DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment if and Itga2b

DIOPT Version :9

Sequence 1:	NP_001162777.1	Gene:	if / 32661	FlyBaseID:	FBgn0001250	Length:	1396	Species:	Drosophila melanogaster
Sequence 2:	NP_034705.2	Gene:	Itga2b / 16399	MGIID:	96601	Length:	1033	Species:	Mus musculus

Alignment Length:	1058	Identity:	292/1058 - (27%)
Similarity:	463/1058 - (43%)	Gaps:	175/1058 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 NIDLPSYVRFRQSSNSMFGFSIAMHKGRSGFYGNQNNVSLIVGAPKFDTSRYQQGVTEAGGVFKC 97
            |:|...:..:...:.|.||||:..||.:.|      :||::||||:...:..:    |.|.||.|
Mouse    33 NLDSEKFSVYAGPNGSHFGFSVDFHKDKHG------SVSIVVGAPRALNASQE----ETGAVFLC 87

  Fly    98 --SLNDDDCKLVPFDSKGNNRNVDKEVVDR-KSYQWLGATVATGRDSDLVVACAPRYVFHTMTPS 159
              ..|...|..:.||.:...||:..::... |:.|.|||:|.:.  :|::|||||...::.:...
Mouse    88 PWKANGGKCNPLLFDLRDETRNLGFQIFQTFKTGQGLGASVVSW--NDVIVACAPWQHWNVLEKR 150

  Fly   160 RAFRIDPVGTCFTSH-NFEEFYEVSPCRTNN----WGYHRQGS---CQAGFSAAINGNGSRLFIG 216
            ......|||.||.:. ......|.||||.|.    :....:|.   |:||||.|:...| .|.:|
Mouse   151 DEAEKTPVGGCFLAQLQSGGRAEYSPCRANTMSSVYAESFRGDKRYCEAGFSLAVTQAG-ELVLG 214

  Fly   217 APGSWYWQGQTYSIPPDAKFPFKPPLYQPFGTGGMASSHDVTRP-------ENQVFSTSESASVN 274
            |||.:::.|....:|.:                .:.||:   ||       .||.|:...|..|.
Mouse   215 APGGYFFLGLLARVPIE----------------NIISSY---RPGTLLWHVSNQRFTYDNSNPVF 260

  Fly   275 DDSYLGYSMVTGDFDGDRS-EDVAIGMPRGGNLVGRIVVNRWNMANIFNITGRQIGEYFGYSLAT 338
            .|.|.|||:..|:||||.| .:...|.|.....:|.:.:.......:..:.|.|:..|||:|:|.
Mouse   261 FDGYRGYSVAVGEFDGDPSTTEYVSGAPTWSWTLGAVEILDSYYQPLHRLHGEQMASYFGHSVAV 325

  Fly   339 SDVDGDGLDDLLIGAPMYTDPDNVEGKYDVGRVYILLQ-GGPTEEKRWTTEHIRDGYHSKGRFGL 402
            :||:|||..|||:|||:|.:........:|||||:.|| .||  :...|...:..|....||||.
Mouse   326 TDVNGDGRHDLLVGAPLYMESRADRKLAEVGRVYLFLQPKGP--QALSTPTLLLTGTQLYGRFGS 388

  Fly   403 ALTTLGDVNGDGYGDFAVGAPYDGPEGRGVVYIFHGSPMGPLAKPSQIIKSEQLVEGAPYP--RT 465
            |:..|||:|.|||.|.||.|||.||.|:|.|.||.|...|...:|||::.|       |:|  ..
Mouse   389 AIAPLGDLNRDGYNDIAVAAPYGGPSGQGQVLIFLGQSEGLSPRPSQVLDS-------PFPTGSG 446

  Fly   466 FGFALSGGLDMDGNTYPDLAVGAYSSDQVFIFKSRPV--AAVNAETSFASNSKLISLDDRSCQLV 528
            |||:|.|.:|:|.|.||||.||||.:.:|.:::::||  |.|......:.|..|     ::|.|.
Mouse   447 FGFSLRGAVDIDDNGYPDLIVGAYGASKVAVYRAQPVVMATVQLMVQDSLNPTL-----KNCVLD 506

  Fly   529 RDHKKVPCMLLTTCWSYTGRYLPEQLDFDVSWLLDAKKLLNPRMFFLRDEGKNI-------RNQT 586
            :....|.|..:..|...||..:|::|.......||.:|   ||      :|:.:       .:.|
Mouse   507 QTKTPVSCFNIQMCVGATGHNIPQKLHLKAELQLDLQK---PR------QGRRVLLLASQQASLT 562

