGLDDLLVGAPLLME-RTADGRPQEVGRVYIYLQRPAGIDPTPTLT 385

  Fly   385 WTTEHIRDGYHSKGRFGLALTTLGDVNGDGYGDFAVGAPYDGPEGRGVVYIFHGSPMGPLAKPSQ 449
            .|      |.....|||.:||.|||::.|||.|.|:|||:.|...:|||:||.|.|.|...||||
Mouse   386 LT------GQDEFSRFGSSLTPLGDLDQDGYNDVAIGAPFGGEAQQGVVFIFPGGPGGLSTKPSQ 444

  Fly   450 IIKSEQLVEGAPYPRTFGFALSGGLDMDGNTYPDLAVGAYSSDQVFIFKSRPVAAVNAE-TSFAS 513
            ::  :.|......|..||.||.||.|:|||.||||.||::..|:..:::.||:.:.:|. |.|.|
Mouse   445 VL--QPLWAAGRTPDFFGSALRGGRDLDGNGYPDLIVGSFGVDKALVYRGRPIISASASLTIFPS 507

  Fly   514 NSKLISLDDRSCQLVRDHKKVPCMLLTTCWSYTGRYLPEQLDFDVSWLLDAKKLLN--PRMFFLR 576
               :.:.::|||.|  :...|.|:.|:.|.:.:|:::|..:.|:|...||.:|...  .|..||.
Mouse   508 ---MFNPEERSCSL--EGNPVSCINLSFCLNASGKHVPNSIGFEVELQLDWQKQKGGVRRALFLT 567

  Fly   577 DEGKNIRNQTIRLNYGQKYCLNETVYLLD--KVQDKLTPLEVEARYNLRSSRPLDPMVRHRRSIL 639
            .:...:....:..|..::.|....:||.:  :.:|||:|:.:...::|....|:|   .|.   |
Mouse   568 SKQATLTQTLLIQNGAREDCREMKIYLRNESEFRDKLSPIHIALNFSLDPKAPMD---SHG---L 626

  Fly   640 EPVIDQNREIVLRDAINIQKNCGPDNICEPDLKLKVSTVDKYLF-GSPEPLVIEVFISNTNE-DA 702
            .||:....:..:.|...|..:||.||||.|||:|.|....|::: |....|.:.....|..| .|
Mouse   627 RPVLHYQSKSRIEDKAQILLDCGEDNICVPDLQLDVYGEKKHVYLGDKNALNLTFHAQNLGEGGA 691

  Fly   703 FEAAFYMVTPPDLQFRKLQQLGEKKDTPITCSPPTPENNHTLKCDIGNPLESGKIAHFKISLVPE 767
            :||...:..|.:.::..|.: .....:.::|.......:..|.||:|||:::|......:.....
Mouse   692 YEAELRVTAPLEAEYSGLVR-HPGNFSSLSCDYFAVNQSRQLVCDLGNPMKAGTSLWGGLRFTVP 755

  Fly   768 EKYGSSSSYDFYWEANSTNLEKPGSEYDNKIRQSVGIWVDTDLDIKGTSLPDYQLYKADDYKELE 832
            ....:..:..|.::..|.||....|   |.:...:.:.....:.:.|.|.|:..::...|:...:
Mouse   756 HLQDTKKTIQFDFQILSKNLNNSQS---NVVSFPLSVEAQAQVSLNGVSKPEAVIFPVSDWNPQD 817

  Fly   833 NATKEDDIGPQVVHIYEIRNNRPSIIEEAEVFIHLPYETIVGDPLMYLLNQPETGGKIQCDDVAF 897
            ...||:|:||.|.|:||:.|..||.|.:..:.:..| :.:.|..|:|:
Mouse   818 QPQKEEDLGPAVHHVYELINQGPSSISQGVLELSCP-QALEGQQLLYV----------------- 864

  Fly   898 NEYNLLLDEKLVKKSYLQAQGAIWNSAQVSGQSSSSSSSGGASVHIEKARGEGFVRGVLVSNSTD 962
                                      .:|:|                            :||.|
Mouse   865 --------------------------TKVTG----------------------------LSNCT- 874

