DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment if and itga8

DIOPT Version :9

Sequence 1:	NP_001162777.1	Gene:	if / 32661	FlyBaseID:	FBgn0001250	Length:	1396	Species:	Drosophila melanogaster
Sequence 2:	XP_021322596.1	Gene:	itga8 / 100141346	ZFINID:	ZDB-GENE-080220-48	Length:	1059	Species:	Danio rerio

Alignment Length:	1426	Identity:	375/1426 - (26%)
Similarity:	581/1426 - (40%)	Gaps:	441/1426 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RMALHCPITSLILLLIAMSAHGYNIDLPSYVRFRQSSNSMFGFSIAMHKGRSGFY---GNQNNVS 71
            ||...|   ..::|.....|..:|:||.....:.....|.||:|:       .||   .::|.:|
Zfish    18 RMRFRC---FFLMLSFFCEAAAFNLDLEKPTVYNGPEGSYFGYSL-------DFYHPTQDRNVMS 72

  Fly    72 LIVGAPKFDTSRYQQGVTEAGGVFKC---SLNDDDCKLVPFDSKGNNR----NVDKEVVDRKSYQ 129
            ::|||||.:||  |.|:.|.|.|:.|   :.:.|.|:.:||| |.|||    |..:|.::.||:|
Zfish    73 VLVGAPKANTS--QPGIVEGGAVYYCPWPASDPDSCRQIPFD-KANNRMIKVNGTREPLEFKSHQ 134

  Fly   130 WLGATVATGRDSDLVVACAPRYVFHTMTPSRAFRIDPVGTCFTS-HNFEEFYEVSPCRTNNWGYH 193
            |.||||.|.:..  ||||||.|.:.|:..|.  .:||||||:.: .||..:.|.|||||||....
Zfish   135 WFGATVRTHKGK--VVACAPLYQWRTVKVSS--EMDPVGTCYVAVQNFSAYAEYSPCRTNNPDPE 195

  Fly   194 RQGSCQAGFSAAINGNGSRLFIGAPGSWYWQGQTYSIPPDAKFPFKPPLYQPFGTGGMA------ 252
            .||.||||||......|: |.:|.|||:|||||..                   |.|:|
Zfish   196 GQGFCQAGFSVDFTKEGT-LVVGGPGSFYWQGQVI-------------------TAGVAEILNGY 240

  Fly   253 SSHDVTRPENQVFSTSESASVNDDSYLGYSMVTGDFDGDRSEDVAIGMPRGGNLVGRI-VVNRWN 316
            |...:.|.......|..::...||||||||:..|:|.||..:::..|:|||.:..|.: |:|..|
Zfish   241 SLKTILRKVQGEKQTVAASDTYDDSYLGYSVAVGEFTGDSEQELVAGVPRGAHNFGYVTVINATN 305

  Fly   317 MANIFNITGRQIGEYFGYSLATSDVDGDGLDDLLIGAPMYTDPDNVEGKYDVGRVYILLQGGPTE 381
            :..|.|.||.|:..||||::|.:|::||||||:|:|||:|.|.:......:|||||:.||    |
Zfish   306 LTFIQNFTGEQMASYFGYTIAVTDLNGDGLDDVLVGAPLYMDREFESKPREVGRVYLYLQ----E 366

  Fly   382 EKRWTTEHIR-DGYHSKGRFGLALTTLGDVNGDGYGDFAVGAPYDGPEGRGVVYIFHGSPMGPLA 445
            :....:..|. .|.|..||:|.|:..|||:|.|||.|.|:|||:.|.:..|.|:|::|...|.:.
Zfish   367 DVLLFSPPITLTGMHLFGRYGSAIAPLGDINQDGYLDVAIGAPFAGEDRGGRVFIYNGQKSGLML 431

  Fly   446 KPSQIIKSEQLVEGAPYPRTFGFALSGGLDMDGNTYPDLAVGAYSSDQVFIFKSRPVAAVNAETS 510
            :.||::|.:....|  .|..|||.|.|..|:|.|.||||.|||:...:|..::||||..|:|:
Zfish   432 QASQVLKGDWASSG--IPAGFGFTLRGDSDLDNNQYPDLLVGAFGVSKVVAYRSRPVVTVDAQ-- 492

  Fly   511 FASNSKLISLDDRSCQLVRDHKKVPCMLLTTCWSYTGRYLPE----QLDFDVSWLLDAKKLLNPR 571
            .....::::.:|:||::......|.|:.:..|...:|..:|:    :::..:.||.....:  .|
Zfish   493 LILRPRILNPEDKSCRMPNSDIMVTCLSVNVCAKISGIGIPDYVALRMELQLDWLKQRGAV--KR 555

  Fly   572 MFFLRDEGKNIRNQTIRLNYG-QKYCLNETVYLLDKVQ--DKLTPLEVEARYNLRSSRPLDPMVR 633
            :.|: |..::.|:|.:.|..| :::|.|.:|||.|:.:  |||:|:.|...|:|..|.|...:.
Zfish   556 VLFM-DSHQHQRSQQLVLGQGDRQHCHNYSVYLRDEAEFRDKLSPISVTLNYSLDQSSPPAGLQ- 618

  Fly   634 HRRSILEPVIDQNREIVLRDAINIQKNCGPDNICEPDLKLKVSTVDK--YLFGSPEPLVIEVFIS 696
                 |.||:|...:....:..||..:||.||:|.|||||. :.:|:  .:.|....|::.:..:
Zfish   619 -----LRPVLDHYSKTFHHEQANILLDCGEDNMCIPDLKLS-AKMDRTELIIGDDNLLMLTINAA 677

