DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4678 and Cpxm1

DIOPT Version :9

Sequence 1:	NP_001138211.1	Gene:	CG4678 / 32652	FlyBaseID:	FBgn0030778	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_062670.2	Gene:	Cpxm1 / 56264	MGIID:	1934569	Length:	722	Species:	Mus musculus

Alignment Length:	462	Identity:	164/462 - (35%)
Similarity:	238/462 - (51%)	Gaps:	68/462 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 EPRAYMPDA------QHLDFVYHDHEELTRFLRATSARYPNLTALYSIGKSIQGRDLWVMVVSSS 115
            :|....|:|      ..|||.:|:::.:.:.::..:.:.||:|.:||||||.||..|:||.:|..
Mouse   267 DPNDLFPEAHTLGSSNSLDFRHHNYKAMRKLMKQVNEQCPNITRIYSIGKSHQGLKLYVMEMSDH 331

  Fly   116 PYEHMVGKPDVKYVGNIHGNEPVGREMLLHLIQYFVTSY-NTDQYVKWLLDNTRIHILPTMNPDG 179
            |.||.:|:|:|:||..:||||.:|||:||.|:|:....: ..|..|..||..||||:||:|||||
Mouse   332 PGEHELGEPEVRYVAGMHGNEALGRELLLLLMQFLCHEFLRGDPRVTRLLTETRIHLLPSMNPDG 396

  Fly   180 Y--AVSKEGTCDG-GQGRYNARGFDLNRNF---------------------------PDYFKQNN 214
            |  |..:.....| .:||:..:|.|||.||                           |.|:...|
Mouse   397 YETAYHRGSELVGWAEGRWTHQGIDLNHNFADLNTQLWYAEDDGLVPDTVPNHHLPLPTYYTLPN 461

  Fly   215 KRGQPETDSVKDWISKIQFVLSGSLHGGALVASYPYDNTPNSRLLKGICRSSALCAMFQTYSAAP 279
            ....|||.:|..|:.:|.||||.:||||.||.|||:|                   |.:|..||.
Mouse   462 ATVAPETWAVIKWMKRIPFVLSANLHGGELVVSYPFD-------------------MTRTPWAAR 507

  Fly   280 SL--TPDDDVFKHLSLVYARNHAKM--SRGVACKSATPAFENGITNGAAWYPLTGGMQDYNYVWY 340
            .|  ||||.||:.||.|||..:..|  :....|.|...:....:.|||.|:.:.|.|.|::|:..
Mouse   508 ELTPTPDDAVFRWLSTVYAGTNRAMQDTDRRPCHSQDFSLHGNVINGADWHTVPGSMNDFSYLHT 572

  Fly   341 GCMEITLEISCCKFPPAYELKKYWEDNQLSLIKFLAEAHRGVQGFVFD-PAGMPIERASIKIKGR 404
            .|.|:|:|:||.|||...||.:.||:|:.:|:.:|.:...|:.|.|.| ...:.|..|.|.::|.
Mouse   573 NCFEVTVELSCDKFPHEKELPQEWENNKDALLTYLEQVRMGITGVVRDKDTELGIADAVIAVEGI 637

  Fly   405 DVGFQTTKYGEFWRILLPGYYKVEVFAEGF-APREVEFVIVEQHPTLLN--VTLQPSKRLEGI-- 464
            :....|...|::||:|.||.|.|...|||: ..|:...|..|:.|...|  :|..|.:||..:
Mouse   638 NHDVTTAWGGDYWRLLTPGDYVVTASAEGYHTVRQHCQVTFEEGPVPCNFLLTKTPKERLRELLA 702

  Fly   465 --GPMGP 469
              |.:.|
Mouse   703 TRGKLPP 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4678	NP_001138211.1	M14_CP_N-E_like	72..377	CDD:199842	127/339 (37%)
CG4678	NP_001138211.1	Peptidase_M14NE-CP-C_like	381..455	CDD:200604	25/77 (32%)
Cpxm1	NP_062670.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..54
		FA58C	106..262	CDD:238014
		FA58C	107..263	CDD:214572
		M14_CPX_like	284..609	CDD:199851	130/343 (38%)
		Peptidase_M14NE-CP-C_like	613..689	CDD:200604	25/75 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2649
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810