DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment if and itgae.2

DIOPT Version :9

Sequence 1:	NP_001162777.1	Gene:	if / 32661	FlyBaseID:	FBgn0001250	Length:	1396	Species:	Drosophila melanogaster
Sequence 2:	XP_003200076.2	Gene:	itgae.2 / 100536705	ZFINID:	ZDB-GENE-130530-671	Length:	1098	Species:	Danio rerio

Alignment Length:	828	Identity:	174/828 - (21%)
Similarity:	313/828 - (37%)	Gaps:	204/828 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 VGTCFTSHNFEEFYEVSPCRTNNWGYHRQGSCQAGFSAAINGNGSRL--FIGAPGSWYWQGQTYS 229
            :||..|.|.|                 :....:||||:.:..|..::  ..||.|::.|.|..:
Zfish   364 IGTEGTQHGF-----------------KLQLAEAGFSSHLLYNEQKVEALFGAVGAYDWSGGVF- 410

  Fly   230 IPPDAKFPFKPPLYQPFGTGGMASSHDVTRPENQVFSTSESASVNDDSYLGYSMVTGDFDGDRSE 294
                                        .:..|.|...::|.:.....|||||:.:....   |:
Zfish   411 ----------------------------LKSGNTVKFLNDSHNETKFGYLGYSVTSAHLP---SK 444

  Fly   295 DVAI-GMPRGGNLVGRIVVNRWNMANIFNITGRQIGEYFGYSLATSDVDGD-GLDDLLIGAPMYT 357
            .:.| |.|| .||.|.:.:  ::....:.:.|.|:|.|||..|...|::.| ..|.||:|||.:
Zfish   445 TLYISGAPR-YNLTGAVFI--FDGLEKYVLHGDQVGSYFGSVLCALDINKDEHTDHLLVGAPHF- 505

  Fly   358 DPDNVEGKYDVGRVYILLQGGPTEEKRWTTEHIRDGYHSKGRFGLALTTLGDVNGDGYGDFAVGA 422
               ::.|  :.|:|.:.........:|...|...|...:..|||.|:.::||::.:.:.|.||||
Zfish   506 ---HLNG--EEGKVLVYKLNQEDRFERAPVELRGDAGQTFARFGAAIGSIGDIDNNKFNDVAVGA 565

  Fly   423 PYDGPEGRGVVYIFHGSPMGPLAKPSQIIKSEQLVEGAPYPRTFGFALSGGLDMDGNTYPDLAVG 487
            |.: ....|.|||:.|...|  .:.||.|..........|   ||.::|.| ....:..|.:|||
Zfish   566 PLE-TGSAGSVYIYSGFEEG--LRFSQKISPSDFGMKLVY---FGQSVSVG-PAPASDIPCIAVG 623

  Fly   488 AYSSDQVFIFKSRPVAAVNAETSFASNSKLISLDDRSCQLVRDHKKVP---CMLLTTCWSY-TGR 548
              |..:|.:|::.||..:         ...|.:|.....|.....|:.   .|.:|.|::. .|:
Zfish   624 --SLGRVSVFETIPVLII---------EPTIKIDTEVIALTHQMNKISSELSMKITVCFNIKKGK 677

  Fly   549 YLPEQ-----LDFDVSWLLDA----KKLLNPRMFFLRDEGKNIRNQTIRLNYGQKYCLNETVYLL 604
            ...|:     :|:::.  ||:    |:|.......::|        |..|...:: |.|:.:..|
Zfish   678 LKAEKSETQAVDYEID--LDSGASKKRLTCGADSLIKD--------TFTLTPDEE-CTNKKLTYL 731

  Fly   605 DKVQDKLTPLEVEARYNLRSSRPLDPMVRHRRSILEPVIDQNREIVLRDAINIQKNCGPDNICEP 669
            . ..|..:|::::..::|.|::...|:         .::|......:...|..:|:|...: |:|
Zfish   732 G-CFDCFSPIKIKLSFSLASNKNEAPI---------RILDAFTPTEVVKEIPFEKDCQAAD-CKP 785

  Fly   670 DLKLKVSTVDK--YLFGSPEPLVIEVFISNTNEDAFEAAFYMVTPPDLQFRKLQQLG--EKKDTP 730
            .:.|..|.:.:  ...|..:.|.|....:||.:.:::....:..|..|..||::...  .|.|..
Zfish   786 SITLSDSKISETTITMGETQNLNINFNFTNTGDPSYKTTLTLTYPSILSERKIEGAACPVKNDNQ 850

  Fly   731 ITCSPPTP-----------------ENNHTLKCDI---------GNPLESGKIAHFKIS-LVPEE 768
            |.|....|                 :.:...|.:|         |..|...:|..|.:. .:|..
Zfish   851 IQCHLQHPVFTRSAQTNLFISWQLNDKSDLKKSEIIANLTSQNNGIQLLDSRIYTFNVMYFLPIL 915

  Fly   769 KYGSSSSYDFYWEANSTNLEKPGS------------EYDNKIRQSVGIWVDTDLDIKGTSL---- 817
            ..||:       |.|...:|:.|.            :.:||...::.:.:...:|...|.|
Zfish   916 IRGSA-------EPNILRIEEGGKGKTQPIKFKIQFQGENKYGATIDVIITIKMDTSKTDLHITK 973

  Fly   818 --PDYQLYKADDYKELENATKEDDIGPQVVHIYEIRNNRPSIIE-EAEVFIHLPYET---IVGDP 876
              |:..:.:|:..||..             :||:.......||. ||.||||...:|   |:.:
Zfish   974 IQPEVCVLEANKVKEAS-------------YIYKCTLKELQIITIEANVFIHDVQDTSEKIIVE- 1024

  Fly   877 LMYLLNQPETGGKIQCDDVAFNEYNLL----LDEKLVKKSYLQAQGAI 920
                       |:...|:..::..:.:    |:..:.|...:.::|.|
Zfish  1025 -----------GQYSYDETLYSAKDTIKSFTLEVPVTKMQVMTSKGPI 1061

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_001162777.1	Int_alpha	46..110	CDD:214549
		Int_alpha	275..>316	CDD:214549	13/41 (32%)
		Int_alpha	398..451	CDD:214549	20/52 (38%)
		Int_alpha	466..>497	CDD:214549	10/30 (33%)
		Integrin_alpha2	499..893	CDD:285619	84/459 (18%)
		DUF2756	<1120..1178	CDD:298627
itgae.2	XP_003200076.2	vWFA	180..355	CDD:320736
		Int_alpha	429..>465	CDD:214549	13/41 (32%)
		Int_alpha	477..>517	CDD:214549	16/45 (36%)
		Int_alpha	540..589	CDD:214549	18/51 (35%)
		Integrin_alpha2	635..>922	CDD:312071	58/324 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574905
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D743479at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.850