DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment if and Itga1

DIOPT Version :9

Sequence 1:	NP_001162777.1	Gene:	if / 32661	FlyBaseID:	FBgn0001250	Length:	1396	Species:	Drosophila melanogaster
Sequence 2:	NP_001028400.2	Gene:	Itga1 / 109700	MGIID:	96599	Length:	1179	Species:	Mus musculus

Alignment Length:	1173	Identity:	256/1173 - (21%)
Similarity:	425/1173 - (36%)	Gaps:	373/1173 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IHRRRMALHCPITSLILLLIAMS-AHGYNIDLPSYVRFRQSSNSMFGFSIAMHKGRSG---FYGN 66
            :.||..:|...:..:.||.:.:. ...:|:|:.:.:.|......|||:::..::...|   ..|
Mouse     2 VPRRPASLEVTVACIWLLTVILGVCISFNVDVKNSMSFSGPVEDMFGYTVQQYENEEGKWVLIG- 65

  Fly    67 QNNVSLIVGAPKFDTSRYQQGVTEAGGVFKCSLNDD---DC-KL-VPFDSKGNNRNVDKEVVDRK 126
                |.:||.||..|          |.|:||.:..:   .| || :|.::...|      |.:.|
Mouse    66 ----SPLVGQPKART----------GDVYKCPVGRERSMPCVKLDLPVNTSIPN------VTEIK 110

  Fly   127 SYQWLGATVATGRDSDLVVACAPRYVF-----HTMT-----PSRAFRI----DPVGTCFT----- 172
            .....|:|:.|...... :||.|.|.:     |..|     .|..|::    .||..|.|
Mouse   111 ENMTFGSTLVTNPKGGF-LACGPLYAYRCGHLHYTTGICSDVSPTFQVVNSFAPVQECSTQLDIV 174

  Fly   173 --------------------------------------------SHNF----------------- 176
                                                        :|.|
Mouse   175 IVLDGSNSIYPWESVTAFLNDLLKRMDIGPKQTQVGIVQYGANVTHEFNLNKYSSTEEVLVAANK 239

  Fly   177 --------------------EEFYE-----------------------------VSPCRTNN--- 189
                                |.|.|                             :..|...|
Mouse   240 IGRRGGLQTMTALGIDTARKEAFTEARGARRGVKKVMVIVTDGESHDNYRLKQVIQDCEDENIQR 304

  Fly   190 -----WGYHRQGS---------------------------------------------------- 197
                 .|::.:|:
Mouse   305 FSIAILGHYNRGNLSTEKFVEEIKSIASEPTEKHFFNVSDELALVTIVKALGERIFALEATADQS 369

  Fly   198 --------CQAGFSAAINGNGSRLFIGAPGSWYWQGQTYSIPPDAKFPFKPPLYQPFGTGGMASS 254
                    .|.||||..:.:.  :.:||.|::.|.                      ||..|..:
Mouse   370 AASFEMEMSQTGFSAHYSQDW--VMLGAVGAYDWN----------------------GTVVMQKA 410

  Fly   255 HDVTRPENQVFSTSESASVNDD--SYLGYSMVTGDFDGDRSEDVAIGMPRGGNLVGRIVVNRWNM 317
            :.:..|.|..|.| |...:|:.  |||||::.:....||..  ...|.|| .|..|::|:.:...
Mouse   411 NQIVIPHNTTFQT-EPTKMNEPLASYLGYTVNSATIPGDVL--YIAGQPR-YNHTGQVVIYKMED 471

  Fly   318 ANIFNI----TGRQIGEYFGYSLATSDVDGDGLDD-LLIGAPMYTDPDNVEGKYDVGRVYILLQG 377
            .:: ||    :|.|||.|||..|.|.|:|.|...| ||:|||||...:    |.:.|:||:....
Mouse   472 GDV-NILQTLSGEQIGSYFGSVLTTIDIDKDSYTDLLLVGAPMYMGTE----KEEQGKVYVYAVN 531

  Fly   378 GPTEEKRWTTEHI--------RDGYHSK--------GRFGLALTTLGDVNGDGYGDFAVGAPYDG 426
            ....|.:.:.|.|        :|...:|        .|||.|:..:.|:|.||:.|..:|||.:
Mouse   532 QTRFEYQMSLEPIKQTCCSSLKDNSCTKENKNEPCGARFGTAVAAVKDLNVDGFNDVVIGAPLE- 595