  Fly   587 IRLNYG---QKYCLNETVYLLDKV--QDKLTPLEVEARYNL--RSSRPLDPMVRHRRSILEPVID 644
            :.|:.|   :..|.....:|.|:.  :|||:|:.:....:|  ..:.....:|.|.    |..:.
Mouse   563 LSLDLGGRDKPICHTTGAFLRDEADFRDKLSPIVLSLNVSLPPEETGGAPAVVLHG----ETHVQ 623

  Fly   645 QNREIVLRDAINIQKNCGPDNICEPDLKLKVSTVDK-YLFGSPEPLVIEVFISNTNEDAFEAAFY 708
            :...|:|        :||.|::|.|.|:|..:..|. .|.|:...|.:::..:|..|.|:||...
Mouse   624 EQTRIIL--------DCGEDDLCVPQLRLTATAGDSPLLIGADNVLELKIEAANDGEGAYEAELA 680

  Fly   709 MVTPPDLQF-RKLQQL-GEKKDTPITCSPPTPENNHTLKCDIGNPLESGKIAHFKISLVPEEKYG 771
            :..||...: |.|..: |.::   :.|:......:....|::|||::........:.:..|....
Mouse   681 VHLPPGAHYMRALSNIEGFER---LVCTQKKENESRVALCELGNPMKKDTRIGITMLVSVENLEE 742

  Fly   772 SSSSYDFYWEANSTNLEKPGSEYDNKIRQSVGIWVDTDLDIKGTSLPDYQLYKADDYKELENATK 836
            :..|..|..:..|.|.:.|.|:.   :...|.|..:..::::|.|.|...:..|:     |...:
Mouse   743 AGESVSFQLQVRSKNSQNPNSKV---VMLPVAIQAEATVELRGNSFPASLVVAAE-----EGDRE 799

  Fly   837 EDDIG---PQVVHIYEIRNNRPSIIEEAEVFIHLPYETIVGDPLMYLLNQPETGGKIQCDDVAFN 898
            ::|:.   .::.|.||:.|..|..:....:.||:|.::...| |:|:|:
Mouse   800 QEDLDRWVSRLEHTYELHNIGPGTVNGLRLLIHIPGQSQPSD-LLYILD---------------- 847

  Fly   899 EYNLLLDEKLVKKSYLQAQGAIWNSAQ----VSGQSSSSSSSGGASVHIEKARGEGFVRG----- 954
                           :|.||.:..|.|    |..:.|:.|.|....||.::.|.:.|::|
Mouse   848 ---------------VQPQGGLLCSTQPSPKVDWKLSTPSPSSIRPVHHQRERRQAFLQGPKPGQ 897

  Fly   955 ---VLVSNSTDAGDKLSPKQVE-------QRRQEDTLEALGDASFVHRDRASQAVQEPQVNQTSF 1009
               |||  |.|.....:..:.|       ||........||.:|...|.:....:|.......|.
Mouse   898 QDPVLV--SCDGSASCTVVECELREMVRGQRAMVTVQVMLGLSSLRQRPQEQFVLQSHAWFNVSS 960

  Fly  1010 TTYSTSSSSSGSGAPSAQ 1027
            ..||....|..||....|
Mouse   961 LPYSVPVVSLPSGQARVQ 978

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_001162777.1	Int_alpha	46..110	CDD:214549	21/65 (32%)
		Int_alpha	275..>316	CDD:214549	14/41 (34%)
		Int_alpha	398..451	CDD:214549	30/52 (58%)
		Int_alpha	466..>497	CDD:214549	17/30 (57%)
		Integrin_alpha2	499..893	CDD:285619	90/415 (22%)
		DUF2756	<1120..1178	CDD:298627
Itga2b	NP_034705.2	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	35..96		21/70 (30%)
		Int_alpha	46..102	CDD:214549	21/65 (32%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	109..173		18/65 (28%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	184..237		16/69 (23%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	252..304		16/51 (31%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	305..370		28/66 (42%)
		Int_alpha	315..366	CDD:214549	24/50 (48%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	372..431		29/58 (50%)
		Int_alpha	383..437	CDD:214549	30/53 (57%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	434..495		26/67 (39%)
		Int_alpha	444..>484	CDD:214549	18/39 (46%)
		Integrin_alpha2	480..916	CDD:285619	109/506 (22%)
		GFFKR motif	1017..1021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832102
Domainoid	1	1.000	146	1.000	Domainoid score	I4513
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	500	1.000	Inparanoid score	I1351
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D325432at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43488
orthoMCL	1	0.900	-	-		OOG6_102088
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X587
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.760