  Fly   963 AGDKLSPKQVEQRRQEDTLEALGDASFVHRDRASQAVQEPQVNQTSFTTYSTSSSSSGSGAPSAQ 1027

Mouse   875 ----------------------------------------------------------------- 874

  Fly  1028 LRGHSTQGHIQMAGPVQHTSSSSSSNYRSWPAQQQQQHQQLLLAGSGGSGLGSPVTFNDKSQFGG 1092
                                    |||                         :|
Mouse   875 ------------------------SNY-------------------------TP----------- 879

  Fly  1093 RNNNFHTGTLDLGTLNRGNVDNELYRSQGQYQNPSQSLGQSQGQFQANANQGHYQGQNQAQFQAR 1157
                                     .|||...:|..|
Mouse   880 -------------------------NSQGLELDPETS---------------------------- 891

  Fly  1158 NPGFQGQTSYQGQTQYSGQPGGYQTHHVTYSSGSKPYYGRENEDFYDEDNLQQATPGHWSSSSSS 1222
                                    .||:.                      ::..||.      |
Mouse   892 ------------------------PHHLQ----------------------KREAPGR------S 904

  Fly  1223 SSSSGTRRLRRSNDKDGATEKPLQIDLNSPCQSARCKSIRCVVTNLGTEDGDAAFVAIRARMVAK 1287
            |::|||:.|:                    |..|:|..:||....|..::..:  :.:..|:.||
Mouse   905 STASGTQVLK--------------------CPEAKCFRLRCEFGPLHRQESRS--LQLHFRVWAK 947

  Fly  1288 TMEKLASNVPLNVSTLAVANVTLLPFIGAPKDAIVKTHEIFYKAEPEPLQVPDVVPLWVVVLAAC 1352
            |..: ....|.::...||.....:|:...|:....|..::....:....:..:.||||:::||..
Mouse   948 TFLQ-REYQPFSLQCEAVYEALKMPYQILPRQLPQKKLQVATAVQWTKAEGSNGVPLWIIILAIL 1011

  Fly  1353 AGALIFLLLVWLLYKCGFFNRNRPTDHSQERQPLR 1387
            .|.|:..||:::|||.|||.|:.|...:.|:..|:
Mouse  1012 FGLLLLGLLIYVLYKLGFFKRSLPYGTAMEKAQLK 1046

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_001162777.1	Int_alpha	46..110	CDD:214549	24/66 (36%)
		Int_alpha	275..>316	CDD:214549	20/41 (49%)
		Int_alpha	398..451	CDD:214549	29/52 (56%)
		Int_alpha	466..>497	CDD:214549	17/30 (57%)
		Integrin_alpha2	499..893	CDD:285619	97/400 (24%)
		DUF2756	<1120..1178	CDD:298627	4/57 (7%)
Itga5	NP_034707.5	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	46..111		25/73 (34%)
		Int_alpha	59..117	CDD:214549	24/66 (36%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	131..191		27/65 (42%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	196..248		20/52 (38%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	262..314		23/51 (45%)
		Int_alpha	271..>313	CDD:214549	20/41 (49%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	315..380		29/65 (45%)
		Int_alpha	325..382	CDD:214549	27/57 (47%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	381..440		28/64 (44%)
		Int_alpha	392..446	CDD:214549	29/53 (55%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	444..507		25/64 (39%)
		Int_alpha	458..510	CDD:214549	23/54 (43%)
		Integrin_alpha2	493..925	CDD:285619	124/769 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	879..910		13/146 (9%)
		GFFKR motif	1024..1028		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832105
Domainoid	1	1.000	176	1.000	Domainoid score	I3588
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	500	1.000	Inparanoid score	I1351
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D325432at33208
OrthoFinder	1	1.000	-	-		FOG0001619
OrthoInspector	1	1.000	-	-		otm43488
orthoMCL	1	0.900	-	-		OOG6_102088
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2711
SonicParanoid	1	1.000	-	-		X587
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790