DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment if and itgav

DIOPT Version :9

Sequence 1:	NP_001162777.1	Gene:	if / 32661	FlyBaseID:	FBgn0001250	Length:	1396	Species:	Drosophila melanogaster
Sequence 2:	XP_012825487.1	Gene:	itgav / 100144691	XenbaseID:	XB-GENE-488969	Length:	1034	Species:	Xenopus tropicalis

Alignment Length:	1416	Identity:	365/1416 - (25%)
Similarity:	559/1416 - (39%)	Gaps:	433/1416 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 ITSLILL---LIAMSAHGYNIDLPSYVRFRQSSNSMFGFSI-AMHKGRSGFYGNQNNVSLIVGAP 77
            ||:|:||   |:...:..:|:|:.:......|..|.|||:: .::...||.|       |:||||
Frog     3 ITALVLLLQFLLIRLSFCFNLDVDNPFVKSGSEGSYFGFAVDFLNSDSSGSY-------LLVGAP 60

  Fly    78 KFDTSRYQQGVTEAGGVFKCSLNDDDCKLVPFDSKGNNRNVDKEVVDRKSYQWLGATVATGRDSD 142
            |.:||  |.|:.|.|.|.||...:.:|:.|.||..||......|.::.||:||.||:|....:.
Frog    61 KANTS--QPGIIEGGDVIKCDWKNSECRSVVFDPNGNRNYAVNESIEFKSHQWFGASVRAKHNK- 122

  Fly   143 LVVACAPRYVFHTMTPSRAFRIDPVGTCFTSHNFEEFYEVSPCRTN-NWGYHRQGSCQAGFSAAI 206
             ::||||.|  |..|..:..| :|||||:.:... ...|.:|||:| ......||.||.|||...
Frog   123 -IMACAPLY--HWRTEIKQER-EPVGTCYLNDGI-TVVEYAPCRSNAKTDAQEQGFCQGGFSIDF 182

  Fly   207 NGNGSRLFIGAPGSWYWQGQTYSIPPDAKF-PFKPPLYQPFGTGGMASSHDVTRPENQVFSTSES 270
            . ..:|:.:|.|||:|||||..|...|... .:||..|            .:|. |||:.:...|
Frog   183 T-EDNRVLLGGPGSFYWQGQLISDQVDEIVKKYKPEKY------------SITY-ENQLATRPAS 233

  Fly   271 ASVNDDSYLGYSMVTGDFDGDRSEDVAIGMPRGGNLVGRI-VVNRWNMANIFNITGRQIGEYFGY 334
            .|. ||||||||:..|||.||..||...|:||....:|.: :.:...|.:::|.||.|:..||||
Frog   234 LSY-DDSYLGYSVTVGDFSGDNIEDFVSGVPRAAKTLGMVSIYDGKTMTSLYNFTGEQMAAYFGY 297

  Fly   335 SLATSDVDGDGLDDLLIGAPMYTDPDNVEGK-YDVGRVYILLQ---GGPTEEKRWTTEHIRDGYH 395
            |:||||::||||.||.||||::.|..: :|| .::|:|.:.||   .||....:.|      |:.
Frog   298 SVATSDINGDGLVDLFIGAPLFMDRGS-DGKLQELGQVSVYLQHSTNGPQHLIKLT------GFE 355

  Fly   396 SKGRFGLALTTLGDVNGDGYGDFAVGAPYDGPEGRGVVYIFHGSPMGPLAKPSQIIKSEQLVEGA 460
            ...||...:..|||::|||:.|.|:.|||.|...:|:|||::|.|.|....||||::.:...:
Frog   356 IFARFSSCIGPLGDIDGDGFNDLAIAAPYGGVNKKGLVYIYNGRPNGMSIVPSQILEGQWASQ-- 418

  Fly   461 PYPRTFGFALSGGLDMDGNTYPDLAVGAYSSDQVFIFKSRPVAAVNAETSFAS-NSKLISLDDRS 524
            ..|.:||::|.|..|:|.|.||||.|||:.:|:..::::|||..|   ||... |..:::.:.::
Frog   419 HMPSSFGYSLKGATDVDENGYPDLLVGAFGADKAILYRARPVITV---TSLLEVNPTILNPESKT 480

  Fly   525 CQLVRDHKKVPCMLLTTCWSYTGR-YLPEQLDFDVSWLLDAKKLLNP--RMFFLRDE-GKNIRNQ 585
            |.| ....||.|..:..|....|: .:|:.|.|.|..:||..|....  |..||... ..:.:|.
Frog   481 CSL-PSGSKVSCFYVKFCLKAVGKGRVPQDLPFRVDVMLDKHKQKGAIRRALFLHTRLSSHSKNM 544

  Fly   586 TIRLNYGQKYCLNETVYLLD--KVQDKLTPLEVEARYNLRSSRPLDPMVRHRRSILEPVIDQNRE 648
            ||:...|.: |.....:|.|  :.:|||||:.:...:.:......|      .|.|.|:::|...
Frog   545 TIQNGSGMR-CEELQAFLRDDSEFRDKLTPITIFMEFQMDYKSTAD------SSGLLPILNQFTP 602

  Fly   649 IVLRDAINIQKNCGPDNICEPDLKLKVSTVDKYLF-GSPEPLVIEVFISNTNEDAFEAAFYMVTP 712
            ..:....:|..:||.||||:|.|||.|.:..|.:| |...||.:.|...|..|.|:||...:..|
Frog   603 TNITKQAHILLDCGEDNICKPSLKLSVESEQKKIFIGDDSPLTLIVNAQNQGEGAYEAELVVQMP 667

