DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment if and Itga3

DIOPT Version :9

Sequence 1:	NP_001162777.1	Gene:	if / 32661	FlyBaseID:	FBgn0001250	Length:	1396	Species:	Drosophila melanogaster
Sequence 2:	NP_001293091.1	Gene:	Itga3 / 16400	MGIID:	96602	Length:	1068	Species:	Mus musculus

Alignment Length:	1117	Identity:	275/1117 - (24%)
Similarity:	456/1117 - (40%)	Gaps:	278/1117 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 ITSLILLLIAMS--AHGYNIDLPSYVRF---RQSSN--SMFGFSIAMHKGRSGFYGNQNNVSLIV 74
            :.:|.|::.|..  |..:|:|    .||   :::.|  |:||:|:|:|:...    .|....|:.
Mouse    16 LRALALMVAACGRVAFAFNLD----TRFLVVKEAVNPGSLFGYSVALHRQTE----RQQRYLLLA 72

  Fly    75 GAPKFDTSRYQQGVTEAGGVFKCSL--NDDDCKLVPFDSKGNNRNVDKEVVDRKSYQWLGATVAT 137
            |||: |.:.........|.|:.|.|  :.|||:.:....|.   :.|..:::.   .|||.|||:
Mouse    73 GAPR-DLAVGDDYTNRTGAVYLCPLTAHKDDCERMDISEKS---DPDHHIIED---MWLGVTVAS 130

  Fly   138 GRDSDLVVACAPRY---VFHTMTPSRAFRIDPVGTCFTSHNFEEF--------YEVSPCRTNNWG 191
            ...:..|:.||.||   ::..:...|..    ||.|:...|..:.        |....|.:|. .
Mouse   131 QGPAGRVLVCAHRYTKVLWSGLEDQRRM----VGKCYVRGNDLQLDPGDDWQTYHNEMCNSNT-D 190

  Fly   192 YHRQGSCQAGFSAAINGNGSRLFIGAPGSWYWQGQTYSIPPDAKFPFKPPLYQPFGTGGMASSHD 256
            |.:.|.||.|.|.....|  .::.||||::.|:|.:|                      |....|
Mouse   191 YLQTGMCQLGTSGGFTQN--TVYFGAPGAYNWKGNSY----------------------MIQRKD 231

  Fly   257 VTRPENQVFSTSESASVNDDSYLGYSMVTGDFDGDRSEDVAI--GMPR--------------GGN 305
            ....|.....:.|..::    |:||::..|:.....::.:.:  |.||              ||:
Mouse   232 WDLSEYSYRGSEEQGNL----YIGYTVQVGNAILHPTDIITVVTGAPRHQHMGAVFLLKQESGGD 292

  Fly   306 LVGRIVVNRWNMANIFNITGRQIGEYFGYSLATSDVDGDGLDDLLIGAPMYTDPDNVEGKYDV-G 369
            |..:.|           :.|.|:|.|||.::|.:|::.||..|||:|||.|     .|.|.:| |
Mouse   293 LQRKQV-----------LKGTQVGAYFGSAIALADLNNDGWQDLLVGAPYY-----FERKEEVGG 341

  Fly   370 RVYI--------------LLQGGPTEEKRWTTEHIRDGYHSKGRFGLALTTLGDVNGDGYGDFAV 420
            .||:              ||..||                |:..||:::.::||:|.||:.|.||
Mouse   342 AVYVFMNQAGASFPDQPSLLLHGP----------------SRSAFGISIASIGDINQDGFQDIAV 390

  Fly   421 GAPYDGPEGRGVVYIFHGSPMGPLAKPSQIIKSEQLVEGAPYPRTFGFALSGGLDMDGNTYPDLA 485
            |||:   ||.|.|||:|.|..|.|.:|.|||..|:|  |.|...|||::|||.:|:|.|.||||.
Mouse   391 GAPF---EGLGKVYIYHSSSGGLLRQPQQIIHGEKL--GLPGLATFGYSLSGKMDVDENLYPDLL 450

  Fly   486 VGAYSSDQVFIFKSRPVAAVNAETSFASNSKLISLDDRSCQLVRDHKKVPCMLLTTCWSY----- 545
            ||:. ||.:.:.::|||..:...|..|   :...||...|      ....|:.:..|::|
Mouse   451 VGSL-SDHIVLLRARPVINILHRTLVA---RPAVLDPALC------TATSCVQVELCFAYNQSAG 505

