Protein Alignment if and itga2

DIOPT Version :9

• Sequence 1: NP_001162777.1
• Gene: if / 32661
• FlyBaseID: FBgn0001250
• Length: 1396
• Species: Drosophila melanogaster
• Sequence 2: XP_031750117.1
• Gene: itga2 / 100492714
• XenbaseID: XB-GENE-982743
• Length: 1172
• Species: Xenopus tropicalis
• Alignment Length: 1083
• Identity: 245/1083 - (22%)
• Similarity: 410/1083 - (37%)
• Gaps: 275/1083 - (25%)

  Fly    25 IAMSAHGYNIDLPSY-VRFRQSSNSMFGFSIAMHKGRSGF------YGNQNNVSLIVGAPKFDTS 82
            ||:...|.|...|.| ||     |.:..|...:..|.|..      |||...|..     |.||.
 Frog   171 IAIVCDGSNSIYPWYAVR-----NFLEKFVQGLDIGPSSTQVSLIQYGNDPQVMY-----KMDTY 225

  Fly    83 RYQQ-------GVTEAGGVFKCSLNDDDCKLVPFDSK-------GNNRNVDKEVV---DRKSYQ- 129
            |.::       |:.:.||.     ..:..|.:.|..|       |...|.:|.:|   |.:|:.
 Frog   226 RTKEEMAKAITGIDQMGGT-----QTNTFKAIDFTRKFAFSKEYGGRPNANKVMVVITDGESHDN 285

  Fly   130 -WLGATVATGRDSDLV--------------------------VACAPRYVFHTMTPSRAFRIDPV 167
             .|...:......:::                          :|..|:..|..........::..
 Frog   286 ALLSKVIGDCEKDNIIRFGIAVLGYYNRYNIDSKNLIKEIESIASVPKEKFFFNVSDEVALLEKA 350

  Fly   168 GTCFTSHNFEEFYEVSPCRTNNWGYHRQGSCQAGFSAAINGNGSRLFIGAPGSWYWQGQTYSIPP 232
            ||.     .|..:.:.........:..:.| |.||||..:.|...|.:||.|::.|.|..  :..
 Frog   351 GTL-----GERIFSIEGTTQGGETFQMEMS-QVGFSAQYSENQGTLMLGAVGAYDWSGTV--VHE 407

  Fly   233 DAK----FPFKPPLYQPFGTGGMASSHDVTRPENQVFSTSESASVNDDSYLGYSMVTGDFDGDRS 293
            .||    ||:|             :...|....||            .||||||:..  .:...|
 Frog   408 KAKQFSVFPYK-------------AFEKVLHDRNQ------------SSYLGYSVAV--INMKNS 445

  Fly   294 EDVAIGMPRGGNLVGRIVV----NRWNMANIFNITGRQIGEYFGYSLATSDVDGDGLDD-LLIGA 353
            .:...|.|| .:..|::||    :|.|::.|....|.|||.|||..|.:.||:.|.:.| ||:||
 Frog   446 VNFVAGAPR-TDYTGQVVVYNITSRGNVSVIQIQRGEQIGSYFGSVLCSVDVNRDSITDVLLVGA 509

  Fly   354 PMYTDPDNVEGKYDVGRVYILLQGGPTEEKRWTTEHIRDGY-----HSKG-------RFGLALTT 406
            |.:.:    |.|.:.|:||:.              .||||.     ..:|       |||.|:..
 Frog   510 PTFMN----EYKKEEGQVYMF--------------SIRDGILVQREQLEGPKSLENTRFGSAIAE 556

  Fly   407 LGDVNGDGYGDFAVGAPYDGPEGRGVVYIFHGSPMGPLAKPSQIIKSEQLVEGAPYPRTFGFALS 471
            |.|::.|||.|..||||.:. :..|.:|||:|:......|.||.|.......|..|   ||.::.
 Frog   557 LSDIDLDGYNDVIVGAPLEN-QNSGAIYIFNGNQNTIRTKYSQKILGSSFNPGLQY---FGRSVD 617

  Fly   472 GGLDMDGNTYPDLAVGAYSSDQVFIFKSRPVAAVNAETSFASNSKLISLDDRSCQLVRDHKKVPC 536
            |..|::|:|..|::||||.  :.....|:.:|.|:.:..|....  |.|.:::|::.
 Frog   618 GHQDLNGDTINDVSVGAYG--KAIQLWSQHIADVSVKAIFIPQQ--IILTNKNCEVT-------- 670

