DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG4678 and CPXM1

DIOPT Version :9

Sequence 1:NP_001138211.1 Gene:CG4678 / 32652 FlyBaseID:FBgn0030778 Length:527 Species:Drosophila melanogaster
Sequence 2:NP_062555.1 Gene:CPXM1 / 56265 HGNCID:15771 Length:734 Species:Homo sapiens


Alignment Length:507 Identity:174/507 - (34%)
Similarity:248/507 - (48%) Gaps:87/507 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 ILRTPLVAGHQLQLLLLPSVLL------LMLHLLLCDAKTVNPGDSMQMQHHQMTAEPGLPEPRA 60
            :|..|.||..   :.|||...|      |...:|.|...  :|.|..            |..|.:
Human   242 LLPEPQVARF---IRLLPQTWLQGGAPCLRAEILACPVS--DPNDLF------------LEAPAS 289

  Fly    61 YMPDAQHLDFVYHDHEELTRFLRATSARYPNLTALYSIGKSIQGRDLWVMVVSSSPYEHMVGKPD 125
            ...|.  |||.:|:::.:.:.::....:.||:|.:||||||.||..|:||.:|..|.||.:|:|:
Human   290 GSSDP--LDFQHHNYKAMRKLMKQVQEQCPNITRIYSIGKSYQGLKLYVMEMSDKPGEHELGEPE 352

  Fly   126 VKYVGNIHGNEPVGREMLLHLIQYFVTSY-NTDQYVKWLLDNTRIHILPTMNPDGYAVSKEGTCD 189
            |:||..:||||.:|||:||.|:|:....: ..:..|..||...|||:||:||||||.::.....:
Human   353 VRYVAGMHGNEALGRELLLLLMQFLCHEFLRGNPRVTRLLSEMRIHLLPSMNPDGYEIAYHRGSE 417

  Fly   190 ---GGQGRYNARGFDLNRNF---------------------------PDYFKQNNKRGQPETDSV 224
               ..:||:|.:..|||.||                           |.|:...|....|||.:|
Human   418 LVGWAEGRWNNQSIDLNHNFADLNTPLWEAQDDGKVPHIVPNHHLPLPTYYTLPNATVAPETRAV 482

  Fly   225 KDWISKIQFVLSGSLHGGALVASYPYDNTPNSRLLKGICRSSALCAMFQTYSAAPSL--TPDDDV 287
            ..|:.:|.||||.:||||.||.|||:|                   |.:|..||..|  ||||.|
Human   483 IKWMKRIPFVLSANLHGGELVVSYPFD-------------------MTRTPWAARELTPTPDDAV 528

  Fly   288 FKHLSLVYARNHAKM---SRGVACKSATPAFENGITNGAAWYPLTGGMQDYNYVWYGCMEITLEI 349
            |:.||.|||.::..|   ||. .|.|...:....|.|||.|:.:.|.|.|::|:...|.|:|:|:
Human   529 FRWLSTVYAGSNLAMQDTSRR-PCHSQDFSVHGNIINGADWHTVPGSMNDFSYLHTNCFEVTVEL 592

  Fly   350 SCCKFPPAYELKKYWEDNQLSLIKFLAEAHRGVQGFVFD-PAGMPIERASIKIKGRDVGFQTTKY 413
            ||.|||...||.:.||:|:.:|:.:|.:...|:.|.|.| ...:.|..|.|.:.|.:....|...
Human   593 SCDKFPHENELPQEWENNKDALLTYLEQVRMGIAGVVRDKDTELGIADAVIAVDGINHDVTTAWG 657

  Fly   414 GEFWRILLPGYYKVEVFAEGF--APREVEFVIVEQHPTLLN--VTLQPSKRL 461
            |::||:|.||.|.|...|||:  ..|... |..|:.|...|  :|..|.:||
Human   658 GDYWRLLTPGDYMVTASAEGYHSVTRNCR-VTFEEGPFPCNFVLTKTPKQRL 708

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4678NP_001138211.1 M14_CP_N-E_like 72..377 CDD:199842 126/340 (37%)
Peptidase_M14NE-CP-C_like 381..455 CDD:200604 25/78 (32%)
CPXM1NP_062555.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 30..62
FA58C 116..273 CDD:238014 9/33 (27%)
FA58C 117..274 CDD:214572 10/34 (29%)
M14_CPX_like 295..620 CDD:199851 129/344 (38%)
Peptidase_M14NE-CP-C_like 624..700 CDD:200604 25/76 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2649
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D101221at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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