Protein Alignment if and itga8

DIOPT Version :10

• Sequence 1: NP_523378.2
• Gene: if / 32661
• FlyBaseID: FBgn0001250
• Length: 1396
• Species: Drosophila melanogaster
• Sequence 2: XP_002939074.2
• Gene: itga8 / 100487624
• XenbaseID: XB-GENE-961825
• Length: 1081
• Species: Xenopus tropicalis
• Alignment Length: 1422
• Identity: 364/1422 - (25%)
• Similarity: 565/1422 - (39%)
• Gaps: 435/1422 - (30%)

  Fly    15 CPITSLILLLIAMSAHGYNIDLPSYVRFRQSSNSMFGFSIAMHKGRSGFY-GNQNNVSLIVGAPK 78
            ||:..:|:|....||  :|:|:.....:....:|.||:|:       .|| .:....|:::||||
 Frog    42 CPMLMVIMLSGVCSA--FNLDVEKVTVYSGPPDSYFGYSV-------DFYLPDSAKTSILIGAPK 97

  Fly    79 FDTSRYQQGVTEAGGVFKCSLND---DDCKLVPFDSKGNNRNV----DKEVVDRKSYQWLGATVA 136
            .:||:.|  :.|.|.|:.|...|   ..||.:|||.. ||||:    .|:.|:.||.||.||||.
 Frog    98 ANTSQPQ--IVEGGAVYYCPFPDTLPTGCKQIPFDIT-NNRNIRLNGTKQPVEFKSNQWFGATVR 159

  Fly   137 TGRDSDLVVACAPRYVFHTMTPSRAFRIDPVGTCFTS-HNFEEFYEVSPCRTNNWGYHRQGSCQA 200
            ..::.  ||||||.|.:.::.|  ....||||||:.: .||..:.|.||||::......||.|||
 Frog   160 AHKEK--VVACAPLYHWRSIKP--ISEKDPVGTCYIAIQNFSAYAEYSPCRSDLADPAGQGVCQA 220

  Fly   201 GFSAAINGNGSRLFIGAPGSWYWQGQ--TYSIPPDAK-FPFKPPLYQPFGTGGMASSHDVTRPEN 262
            |||.....||. |.:|.|||:|||||  |.||....| :.||..:.:..|             |.
 Frog   221 GFSLDFYKNGD-LALGGPGSFYWQGQVFTASIADIIKDYSFKSIIRKISG-------------EK 271

  Fly   263 QVFSTSESASVNDDSYLGYSMVTGDFDGDRSEDVAIGMPRGGNLVGRI-VVNRWNMANIFNITGR 326
            |   |..:.|..||||||||:..|:|..|..::|..|:|||....|.: ::|..:|..|.|.||.
 Frog   272 Q---TKMAQSAYDDSYLGYSVAVGEFTDDSVQEVVAGVPRGAQNFGYVSIINSTDMTFIQNFTGD 333

  Fly   327 QIGEYFGYSLATSDVDGDGLDDLLIGAPMYTDPDNVEGKYDVGRVYILLQGGPTEEKRWTTEHIR 391
            |:..||||::|.|||:.|||||:|:|||::.|.:......:||:||:.:|....|   :....:.
 Frog   334 QMASYFGYTVAVSDVNNDGLDDILVGAPLFMDREFESNPREVGKVYLYMQESALE---FRDPQVL 395

  Fly   392 DGYHSKGRFGLALTTLGDVNGDGYGDFAVGAPYDGPEGRGVVYIFHGSPMGPLAKPSQIIKSEQL 456
            .|....||||.|:..|||:|.|||.|.|||:|:.|.:.:|.|:|::|:..|.....|||:
 Frog   396 KGTEVFGRFGSAIAHLGDLNQDGYNDIAVGSPFAGEDRKGRVFIYNGNSNGLNTDTSQIL----- 455

  Fly   457 VEGA----PYPRTFGFALSGGLDMDGNTYPDLAVGAYSSDQVFIFKSRPVAAVNAETSFASNSKL 517
             |||    ..|..|||.|.|..|:|.|.||||.|||:.:.:..::::|||..|:|:  ...:..:
 Frog   456 -EGAWASQSMPAGFGFTLRGDSDIDKNDYPDLIVGAFGAGKAVVYRARPVITVDAQ--LLLHPMI 517

  Fly   518 ISLDDRSCQLVRDHKKVPCMLLTTCWSYTGRYLPEQL----DFDVSWLLDAKKLLNPRMFFLRDE 578
            ::.::::|||......|.|..:..|.:.:|:.:|..:    |.::.||  .:|....|..|:...
 Frog   518 LNPENKTCQLPNSEFLVTCFTVRVCVTVSGQSIPSNIVVKADLELDWL--KQKGAVKRTLFMESH 580

  Fly   579 GKNIRNQTIRLNYGQKYCLNETVYLLD--KVQDKLTPLEVEARYNLRSSRPLDPMVRHRRSILEP 641
            ..:.....|........||:..|||.:  :.:|||||:.|...|:|..|..|....      |:|
 Frog   581 QAHHSFDLIINKQRLSQCLDFLVYLREESEFRDKLTPISVNLNYSLDESAYLGDQE------LKP 639

