DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment if and Itga4

DIOPT Version :9

Sequence 1:NP_001162777.1 Gene:if / 32661 FlyBaseID:FBgn0001250 Length:1396 Species:Drosophila melanogaster
Sequence 2:NP_034706.3 Gene:Itga4 / 16401 MGIID:96603 Length:1032 Species:Mus musculus


Alignment Length:1056 Identity:272/1056 - (25%)
Similarity:455/1056 - (43%) Gaps:187/1056 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 LILLLIAMSAHGYNIDLPSYVRFRQSSNSMFGFSIAMHKGRSGFYGNQNNVSLIVGAPKFDTSRY 84
            |:|.....:.|.||:|..:.:.::..|.::||:|:.:|.     :|::.  .||||||   |:.:
Mouse    22 LLLYFGVPTGHSYNLDPENALLYQGPSGTLFGYSVVLHS-----HGSKR--WLIVGAP---TASW 76

  Fly    85 --QQGVTEAGGVFKCSLN---DDDCKLVPFDSKGNNRNVDKEVVDRKSYQWLGATVA--TGRDSD 142
              ...|...|.:::|.:.   :..|:.:...|. :.....|..::.:..||||.|::  .|.:..
Mouse    77 LSNASVVNPGAIYRCGIRKNPNQTCEQLQLGSP-SGEPCGKTCLEERDNQWLGVTLSRQPGENGS 140

  Fly   143 LVVACAPRY--VFHTMTPSRAFRIDPVGTCF---TSHNFEEFYEVSPC---RTNNWGYHRQGSCQ 199
             :|.|..|:  :|:..:.::.    |.|.|:   :....|....::||   .|..:| ....|||
Mouse   141 -IVTCGHRWKNIFYMKSDNKL----PTGICYVMPSDLRTELSKRMAPCYKDYTRKFG-ENFASCQ 199

  Fly   200 AGFSAAINGNGSRLFIGAPGSWYWQGQTYSIPPDAKFPFKPPLYQPFGTGGMASSHDVTRPENQV 264
            ||.|:....:  .:.:|||||.||.|..:                         .:::|..:.:.
Mouse   200 AGISSFYTQD--LIVMGAPGSSYWTGTVF-------------------------VYNITTNQYKA 237

  Fly   265 FSTSESASVNDDSYLGYSMVTGDFDGDRSEDVAIGMPR----GGNLVGRIVVNRWNMANIFNITG 325
            |...:: .|...||||||:..|.|....:.:|..|.|:    |...:..|..|..|:  ::.:.|
Mouse   238 FVDRQN-QVKFGSYLGYSVGAGHFRSPHTTEVVGGAPQHEQIGKAYIFSIDENELNI--VYEMKG 299

  Fly   326 RQIGEYFGYSLATSDVDGDGLDDLLIGAPMYTDPDNVEGKYDVGRVYILLQGG----PTEEKRWT 386
            :::|.|||.|:...|::.||..|||:||||.:.      ..:.|||::.:..|    ..|.:|..
Mouse   300 KKLGSYFGASVCAVDLNADGFSDLLVGAPMQST------IREEGRVFVYINSGMGAVMVEMERVL 358

  Fly   387 TEHIRDGYHSKGRFGLALTTLGDVNGDGYGDFAVGAPYDGPEGRGVVYIFHGSPMGPLAKPSQII 451
            ..  .|.|  ..|||.::..|||::.||:.|.|:|||.: .:.||.|||::|...|..:..||.|
Mouse   359 VG--SDKY--AARFGESIANLGDIDNDGFEDIAIGAPQE-DDLRGAVYIYNGRVDGISSTYSQRI 418

  Fly   452 KSEQLVEGAPYPRTFGFALSGGLDMDGNTYPDLAVGAYSSDQVFIFKSRPVAAVNAETSFASNSK 516
            :.:|:.:..   |.||.::||.:|.|.|.|.|:||||:.||...:.::|||..|.|..|...:..
Mouse   419 EGQQISKSL---RMFGQSISGQIDADNNGYVDVAVGAFQSDSAVLLRTRPVVIVEASLSHPESVN 480

