Protein Alignment if and itga3b

DIOPT Version :10

• Sequence 1: NP_523378.2
• Gene: if / 32661
• FlyBaseID: FBgn0001250
• Length: 1396
• Species: Drosophila melanogaster
• Sequence 2: NP_001177238.1
• Gene: itga3b / 100331874
• ZFINID: ZDB-GENE-050411-55
• Length: 1041
• Species: Danio rerio
• Alignment Length: 1471
• Identity: 336/1471 - (22%)
• Similarity: 523/1471 - (35%)
• Gaps: 558/1471 - (37%)

  Fly     1 MSGDSIHRRRMALHCPITSLILLLIAMSAH-GYNIDLP-SYVRFRQSSNSMFGFSIAMHKGRSGF 63
            |:|.|:|.      |     :.::.|:..: |:|||:. ..::..::..|:||||:|:||.....
Zfish     1 MAGKSLHL------C-----VFVICAIQTNTGFNIDVQFPVIKEGKTKGSLFGFSVALHKQTEKA 54

  Fly    64 YGNQNNVSLIVGAPKF----DTSRYQQGVTEAGGVFKC--SLNDDDCKLVPFDSKGNNRNVDKEV 122
            ..|    .|:||||:.    ..|:::  :.|.|.|:.|  ::|.|||..:...|...:
Zfish    55 KKN----LLLVGAPQEKAQPQLSKFK--INETGAVYYCPITVNLDDCGSMDLISPPKS------- 106

  Fly   123 VDRKSYQWLGATVATGRDSDLVVACAPRYVFHTMTPSRAFRIDPVGTCFTSHN----------FE 177
            .|.....|||.|||:.|:...|:||..|||...:......|:  ||.|:...|          ..
Zfish   107 TDMLEGMWLGVTVASQRNGGRVLACGHRYVKKLLGAEEQQRM--VGKCYVRGNDLSYDPSDYWQS 169

  Fly   178 EFYEVSPCRTNNWGYHRQ---GSCQAGFSAAINGNGSRLFIGAPGSWYWQGQTYSIPPDAKFPFK 239
            |.||:  |..|    |.|   |.|..|.|..:....  ::.|.|||:.|||..:....|....:
Zfish   170 ETYEL--CDFN----HDQDLEGMCNMGISGGMTEKD--VYFGTPGSFTWQGTVHMKCRDTDSDY- 225

  Fly   240 PPLYQPFGTGGMASSHDVTRPENQVFSTSESASVNDDSYLGYSMVTGDFDGDRSE-DVAIGMPRG 303
                     .|.|:.....:.....|:.          |:|||::......|||. .|.:|.||.
Zfish   226 ---------AGDANDRSFGKLGEDKFNI----------YIGYSVLEDIKLLDRSVFTVVMGAPRD 271

  Fly   304 GNLVGRIVVNRWN--MANIFNITGRQIGEYFGYSLATSDVDGDGLDDLLIGAPMYTDPDNVEGKY 366
            ......|:.::.:  :..:.||||.|||.|||..||.:|::.|..:||::|||.|.|....||
Zfish   272 EFKGSVILADKQDLILKQLMNITGEQIGSYFGSCLAVTDLNNDDWNDLIVGAPFYFDRYKEEG-- 334

  Fly   367 DVGRVYILLQGGPTEEKRWTTEHIRDGYHSKGRFGLALTTLGDVNGDGYGDFAVGAPYDGPEGRG 431
              |.|||.:....:.:|:  ...:..|....| ||.|:..:||||.||:.|.|||||:   :..|
Zfish   335 --GAVYIFMNENGSFQKK--ASLVLKGKKGSG-FGFAIAAVGDVNQDGFQDIAVGAPF---QDSG 391

  Fly   432 VVYIFHGSPMGPLAKPSQIIKSEQLVEGAPYPRTFGFALSGGLDMDGNTYPDLAVGAYSSDQVFI 496
            .|||:.||..|...:|||:|:.:.|  |....:|||::||||:|||||.|||:.||:. .|::.:
Zfish   392 KVYIWMGSKSGITKEPSQVIEGKSL--GPSGFQTFGYSLSGGMDMDGNDYPDILVGSL-DDRIAL 453

  Fly   497 FKSRPVAAVNAETSFASNSKLISLDDRSCQLVRDHKKVP------CMLLTTCWSYT-----GRYL 550
            .:||||  ::...:|....|::               :|      |:.:..|:|||     ..:.
Zfish   454 LRSRPV--IHLSKNFTVEPKIV---------------IPSQCGNSCIKVKVCFSYTLSNGNSNFR 501

  Fly   551 PEQLDFDVSWLLDA-KKLLNPRMFFLRDEGKNIRNQTIRLNYGQKYCLNETVYLLDKVQDKLTPL 614
            .|   ..|.:.:|| :.....|:.|:.::....   |..|::....|....:.:.:.|.|||.|:
Zfish   502 KE---ITVKFTIDADQNRRGARVRFIDNKQSTF---TGLLSFSASSCQELELSVNNPVTDKLQPI 560

  Fly   615 -----------EVEARYNLRSSRPLDPMVRHRRSILEPVIDQNREIVLRDAINIQKNCGPDNICE 668
                       :.||:..|:|   ||..         ||:...:.:..:..||..|.||.||.|.
Zfish   561 VFSLNVSLNQQKAEAQQTLQS---LDSF---------PVLSGQQILTDKAEINFHKECGDDNRCS 613

