Protein Alignment if and itga2b.2

DIOPT Version :10

• Sequence 1: NP_523378.2
• Gene: if / 32661
• FlyBaseID: FBgn0001250
• Length: 1396
• Species: Drosophila melanogaster
• Sequence 2: XP_031750577.1
• Gene: itga2b.2 / 100495138
• XenbaseID: XB-GENE-5950162
• Length: 1034
• Species: Xenopus tropicalis
• Alignment Length: 1423
• Identity: 335/1423 - (23%)
• Similarity: 531/1423 - (37%)
• Gaps: 458/1423 - (32%)

  Fly    20 LILLLIAMSAHGYNIDLPSYVRFRQSSNSMFGFSIAMHKGRSGFYGN-QNNVSLIVGAPKFDTSR 83
            |:|||:..|.|..|:|....: ......|.||||:       .||.. .:.:|::||||:..||
 Frog     5 LLLLLLPTSVHNLNLDKNPQI-LSGPPGSYFGFSM-------DFYTTADHGMSIVVGAPRMQTS- 60

  Fly    84 YQQGVTEAGGVFKC--SLNDDDCKLVPFDSKGNNRNVDKEVVDR-------KSYQWLGATVATGR 139
             |..||..||||.|  ......|..:.||..|     |:.|:..       ||.||.||||.|.
 Frog    61 -QINVTVGGGVFLCPWKPKGSSCTNIEFDGTG-----DRSVLFAGYTMKVFKSNQWFGATVRTW- 118

  Fly   140 DSDLVVACAPRYVFHTMTPSRAFRIDPVGTCFTSHNFEEFYEVSPCRTNNWGYHRQGS---CQAG 201
             ...:|||||...::.:.........|.|.|:.::|.::.||.:|||.:...::....   |:.|
 Frog   119 -DKAIVACAPFQQWNVIREGNESGTTPTGACYITNNLQDIYEFAPCRESKTVHNYVADKRFCELG 182

  Fly   202 FSAAINGNGSRLFIGAPGSW-YWQGQTYSIPPDAKFPFKPPLYQPFGTGGMASSHDVTRPENQVF 265
            |||.||.:|: |..|||  | |:.|                ||...|...:.:.|..:.|.....
 Frog   183 FSAEINKDGT-LLAGAP--WGYYLG----------------LYVTAGLPNILARHPSSAPMQSYH 228

  Fly   266 STSESASVND--DSYLGYSMVTGDFDGDRSEDVAIGMPR---GGNLVGRIVVNRWNMANIFNITG 325
            |...|..:..  |||.|:|:..|:|.||.:.::.:|.|:   .|.:....|.|.|.  |:.:..|
 Frog   229 SQQISPVIGSSYDSYKGFSVAYGEFTGDNTPEIILGSPKYQDKGIVEIYTVSNPWK--NLISFIG 291

  Fly   326 RQIGEYFGYSLATSDVDGDGLDDLLIGAPMYTDPDNVEGK-YDVGRVYILLQGGPTEEKRWTTEH 389
            :||..|||:|:|.:||:.||.||:|:|||::. .....|| .:.|:||:.||   ...:|::..|
 Frog   292 KQIASYFGHSVAATDVNNDGKDDVLVGAPLFM-VRRTGGKLQEFGQVYVYLQ---RNNRRFSFNH 352

  Fly   390 -IRDGYHSKGRFGLALTTLGDVNGDGYGDFAVGAPYDGPEGRGVVYIFHGSPMGPLAKPSQIIKS 453
             :..|....||||.::..|||::.||:.|.|||||:.|..|.|.|||:.||..|...:||||::|
 Frog   353 PVLTGSRVYGRFGSSIAPLGDIDQDGFNDVAVGAPFGGESGGGCVYIYRGSTAGLFPQPSQILES 417

  Fly   454 EQLVEGAPYPRTFGFALSGGLDMDGNTYPDLAVGAYSSDQVFIFKSRPVAAVNAETSFASNSKLI 518
            .     .|.|..|||||.||.|:|.|.||||.|||:.:|:||||:::||..:.|...|  :.:.:
 Frog   418 P-----LPPPTQFGFALRGGTDIDNNGYPDLLVGAFEADKVFIFRAQPVVVLQASLFF--HPEAL 475

  Fly   519 SLDDRSCQLVRDHKKVPCMLLTTCWSYTGRYLPEQLDFDVSWLLDAKKLLNPRMFFLRDEGKNIR 583
            :.|.:.|.|.::...|.|..:..|...:||.||:::.......||..|....|..|..|..:..:
 Frog   476 NPDVKLCNLPQNGAAVSCFTVRVCARASGRSLPKKISLSADLQLDRLKTRFARRTFFLDSSQPSK 540

  Fly   584 NQTIRLNYGQ-KYCLNETVYLL--DKVQDKLTPLEVEARYNLRSSRPLDPMVRHRRSILEPVIDQ 645
            ...:.|:... :.|.|.|.||.  .:.:|||:|:.:...::|..::.:|        .::|.:
 Frog   541 TIDMELHSNSAQLCHNLTAYLRGESEFKDKLSPIAMSVNFSLTRAQSMD--------TVQPTL-- 595