  Fly   546 TGRYLPEQLDFDVSWLLDA-KKLLNPRMFFLRDEGKNIRNQTIRLNYGQKYCLNETVYLLDKVQD 609
            ...|   :.:..:::.|:| :....||:.|.|.:......   ..:..:.:|....:.|:|.|:|
Mouse   506 NPNY---RRNITLAYTLEADRDRRPPRLRFARSQSSVFHG---FFSMPETHCQTLELLLMDNVRD 564

  Fly   610 KLTPLEVEARYNLRSSRPLDPMVRHRRSI-LEPVIDQNREIVLRDAINIQKNCGPDNICEPDLKL 673
            ||.|:.:...|:|....| |.:....||: ..||::|.:.:.....::.||.|||||.|:.:|::
Mouse   565 KLRPIVIAMNYSLPLRMP-DRLKLGLRSLDAYPVLNQAQAMENHTEVHFQKECGPDNKCDSNLQM 628

  Fly   674 KVSTVDKYLFGSP----------EPLVIEVFISNT------NEDAFEAAFYMVTPPDLQFRKLQQ 722
            :.:.:.:.|  .|          :.|.:.:.::|:      .|||.||...:..|..|....::.
Mouse   629 RAAFLSEQL--QPLSRLQYSRDTKKLFLSINVTNSPSSQRAGEDAHEALLTLEVPSALLLSSVRP 691

  Fly   723 LGEKKDTPITCSPPTPENNHTLKCDIGNPLESGKIAHFKISL-----------VPEEKYGSSSSY 776
            .|       ||.    .||.|:.|::|||.:..:.....|:.           :|.....|:||:
Mouse   692 SG-------TCQ----ANNETILCELGNPFKRNQRMELLIAFEVIGVTLHTRDLPVLLQLSTSSH 745

  Fly   777 DFYWEANSTNLEKPGSEYDNKIRQSVGIWVDTDLDIKGT-SLPDYQLYKADDYKELENATKE--D 838
            .                 ||  .|.|.:.:..|..::.: ||.:::|........:..|..:  :
Mouse   746 Q-----------------DN--LQPVLLTLQVDYTLQASLSLMNHRLQSFFGGTVMGEAAMKTAE 791

  Fly   839 DIGPQVVHIYEIRNNRPSIIEEAEVFIHL--PYETIVGDPLMYLLNQP-----ETGGKIQCDDVA 896
            |:|..:.:.:::......:.....:.:.|  |||...|..|:|    |     .:.|...|....
Mouse   792 DVGSPLKYEFQVSPVGDGLAALGTLVLGLEWPYEVTNGKWLLY----PTEITIHSNGSWPCQPSG 852

  Fly   897 --FNEYNLLLDEKLV-------KKSYLQAQGAIWNSAQVSGQSSSSSSSGGASVHIEKARGE--- 949
              .|..||.|.:..|       ::..|...|         .|||...:...|    :||:.|
Mouse   853 NLVNPLNLTLSDPGVTPLSPQRRRRQLDPGG---------DQSSPPVTLAAA----KKAKSETVL 904

  Fly   950 ----GFVRGVLV-------SNSTDAGDKL---SPKQVEQRRQEDTLEALGDASFVHRDRASQAVQ 1000
                |..|.|.:       ||.|:...|.   :...:|..:..|.:...|.|:...|      ..
Mouse   905 TCSNGRARCVWLECPLPDTSNITNVTVKARVWNSTFIEDYKDFDRVRVDGWATLFLR------TS 963

  Fly  1001 EPQVNQTSFTTY 1012
            .|.:|..:.||:
Mouse   964 IPTINMENKTTW 975

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_001162777.1	Int_alpha	46..110	CDD:214549	20/67 (30%)
		Int_alpha	275..>316	CDD:214549	11/56 (20%)
		Int_alpha	398..451	CDD:214549	25/52 (48%)
		Int_alpha	466..>497	CDD:214549	16/30 (53%)
		Integrin_alpha2	499..893	CDD:285619	90/437 (21%)
		DUF2756	<1120..1178	CDD:298627
Itga3	NP_001293091.1	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	38..103		20/69 (29%)
		Int_alpha	48..108	CDD:214549	19/64 (30%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	110..171		18/70 (26%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	185..235		18/74 (24%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	236..293		11/60 (18%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	294..355		24/76 (32%)
		Int_alpha	305..353	CDD:214549	21/52 (40%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	357..412		27/73 (37%)
		Int_alpha	368..418	CDD:214549	25/52 (48%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	416..478		29/67 (43%)
		Integrin_alpha2	463..918	CDD:369878	108/519 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	865..890		6/33 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832094
Domainoid	1	1.000	57	1.000	Domainoid score	I10823
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D325432at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.750