DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment if and itga2b.2

DIOPT Version :9

Sequence 1:	NP_001162777.1	Gene:	if / 32661	FlyBaseID:	FBgn0001250	Length:	1396	Species:	Drosophila melanogaster
Sequence 2:	XP_031750577.1	Gene:	itga2b.2 / 100495138	XenbaseID:	XB-GENE-5950162	Length:	1034	Species:	Xenopus tropicalis

Alignment Length:	1423	Identity:	335/1423 - (23%)
Similarity:	531/1423 - (37%)	Gaps:	458/1423 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LILLLIAMSAHGYNIDLPSYVRFRQSSNSMFGFSIAMHKGRSGFYGN-QNNVSLIVGAPKFDTSR 83
            |:|||:..|.|..|:|....: ......|.||||:       .||.. .:.:|::||||:..||
Frog     5 LLLLLLPTSVHNLNLDKNPQI-LSGPPGSYFGFSM-------DFYTTADHGMSIVVGAPRMQTS- 60

  Fly    84 YQQGVTEAGGVFKC--SLNDDDCKLVPFDSKGNNRNVDKEVVDR-------KSYQWLGATVATGR 139
             |..||..||||.|  ......|..:.||..|     |:.|:..       ||.||.||||.|.
Frog    61 -QINVTVGGGVFLCPWKPKGSSCTNIEFDGTG-----DRSVLFAGYTMKVFKSNQWFGATVRTW- 118

  Fly   140 DSDLVVACAPRYVFHTMTPSRAFRIDPVGTCFTSHNFEEFYEVSPCRTNNWGYHRQGS---CQAG 201
             ...:|||||...::.:.........|.|.|:.::|.::.||.:|||.:...::....   |:.|
Frog   119 -DKAIVACAPFQQWNVIREGNESGTTPTGACYITNNLQDIYEFAPCRESKTVHNYVADKRFCELG 182

  Fly   202 FSAAINGNGSRLFIGAPGSW-YWQGQTYSIPPDAKFPFKPPLYQPFGTGGMASSHDVTRPENQVF 265
            |||.||.:|: |..|||  | |:.|                ||...|...:.:.|..:.|.....
Frog   183 FSAEINKDGT-LLAGAP--WGYYLG----------------LYVTAGLPNILARHPSSAPMQSYH 228

  Fly   266 STSESASVND--DSYLGYSMVTGDFDGDRSEDVAIGMPR---GGNLVGRIVVNRWNMANIFNITG 325
            |...|..:..  |||.|:|:..|:|.||.:.::.:|.|:   .|.:....|.|.|.  |:.:..|
Frog   229 SQQISPVIGSSYDSYKGFSVAYGEFTGDNTPEIILGSPKYQDKGIVEIYTVSNPWK--NLISFIG 291

  Fly   326 RQIGEYFGYSLATSDVDGDGLDDLLIGAPMYTDPDNVEGK-YDVGRVYILLQGGPTEEKRWTTEH 389
            :||..|||:|:|.:||:.||.||:|:|||::. .....|| .:.|:||:.||   ...:|::..|
Frog   292 KQIASYFGHSVAATDVNNDGKDDVLVGAPLFM-VRRTGGKLQEFGQVYVYLQ---RNNRRFSFNH 352

  Fly   390 -IRDGYHSKGRFGLALTTLGDVNGDGYGDFAVGAPYDGPEGRGVVYIFHGSPMGPLAKPSQIIKS 453
             :..|....||||.::..|||::.||:.|.|||||:.|..|.|.|||:.||..|...:||||::|
Frog   353 PVLTGSRVYGRFGSSIAPLGDIDQDGFNDVAVGAPFGGESGGGCVYIYRGSTAGLFPQPSQILES 417

  Fly   454 EQLVEGAPYPRTFGFALSGGLDMDGNTYPDLAVGAYSSDQVFIFKSRPVAAVNAETSFASNSKLI 518
            .     .|.|..|||||.||.|:|.|.||||.|||:.:|:||||:::||..:.|...|  :.:.:
Frog   418 P-----LPPPTQFGFALRGGTDIDNNGYPDLLVGAFEADKVFIFRAQPVVVLQASLFF--HPEAL 475

  Fly   519 SLDDRSCQLVRDHKKVPCMLLTTCWSYTGRYLPEQLDFDVSWLLDAKKLLNPRMFFLRDEGKNIR 583
            :.|.:.|.|.::...|.|..:..|...:||.||:::.......||..|....|..|..|..:..:
Frog   476 NPDVKLCNLPQNGAAVSCFTVRVCARASGRSLPKKISLSADLQLDRLKTRFARRTFFLDSSQPSK 540

  Fly   584 NQTIRLNYGQ-KYCLNETVYLL--DKVQDKLTPLEVEARYNLRSSRPLDPMVRHRRSILEPVIDQ 645
            ...:.|:... :.|.|.|.||.  .:.:|||:|:.:...::|..::.:|        .::|.:
Frog   541 TIDMELHSNSAQLCHNLTAYLRGESEFKDKLSPIAMSVNFSLTRAQSMD--------TVQPTL-- 595

