DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment if and Itga6

DIOPT Version :9

Sequence 1:	NP_001162777.1	Gene:	if / 32661	FlyBaseID:	FBgn0001250	Length:	1396	Species:	Drosophila melanogaster
Sequence 2:	XP_038960023.1	Gene:	Itga6 / 114517	RGDID:	621633	Length:	1090	Species:	Rattus norvegicus

Alignment Length:	1480	Identity:	338/1480 - (22%)
Similarity:	545/1480 - (36%)	Gaps:	532/1480 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LIAMSAHGYNIDL--PSYVRFRQSSNSMFGFSIAMHKGRSGFYGNQNNVSLIVGAPKFDTSRYQQ 86
            |:|..:..:|:|.  .:.:|......|:||||:|||....    .::...|:||||:.:....|:
  Rat    16 LLARLSTAFNLDTREDNVIRKSGDPGSLFGFSLAMHWQLQ----PEDKRLLLVGAPRAEALPLQK 76

  Fly    87 GVTEAGGVFKCSLND-DDCKLVPFDSKGNNRNVDKEVVDRKSYQWLGATVATGRDSDLVVACAPR 150
             ....||::.|.:.. ..|..:.||:..:..:..||      .||:|.||.:......||.||.|
  Rat    77 -ANRTGGLYSCDITSRGPCTRIVFDNDADPMSESKE------DQWMGVTVQSQGPGGKVVTCAHR 134

  Fly   151 YV----FHTMTPSRAFRIDPVGTCFT-SHNFE-----EFYEVSPCRTNNWGYHRQGSCQAGFSAA 205
            |.    .:|...||    |..|.|:. |.|..     :..:.|.|.....|:.:.||||.|.:|.
  Rat   135 YEKRQHVNTKQESR----DIFGRCYVLSQNLRIEDDMDGGDWSFCDGRLRGHEKFGSCQQGVAAT 195

  Fly   206 INGNGSRLFIGAPGSWYWQGQTYSIPPDAKFPFKPPLYQ--PFGTGGMASSHD---VTRPENQVF 265
            ...:...:..||||::.|:|.......:..| |...:::  |:..|| .:.||   |..|.|
  Rat   196 FTKDFHYIVFGAPGTYNWKGIVRVEQKNNTF-FDMNIFEDGPYEVGG-ETDHDESLVPVPAN--- 255

  Fly   266 STSESASVNDDSYLGYSMVTGDFDGDRSED---VAIGMPRGGNLVGRIVVNRWNMAN-------I 320
                       ||||:|:.:|  .|..|:|   ...|.|| .|..|.:|:.:.:|.:       |
  Rat   256 -----------SYLGFSLDSG--KGIVSKDDITFVSGAPR-ANHSGAVVLLKRDMKSAHLLLEYI 306

  Fly   321 FNITGRQIGEYFGYSLATSDVDGDGLDDLLIGAPMYTDPDNVEGKYDVGRVYILLQGGPTEEKRW 385
            |:  |..:...|||.:|..|::.||..|::||||.|.|.|...|    |.||:.:    .::.||
  Rat   307 FD--GEGLASSFGYDVAVVDLNADGWQDIVIGAPQYFDRDGEVG----GAVYVYI----NQQGRW 361

  Fly   386 T-TEHIRDGYHSKGRFGLALTTLGDVNGDGYGDFAVGAPYDGPEGRGVVYIFHGSPMGPLAKPSQ 449
            : .:.:|........||:|:..:||:|.|||.|.|||||||   ..|.|:|:||||.|.:.||:|
  Rat   362 SNVKPVRLNGTKDSMFGIAVKNIGDINQDGYPDIAVGAPYD---DLGKVFIYHGSPTGIITKPTQ 423

  Fly   450 IIKSEQLVEG-APYPRTFGFALSGGLDMDGNTYPDLAVGAYSSDQVFIFKSRPVAAVNAETSFAS 513
            ::      || .|:   ||::::|.:|:|.|:|||:|||:. ||.|.||:||||  :|...:...
  Rat   424 VL------EGTTPF---FGYSIAGNMDLDRNSYPDVAVGSL-SDSVTIFRSRPV--INILKTITV 476

  Fly   514 NSKLISLDDRS-CQLVRDHKKVPCMLLTTCWSYTGR---YLPEQLDFDVSWLLDAKKL-----LN 569
            ....|.|..:| |    ......|:.:..|:.||.:   |.|   ...:..:|:|:|.     |:
  Rat   477 TPSRIDLRQKSMC----GSPSGICLKVKACFEYTAKPSGYNP---PISILGILEAEKERRKSGLS 534

  Fly   570 PRMFFLRDEGKNIR-NQTIRLN-YGQKYCLNETVYLLDKVQDKLTPLEVEARYNLRSSRPLDPMV 632
            .|:.| |::|...: .|.:.|| ..|:.|:.||::|.:.::|||.|:.:.|...::     :|..
  Rat   535 SRVQF-RNQGSEPKYTQELTLNRQKQRACMEETLWLQENIRDKLRPIPITASVEIQ-----EPSS 593

  Fly   633 RHRRSILE---PVIDQNR-EIVLRDAINIQKNCGPDNICEPDLKL------KVSTVDKYLF---- 683
            |.|.:.|.   |:::.|. :.|..|...:::.||.||:|..:|||      :....||:.:
  Rat   594 RRRVNSLPEVLPILNSNEAKTVQTDVHFLKEGCGDDNVCNSNLKLEYKFGTREGNQDKFSYLPIQ 658