  Fly   713 PDLQFRKLQQLGEKKD----TPITCSPPTPENNHTLKCDIGNPLESG---KIA-HFKISLVPEEK 769
            |:..|     :|..::    :.::|:..|....|.:.||:|||:::|   |.| .|.:..:.|
Frog   668 PETDF-----IGVIRNNETFSRLSCAFKTENKTHLVVCDLGNPMKAGTQIKAALLFSVHQLTE-- 725

  Fly   770 YGSSSSYDFYWEANSTNLEKPGSEYDNKIR-QS--VGIWVDTDLDIKGTSLPDYQLYKADDYKEL 831
              ..:|..|..:..|:|      :|:|... ||  :.:.|...::::|.|.|:.......::::.
Frog   726 --MDNSVKFDLQIQSSN------QYENSSTVQSIEIALAVLAAVEVRGVSTPNEVFLPIANWEQK 782

  Fly   832 ENATKEDDIGPQVVHIYEIRNNRPSIIEEAEVFIHLPYETIVGDPLMYLLNQPETGGKIQC-DDV 895
            .|...|:||||.|.||:|:|||.||...:|.:.:..||. ...|.|:|::.. |..|.:.| .||
Frog   783 MNPETEEDIGPLVQHIFELRNNGPSGFSKAILNLQWPYR-YNNDTLLYIVKY-EIDGPMNCTSDV 845

  Fly   896 AFNEYNLLLDEKLVKKSYLQAQGAIWNSAQVSGQSSSSSSSGGASVHIEKARGEGFVRGVLVSNS 960
            ..|..|:
Frog   846 EINPLNV---------------------------------------------------------- 852

  Fly   961 TDAGDKLSPKQVEQRRQEDTLEALGDASFVHRDRASQAVQEPQVNQTSFTTYSTSSSSSGSGAPS 1025
                 |:|..|..::.:                  |:.....|.|:...|
Frog   853 -----KISASQSNEKNE------------------SRVPDNRQRNRRDLT--------------- 879

  Fly  1026 AQLRGHSTQGHIQMAGPVQHTSSSSSSNYRSWPAQQQQQHQQLLLAGSGGSGLGSPVTFNDKSQF 1090
                  :..||:|..|
Frog   880 ------AMNGHLQTLG------------------------------------------------- 889

  Fly  1091 GGRNNNFHTGTLDLGTLNRGNVDNELYRSQGQYQNPSQSLGQSQGQFQANANQGHYQGQNQAQFQ 1155

Frog   890 ----------------------------------------------------------------- 889

  Fly  1156 ARNPGFQGQTSYQGQTQYSGQPGGYQTHHVTYSSGSKPYYGRENEDFYDEDNLQQATPGHWSSSS 1220

Frog   890 ----------------------------------------------------------------- 889

  Fly  1221 SSSSSSGTRRLRRSNDKDGATEKPLQIDLNSPCQSARCKSIRCVVTNLGTEDGDAAFVAIRARMV 1285
                                            |..|.|..|.|.|..|  :.|.:|.:.:|:|:.
Frog   890 --------------------------------CGQADCLKIECHVGRL--DKGKSAILYVRSRLW 920

  Fly  1286 AKTMEK---------LASNVPLNVSTLAVANVTLLPFIGAPKDAIVKTHEIFYKAEPEPLQVPDV 1341
            ..|..|         |.|:...:|......|:. :|.|   :::.|.|..|.:..:...|.
Frog   921 TLTFLKNGNQNHSYSLKSSASFSVLEFPYKNIH-IPDI---QNSTVVTTNILWVNQAASLP---- 977

  Fly  1342 VPLWVVVLAACAGALIFLLLVWLLYKCGFFNRNRPTDHSQER---QPLRNG 1389
            ||:||::||..:|.|:..|:|:::||.|||.|.||.....||   ||..||
Frog   978 VPVWVIILAVLSGLLLLSLMVFIMYKLGFFKRVRPPQEEAEREQLQPQENG 1028

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_001162777.1	Int_alpha	46..110	CDD:214549	24/64 (38%)
		Int_alpha	275..>316	CDD:214549	19/41 (46%)
		Int_alpha	398..451	CDD:214549	24/52 (46%)
		Int_alpha	466..>497	CDD:214549	15/30 (50%)
		Integrin_alpha2	499..893	CDD:285619	117/413 (28%)
		DUF2756	<1120..1178	CDD:298627	0/57 (0%)
itgav	XP_012825487.1	Int_alpha	36..>80	CDD:214549	22/52 (42%)
		WD40 repeat	177..230	CDD:293791	22/66 (33%)
		Int_alpha	237..>277	CDD:214549	19/39 (49%)
		WD40 repeat	243..287	CDD:293791	15/43 (35%)
		Int_alpha	291..344	CDD:214549	26/53 (49%)
		WD40 repeat	296..352	CDD:293791	26/56 (46%)
		Int_alpha	356..411	CDD:214549	24/54 (44%)
		WD40 repeat	361..412	CDD:293791	23/50 (46%)
		Int_alpha	420..466	CDD:214549	21/48 (44%)
		Integrin_alpha2	457..900	CDD:369878	136/783 (17%)
		Integrin_alpha	1003..1017	CDD:334029	7/13 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	175	1.000	Domainoid score	I3587
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	491	1.000	Inparanoid score	I1380
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D325432at33208
OrthoFinder	1	1.000	-	-		FOG0001619
OrthoInspector	1	1.000	-	-		otm48649
Panther	1	1.100	-	-	LDO	PTHR23220
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X587
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.070