  Fly   642 VIDQNREIVLRDAINIQKNCGPDNICEPDLKLKVSTVDK--YLFGSPEPLVIEVFISNTNEDAFE 704
            ::::.::..:::..:|..:||.||:|.|||||. :..||  .:.|....::..:...|..|.|:|
 Frog   640 ILNRYKKATIQEQAHILVDCGEDNMCIPDLKLS-ARPDKNQLVIGEENHILFIINTKNQGEGAYE 703

  Fly   705 AAFYMVTPPDLQF----RKLQQLGEKKDTPITCSPPTPENNHTLKCDIGNPLESGKIAHFKISL- 764
            |...|:.||:..:    |.::.|.:     :.|.......:..:.||:|||:.:|  .:..:.|
 Frog   704 AELRMIIPPEADYVGIERNMEGLRQ-----LNCEYKMENESRLVVCDLGNPMVAG--TNLSVGLR 761

  Fly   765 --VPEEKYGSSSSYDFYWEANSTNLEKPGSEYDNKIRQSVGIWVDTDLDIKGTSLPDYQLYKADD 827
              |...:...:.::|.|  ..|:|.:.|.|   |.:...|.|.....::|:|.|.|...:....:
 Frog   762 FVVQRLETVDAITFDLY--IKSSNKDNPNS---NFVSLQVNITAVAQVEIRGVSHPPQIILPIPN 821

  Fly   828 YKELENATKEDDIGPQVVHIYEIRNNRPSIIEEAEVFIHLPYETIVGDPLMYLLNQPETGGKIQC 892
            ::..|..::|.|:||.|.||||:.|..||.|.|.::.:..|.::
 Frog   822 WEPKEKPSEEKDVGPLVQHIYELHNIGPSAISETQLNVGWPSQS--------------------- 865

  Fly   893 DDVAFNEYNLLLDEKLVKKSYLQAQGAIWNSAQVSGQSSSSSSSGGASVHIEKARGEGFVRGVLV 957
                       .||.|:...::|.:|.:
 Frog   866 -----------RDEFLLYVFHIQTEGPL------------------------------------- 882

  Fly   958 SNSTDAGDKLSPKQVEQRRQEDTLEALGDASFVHRDRASQAVQEPQVNQTSFTTYSTSSSSSGSG 1022
              ...||..::...::....|||.|.   |:|:.....|.||....|
 Frog   883 --KCQAGSAINTLNIKPSEPEDTPEL---AAFLRNTSVSHAVSRRDV------------------ 924

  Fly  1023 APSAQLRGHSTQGHIQMAGPVQHTSSSSSSNYRSWPAQQQQQHQQLLLAGSGGSGLGSPVTFNDK 1087
            |.:..||      ||
 Frog   925 AVAEALR------HI-------------------------------------------------- 933

  Fly  1088 SQFGGRNNNFHTGTLDLGTLNRGNVDNELYRSQGQYQNPSQSLGQSQGQFQANANQGHYQGQNQA 1152
                                                                             
 Frog   934 ----------------------------------------------------------------- 933

  Fly  1153 QFQARNPGFQGQTSYQGQTQYSGQPGGYQTHHVTYSSGSKPYYGRENEDFYDEDNLQQATPGHWS 1217
                                                                      .||
 Frog   934 ----------------------------------------------------------PTP---- 936

  Fly  1218 SSSSSSSSSGTRRLRRSNDKDGATEKPLQIDLNSPCQSARCKSIRCVVTNLGTEDGDAAFVAIRA 1282
                      |:.|.                    |.:.:|..|.|.|.:||  .|..|.|.||:
 Frog   937 ----------TKLLN--------------------CTNVKCLMISCKVGHLG--GGQRAVVKIRS 969

  Fly  1283 RMVAKTM-------EKLASNV-------PLNVSTLAVANVTLLPFIGAPKDAIVKTHEIFYKAEP 1333
            |:.|.|.       ..|.:||       |.::....:...|:|          :||..|:  |.|
 Frog   970 RLWAPTFLQRKNDYYSLIANVSFEVKKMPYDIQPAKLPAATIL----------IKTSVIW--ATP 1022

  Fly  1334 EPLQVPDVVPLWVVVLAACAGALIFLLLVWLLYKCGFFNRNRP--TDHSQERQPLRN 1388
               .:...:||||::||...|.|:..:|..:::|||||:|.||  .|.:.:.|.|.|
 Frog  1023 ---NISFAIPLWVILLAILLGILVLAILTLVMWKCGFFDRARPPQDDVADDTQQLTN 1076

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_523378.2	Int_alpha	46..110	CDD:214549	22/67 (33%)
		Int_alpha	275..>316	CDD:214549	18/41 (44%)
		Int_alpha	398..451	CDD:214549	25/52 (48%)
		Int_alpha	466..>497	CDD:214549	15/30 (50%)
		Integrin_alpha2	500..892	CDD:462478	99/406 (24%)
		Glutenin_hmw	<1121..1216	CDD:367362	2/94 (2%)
itga8	XP_002939074.2	Int_alpha	71..130	CDD:214549	22/67 (33%)
		Int_alpha	335..>385	CDD:214549	23/49 (47%)
		Int_alpha	401..455	CDD:214549	25/53 (47%)
		Int_alpha	468..510	CDD:214549	19/41 (46%)
		Integrin_alpha2	502..952	CDD:462478	128/777 (16%)