  Fly   427 PEGRGVVYIFHGSPMGPLAKPSQIIKSE--QLVEGAPYPRT---FGFALSGGLDMDGNTYPDLAV 486
            .:..|.|||:|||        .:.|:.|  |.:......:|   ||.::.|.:|::|:...|:.:
Mouse   596 DDHAGAVYIYHGS--------GKTIRKEYAQRIPSGGDGKTLKFFGQSIHGEMDLNGDGLTDVTI 652

  Fly   487 GAYSSDQVFIFKSRPVAAVNAETSFASNSKLISLDDRSCQLVRDHKKVPCMLLTTCW-----SYT 546
            |....  ..:|.:|.||.|....:|..|.  :::..::|::  :.|:..|:..|.|:     |..
Mouse   653 GGLGG--AALFWARDVAVVKVTMNFEPNK--VNIQKKNCRV--EGKETVCINATMCFHVKLKSKE 711

  Fly   547 GRYLPEQLDFDVSWLLDAKKLLNPRMFFLRDEGKNI-RNQTIRLNYGQKYCLNETVYLLDKVQDK 610
            .......|.:.|:  ||:.:.:: |.||...:.:.| ||.|:|    :..|:..:.|:||| .|.
Mouse   712 DSVYEADLQYRVT--LDSLRQIS-RSFFSGTQERRIQRNLTVR----ESECIRHSFYMLDK-HDF 768

  Fly   611 LTPLEVEARYNLRSSRPLDPMVRHRRSILE--PVIDQNREIVLRDAINIQKNCGPDNICEPDLKL 673
            ...:.|...:||     .||         |  ||:|......:...|...|:||....|..||.|
Mouse   769 QDSVRVTLDFNL-----TDP---------ENGPVLDDALPNSVHGHIPFAKDCGNKERCVSDLTL 819

  Fly   674 KVSTVDKYLF---GSPEPLVIEVFISNTNEDAFEAAFYMVTPPDLQFRKLQQLGEKKDTPITCSP 735
            .|||.:|.|.   ...:...:.:.:.|..:.|:.....:...|:|.|..::::  :||   :|
Mouse   820 DVSTTEKNLLIVRSQNDKFNVSLTVKNKGDSAYNTRTVVQYSPNLIFSGIEEI--QKD---SC-- 877

  Fly   736 PTPENNHTLKCDIGNP-LESGKIAHFKISLVPEEKYGSSSSYDFYWEANSTNLEKPGSEYDNKIR 799
               |:|..:.|.:|.| |.:|.:.:|||.......:.|.::. .:..|.|.:.|...|.|||::.
Mouse   878 ---ESNQNITCRVGYPFLRTGDVVNFKIIFQFNTSHLSENAI-IHLSATSDSEEPLESLYDNEVN 938

  Fly   800 QSVGIWVDTDLDIKGTSLPDYQLYKADD-YKELENATKEDDIGPQVVHIYEIRNNRPSIIEEAEV 863
            .|:.:..:..|....::...:....|:: ..||.|:||  |||.::...|.||......:.|..:
Mouse   939 ISIPVKYEVGLQFYSSASEHHISVAANETVPELINSTK--DIGDEINVFYTIRKRGHFPMPELRL 1001

  Fly   864 FIHLPYETIVGDPLMYLLNQPETG----GKIQC------DDVAFNEYNLLLDEKL-VKKSYLQAQ 917
            .|..|..|..|.|::|     .||    ..:.|      |.:..|.     .:|: :.||.:..:
Mouse  1002 AISFPNLTSDGYPVLY-----PTGWSSSDNVNCRPRSLEDPLGINS-----GKKMTISKSEVLKR 1056

  Fly   918 GAI 920
            |.|
Mouse  1057 GTI 1059

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_001162777.1	Int_alpha	46..110	CDD:214549	19/71 (27%)
		Int_alpha	275..>316	CDD:214549	13/42 (31%)
		Int_alpha	398..451	CDD:214549	19/52 (37%)
		Int_alpha	466..>497	CDD:214549	7/30 (23%)
		Integrin_alpha2	499..893	CDD:285619	102/416 (25%)
		DUF2756	<1120..1178	CDD:298627
Itga1	NP_001028400.2	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	30..91		18/75 (24%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	101..160		14/65 (22%)
		vWA_integrins_alpha_subunit	171..351	CDD:238746	9/179 (5%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	365..417		12/75 (16%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	422..474		16/55 (29%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	475..537		26/65 (40%)
		Int_alpha	485..>528	CDD:214549	22/46 (48%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	556..614		21/66 (32%)
		Int_alpha	567..620	CDD:214549	22/61 (36%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	618..678		15/61 (25%)
		Integrin_alpha2	663..1045	CDD:285619	104/430 (24%)
		GFFKR motif	1167..1171
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832091
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740