DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4678 and Cpz

DIOPT Version :9

Sequence 1:	NP_001138211.1	Gene:	CG4678 / 32652	FlyBaseID:	FBgn0030778	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	XP_038948430.1	Gene:	Cpz / 83575	RGDID:	620496	Length:	660	Species:	Rattus norvegicus

Alignment Length:	499	Identity:	178/499 - (35%)
Similarity:	251/499 - (50%)	Gaps:	82/499 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 DSMQMQHHQMTAEPGLPE--PRAYMPDAQHLDFVYHDHEELTRFLRATSARYPNLTALYSIGKSI 102
            |.::....::..|..||.  |..:      :.|.:|.:.::.|.|:.|:||...:...||||:|.
  Rat   170 DPLEQLRGELDVEEALPSGLPPTF------IRFAHHSYAQMVRVLKRTAARCSQVAKTYSIGRSF 228

  Fly   103 QGRDLWVMVVSSSPYEHMVGKPDVKYVGNIHGNEPVGREMLLHLIQYFVTSYNT-DQYVKWLLDN 166
            :|:||.|:..||.|.:|.:.:|:||.:|||||||..|||:|::|.||..:.|.. :..::.||:.
  Rat   229 EGKDLVVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREILIYLAQYLCSEYLLGNPRIQRLLNT 293

  Fly   167 TRIHILPTMNPDGYAV-SKEGTCDGG--QGRYNARGFDLNRNFPD----YFKQNNKRG------- 217
            ||||:||:||||||.| :.||....|  .||.||:..||||||||    |::..:.||
  Rat   294 TRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLASTRGVRTDHIP 358

  Fly   218 ----------QPETDSVKDWISKIQFVLSGSLHGGALVASYPYDNTPNSRLLKGICRSSALCAMF 272
                      .|||.::..||..|.||||.|||||.||.|||:|.:.:....|          ||
  Rat   359 ISQYYWWGKVAPETKAIMKWIQTIPFVLSASLHGGDLVVSYPFDFSKHPHEEK----------MF 413

  Fly   273 QTYSAAPSLTPDDDVFKHLSLVYARNHAKMSRGVACKSATPAFENG-ITNGAAWYPLTGGMQDYN 336
                   |.|||:.:||.|:..||..|..|......:......:.| |.|||.||..||||.|:|
  Rat   414 -------SPTPDEKMFKLLARAYADVHPMMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFN 471

  Fly   337 YVWYGCMEITLEISCCKFPPAYELKKYWEDNQLSLIKFLAEAHRGVQGFVFDPAGMPIERASIKI 401
            |:...|.|||:|:.|.||||...|...|:.|:..|:.||...|||::|.|.|..|.|::.|.|.:
  Rat   472 YLHTNCFEITVELGCVKFPPEEALYGLWQHNKEPLLNFLEMVHRGIKGVVTDKYGKPVKNARILV 536

  Fly   402 KGRDVGFQTTKYGEFWRILLPGYYKVEVFAEGFAPREVEFVIVEQHPTLLNVTLQPSKRLEG--- 463
            ||......|...|::||:|.||.:.|...|.|::            ..:..||:....:..|
  Rat   537 KGIRHDVTTAPDGDYWRLLPPGSHIVIAQAPGYS------------KVMKRVTIPLRMKRAGRVD 589

  Fly   464 --IGPMGPGGVPVGGVVGPGGLYRPIP---SPQ------HYRPP 496
              :.|:|.|  |...:.||.   |.:|   .||      .:.||
  Rat   590 FILQPLGTG--PKNFLPGPS---RALPRSLDPQGAPAQLDFEPP 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4678	NP_001138211.1	M14_CP_N-E_like	72..377	CDD:199842	135/330 (41%)
CG4678	NP_001138211.1	Peptidase_M14NE-CP-C_like	381..455	CDD:200604	21/73 (29%)
Cpz	XP_038948430.1	CRD_FZ	51..178	CDD:413323	1/7 (14%)
		M14_CPZ	198..512	CDD:349439	135/330 (41%)
		Peptidase_M14NE-CP-C_like	516..592	CDD:200604	23/87 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2649
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101221at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820