DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment if and Itga9

DIOPT Version :9

Sequence 1:	NP_001162777.1	Gene:	if / 32661	FlyBaseID:	FBgn0001250	Length:	1396	Species:	Drosophila melanogaster
Sequence 2:	NP_598482.2	Gene:	Itga9 / 104099	MGIID:	104756	Length:	1036	Species:	Mus musculus

Alignment Length:	913	Identity:	257/913 - (28%)
Similarity:	435/913 - (47%)	Gaps:	134/913 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 ITSLILLLIA--MSAHGYNIDLPSYVRFRQSSNSMFGFSIAMHKGRSGFYGNQNNVSLIVGAPKF 79
            :.:|:|.|:|  :.|..||:|....|||:..|.|.||:::..|     |:.|...|  :|||||.
Mouse    14 LRALLLALVAAGVPAGAYNLDAQRPVRFQGPSGSFFGYAVLEH-----FHDNTRWV--LVGAPKA 71

  Fly    80 DTSRYQQGVTEAGGVFKCSLN-DDDCKLVPFD-SKGNNRNV--DKEVVDRKSYQWLGATVATGRD 140
            | |:|...|...|.||||.:: :.|.:....| ::|..|..  .|.....:..:|:|.::|....
Mouse    72 D-SKYSTSVKSPGAVFKCRVHTNPDRRCTELDMARGRTRGAPCGKTCRGDRDDEWMGVSLARQPR 135

  Fly   141 SD-LVVACAPRY--VFHTMTPSRAFRIDPVGTCF-TSHNFEEFYEV-SPC---RTNNWGYHRQGS 197
            :| .|:|||.|:  :::     .|..|.|.|.|: ...|.:...:| .||   ....:| ...||
Mouse   136 ADGRVLACAHRWKNIYY-----EADHILPHGFCYLIPSNLQAKGKVLIPCYEEYKKKYG-EEHGS 194

  Fly   198 CQAGFSAAINGNGSRLFIGAPGSWYWQGQTYSIPPDAKFPFKPPLYQPFGTGGMASSHDVTRPEN 262
            ||||.:...  ....:.:|||||:||.| |..:                          :...:|
Mouse   195 CQAGIAGFF--TEELVVMGAPGSFYWAG-TLKV--------------------------LNLTDN 230

  Fly   263 QVFSTSESASVNDD-SYLGYSMVTGDFDGDRSEDVAIGMPRGGNLVGRIVVNR-----WNMANIF 321
            ..|..::.|.:|.. :||||::..|.|......||..|.|:... :|::.:.|     ..:..||
Mouse   231 TYFKLNDEAIMNRRYTYLGYAVTAGHFSHPSITDVVGGAPQDEG-IGKVYIFRADRRSGTLIKIF 294

  Fly   322 NITGRQIGEYFGYSLATSDVDGDGLDDLLIGAPMYTDPDNVEGKYDVGRVYILL-QG-GPTEEKR 384
            ..:|:::|.|||.||...|::.|||.|||:||||:::      ..|.|:|.:.| || |..||:.
Mouse   295 QASGKKMGSYFGSSLCAVDLNMDGLSDLLVGAPMFSE------IRDEGQVTVYLNQGHGALEEQL 353

  Fly   385 WTTEHIRDGYHSKGRFGLALTTLGDVNGDGYGDFAVGAPYDGPEGRGVVYIFHGSPMGPLAKPSQ 449
            ..|.......|    ||.::..|||::.||:.|.|||||.: .:..|.|||:||...|.:.|.|.
Mouse   354 TLTGDAAYNAH----FGESIANLGDIDDDGFPDVAVGAPKE-EDFAGAVYIYHGDANGIVPKYSM 413

  Fly   450 IIKSEQLVEGAPYPRTFGFALSGGLDMDGNTYPDLAVGAYSSDQVFIFKSRPVAAVNAETSFASN 514
            .:...:|   .|..|.||.::|||:|||||.|||:.:||:.||.|.:.::|||..|:. :.|...
Mouse   414 KLSGRRL---NPTLRMFGQSISGGIDMDGNGYPDVTIGAFLSDSVVLLRARPVITVDV-SIFLPG 474

