DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment if and Itga2

DIOPT Version :9

Sequence 1:	NP_001162777.1	Gene:	if / 32661	FlyBaseID:	FBgn0001250	Length:	1396	Species:	Drosophila melanogaster
Sequence 2:	NP_032422.2	Gene:	Itga2 / 16398	MGIID:	96600	Length:	1178	Species:	Mus musculus

Alignment Length:	860	Identity:	212/860 - (24%)
Similarity:	335/860 - (38%)	Gaps:	192/860 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 VACAP--RYVFHTMTPSRAFRIDPVGTCFTSHNFEEFYEVSPCRTNNWGYHRQGSCQAGFSAAIN 207
            :|..|  ||.|:  ....|..::..||.     .|:.:.:.........:..: ..|.||||...
Mouse   329 IASTPTERYFFN--VADEAALLEKAGTL-----GEQIFSIEGTVQGGDNFQME-MAQVGFSADYA 385

  Fly   208 GNGSRLFIGAPGSWYWQGQTYSIPPDAKFPFKPPLY--QPFGTGGMASSHDVTRPENQVFSTSES 270
            .....|.:||.|::.|.|....     :...||.::  |.|               :||....
Mouse   386 PQNDILMLGAVGAFDWSGTLVQ-----ETSHKPVIFPKQAF---------------DQVLQDR-- 428

  Fly   271 ASVNDDSYLGYSMVTGDFDGDRSED---VAIGMPRGGNLVGRIV---VNR-WNMANIFNITGRQI 328
               |..|:||||:.     ...:||   ...|.|| .|..|:||   ||: .|:..|.:..|.||
Mouse   429 ---NHSSFLGYSVA-----AISTEDGVHFVAGAPR-ANYTGQIVLYSVNKQGNVTVIQSHRGDQI 484

  Fly   329 GEYFGYSLATSDVDGDGLDD-LLIGAPMYTDPDNVEGKYDVGRVYILLQGGPTEEKRWTTEH-IR 391
            |.|||..|.:.|||.|.:.| ||:|||.|.:    :.|.:.|:||:.     |..|....:| ..
Mouse   485 GSYFGSVLCSVDVDKDTITDVLLVGAPTYMN----DLKKEEGKVYLF-----TITKGILNQHQFL 540

  Fly   392 DGYHSKG--RFGLALTTLGDVNGDGYGDFAVGAPYDGPEGRGVVYIFHGSPMGPLAKPSQIIKSE 454
            :|....|  |||.|:..|.|:|.||:.|..||:|.:. |..|.|||::|.......|.||.|...
Mouse   541 EGPEGTGNARFGSAIAALSDINMDGFNDVIVGSPVEN-ENSGAVYIYNGHQGTIRTKYSQKILGS 604

  Fly   455 QLVEGA--PYPRTFGFALSGGLDMDGNTYPDLAVGAYSSDQVFIFKSRPVAAVNAETSFASNSKL 517
               .||  .:.:.||.:|.|..|::|::..|:::||..  ||....|:.:|.|..|..|.
Mouse   605 ---NGAFRRHLQFFGRSLDGYGDLNGDSITDVSIGALG--QVIQLWSQSIADVAIEALFT----- 659

  Fly   518 ISLDDRSCQLVRDHKKVPCMLLTTCWSYTGRYLPEQLDFDVSWL----LDA---KKLLNPRMFFL 575
               .|:...|.:|.|    :.|..|  :...:.|...:..|:.|    |||   ...:..|..|
Mouse   660 ---PDKITLLNKDAK----ITLKLC--FRAEFRPAGQNNQVAILFNMTLDADGHSSRVTSRGVF- 714

  Fly   576 RDEGKNIRNQTIRLNYGQKYCLNETVYLLDKVQDKLTPLEVEARYNLRSSRPLDPMVRHRRSILE 640
            |:..:....:.:.:|..|| | :|....:.|..|.:.||::....:|.:..            ..
Mouse   715 RENSERFLQKNMVVNEVQK-C-SEHHISIQKPSDVVNPLDLRVDISLENPG------------TS 765

  Fly   641 PVIDQNREIVLRDAINIQKNCGPDNICEPDLKLKV------STVDKYLFGSPEPLVIEVFISNTN 699
            |.::...|.|...:|...|.||.|.||..||.|.|      .|....:....:.|...|.:.|..
Mouse   766 PALEAYSETVKVFSIPFYKECGSDGICISDLILDVQQLPAIQTQSFIVSNQNKRLTFSVILKNRG 830

  Fly   700 EDAFEAAFYMVTPPDLQFRKLQQLGEKKDTPITCSPPTPENNHTLKCDIGNPLESGKIAHFKISL 764
            |.|:..........:|.|.....  ....|.:||...:.:.:.|  ||:|.|           :|
Mouse   831 ESAYNTVVLAEFSENLFFASFSM--PVDGTEVTCEVGSSQKSVT--CDVGYP-----------AL 880

  Fly   765 VPEEKYGSSSSYDFYWEANSTNLEKPG-------------SEYDNKIRQSVGIWVDTDLDI-KGT 815
            ..|::...:.::||    |..||:...             ::.||.:..::.:..|.:|.: :.|
Mouse   881 KSEQQVTFTINFDF----NLQNLQNQAAINFQAFSESQETNKADNSVSLTIPLLYDAELHLTRST 941

  Fly   816 SLPDYQLYKADDYKELENA----TKEDDIGPQVVHIYEI-RNNRPSIIEEAEVFIHLPYETIVGD 875
            ::..|::  :.|    |||    ...:||||:.:...:: ..:.|  :..|.|.||:|..|...:
Mouse   942 NINFYEI--SSD----ENAPSVIKSVEDIGPKFIFSLKVTAGSAP--VSMALVTIHIPQYTKEKN 998

  Fly   876 PLMYLLN-QPETGGKIQC-------------DDVAFNEYNL-------------------LLDEK 907
            ||:||.. |.:..|.|.|             ..|:|...|.                   |.|..
Mouse   999 PLLYLTGIQTDQAGDISCTAEINPLKLPHTAPSVSFKNENFRHTKELDCRTTSCSNITCWLKDLH 1063

  Fly   908 LVKKSYLQAQGAIWN 922
            :..:.::.....:||
Mouse  1064 MKAEYFINVTTRVWN 1078

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_001162777.1	Int_alpha	46..110	CDD:214549
		Int_alpha	275..>316	CDD:214549	16/47 (34%)
		Int_alpha	398..451	CDD:214549	23/54 (43%)
		Int_alpha	466..>497	CDD:214549	11/30 (37%)
		Integrin_alpha2	499..893	CDD:285619	96/439 (22%)
		DUF2756	<1120..1178	CDD:298627
Itga2	NP_032422.2	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	31..89
		Int_alpha	44..92	CDD:214549
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	98..158
		vWA_integrins_alpha_subunit	170..350	CDD:238746	6/22 (27%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	363..417		13/59 (22%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	420..472		20/77 (26%)
		Int_alpha	430..473	CDD:214549	16/48 (33%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	474..536		26/70 (37%)
		Cell attachment site. /evidence=ECO:0000255	480..482		0/1 (0%)
		Int_alpha	484..532	CDD:214549	22/56 (39%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	537..595		22/58 (38%)
		Int_alpha	548..601	CDD:214549	22/53 (42%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	601..661		19/72 (26%)
		Int_alpha	611..>637	CDD:214549	7/25 (28%)
		Integrin_alpha2	646..1057	CDD:285619	99/466 (21%)
		Integrin_alpha	1152..1166	CDD:278771
		GFFKR motif	1154..1158
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832039
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740