Protein Alignment if and itgae.2

DIOPT Version :10

• Sequence 1: NP_523378.2
• Gene: if / 32661
• FlyBaseID: FBgn0001250
• Length: 1396
• Species: Drosophila melanogaster
• Sequence 2: XP_003200076.2
• Gene: itgae.2 / 100536705
• ZFINID: ZDB-GENE-130530-671
• Length: 1098
• Species: Danio rerio
• Alignment Length: 828
• Identity: 174/828 - (21%)
• Similarity: 313/828 - (37%)
• Gaps: 204/828 - (24%)

  Fly   167 VGTCFTSHNFEEFYEVSPCRTNNWGYHRQGSCQAGFSAAINGNGSRL--FIGAPGSWYWQGQTYS 229
            :||..|.|.|                 :....:||||:.:..|..::  ..||.|::.|.|..:
Zfish   364 IGTEGTQHGF-----------------KLQLAEAGFSSHLLYNEQKVEALFGAVGAYDWSGGVF- 410

  Fly   230 IPPDAKFPFKPPLYQPFGTGGMASSHDVTRPENQVFSTSESASVNDDSYLGYSMVTGDFDGDRSE 294
                                        .:..|.|...::|.:.....|||||:.:....   |:
Zfish   411 ----------------------------LKSGNTVKFLNDSHNETKFGYLGYSVTSAHLP---SK 444

  Fly   295 DVAI-GMPRGGNLVGRIVVNRWNMANIFNITGRQIGEYFGYSLATSDVDGD-GLDDLLIGAPMYT 357
            .:.| |.|| .||.|.:.:  ::....:.:.|.|:|.|||..|...|::.| ..|.||:|||.:
Zfish   445 TLYISGAPR-YNLTGAVFI--FDGLEKYVLHGDQVGSYFGSVLCALDINKDEHTDHLLVGAPHF- 505

  Fly   358 DPDNVEGKYDVGRVYILLQGGPTEEKRWTTEHIRDGYHSKGRFGLALTTLGDVNGDGYGDFAVGA 422
               ::.|  :.|:|.:.........:|...|...|...:..|||.|:.::||::.:.:.|.||||
Zfish   506 ---HLNG--EEGKVLVYKLNQEDRFERAPVELRGDAGQTFARFGAAIGSIGDIDNNKFNDVAVGA 565

  Fly   423 PYDGPEGRGVVYIFHGSPMGPLAKPSQIIKSEQLVEGAPYPRTFGFALSGGLDMDGNTYPDLAVG 487
            |.: ....|.|||:.|...|  .:.||.|..........|   ||.::|.| ....:..|.:|||
Zfish   566 PLE-TGSAGSVYIYSGFEEG--LRFSQKISPSDFGMKLVY---FGQSVSVG-PAPASDIPCIAVG 623

  Fly   488 AYSSDQVFIFKSRPVAAVNAETSFASNSKLISLDDRSCQLVRDHKKVP---CMLLTTCWSY-TGR 548
              |..:|.:|::.||..:         ...|.:|.....|.....|:.   .|.:|.|::. .|:
Zfish   624 --SLGRVSVFETIPVLII---------EPTIKIDTEVIALTHQMNKISSELSMKITVCFNIKKGK 677

  Fly   549 YLPEQ-----LDFDVSWLLDA----KKLLNPRMFFLRDEGKNIRNQTIRLNYGQKYCLNETVYLL 604
            ...|:     :|:::.  ||:    |:|.......::|        |..|...:: |.|:.:..|
Zfish   678 LKAEKSETQAVDYEID--LDSGASKKRLTCGADSLIKD--------TFTLTPDEE-CTNKKLTYL 731

  Fly   605 DKVQDKLTPLEVEARYNLRSSRPLDPMVRHRRSILEPVIDQNREIVLRDAINIQKNCGPDNICEP 669
            . ..|..:|::::..::|.|::...|:         .::|......:...|..:|:|...: |:|
Zfish   732 G-CFDCFSPIKIKLSFSLASNKNEAPI---------RILDAFTPTEVVKEIPFEKDCQAAD-CKP 785

  Fly   670 DLKLKVSTVDK--YLFGSPEPLVIEVFISNTNEDAFEAAFYMVTPPDLQFRKLQQLG--EKKDTP 730
            .:.|..|.:.:  ...|..:.|.|....:||.:.:::....:..|..|..||::...  .|.|..
Zfish   786 SITLSDSKISETTITMGETQNLNINFNFTNTGDPSYKTTLTLTYPSILSERKIEGAACPVKNDNQ 850

  Fly   731 ITCSPPTP-----------------ENNHTLKCDI---------GNPLESGKIAHFKIS-LVPEE 768
            |.|....|                 :.:...|.:|         |..|...:|..|.:. .:|..
Zfish   851 IQCHLQHPVFTRSAQTNLFISWQLNDKSDLKKSEIIANLTSQNNGIQLLDSRIYTFNVMYFLPIL 915

  Fly   769 KYGSSSSYDFYWEANSTNLEKPGS------------EYDNKIRQSVGIWVDTDLDIKGTSL---- 817
            ..||:       |.|...:|:.|.            :.:||...::.:.:...:|...|.|
Zfish   916 IRGSA-------EPNILRIEEGGKGKTQPIKFKIQFQGENKYGATIDVIITIKMDTSKTDLHITK 973

  Fly   818 --PDYQLYKADDYKELENATKEDDIGPQVVHIYEIRNNRPSIIE-EAEVFIHLPYET---IVGDP 876
              |:..:.:|:..||..             :||:.......||. ||.||||...:|   |:.:
Zfish   974 IQPEVCVLEANKVKEAS-------------YIYKCTLKELQIITIEANVFIHDVQDTSEKIIVE- 1024

  Fly   877 LMYLLNQPETGGKIQCDDVAFNEYNLL----LDEKLVKKSYLQAQGAI 920
                       |:...|:..::..:.:    |:..:.|...:.::|.|
Zfish  1025 -----------GQYSYDETLYSAKDTIKSFTLEVPVTKMQVMTSKGPI 1061

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_523378.2	Int_alpha	46..110	CDD:214549
		Int_alpha	275..>316	CDD:214549	13/41 (32%)
		Int_alpha	398..451	CDD:214549	20/52 (38%)
		Int_alpha	466..>497	CDD:214549	10/30 (33%)
		Integrin_alpha2	500..892	CDD:462478	84/457 (18%)
		Glutenin_hmw	<1121..1216	CDD:367362
itgae.2	XP_003200076.2	vWFA	180..355	CDD:469594
		Int_alpha	429..>465	CDD:214549	13/41 (32%)
		Int_alpha	477..>517	CDD:214549	16/45 (36%)
		Int_alpha	540..589	CDD:214549	18/51 (35%)
		Integrin_alpha2	635..>850	CDD:462478	46/245 (19%)