Protein Alignment if and Itga4

DIOPT Version :10

• Sequence 1: NP_523378.2
• Gene: if / 32661
• FlyBaseID: FBgn0001250
• Length: 1396
• Species: Drosophila melanogaster
• Sequence 2: NP_034706.3
• Gene: Itga4 / 16401
• MGIID: 96603
• Length: 1032
• Species: Mus musculus
• Alignment Length: 1056
• Identity: 272/1056 - (25%)
• Similarity: 455/1056 - (43%)
• Gaps: 187/1056 - (17%)

  Fly    20 LILLLIAMSAHGYNIDLPSYVRFRQSSNSMFGFSIAMHKGRSGFYGNQNNVSLIVGAPKFDTSRY 84
            |:|.....:.|.||:|..:.:.::..|.::||:|:.:|.     :|::.  .||||||   |:.:
Mouse    22 LLLYFGVPTGHSYNLDPENALLYQGPSGTLFGYSVVLHS-----HGSKR--WLIVGAP---TASW 76

  Fly    85 --QQGVTEAGGVFKCSLN---DDDCKLVPFDSKGNNRNVDKEVVDRKSYQWLGATVA--TGRDSD 142
              ...|...|.:::|.:.   :..|:.:...|. :.....|..::.:..||||.|::  .|.:..
Mouse    77 LSNASVVNPGAIYRCGIRKNPNQTCEQLQLGSP-SGEPCGKTCLEERDNQWLGVTLSRQPGENGS 140

  Fly   143 LVVACAPRY--VFHTMTPSRAFRIDPVGTCF---TSHNFEEFYEVSPC---RTNNWGYHRQGSCQ 199
             :|.|..|:  :|:..:.::.    |.|.|:   :....|....::||   .|..:| ....|||
Mouse   141 -IVTCGHRWKNIFYMKSDNKL----PTGICYVMPSDLRTELSKRMAPCYKDYTRKFG-ENFASCQ 199

  Fly   200 AGFSAAINGNGSRLFIGAPGSWYWQGQTYSIPPDAKFPFKPPLYQPFGTGGMASSHDVTRPENQV 264
            ||.|:....:  .:.:|||||.||.|..:                         .:::|..:.:.
Mouse   200 AGISSFYTQD--LIVMGAPGSSYWTGTVF-------------------------VYNITTNQYKA 237

  Fly   265 FSTSESASVNDDSYLGYSMVTGDFDGDRSEDVAIGMPR----GGNLVGRIVVNRWNMANIFNITG 325
            |...:: .|...||||||:..|.|....:.:|..|.|:    |...:..|..|..|:  ::.:.|
Mouse   238 FVDRQN-QVKFGSYLGYSVGAGHFRSPHTTEVVGGAPQHEQIGKAYIFSIDENELNI--VYEMKG 299

  Fly   326 RQIGEYFGYSLATSDVDGDGLDDLLIGAPMYTDPDNVEGKYDVGRVYILLQGG----PTEEKRWT 386
            :::|.|||.|:...|::.||..|||:||||.:.      ..:.|||::.:..|    ..|.:|..
Mouse   300 KKLGSYFGASVCAVDLNADGFSDLLVGAPMQST------IREEGRVFVYINSGMGAVMVEMERVL 358

  Fly   387 TEHIRDGYHSKGRFGLALTTLGDVNGDGYGDFAVGAPYDGPEGRGVVYIFHGSPMGPLAKPSQII 451
            ..  .|.|  ..|||.::..|||::.||:.|.|:|||.: .:.||.|||::|...|..:..||.|
Mouse   359 VG--SDKY--AARFGESIANLGDIDNDGFEDIAIGAPQE-DDLRGAVYIYNGRVDGISSTYSQRI 418

  Fly   452 KSEQLVEGAPYPRTFGFALSGGLDMDGNTYPDLAVGAYSSDQVFIFKSRPVAAVNAETSFASNSK 516
            :.:|:.:..   |.||.::||.:|.|.|.|.|:||||:.||...:.::|||..|.|..|...:..
Mouse   419 EGQQISKSL---RMFGQSISGQIDADNNGYVDVAVGAFQSDSAVLLRTRPVVIVEASLSHPESVN 480