  Fly   517 LISLDDRSCQLVRDHKKVP--CMLLTTCWSYTGRYLPEQ--LDFDVSWLLDA-KKLLNP-RMFFL 575
            ....|   |    ....:|  ||.||.|:||.|:.:|..  |.::||  ||. :|..:| |.:|.
Mouse   481 RTKFD---C----TENGLPSVCMHLTLCFSYKGKEVPGYIVLFYNVS--LDVHRKAESPSRFYFF 536

  Fly   576 RDEGKNIRNQTIRLNYGQKYCLNETVYLLDKVQDKLTPLEVEARYNL-------RSSRPLDPMVR 633
            .:...::...:||::...:.|.....::...|:|.|||:.|||.|:|       |::....|   
Mouse   537 SNGTSDVITGSIRVSSSGEKCRTHQAFMRKDVRDILTPIHVEATYHLGHHVITKRNTEEFPP--- 598

  Fly   634 HRRSILEPVIDQNRE-IVLRDAINIQKNCGPDNICEPDLKL--KVSTVDKY------LFGSPEPL 689
                 |:|::.|.:| .|:|..||..:.|..:| |..||::  ||..:..|      ..||.:.:
Mouse   599 -----LQPILQQKKEKDVIRKMINFARFCAYEN-CSADLQVSAKVGFLKPYENKTYLAVGSMKTI 657

  Fly   690 VIEVFISNTNEDAFEAAFYMVTPPDLQFRKLQQLGEKKDTPITCSPPTPENNHTLKCDIGNPLES 754
            ::.|.:.|..:||:|....:..|..|.|.|:..|.||:   |.|..........|.|.:|. :..
Mouse   658 MLNVSLFNAGDDAYETTLNVQLPTGLYFIKILDLEEKQ---INCEVTESSGIVKLACSLGY-IYV 718

  Fly   755 GKIAHFKISLVPEEKYGSSSSYDFYWEANSTNLEKPG---SEYDNKIRQSVGIWVDTDLDIKGTS 816
            .:::...||.:.:....|.:..|.....:: :.|..|   ...||::..::.:..:..|.:.|..
Mouse   719 DRLSRIDISFLLDVSSLSRAHEDLSISVHA-SCENEGELDQVRDNRVTLTIPLRYEVMLTVHGLV 782

  Fly   817 LPDYQLYKADDYKELENATKEDDIGPQVVHIYEIRNNRPSIIEEAEVFIHLPYETI-VGDPLMYL 880
            .|...:|.:.:..|.|....|     ::...:.:.|...|:.....|.|.:|...: ..|.|..:
Mouse   783 NPTSFVYGSSEENEPETCMAE-----KLNLTFHVINTGISMAPNVSVKIMVPNSFLPQDDKLFNV 842

  Fly   881 LNQPETGGKIQCDDVAFNEY-------------NLLLDEKLVK------KSYLQAQGAIWNSAQV 926
            |:...|.|  ||.   |..|             ..|.|  :||      |..|....|..:....
Mouse   843 LDVQTTTG--QCH---FKHYGRECTFAQQKGIAGTLTD--IVKFLSKTDKRLLYCMKADQHCLDF 900

  Fly   927 SGQSSSSSSSGGASVHIEKARGEGFVRGVLVSNSTD---------AGDKLSPKQVEQRRQEDT-- 980
            ........|...|||||:.   || ...:|..:.|.         |..:..||.:|..:.|:.  
Mouse   901 LCNFGKMESGKEASVHIQL---EG-RPSILEMDETSSLKFEIKATAFPEPHPKVIELNKDENVAH 961

  Fly   981 --LEALGDASFVHRDR 994
              ||.|      |..|
Mouse   962 VFLEGL------HHQR 971

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ifNP_001162777.1 Int_alpha 46..110 CDD:214549 17/68 (25%)
Int_alpha 275..>316 CDD:214549 14/44 (32%)
Int_alpha 398..451 CDD:214549 22/52 (42%)
Int_alpha 466..>497 CDD:214549 15/30 (50%)
Integrin_alpha2 499..893 CDD:285619 103/419 (25%)
DUF2756 <1120..1178 CDD:298627
Itga4NP_034706.3 Int_alpha 48..105 CDD:214549 17/66 (26%)
Int_alpha 303..351 CDD:214549 19/53 (36%)
Int_alpha 366..418 CDD:214549 22/52 (42%)
Int_alpha 429..479 CDD:214549 21/49 (43%)
Integrin_alpha2 463..902 CDD:285619 113/473 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167832104
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3637
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.740

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