  Fly   669 PDLKLKVSTVDKYLFGSPEP------------LVIEVFISNT------NEDAFEAAFYMVTPPDL 715
            .:|:||....|:..  :|.|            ||:.|.:|||      .|||.:|...:..|..|
Zfish   614 SNLQLKARFADENY--NPFPSQTLEFSSNVKKLVLMVEVSNTADENKPAEDAHQATLNISIPYSL 676

  Fly   716 QFRKLQQLGEKKDTPITCSPPTP-----ENNHTLKCDIGNPLESGKIAHFKISLVPEEKYGSSSS 775
            ::..::             ||..     ..:..:.||:|||.:|.:...|.|
Zfish   677 KYSGVR-------------PPAGFDMECSADEAVICDLGNPFKSNQKVSFII------------- 715

  Fly   776 YDFYWEANSTNLEKPGSEYDNKIRQSVGIWVDTDLDIKGTSLPDYQLYKADDYKELENATKEDDI 840
                                  |.::.||                .||......:|:.:|
Zfish   716 ----------------------IFETSGI----------------TLYTEQIQSQLQLST----- 737

  Fly   841 GPQVVHIYEIRNNRPSIIEEAEVFIHLPYETIVGDPLMYLLNQPETGGKIQCDDVAFNEYNLLLD 905
                            |.|:|::|           |::..||...|         ....::|
Zfish   738 ----------------ISEQADLF-----------PVLVTLNVKNT---------ILTTFSL--- 763

  Fly   906 EKLVKKSYLQAQGAIWNSAQVSGQSSSSSSSGGASVHIEKARGEGFVRGVLVSNSTDAGDKLSPK 970
            |||:..:..        |..|.|:|:.||:|                         |.|..|
Zfish   764 EKLIIDTSF--------SGNVIGESAMSSTS-------------------------DVGSPL--- 792

  Fly   971 QVEQRRQEDTLEALGDASFVHRDRASQAVQEPQVNQTSFTTYSTSSSSSGSGAPSAQLRGHSTQG 1035
                             .||.|
Zfish   793 -----------------EFVFR------------------------------------------- 797

  Fly  1036 HIQMAGPVQHTSSSSSSNYRSWPAQQQQQHQQLLLAGSGGSGLGSPVTFNDKSQFGGRNNNFHTG 1100
             :|:                                      ||.|:.
Zfish   798 -VQV--------------------------------------LGEPLG----------------- 806

  Fly  1101 TLDLGTLNRGNVDNE-----------LYRSQGQYQNPSQSLGQSQGQFQANANQGHYQGQNQAQF 1154
              |||||   .:|.:           ||.::...:..|:|
Zfish   807 --DLGTL---VIDFDWPYAVANGKWLLYLTEIVIKGSSES------------------------- 841

  Fly  1155 QARNPGFQGQTSYQGQTQYSGQPGGYQTHHVTYSSGSKPYYGRENEDFYDEDNLQQATPGHWSSS 1219
                              :...||..    |.|.                  ||
Zfish   842 ------------------HCVPPGNI----VNYL------------------NL----------- 855

  Fly  1220 SSSSSSSGTRRLRRSNDKDG----------ATEKPLQIDLNSPCQSARCKSIRCVVTNLGTEDGD 1274
              :.|..||:|.:|..|...          ||.|.... |:...::|.|::..|.:.|:.|:
Zfish   856 --TLSKEGTKRNKREVDSGFPHAEASVTVLATRKVAHF-LDCSKKTALCQTFSCPLLNMSTQ--- 914

  Fly  1275 AAFVAIRARMVAKT-MEKLASNVPLNVSTLAVANVTLLPFIGAPKDAIV---KTHEIFYKAEPEP 1335
             |.|.:|||:...| :|..|.  .|.|.....|.:.||    ..|.||.   :|.|  :....:|
Zfish   915 -AEVRVRARVWNGTLLEDYAK--ALRVEVKGQATLRLL----TDKPAIKMDNQTRE--FSVNIDP 970

  Fly  1336 L---QVPDVVPLWVVVLAACAGALIFLLLVWLLYKCGFFNR 1373
            :   :.|..||||::::||.||.|:..::..:|:|||||.|
Zfish   971 VLGEETPYEVPLWIIIVAAVAGILLLGIISLILWKCGFFRR 1011

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_523378.2	Int_alpha	46..110	CDD:214549	23/69 (33%)
		Int_alpha	275..>316	CDD:214549	12/41 (29%)
		Int_alpha	398..451	CDD:214549	26/52 (50%)
		Int_alpha	466..>497	CDD:214549	17/30 (57%)
		Integrin_alpha2	500..892	CDD:462478	84/437 (19%)
		Glutenin_hmw	<1121..1216	CDD:367362	8/94 (9%)
itga3b	NP_001177238.1	Int_alpha	38..101	CDD:214549	23/68 (34%)
		Int_alpha	298..346	CDD:214549	22/51 (43%)
		Int_alpha	360..411	CDD:214549	26/54 (48%)
		Integrin_alpha2	457..906	CDD:462478	133/829 (16%)