  Fly   697 NTNEDAFEAAFYMVTPPDLQFRKLQQLGEKKDTPITCSPPTPENNHTLKCDIGNPL--ESGKIAH 759
            |..|.|:||..::..||:..:..:::..|.... :.|...|..:...:.||:|||:  ::.....
Zfish   678 NEGEGAYEAELHVTLPPEADYIGVERRREDLQR-LNCEHRTENDTRIVVCDLGNPMVADTNLSVG 741

  Fly   760 FKISLVPEEKYGSSSSYDFYWEANSTNLEKPGSEYDNKIRQSVGIWVDTDLDIKGTSLPDYQLYK 824
            .:.|:...|  .:..:..|..:.:|:|.:...|.   .:..::.|....:::|:|.|.|...:..
Zfish   742 LRFSVARLE--DAPPTIGFEVQIHSSNKDNSRSV---PVNLTLSIVARAEVEIRGVSHPAQVVLP 801

  Fly   825 ADDYKELENATKEDDIGPQVVHIYEIRNNRPSIIEEAEVFIHLP--YETIVGDPLMYLLNQPETG 887
            ...::..|...:||::||||.||||:.|..||.|....:.:..|  |..   :.|:|.| |..|.
Zfish   802 FPRWEPKEKPVREDEVGPQVQHIYELHNKGPSSISRTVLEVGWPSRYRE---EHLLYAL-QVITD 862

  Fly   888 GKIQCDDVAFNEYNLLLDEKLVKKSYLQAQGAIWNSAQVSGQSSSSSSSGGASVHIEKARGEGFV 952
            |.:.|                                       |::||
Zfish   863 GPVHC---------------------------------------STNSS---------------- 872

  Fly   953 RGVLVSNSTDAGDKLSPKQVEQRRQEDTLEALGDASFVHRDRASQAVQEPQVNQTSFTTYSTSSS 1017
                          |:|.::|....:||.|.||
Zfish   873 --------------LNPLELETSTLQDTPELLG-------------------------------- 891

  Fly  1018 SSGSGAPSAQLRGHSTQGHIQMAGPVQHTSSSSSSNYRSWPAQQQQQHQQLLLAGSGGSGLGSPV 1082
                                                               .|..|.|.
Zfish   892 ---------------------------------------------------FLRNSSGV------ 899

  Fly  1083 TFNDKSQFGGRNNNFHTGTLDLGTLNRGNVDNELYRSQGQYQNPSQSLGQSQGQFQANANQGHYQ 1147
                                   |..|.:|                |:||
Zfish   900 -----------------------TRRRRSV----------------SIGQ--------------- 910

  Fly  1148 GQNQAQFQARNPGFQGQTSYQGQTQYSGQPGGYQTHHVTYSSGSKPYYGRENEDFYDEDNLQQAT 1212
                              ||..:|
Zfish   911 ------------------SYNSKT----------------------------------------- 916

  Fly  1213 PGHWSSSSSSSSSSGTRRLRRSNDKDGATEKPLQIDLNSPCQSARCKSIRCVVTNLGTEDGDAAF 1277
                                                ||  |.:..|..:.|||..|  :.|.:|.
Zfish   917 ------------------------------------LN--CSNINCLMVECVVDRL--DRGQSAV 941

  Fly  1278 VAIRARMVAKT-MEKLASNVPLNVSTLAVANVTLLPFIGAPKDAIVKTHEIFYKAEPEPLQ---- 1337
            :..|:|:.|.| :::...:..|| ||::. .||.:|:              ..|||..|.|
Zfish   942 IKFRSRLWAYTFLQRRNDHYTLN-STVSF-QVTAMPY--------------RIKAETLPRQSKSI 990

  Fly  1338 -------VPDV---VPLWVVVLAACAGALIFLLLVWLLYKCGFFNRNRP--TDHSQERQPL 1386
                   :|||   :||||::||...|.|:..:|...::|||||:|.||  .|...:|:.|
Zfish   991 GTFVVWAIPDVSFAIPLWVIILAILLGLLVLAVLSLAMWKCGFFDRARPPKDDDVSDREQL 1051

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
if	NP_001162777.1	Int_alpha	46..110	CDD:214549	24/69 (35%)
		Int_alpha	275..>316	CDD:214549	19/41 (46%)
		Int_alpha	398..451	CDD:214549	24/52 (46%)
		Int_alpha	466..>497	CDD:214549	16/30 (53%)
		Integrin_alpha2	499..893	CDD:285619	106/406 (26%)
		DUF2756	<1120..1178	CDD:298627	6/57 (11%)
itga8	XP_021322596.1	Int_alpha	52..112	CDD:214549	24/68 (35%)
		Int_alpha	263..311	CDD:214549	21/47 (45%)
		Int_alpha	317..>367	CDD:214549	25/53 (47%)
		Int_alpha	383..437	CDD:214549	24/53 (45%)
		Int_alpha	450..492	CDD:214549	21/41 (51%)
		Integrin_alpha2	483..924	CDD:312071	133/771 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574978
Domainoid	1	1.000	184	1.000	Domainoid score	I3343
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	509	1.000	Inparanoid score	I1285
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D325432at33208
OrthoFinder	1	1.000	-	-		FOG0001619
OrthoInspector	1	1.000	-	-		otm24347
orthoMCL	1	0.900	-	-		OOG6_102088
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2711
SonicParanoid	1	1.000	-	-		X587
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.790