  Fly   537 MLLTTCWSYTGRYLPEQLDFDVSW--LLDAKKLLNPRMFFLRDEGKNIRNQTIRLN--YGQKYCL 597
              :..|:|...|....|....|::  .||| .||:.|: ..|.:.:...::.::.|  .|.....
 Frog   671 --VRICFSAVFRPTNSQNSVAVTYNATLDA-DLLSSRV-TSRGQFRESNDRFLQRNIAIGPTESC 731

  Fly   598 NETVYLLDKVQDKLTPLEVEARYNLRSSRP-LDPMVRHRRSILEPVIDQNREIVLRDAINIQKNC 661
            .|.::.:.:..:  |...:..|.|:.:..| ..|       :|.|....:.|..    |...|:|
 Frog   732 FEHIFNVQETSN--TENALALRINVIAQNPGTSP-------VLNPYSSSSTEWF----IPFLKDC 783

  Fly   662 GPDNICEPDLKLKVSTVDK-----YLFGSPE-PLVIEVFISNTNEDAFEAAFYMVTPPDLQFRKL 720
            |.|.||..||.|::..:..     |:....: .|:.:|.::|..|:|:......|...:|.|
 Frog   784 GDDKICISDLSLQIQQIPNDIKLPYIVSMKDRRLLFQVTVTNKQENAYNTRLNAVFSENLFF--- 845

  Fly   721 QQLGEKKDTPITCSPPTPENNHTLKCDIGNPLESGKIAHFKISLV---PEEKYGSSSSYDFYWEA 782
                        .|..||.:...:.|.:||       |...:|.:   |..|.|....:|.:::.
 Frog   846 ------------ASSTTPRDGTEVLCQVGN-------AQNSVSCLIGFPFLKDGQKVIFDIWFDF 891

  Fly   783 NSTNLE-------------KPGSEYDNKIRQSVGIWVDTDLDI-KGTSLPDYQLYKADDYKELEN 833
            |..||:             :...|.||.:..|:.:..|.::.: :..::..|:::...:...:.|
 Frog   892 NLNNLQNKAFIYFQTMSDSREARENDNSVNISLPVQYDAEIHLTREANINFYEVFPGLNIPSVVN 956

  Fly   834 ATKEDDIGPQVVHIYEIRNNRPSI-IEEAEVFIHLPYETIVGDPLMYLLN-QPETGGKIQCD--- 893
              |.||||  :...:.::.:..:: ::.|.:.|::|..|...:||:|:.: |.:....:.|:
 Frog   957 --KFDDIG--LEFNFSVKVSTGTVPLKTAFLSINVPQFTKSNNPLLYITSVQTDQMSGVSCNANI 1017

  Fly   894 ----------DVAFNEYNL-----------------LLDEKLVKKSYLQAQGAIWNSAQVSGQSS 931
                      :.:|.|.||                 |...:|.:..|:.....|||....:....
 Frog  1018 NPDHIGRIPYETSFKEENLKNELNCKSARCAAIQCSLEGLQLREDYYVNVSTRIWNGTFAAAHFQ 1082

  Fly   932 SSSSSGGASVHIEKARGEGFVRGVLVSNS--------TDAGDK 966
            :....  |:..||....|.||    :||.        |..|:|
 Frog  1083 TIELV--ANAKIETMDSEIFV----ISNKDAMIPLTITKPGEK 1119

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_001162777.1	Int_alpha	46..110	CDD:214549	16/76 (21%)
		Int_alpha	275..>316	CDD:214549	14/44 (32%)
		Int_alpha	398..451	CDD:214549	23/59 (39%)
		Int_alpha	466..>497	CDD:214549	11/30 (37%)
		Integrin_alpha2	499..893	CDD:285619	84/423 (20%)
		DUF2756	<1120..1178	CDD:298627
itga2	XP_031750117.1	Int_alpha	40..88	CDD:214549
		vWFA	169..349	CDD:412136	36/192 (19%)
		Int_alpha	431..473	CDD:214549	15/44 (34%)
		Int_alpha	483..531	CDD:214549	22/65 (34%)
		Int_alpha	547..600	CDD:214549	22/53 (42%)
		Int_alpha	610..>634	CDD:214549	9/26 (35%)
		Integrin_alpha2	643..1052	CDD:400650	89/461 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000