DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment if and itgav

DIOPT Version :10

Sequence 1:NP_523378.2 Gene:if / 32661 FlyBaseID:FBgn0001250 Length:1396 Species:Drosophila melanogaster
Sequence 2:XP_012825487.1 Gene:itgav / 100144691 XenbaseID:XB-GENE-488969 Length:1034 Species:Xenopus tropicalis


Alignment Length:1412 Identity:365/1412 - (25%)
Similarity:561/1412 - (39%) Gaps:425/1412 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 ITSLILL---LIAMSAHGYNIDLPSYVRFRQSSNSMFGFSI-AMHKGRSGFYGNQNNVSLIVGAP 77
            ||:|:||   |:...:..:|:|:.:......|..|.|||:: .::...||.|       |:||||
 Frog     3 ITALVLLLQFLLIRLSFCFNLDVDNPFVKSGSEGSYFGFAVDFLNSDSSGSY-------LLVGAP 60

  Fly    78 KFDTSRYQQGVTEAGGVFKCSLNDDDCKLVPFDSKGNNRNVDKEVVDRKSYQWLGATVATGRDSD 142
            |.:||  |.|:.|.|.|.||...:.:|:.|.||..||......|.::.||:||.||:|....:. 
 Frog    61 KANTS--QPGIIEGGDVIKCDWKNSECRSVVFDPNGNRNYAVNESIEFKSHQWFGASVRAKHNK- 122

  Fly   143 LVVACAPRYVFHTMTPSRAFRIDPVGTCFTSHNFEEFYEVSPCRTN-NWGYHRQGSCQAGFSAAI 206
             ::||||.|  |..|..:..| :|||||:.:... ...|.:|||:| ......||.||.|||...
 Frog   123 -IMACAPLY--HWRTEIKQER-EPVGTCYLNDGI-TVVEYAPCRSNAKTDAQEQGFCQGGFSIDF 182

  Fly   207 NGNGSRLFIGAPGSWYWQGQTYSIPPDAKF-PFKPPLYQPFGTGGMASSHDVTRPENQVFSTSES 270
            . ..:|:.:|.|||:|||||..|...|... .:||..|            .:|. |||:.:...|
 Frog   183 T-EDNRVLLGGPGSFYWQGQLISDQVDEIVKKYKPEKY------------SITY-ENQLATRPAS 233

  Fly   271 ASVNDDSYLGYSMVTGDFDGDRSEDVAIGMPRGGNLVGRI-VVNRWNMANIFNITGRQIGEYFGY 334
            .|. ||||||||:..|||.||..||...|:||....:|.: :.:...|.:::|.||.|:..||||
 Frog   234 LSY-DDSYLGYSVTVGDFSGDNIEDFVSGVPRAAKTLGMVSIYDGKTMTSLYNFTGEQMAAYFGY 297

  Fly   335 SLATSDVDGDGLDDLLIGAPMYTDPDNVEGK-YDVGRVYILLQ---GGPTEEKRWTTEHIRDGYH 395
            |:||||::||||.||.||||::.|..: :|| .::|:|.:.||   .||....:.|      |:.
 Frog   298 SVATSDINGDGLVDLFIGAPLFMDRGS-DGKLQELGQVSVYLQHSTNGPQHLIKLT------GFE 355

  Fly   396 SKGRFGLALTTLGDVNGDGYGDFAVGAPYDGPEGRGVVYIFHGSPMGPLAKPSQIIKSEQLVEGA 460
            ...||...:..|||::|||:.|.|:.|||.|...:|:|||::|.|.|....||||::.:...:  
 Frog   356 IFARFSSCIGPLGDIDGDGFNDLAIAAPYGGVNKKGLVYIYNGRPNGMSIVPSQILEGQWASQ-- 418

  Fly   461 PYPRTFGFALSGGLDMDGNTYPDLAVGAYSSDQVFIFKSRPVAAVNAETSFAS-NSKLISLDDRS 524
            ..|.:||::|.|..|:|.|.||||.|||:.:|:..::::|||..|   ||... |..:::.:.::
 Frog   419 HMPSSFGYSLKGATDVDENGYPDLLVGAFGADKAILYRARPVITV---TSLLEVNPTILNPESKT 480

  Fly   525 CQLVRDHKKVPCMLLTTCWSYTGR-YLPEQLDFDVSWLLDAKKLLNP--RMFFLRDE-GKNIRNQ 585
            |.| ....||.|..:..|....|: .:|:.|.|.|..:||..|....  |..||... ..:.:|.
 Frog   481 CSL-PSGSKVSCFYVKFCLKAVGKGRVPQDLPFRVDVMLDKHKQKGAIRRALFLHTRLSSHSKNM 544

  Fly   586 TIRLNYGQKYCLNETVYLLD--KVQDKLTPLEVEARYNLRSSRPLDPMVRHRRSILEPVIDQNRE 648
            ||:...|.: |.....:|.|  :.:|||||:.:...:.:......|      .|.|.|:::|...
 Frog   545 TIQNGSGMR-CEELQAFLRDDSEFRDKLTPITIFMEFQMDYKSTAD------SSGLLPILNQFTP 602

  Fly   649 IVLRDAINIQKNCGPDNICEPDLKLKVSTVDKYLF-GSPEPLVIEVFISNTNEDAFEAAFYMVTP 712
            ..:....:|..:||.||||:|.|||.|.:..|.:| |...||.:.|...|..|.|:||...:..|
 Frog   603 TNITKQAHILLDCGEDNICKPSLKLSVESEQKKIFIGDDSPLTLIVNAQNQGEGAYEAELVVQMP 667

