Protein Alignment goe and MMEL1

DIOPT Version :10

• Sequence 1: NP_573160.1
• Gene: goe / 32660
• FlyBaseID: FBgn0027528
• Length: 879
• Species: Drosophila melanogaster
• Sequence 2: NP_258428.2
• Gene: MMEL1 / 79258
• HGNCID: 14668
• Length: 779
• Species: Homo sapiens
• Alignment Length: 876
• Identity: 193/876 - (22%)
• Similarity: 326/876 - (37%)
• Gaps: 210/876 - (23%)

  Fly    81 AAGGAGGRTPAAITPNSTHPSANGLRALLLPGRRSFDALMSLSRKRRILYVTTACLCALLLL--- 142
            :||.||.:.|..:        ..||..|||                    :.||.|.||.:|
Human    13 SAGRAGQKRPGFL--------EGGLLLLLL--------------------LVTAALVALGVLYAD 49

  Fly   143 --------IIILLLAFWPEVPFYLRAP-----------LCLDKECVESSRQLLLWANTSKSPCHE 188
                    :...|.....|..|..|.|           :|....||.::.::|...:.:..||.:
Human    50 RRGKQLPRLASRLCFLQEERTFVKRKPRGIPEAQEVSEVCTTPGCVIAAARILQNMDPTTEPCDD 114

  Fly   189 TYEWACGNFASDYANHEYFVIKRGEWNYETYNEYQELNELNRFI-AMLPNS---QEGSVESTVSS 249
            .|::|||.:...:      ||......|..::..::  ||...: |:|.||   ...:||. ..:
Human   115 FYQFACGGWLRRH------VIPETNSRYSIFDVLRD--ELEVILKAVLENSTAKDRPAVEK-ART 170

  Fly   250 LYRSCRETDVLDKSQSDLLLKRAINAVYGWQAFRDS-NRL--QSWEYKRVLVVLQAKHGIFPYYR 311
            |||||....|::|..|..||. .:..|.||....|. |..  ..||.:|.|.::.::..    .|
Human   171 LYRSCMNQSVIEKRGSQPLLD-ILEVVGGWPVAMDRWNETVGLEWELERQLALMNSQFN----RR 230

  Fly   312 VTVE----NGFSNPHDYVITLDEGELGLPDKYFYGNDADEEVVRGYKLLLRDFAINMGIVSRE-A 371
            |.::    |...|...::|.:|:..||:|.:.:|.|......||...|   .|.:::..:.|| |
Human   231 VLIDLFIWNDDQNSSRHIIYIDQPTLGMPSREYYFNGGSNRKVREAYL---QFMVSVATLLREDA 292

  Fly   372 DLFADDIFHYERRI-VNHIEDAKADANRPINKLMRLADLKIKAPSLPILESLQAIF--------- 426
            :|..|.....|..: |..:|...|.|..|..:...:..|..:..    ||.||:.|
Human   293 NLPRDSCLVQEDMVQVLELETQLAKATVPQEERHDVIALYHRMG----LEELQSQFGLKGFNWTL 353

  Fly   427 --------PKTKITEDTEVLVRDPEVMHALSVLLSTSDKKPINNFIVWSLARKMLPHLSKEYRTL 483
                    .|.|:..|.||:|.....:..|..::.|...:.|.|::||.|....:..||:.::..
Human   354 FIQTVLSSVKIKLLPDEEVVVYGIPYLQNLENIIDTYSARTIQNYLVWRLVLDRIGSLSQRFKDT 418

  Fly   484 AETFDHALYGRTASYPRWLICSKVVRDWLPFAVDALQQQPPRQQFETMTSKSRGLNKTQGNEELL 548
            ...:..||:|......||..|...|...:..||.:|.   .|:.|.. .|||           ::
Human   419 RVNYRKALFGTMVEEVRWRECVGYVNSNMENAVGSLY---VREAFPG-DSKS-----------MV 468

  Fly   549 KLMFFSLRNQLKDSLEQAKWLEPAARQFIQKKLNEMRLQFGIPDEVLQQPT-YLAQYYNEL-ILN 611
            :.:...:|....::|::..|::..:::..|:|...:|.|.|.||.:|::.. .|.:.|:.| ...
Human   469 RELIDKVRTVFVETLDELGWMDEESKKKAQEKAMSIREQIGHPDYILEEMNRRLDEEYSNLNFSE 533

  Fly   612 NVFFVEHLEWIWTFRRSQMEK---KLGP-LAILDVIVSEMYTRDNPQAIAYSNKLNMLLVSKVLI 672
            :::|...|:.:....:..:.|   |:.| |.|:...|...:         ||...|.::....::
Human   534 DLYFENSLQNLKVGAQRSLRKLREKVDPNLWIIGAAVVNAF---------YSPNRNQIVFPAGIL 589

  Fly   673 SSNYYDYRYPVAVNFARIGT----DILEALID----------------NFST---------FLLQ 708
            ...::....|.|:||..||.    :|.....|                ||||         .:.|
Human   590 QPPFFSKEQPQALNFGGIGMVIGHEITHGFDDNGRNFDKNGNMMDWWSNFSTQHFREQSECMIYQ 654

  Fly   709 FNTQSTDISDAAPEIRYAQPDVNCLAAGQPPRLVHELNELSSNALKSFHVTLSAARTAARALSNF 773
            :...|.|::|        :.:||            ..|.|..|...:     ...|.|.:|...:
Human   655 YGNYSWDLAD--------EQNVN------------GFNTLGENIADN-----GGVRQAYKAYLKW 694

  Fly   774 VNAIDAGSAIQGSGIDQANTYEALGLTRRLRIPGLRSFNENELFTLSYMQQHCSTTIADKDYARI 838
            :        .:| |.||             ::||| .....:||.::|.|..|.:...:.....|
Human   695 M--------AEG-GKDQ-------------QLPGL-DLTHEQLFFINYAQVWCGSYRPEFAIQSI 736

  Fly   839 KPLVESQLAESYLFNATWQHIQFLPRSTNCA 869
            |..|.|.|  .|....:.|::.....:.:||
Human   737 KTDVHSPL--KYRVLGSLQNLAAFADTFHCA 765

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
goe	NP_573160.1	GluZincin	184..>692	CDD:472708	128/543 (24%)
MMEL1	NP_258428.2	M13	111..777	CDD:341056	168/750 (22%)