DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4678 and CPZ

DIOPT Version :9

Sequence 1:	NP_001138211.1	Gene:	CG4678 / 32652	FlyBaseID:	FBgn0030778	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001014447.2	Gene:	CPZ / 8532	HGNCID:	2333	Length:	652	Species:	Homo sapiens

Alignment Length:	496	Identity:	182/496 - (36%)
Similarity:	256/496 - (51%)	Gaps:	69/496 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 DSMQMQHHQMTAEPGLPE--PRAYMPDAQHLDFVYHDHEELTRFLRATSARYPNLTALYSIGKSI 102
            |.::.....:.|:..||.  |..:      :.|.:|.:.::.|.||.|::|..::...||||:|.
Human   159 DPLEKLRGGLEADEALPSGLPPTF------IRFSHHSYAQMVRVLRRTASRCAHVARTYSIGRSF 217

  Fly   103 QGRDLWVMVVSSSPYEHMVGKPDVKYVGNIHGNEPVGREMLLHLIQYFVTSYNT-DQYVKWLLDN 166
            .||:|.|:..||.|.:|.:.:|:||.:|||||||..|||||::|.||..:.|.. :..::.||:.
Human   218 DGRELLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNT 282

  Fly   167 TRIHILPTMNPDGYAV-SKEGTCDGG--QGRYNARGFDLNRNFPD----YFKQNNKRG------- 217
            ||||:||:||||||.| :.||....|  .||.||:..||||||||    |::....||
Human   283 TRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHIP 347

  Fly   218 ----------QPETDSVKDWISKIQFVLSGSLHGGALVASYPYDNTPNSRLLKGICRSSALCAMF 272
                      .|||.::..|:..|.||||.|||||.||.|||:|.:.:.:..|          ||
Human   348 IPQHYWWGKVAPETKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFSKHPQEEK----------MF 402

  Fly   273 QTYSAAPSLTPDDDVFKHLSLVYARNHAKMSRGVACKSATPAFENG-ITNGAAWYPLTGGMQDYN 336
                   |.|||:.:||.||..||..|..|......:......:.| |.|||.||..||||.|:|
Human   403 -------SPTPDEKMFKLLSRAYADVHPMMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFN 460

  Fly   337 YVWYGCMEITLEISCCKFPPAYELKKYWEDNQLSLIKFLAEAHRGVQGFVFDPAGMPIERASIKI 401
            |:...|.|||:|:.|.||||...|...|:.|:.||:.|:...|||::|.|.|..|.|::.|.|.:
Human   461 YLHTNCFEITVELGCVKFPPEEALYILWQHNKESLLNFVETVHRGIKGVVTDKFGKPVKNARISV 525

  Fly   402 KGRDVGFQTTKYGEFWRILLPGYYKVEVFAEGFAPREVEFVIVE---QHPTLLNVTLQPSKRLEG 463
            ||......|...|::||:|.||.:.|...|.|:| :.::.||:.   :....::..|||.    |
Human   526 KGIRHDITTAPDGDYWRLLPPGIHIVIAQAPGYA-KVIKKVIIPARMKRAGRVDFILQPL----G 585

  Fly   464 IGP---------MGPGGVPVGGVVGPGGLYRPIPSPQHYRP 495
            :||         .||.. |:||....|....|.|.....:|
Human   586 MGPKNFIHGLRRTGPHD-PLGGASSLGEATEPDPLRARRQP 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4678	NP_001138211.1	M14_CP_N-E_like	72..377	CDD:199842	136/330 (41%)
CG4678	NP_001138211.1	Peptidase_M14NE-CP-C_like	381..455	CDD:200604	23/76 (30%)
CPZ	NP_001014447.2	CRD_Carboxypeptidase_Z	40..167	CDD:143556	1/7 (14%)
		M14_CPZ	187..501	CDD:199849	136/330 (41%)
		Peptidase_M14NE-CP-C_like	505..581	CDD:200604	23/76 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	595..629		9/32 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2649
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101221at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820