  Fly   713 PDLQFRKLQQLGEKKD----TPITCSPPTPENNHTLKCDIGNPLESG---KIA-HFKISLVPEEK 769
            |:..|     :|..::    :.::|:..|....|.:.||:|||:::|   |.| .|.:..:.|  
 Frog   668 PETDF-----IGVIRNNETFSRLSCAFKTENKTHLVVCDLGNPMKAGTQIKAALLFSVHQLTE-- 725

  Fly   770 YGSSSSYDFYWEANSTNLEKPGSEYDNKIR-QS--VGIWVDTDLDIKGTSLPDYQLYKADDYKEL 831
              ..:|..|..:..|:|      :|:|... ||  :.:.|...::::|.|.|:.......::::.
 Frog   726 --MDNSVKFDLQIQSSN------QYENSSTVQSIEIALAVLAAVEVRGVSTPNEVFLPIANWEQK 782

  Fly   832 ENATKEDDIGPQVVHIYEIRNNRPSIIEEAEVFIHLPYETIVGDPLMYLLNQPETGGKIQC-DDV 895
            .|...|:||||.|.||:|:|||.||...:|.:.:..||. ...|.|:|::.. |..|.:.| .||
 Frog   783 MNPETEEDIGPLVQHIFELRNNGPSGFSKAILNLQWPYR-YNNDTLLYIVKY-EIDGPMNCTSDV 845

  Fly   896 AFNEYNLLLDEKLVKKSYLQAQGAIWNSAQVSGQSSSSSSSGGASVHIEKARGEGFVRGVLVSNS 960
            ..|..|:                                                          
 Frog   846 EINPLNV---------------------------------------------------------- 852

  Fly   961 TDAGDKLSPKQVEQRRQEDTLEALGDASFVHRDRASQAVQEPQVNQTSFTTYSTSSSSSGSGAPS 1025
                 |:|..|..::.:                  |:.....|.|:...|               
 Frog   853 -----KISASQSNEKNE------------------SRVPDNRQRNRRDLT--------------- 879

  Fly  1026 AQLRGHSTQGHIQMAGPVQHTSSSSSSNYRSWPAQQQQQHQQLLLAGSGGSGLGSPVTFNDKSQF 1090
                  :..||:|..|                                                 
 Frog   880 ------AMNGHLQTLG------------------------------------------------- 889

  Fly  1091 GGRNNNFHTGTLDLGTLNRGNVDNELYRSQGQYQNPSQSLGQSQGQFQANANQGHYQGQNQAQFQ 1155
                                                                             
 Frog   890 ----------------------------------------------------------------- 889

  Fly  1156 ARNPGFQGQTSYQGQTQYSGQPGGYQTHHVTYSSGSKPYYGRENEDFYDEDNLQQATPGHWSSSS 1220
                                                                             
 Frog   890 ----------------------------------------------------------------- 889

  Fly  1221 SSSSSSGTRRLRRSNDKDGATEKPLQIDLNSPCQSARCKSIRCVVTNLGTEDGDAAFVAIRARMV 1285
                                            |..|.|..|.|.|..|  :.|.:|.:.:|:|:.
 Frog   890 --------------------------------CGQADCLKIECHVGRL--DKGKSAILYVRSRLW 920

  Fly  1286 AKTMEKLAS-NVPLNVSTLAVANVTLLPF--IGAP--KDAIVKTHEIFYKAEPEPLQVPDVVPLW 1345
            ..|..|..: |...::.:.|..:|...|:  |..|  :::.|.|..|.:..:...|.    ||:|
 Frog   921 TLTFLKNGNQNHSYSLKSSASFSVLEFPYKNIHIPDIQNSTVVTTNILWVNQAASLP----VPVW 981

  Fly  1346 VVVLAACAGALIFLLLVWLLYKCGFFNRNRPTDHSQER---QPLRNG 1389
            |::||..:|.|:..|:|:::||.|||.|.||.....||   ||..||
 Frog   982 VIILAVLSGLLLLSLMVFIMYKLGFFKRVRPPQEEAEREQLQPQENG 1028

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ifNP_523378.2 Int_alpha 46..110 CDD:214549 24/64 (38%)
Int_alpha 275..>316 CDD:214549 19/41 (46%)
Int_alpha 398..451 CDD:214549 24/52 (46%)
Int_alpha 466..>497 CDD:214549 15/30 (50%)
Integrin_alpha2 500..892 CDD:462478 116/410 (28%)
Glutenin_hmw <1121..1216 CDD:367362 0/94 (0%)
itgavXP_012825487.1 Int_alpha 36..>80 CDD:214549 22/52 (42%)
WD40 repeat 177..230 CDD:293791 22/66 (33%)
Int_alpha 237..>277 CDD:214549 19/39 (49%)
WD40 repeat 243..287 CDD:293791 15/43 (35%)
Int_alpha 291..344 CDD:214549 26/53 (49%)
WD40 repeat 296..352 CDD:293791 26/56 (46%)
Int_alpha 356..411 CDD:214549 24/54 (44%)
WD40 repeat 361..412 CDD:293791 23/50 (46%)
Int_alpha 420..466 CDD:214549 21/48 (44%)
Integrin_alpha2 458..900 CDD:462478 136/782 (17%)
Integrin_alpha 1003..1017 CDD:459778 7/13 (54%)

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