  Fly   684 -GSPE-------PLVIEVFISN----------TNEDAFEAAFYMVTPPDLQFRKLQQLGEKKDTP 730
             |.||       .:.:|:.::|          ..:||.||......|..|.:...::|....:..
  Rat   659 KGIPELVLKDQKDIALEITVTNGPSDPRNPRKDGDDAHEAKLIATFPDTLTYSAYRELRAFPEKQ 723

  Fly   731 ITCSPPTPENNHTLKCDIGNPLESGKIAHFKISLVPEEKYGSSSSYDFYWEANSTNLEKPGSEYD 795
            ::|  ...:|.....|::|||        ||          .:||..||...::|.:     .:|
  Rat   724 LSC--VANQNGSQADCELGNP--------FK----------RNSSVTFYLILSTTEV-----TFD 763

  Fly   796 NKIRQSVGIWVDTDLDIKGTSLPDYQLYKADDYKELENATKEDDIGPQVVHIYEIRNNRPSIIEE 860
            .           |||||.               .:||..:.:|::.|              |..:
  Rat   764 T-----------TDLDIN---------------LKLETTSNQDNLAP--------------ITAK 788

  Fly   861 AEVFIHL---------PYE-----TIVGDPLMYLLNQPETGGKIQCDDVAFNEYNLLLDEKLVKK 911
            |:|.|.|         |.:     |:||:..|  .::.|.|..|:.:   |...||   .|.:|.
  Rat   789 AKVVIELLLSVSGVAKPSQVYFGGTVVGEQAM--KSEDEVGSLIEYE---FRVINL---GKPLKN 845

  Fly   912 SYLQAQGAIWNSAQVSGQSSSSSSSGGASVHIEKARGEGFVRGVLVSNSTDAGDKLSPKQVEQRR 976
                     ..:|.::.|.....|:|...:::.|...:|.
  Rat   846 ---------LGTATLNIQWPKEISNGKWLLYLMKVESKGL------------------------- 876

  Fly   977 QEDTLEALGDASFVHRDRASQAVQEPQVNQTSFTTYSTSSSSSGSGAPSAQLRGHSTQGHIQMAG 1041
                               .|.|.||. |:.:|
  Rat   877 -------------------EQVVCEPH-NEINF-------------------------------- 889

  Fly  1042 PVQHTSSSSSSNYRSWPAQQQQQHQQLLLAGSGGSGLGSPVTFNDKSQFGGRNNNFHTGTLDLGT 1106
             ::...|.:|...|..|.:|                      .:|..:|
  Rat   890 -LKLKESHNSRKKRELPEKQ----------------------IDDSRKF---------------- 915

  Fly  1107 LNRGNVDNELYRSQGQYQNPSQSLGQSQGQFQANANQGHYQGQNQAQFQARNPGFQGQTSYQGQT 1171
                                                         :.|..|.
  Rat   916 ---------------------------------------------SLFSERK------------- 922

  Fly  1172 QYSGQPGGYQTHHVTYSSGSKPYYGRENEDFYDEDNLQQATPGHWSSSSSSSSSSGTRRLRRSND 1236
                    |||
  Rat   923 --------YQT------------------------------------------------------ 925

  Fly  1237 KDGATEKPLQIDLNSPCQSARCKSIRCVVTNLGTEDGDAAFVAIRARMVAKT-MEKLASNVPLNV 1300
                    |...:|     .||.:|||.:..|   |..|:.| :|:|:...| :|:.:....|::
  Rat   926 --------LNCSVN-----VRCVNIRCPLRGL---DSKASLV-LRSRLWNSTFLEEYSKLNYLDI 973

  Fly  1301 STLAVANVTL------LPFIGA-------PKDAIVKTHEIFYKAEPEPLQVPDVVPLWVVVLAAC 1352
            ...|..:||.      ||..|.       |...:.:...|.:               |:::||..
  Rat   974 LVRASIDVTAAAQNIKLPHAGTQVRVTVFPSKTVAQYSGIAW---------------WIILLAVL 1023

  Fly  1353 AGALIFLLLVWLLYKCGFFNRNR-----PTDHS----QERQPLRNGYHGD 1393
            ||.|:..|||:||:|||||.|:|     |..|:    :|.:.:.:..|.|
  Rat  1024 AGILMLALLVFLLWKCGFFKRSRYDDSVPRYHAVRIRKEEREINDEKHTD 1073

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_001162777.1	Int_alpha	46..110	CDD:214549	18/64 (28%)
		Int_alpha	275..>316	CDD:214549	15/43 (35%)
		Int_alpha	398..451	CDD:214549	28/52 (54%)
		Int_alpha	466..>497	CDD:214549	15/30 (50%)
		Integrin_alpha2	499..893	CDD:285619	102/450 (23%)
		DUF2756	<1120..1178	CDD:298627	2/57 (4%)
Itga6	XP_038960023.1	Int_alpha	40..100	CDD:214549	18/64 (28%)
		Int_alpha	254..>292	CDD:214549	16/54 (30%)
		Int_alpha	314..364	CDD:214549	21/57 (37%)
		Int_alpha	374..425	CDD:214549	28/53 (53%)
		Integrin_alpha2	464..939	CDD:400650	136/820 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335774
Domainoid	1	1.000	57	1.000	Domainoid score	I10607
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D325432at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.850