  Fly   517 LISLDDRSCQLVRDHKKVP--CMLLTTCWSYTGRYLPEQ--LDFDVSWLLDA-KKLLNP-RMFFL 575
            ....|   |    ....:|  ||.||.|:||.|:.:|..  |.::||  ||. :|..:| |.:|.
Mouse   481 RTKFD---C----TENGLPSVCMHLTLCFSYKGKEVPGYIVLFYNVS--LDVHRKAESPSRFYFF 536

  Fly   576 RDEGKNIRNQTIRLNYGQKYCLNETVYLLDKVQDKLTPLEVEARYNL-------RSSRPLDPMVR 633
            .:...::...:||::...:.|.....::...|:|.|||:.|||.|:|       |::....|
Mouse   537 SNGTSDVITGSIRVSSSGEKCRTHQAFMRKDVRDILTPIHVEATYHLGHHVITKRNTEEFPP--- 598

  Fly   634 HRRSILEPVIDQNRE-IVLRDAINIQKNCGPDNICEPDLKL--KVSTVDKY------LFGSPEPL 689
                 |:|::.|.:| .|:|..||..:.|..:| |..||::  ||..:..|      ..||.:.:
Mouse   599 -----LQPILQQKKEKDVIRKMINFARFCAYEN-CSADLQVSAKVGFLKPYENKTYLAVGSMKTI 657

  Fly   690 VIEVFISNTNEDAFEAAFYMVTPPDLQFRKLQQLGEKKDTPITCSPPTPENNHTLKCDIGNPLES 754
            ::.|.:.|..:||:|....:..|..|.|.|:..|.||:   |.|..........|.|.:|. :..
Mouse   658 MLNVSLFNAGDDAYETTLNVQLPTGLYFIKILDLEEKQ---INCEVTESSGIVKLACSLGY-IYV 718

  Fly   755 GKIAHFKISLVPEEKYGSSSSYDFYWEANSTNLEKPG---SEYDNKIRQSVGIWVDTDLDIKGTS 816
            .:::...||.:.:....|.:..|.....:: :.|..|   ...||::..::.:..:..|.:.|..
Mouse   719 DRLSRIDISFLLDVSSLSRAHEDLSISVHA-SCENEGELDQVRDNRVTLTIPLRYEVMLTVHGLV 782

  Fly   817 LPDYQLYKADDYKELENATKEDDIGPQVVHIYEIRNNRPSIIEEAEVFIHLPYETI-VGDPLMYL 880
            .|...:|.:.:..|.|....|     ::...:.:.|...|:.....|.|.:|...: ..|.|..:
Mouse   783 NPTSFVYGSSEENEPETCMAE-----KLNLTFHVINTGISMAPNVSVKIMVPNSFLPQDDKLFNV 842

  Fly   881 LNQPETGGKIQCDDVAFNEY-------------NLLLDEKLVK------KSYLQAQGAIWNSAQV 926
            |:...|.|  ||.   |..|             ..|.|  :||      |..|....|..:....
Mouse   843 LDVQTTTG--QCH---FKHYGRECTFAQQKGIAGTLTD--IVKFLSKTDKRLLYCMKADQHCLDF 900

  Fly   927 SGQSSSSSSSGGASVHIEKARGEGFVRGVLVSNSTD---------AGDKLSPKQVEQRRQEDT-- 980
            ........|...|||||:.   || ...:|..:.|.         |..:..||.:|..:.|:.
Mouse   901 LCNFGKMESGKEASVHIQL---EG-RPSILEMDETSSLKFEIKATAFPEPHPKVIELNKDENVAH 961

  Fly   981 --LEALGDASFVHRDR 994
              ||.|      |..|
Mouse   962 VFLEGL------HHQR 971

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_523378.2	Int_alpha	46..110	CDD:214549	17/68 (25%)
		Int_alpha	275..>316	CDD:214549	14/44 (32%)
		Int_alpha	398..451	CDD:214549	22/52 (42%)
		Int_alpha	466..>497	CDD:214549	15/30 (50%)
		Integrin_alpha2	500..892	CDD:462478	102/417 (24%)
		Glutenin_hmw	<1121..1216	CDD:367362
Itga4	NP_034706.3	Int_alpha	48..105	CDD:214549	17/66 (26%)
		Int_alpha	303..351	CDD:214549	19/53 (36%)
		Int_alpha	366..418	CDD:214549	22/52 (42%)
		Int_alpha	429..479	CDD:214549	21/49 (43%)
		Integrin_alpha2	464..902	CDD:462478	113/472 (24%)