  Fly   646 NREIVLRDAINIQKNCGPDNICEPDLKLKVS-TVDKYLFGSPEPLVIEVFISNTNEDAFEAAFYM 709
            :....|::..||..:||.||:|.|:|.|..: :.|..:.|....:.||...:|:.|.|:||..|:
Frog   596 HGTTFLQEQTNILLDCGDDNVCIPNLHLTANWSADPLVIGVDNLVHIEFIATNSGEGAYEAELYV 660

  Fly   710 VTPPDLQFRKLQQLGEKKDTPITCSPPTPENNHTLKCDIGNPLESGKIAHFKISLVPEEKYGSSS 774
            ..||...:  :|.|||.:: .|.|||.....:..:.|::|||:::....|..:.|.......|.|
Frog   661 WLPPGAHY--MQVLGEAEE-KILCSPKKGNESEVVVCELGNPMKNKAEIHADLQLSFSNLEDSGS 722

  Fly   775 SYDFYWEANSTNLEKPGSEYDNKIRQSVGIWVDTDLDIKGTSLPDYQLYKADDYKELENATKEDD 839
            :..|..:..|.|.....|   :.....:.:.|...|:::|:|.|...:....:::..|.:||..|
Frog   723 TVTFQMQIKSRNTVNSTS---SVFLVEMAVKVTAFLELRGSSHPAEVVLPLPNWEPREESTKAQD 784

  Fly   840 IGPQVVHIYEIRNNRPSIIEEAEVFIHLPYETIVGDPLMYLLNQPETGGKIQCDDVAFNEYNLLL 904
            .|.:|.|:||:.|..|..: ..::.:..| ||..||..:|.|       :::.||
Frog   785 YGEEVTHVYELHNAGPGSV-HVQLVLQSP-ETYQGDYFLYPL-------RLEADD---------- 830

  Fly   905 DEKLVKKSYLQAQGAIWNSAQVSGQSSSSSSSGGASVHIEKARGEGFVRGVLVSNSTDAGDKLSP 969

Frog   831 ----------------------------------------------------------------- 830

  Fly   970 KQVEQRRQEDTLEALGDASFVHRDRASQAVQEPQVNQTSFTTYSTSSSSSGSGAPSAQLRGHSTQ 1034
                                                                         ..|.
Frog   831 -------------------------------------------------------------RMTC 834

  Fly  1035 GHIQMAGPVQHTSSSSSSNYRSWPAQQQQQHQQLLLAGSGGSGLGSPVTFNDKSQFGGRNNNFHT 1099
            |:..|..|:|
Frog   835 GNQSMLNPLQ------------------------------------------------------- 844

  Fly  1100 GTLDLGTLNRGNVDNELYRSQGQYQNPSQSLGQSQGQFQANANQGHYQGQNQAQFQARNPGFQGQ 1164
              ||:.|                   |::
Frog   845 --LDILT-------------------PTE------------------------------------ 852

  Fly  1165 TSYQGQTQYSGQPGGYQTHHVTYSSGSKPYYGRENEDFYDEDNLQQATPGHWSSSSSSSSSSGTR 1229
                       :|..|                                          ||.||..
Frog   853 -----------EPANY------------------------------------------SSRSGDH 864

  Fly  1230 RLRRSNDKDGATEKPLQIDLNSP---------------CQSARCKSIRCVVTNLGTEDGDAAFVA 1279
            ||.:...:...|::.::..:||.               |.|..|..:.|.:.||  |.|:.|.|.
Frog   865 RLEKRELRRWDTDEGMEGGMNSTKKGEKTPRNHTVLLNCSSFLCWKVECSIQNL--ERGERATVK 927

  Fly  1280 IRARMVAKTMEK--------------LASNVPLNVSTL------AVANVTLLPFIGAPKDAIVKT 1324
            :.:.:...:..|              ..::||..:...      |.||.|:|
Frog   928 LHSILWVPSFLKRQQQQFILLSQGSFRVTSVPYKIQPAILLAGKATANTTVL------------- 979

  Fly  1325 HEIFYKAEPEPLQVPDVVPLWVVVLAACAGALIFLLLVWLLYKCGFFNRNRPTDHSQE 1382
                 .|.|:..:   .:|||.:::.|..|..:..|.|::::|.|||:|.||....||
Frog   980 -----WASPDGQK---EIPLWWIIVGALGGLFLLALFVFVMWKLGFFHRTRPPSDDQE 1029

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_001162777.1	Int_alpha	46..110	CDD:214549	23/66 (35%)
		Int_alpha	275..>316	CDD:214549	14/45 (31%)
		Int_alpha	398..451	CDD:214549	27/52 (52%)
		Int_alpha	466..>497	CDD:214549	20/30 (67%)
		Integrin_alpha2	499..893	CDD:285619	99/397 (25%)
		DUF2756	<1120..1178	CDD:298627	1/57 (2%)
itga2b.2	XP_031750577.1	Int_alpha	30..88	CDD:214549	23/66 (35%)
		VCBS	253..317	CDD:404411	24/65 (37%)
		Int_alpha	294..345	CDD:214549	23/54 (43%)
		Int_alpha	361..415	CDD:214549	27/53 (51%)
		Int_alpha	421..>457	CDD:214549	22/35 (63%)
		Integrin_alpha2	458..913	CDD:400650	124/782 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	136	1.000	Domainoid score	I4884
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	491	1.000	Inparanoid score	I1380
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D325432at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm48649
Panther	1	1.100	-	-	O	PTHR23220
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X587
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.160