DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment if and itgam.1

DIOPT Version :9

Sequence 1:	NP_001162777.1	Gene:	if / 32661	FlyBaseID:	FBgn0001250	Length:	1396	Species:	Drosophila melanogaster
Sequence 2:	XP_005156064.1	Gene:	itgam.1 / 101882585	ZFINID:	ZDB-GENE-110411-175	Length:	1136	Species:	Danio rerio

Alignment Length:	893	Identity:	212/893 - (23%)
Similarity:	345/893 - (38%)	Gaps:	216/893 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 RQGSCQAGFSAAINGNGSRLFIGAPGSWYWQGQTYSIPPDAKFPFKPPLYQPFGTGGMASSHDVT 258
            |....|.|||||:..: :.|.:.|.|::.|:|.                ||.|......|
Zfish   353 RMEFAQDGFSAALTSD-TDLIMTAVGAFQWKGG----------------YQLFKLNDQTS----- 395

  Fly   259 RPENQVFSTSESASVNDDSYLGYSMVTGDFDGDRSEDVAIGMPRGGNLVGRIVVNRWN-MANIFN 322
                 ||    .|....:||||||:.....  ..::...:|.||..: .|.:.|.|.: |::...
Zfish   396 -----VF----QAGSEHNSYLGYSLAIATV--YNTKYAVMGAPRHKH-EGLVTVTRIDRMSDQIQ 448

  Fly   323 I--TGRQIGEYFGYSLATSDVDGDGLDD-LLIGAPMYTDPDNVEGK-----------YDVGRVYI 373
            :  ...|||.|||..:...|::.|...| ||:.||.||:.:. |||           :....|.:
Zfish   449 LDPPKTQIGSYFGAEVCVVDLNSDSNTDLLLVSAPTYTESER-EGKVFVYSYTRRPFFSFSDVVL 512

  Fly   374 LLQGGPTEEKRWTTEHIRDGYHSKGRFGLALTTLGDVNGDGYGDFAVGAPYDGPEGRGVVYIFHG 438
            :...|                 .:||||.:|.:..|:||||:.|..||||.: .:|:|.:|||:|
Zfish   513 VGMAG-----------------QRGRFGSSLASPADLNGDGFKDVLVGAPLE-EDGKGSIYIFNG 559

  Fly   439 SPMGPLAKPSQIIKSEQLVEGAPYPRTFGFALS-GGLDMDGNTYPDLAVGAYSSDQVFIFKSRPV 502
            ...|.::..||.|....:..|..|   ||.:|| ...|...::.||:|||  |...|.:.:|||:
Zfish   560 RDGGIISSYSQRIAGSSVQSGLQY---FGVSLSQSSPDQTADSLPDIAVG--SKGAVLLLRSRPI 619

  Fly   503 AAVNAETSFASNSKLISLDDRSCQLVRDHKKVPCMLLTTCWSYTG-----RYLPEQLDFDVSWLL 562
            ..:  ||..:.|...||.....|      |......|..|::..|     |.|..::.::::  |
Zfish   620 MLL--ETKVSYNPSKISTGHTDC------KNQLQTTLIVCFTMKGYRHHKRDLNAKITYNIT--L 674

  Fly   563 DAKKLLNPRMFFLRDEGKNIRNQTIRLNYGQKYCLNETVYLLDKVQDKLTPLEVEARY---NLRS 624
            |||: .|.|.||...:  |:.:..|.:. ..:.|.|....:....:|.|.||..:.::   .|.|
Zfish   675 DAKR-QNHRAFFSAKD--NLLSNVIDIG-NTEVCKNHDFLIEACPEDALNPLSNQLKFTFEGLPS 735

  Fly   625 SRPLDPMVRHRRSILEPVIDQNREIVLRDAINIQKNCGPDNICEPDLKLKVSTVDKYLFGSP--- 686
            |:     :::.|.||.|.|....:    ..::.::.||.||:|..:|:     ||....||.
Zfish   736 SQ-----MQNLRPILLPEIKTTSD----HDLDFERECGKDNVCVDNLR-----VDFNFSGSTNIE 786

  Fly   687 ----EPLVIEVFISNTNEDAFEAAFYMVTPPDLQFRKLQQLGEKKDTPITCSPPTPENNHTL--- 744
                :.:.:.||:.|..|:::...|.:..|....:|::    ..|...:.||....|....|
Zfish   787 VGIMQEINVTVFVENRGENSYNTHFTLNYPYGFSYRRI----TSKQGRVECSSLDGEQGVRLGET 847

  Fly   745 KCDIGNPL--ESGKIAHFKISLVPEEKYGSSSSYDFYWEANSTNLEKPGSEYDNKIRQSVGIWVD 807
            :|.|..|:  ::.||. |:|:....::.....:..|.....|.|         :|..:|..:...
Zfish   848 ECAISKPILKDNTKIV-FEITYSINKEVTLGQNVIFSASVKSGN---------DKHSESSELSKK 902

  Fly   808 TDLDIKGTSLPDYQLYKADDYKELENAT-------KEDDIGPQVVHIYEIRNN-RPSIIEEAEVF 864
            ..:|:|      |.:|.|  ....||:|       .:.|:...|....:|.|: ||...   ..|
Zfish   903 KSIDVK------YGIYVA--LIRHENSTIHINFTSGKKDLSKPVQQTIKIENDLRPLAF---TAF 956

  Fly   865 IHLPYETIVGDPLMYLLNQPETGGKIQCDDVAFNEYNLLLDEKLVKKSYLQAQGAIWNSAQVSGQ 929
            |.:|.:                                |.|..:.|:|.||....:.|..:   :
Zfish   957 IRVPLK--------------------------------LGDTDIWKESTLQVSDCVKNKTE---K 986

  Fly   930 SSSSSSSGGASVH----IEKARGEGFVRGV-LVSNST---DAGDKLSPKQVEQRRQEDTLEALGD 986
            .|.::.......|    ...|....|:..| |:.|..   :....:|...:||...:..:..|..
Zfish   987 PSVTNYMDDIKKHHVLNCSVAVCAVFICDVNLIKNERKLYNITGNVSSAWIEQTGLKSAVFELVS 1051

  Fly   987 ASFVHRDRASQAVQEPQVNQTSFTTYSTSSSSSGSGAPSAQLRGHSTQ 1034
            .:.:..|               .:||...||.|.:.|||.|:   |||
Zfish  1052 TTTMDYD---------------MSTYVFFSSDSRNTAPSLQI---STQ 1081

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_001162777.1	Int_alpha	46..110	CDD:214549
		Int_alpha	275..>316	CDD:214549	12/40 (30%)
		Int_alpha	398..451	CDD:214549	24/52 (46%)
		Int_alpha	466..>497	CDD:214549	12/31 (39%)
		Integrin_alpha2	499..893	CDD:285619	90/421 (21%)
		DUF2756	<1120..1178	CDD:298627
itgam.1	XP_005156064.1	vWFA	158..331	CDD:294047
		Int_alpha	456..>498	CDD:214549	17/42 (40%)
		Int_alpha	520..572	CDD:214549	24/52 (46%)
		Integrin_alpha2	616..>908	CDD:285619	74/333 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574989
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740