  Fly   515 SKLISLDDRSCQLVRDHKKVPCMLLTTCWSYTGRYLPEQLDFDVSWLLDA---KKLLNPRMFF-L 575
            |  |::....|.  ...:.|.|:.:|.|:.:.|:.:|.::..:.:...|.   :|...||::| |
Mouse   475 S--INITAPQCH--DGQQPVNCLNVTVCFRFHGKNVPGEIGLNYNLTADVAQKEKGQLPRVYFVL 535

  Fly   576 RDEGKNIRNQTIRLNYGQKYCLNETVYLLDKVQDKLTPLEVEARYNL---------RSSRPLDPM 631
            ..|.....::.::|::..:.|.:...::..:|||.::|:..||.|:|         |....|.|:
Mouse   536 FGETAGQVSERLQLSHMDEVCHHYVAHVKRRVQDVISPIVFEAAYSLDEHVMGEEDRELPDLTPV 600

  Fly   632 VRHRRSILEPVIDQNREIVLRDAINIQKNCGPDNICEPDL----KLKVSTVDK----YLFGSPEP 688
            :|.::.  :.:..:|:.:       .::||..:: |..||    ||.:|:||:    ...|:.:.
Mouse   601 LRWKKG--QRISQKNQTV-------FERNCQSED-CAADLQLRGKLLLSSVDEKTPHLALGAVKN 655

  Fly   689 LVIEVFISNTNEDAFEAAFYMVTPPDLQFRKLQQLGEKKDTPITCSPPTPENNHTLKCDIGNPLE 753
            :.:.:.|||..:||::|........:|.|..:.|   |::..|:|.  ..|::. |||.:|.|..
Mouse   656 ISLNISISNLGDDAYDANVSFNVSRELFFINMWQ---KEEMGISCE--LLESDF-LKCSVGFPFM 714

  Fly   754 SGKIAHFKISLVPEEKY--GSSSSYDFYWEANSTNLEKPGSEYDNKIRQSVGIWVDTDLDIKGTS 816
            ..| :.::.|::.:..:  |......|...|.|.|||:..:.:||.:..:|.:..:.|..|.|..
Mouse   715 RSK-SKYEFSVIFDTSHLSGEEEILSFIVTAQSGNLERSEALHDNTLTLTVPLVHEVDTSITGIV 778

  Fly   817 LPDYQLY----KADDYKELENATKEDDIGPQVVHI-YEIRNNRPSIIEEAEVFIHLPYETIVGDP 876
            .|...:|    .|.::.:|:    :.:...|.|:| .::.|..||.:..:.|.|..|.....|..
Mouse   779 SPTSFVYGESVDASNFIQLD----DQECHFQPVNITLQVYNMGPSTLPGSSVSISFPSRLSPGGA 839

  Fly   877 LMY 879
            .|:
Mouse   840 EMF 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_001162777.1	Int_alpha	46..110	CDD:214549	23/64 (36%)
		Int_alpha	275..>316	CDD:214549	12/46 (26%)
		Int_alpha	398..451	CDD:214549	22/52 (42%)
		Int_alpha	466..>497	CDD:214549	18/30 (60%)
		Integrin_alpha2	499..893	CDD:285619	95/409 (23%)
		DUF2756	<1120..1178	CDD:298627
Itga9	NP_598482.2	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	36..97		26/68 (38%)
		Int_alpha	45..102	CDD:214549	23/64 (36%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	109..175		17/70 (24%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	183..233		17/79 (22%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	234..290		14/56 (25%)
		Int_alpha	245..295	CDD:214549	13/50 (26%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	291..350		27/64 (42%)
		Int_alpha	301..348	CDD:214549	23/52 (44%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	352..409		22/61 (36%)
		Int_alpha	362..415	CDD:214549	23/57 (40%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	412..475		27/66 (41%)
		Int_alpha	426..>467	CDD:214549	21/40 (53%)
		Integrin_alpha2	460..904	CDD:285619	95/409 (23%)
		GFFKR motif. /evidence=ECO:0000250\|UniProtKB:Q13797	1006..1010
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832103
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740