  Fly   646 NREIVLRDAINIQKNCGPDNICEPDLKLKVS-TVDKYLFGSPEPLVIEVFISNTNEDAFEAAFYM 709
            :....|::..||..:||.||:|.|:|.|..: :.|..:.|....:.||...:|:.|.|:||..|:
 Frog   596 HGTTFLQEQTNILLDCGDDNVCIPNLHLTANWSADPLVIGVDNLVHIEFIATNSGEGAYEAELYV 660

  Fly   710 VTPPDLQFRKLQQLGEKKDTPITCSPPTPENNHTLKCDIGNPLESGKIAHFKISLVPEEKYGSSS 774
            ..||...:  :|.|||.:: .|.|||.....:..:.|::|||:::....|..:.|.......|.|
 Frog   661 WLPPGAHY--MQVLGEAEE-KILCSPKKGNESEVVVCELGNPMKNKAEIHADLQLSFSNLEDSGS 722

  Fly   775 SYDFYWEANSTNLEKPGSEYDNKIRQSVGIWVDTDLDIKGTSLPDYQLYKADDYKELENATKEDD 839
            :..|..:..|.|.....|   :.....:.:.|...|:::|:|.|...:....:::..|.:||..|
 Frog   723 TVTFQMQIKSRNTVNSTS---SVFLVEMAVKVTAFLELRGSSHPAEVVLPLPNWEPREESTKAQD 784

  Fly   840 IGPQVVHIYEIRNNRPSIIEEAEVFIHLPYETIVGDPLMYLLNQPETGGKIQCDDVAFNEYNLLL 904
            .|.:|.|:||:.|..|..: ..::.:..| ||..||..:|.|       :::.||
 Frog   785 YGEEVTHVYELHNAGPGSV-HVQLVLQSP-ETYQGDYFLYPL-------RLEADD---------- 830

  Fly   905 DEKLVKKSYLQAQGAIWNSAQVSGQSSSSSSSGGASVHIEKARGEGFVRGVLVSNSTDAGDKLSP 969
                                                                             
 Frog   831 ----------------------------------------------------------------- 830

  Fly   970 KQVEQRRQEDTLEALGDASFVHRDRASQAVQEPQVNQTSFTTYSTSSSSSGSGAPSAQLRGHSTQ 1034
                                                                         ..|.
 Frog   831 -------------------------------------------------------------RMTC 834

  Fly  1035 GHIQMAGPVQHTSSSSSSNYRSWPAQQQQQHQQLLLAGSGGSGLGSPVTFNDKSQFGGRNNNFHT 1099
            |:..|..|:|
 Frog   835 GNQSMLNPLQ------------------------------------------------------- 844

  Fly  1100 GTLDLGTLNRGNVDNELYRSQGQYQNPSQSLGQSQGQFQANANQGHYQGQNQAQFQARNPGFQGQ 1164
              ||:.|                   |::
 Frog   845 --LDILT-------------------PTE------------------------------------ 852

  Fly  1165 TSYQGQTQYSGQPGGYQTHHVTYSSGSKPYYGRENEDFYDEDNLQQATPGHWSSSSSSSSSSGTR 1229
                       :|..|                                          ||.||..
 Frog   853 -----------EPANY------------------------------------------SSRSGDH 864

  Fly  1230 RLRRSNDKDGATEKPLQIDLNSP---------------CQSARCKSIRCVVTNLGTEDGDAAFVA 1279
            ||.:...:...|::.::..:||.               |.|..|..:.|.:.||  |.|:.|.|.
 Frog   865 RLEKRELRRWDTDEGMEGGMNSTKKGEKTPRNHTVLLNCSSFLCWKVECSIQNL--ERGERATVK 927

  Fly  1280 IRARMVAKTMEK--------------LASNVPLNVSTL------AVANVTLLPFIGAPKDAIVKT 1324
            :.:.:...:..|              ..::||..:...      |.||.|:|
 Frog   928 LHSILWVPSFLKRQQQQFILLSQGSFRVTSVPYKIQPAILLAGKATANTTVL------------- 979

  Fly  1325 HEIFYKAEPEPLQVPDVVPLWVVVLAACAGALIFLLLVWLLYKCGFFNRNRPTDHSQE 1382
                 .|.|:..:   .:|||.:::.|..|..:..|.|::::|.|||:|.||....||
 Frog   980 -----WASPDGQK---EIPLWWIIVGALGGLFLLALFVFVMWKLGFFHRTRPPSDDQE 1029

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_523378.2	Int_alpha	46..110	CDD:214549	23/66 (35%)
		Int_alpha	275..>316	CDD:214549	14/45 (31%)
		Int_alpha	398..451	CDD:214549	27/52 (52%)
		Int_alpha	466..>497	CDD:214549	20/30 (67%)
		Integrin_alpha2	500..892	CDD:462478	99/395 (25%)
		Glutenin_hmw	<1121..1216	CDD:367362	3/94 (3%)
itga2b.2	XP_031750577.1	Int_alpha	30..88	CDD:214549	23/66 (35%)
		FG-GAP_3	253..317	CDD:433275	24/65 (37%)
		Int_alpha	294..345	CDD:214549	23/54 (43%)
		Int_alpha	361..415	CDD:214549	27/53 (51%)
		Int_alpha	421..>457	CDD:214549	22/35 (63%)
		Integrin_alpha2	459..913	CDD:462478	124/781 (16%)