DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment if and Gpld1

DIOPT Version :9

Sequence 1:	NP_001162777.1	Gene:	if / 32661	FlyBaseID:	FBgn0001250	Length:	1396	Species:	Drosophila melanogaster
Sequence 2:	NP_032182.2	Gene:	Gpld1 / 14756	MGIID:	106604	Length:	842	Species:	Mus musculus

Alignment Length:	598	Identity:	125/598 - (20%)
Similarity:	202/598 - (33%)	Gaps:	209/598 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   227 TYSIPPDAKFPFKPPLYQPFGTGGM-------------------ASSHDVTRPENQVFSTSESAS 272
            |||    .|.||....:|.:..||:                   ..:.|...|||.:|.:.:.
Mouse   231 TYS----TKSPFLVEQFQDYFLGGLDDMAFWSTNIYRLTSFMLENGTSDCNLPENPLFISCDG-- 289

  Fly   273 VNDDSYLGYSMVTGDFDGDRSEDVAIGMPRGGNLVGRIV---VNRWNMANI-------------- 320
             .:.:..|..:...||..:.:..::..:.:..|...|.|   ...|...::
Mouse   290 -RNHTLSGSKVQKNDFHRNLTMFISRDIRKNLNYTERGVFYSTGSWAPESVTFMYQTLERNLRLM 353

  Fly   321 --------FNITGRQIGEY--------FGYSLATSDVDGDGLDDLLIGAPMYTDPDNVEGKYDVG 369
                    .|........|        .|:.:.::|::.||..||::|||.|:.|    |::.:|
Mouse   354 LAGSSQKNLNHVSSPSASYTLSVPYARLGWVMTSADLNQDGHGDLVVGAPGYSHP----GRFQIG 414

  Fly   370 RVYILL---QGGPTEEKRWTTE-H-IRDGYHSKGRFGLALTTLGDVNGDGYGDFAVGAPYDGPEG 429
            ||||:.   .|.|..:.....| | |.:|:...||||.||..| |.|.||..|.|||||..| .|
Mouse   415 RVYIIYGNDLGLPPIDLDLDKEAHGILEGFQPSGRFGSALAVL-DFNQDGLPDLAVGAPSVG-SG 477

  Fly   430 R----GVVYIFHGSPMGPL-AKPSQIIKSEQLVEGAPYPRTF---GFALSGGLDMDGNTYPDLAV 486
            :    |.||:::||..|.| :.|:..|..:.         |:   |:.|. ..|.||:...||.:
Mouse   478 QLTYNGSVYVYYGSQQGRLSSSPNVTISCKD---------TYCNLGWTLL-ATDADGDGRHDLVI 532

  Fly   487 -------GAYSSDQVFIFKSRPVAAVNAETSFASNSKLISLDDRSCQLVRDHKKVPCMLLTTCWS 544
                   |......|..|.|.|         ..::.:|::|::..                  |.
Mouse   533 SSPFAPGGGKQRGIVATFYSHP---------RRNDKELLTLEEAD------------------WK 570

  Fly   545 YTGRYLPEQLDFDVSWLLDAKKLLNPRMFFLRDEGKNIRNQTIRLNYGQKYCLNETVYLLDKVQD 609
            ..|       :.|.||.                 |.::...|:         .|.::.|:.
Mouse   571 VNG-------EEDFSWF-----------------GYSLHGVTV---------ANRSLLLIG---- 598

  Fly   610 KLTPLEVEARYNLRSSRPLDPMVRHRRSILEPVIDQ-------NREIVLRDAINIQKNCGPDNIC 667
              :|.........|||        |:::..|..:.:       ||:..:  .|:..|..|
Mouse   599 --SPTWKNVSRMARSS--------HKKNQEEKSLGKVYGYFLPNRQSTI--TISGDKAMG----- 646

  Fly   668 EPDLKLKVSTVDKY-----------LFGSPEPLVIEVFISNTNEDAFEAAFYMVTPPDLQFRKLQ 721
                ||..|....|           |.|:|           |::|..:.||..:|.......::.
Mouse   647 ----KLGTSLSSGYVRVNGTLTQVLLVGAP-----------THDDVSKMAFLTMTLHQGGATRMY 696

  Fly   722 QLGEKKDTPITCS 734
            :|..:|..|...|
Mouse   697 ELAPEKTQPALLS 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_001162777.1	Int_alpha	46..110	CDD:214549
		Int_alpha	275..>316	CDD:214549	6/43 (14%)
		Int_alpha	398..451	CDD:214549	27/57 (47%)
		Int_alpha	466..>497	CDD:214549	9/40 (23%)
		Integrin_alpha2	499..893	CDD:285619	40/254 (16%)
		DUF2756	<1120..1178	CDD:298627
Gpld1	NP_032182.2	Zn_dep_PLPC	28..219	CDD:376406
		FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	367..428		19/64 (30%)
		Int_alpha	377..434	CDD:214549	19/60 (32%)
		Int_alpha	446..502	CDD:214549	27/57 (47%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	499..559		15/78 (19%)
		FG-GAP	514..547	CDD:366834	8/33 (24%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	566..624		15/122 (12%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	634..694		15/81 (19%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	706..772		1/4 (25%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	790..842
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D743479at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910